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Articles 122251 - 122280 of 255948
Full-Text Articles in Life Sciences
Ici, Sprayseed And The W.A. Department Of Agriculture, Geoff Pearce
Ici, Sprayseed And The W.A. Department Of Agriculture, Geoff Pearce
All other publications
The story which follows tells how the systems for planting cereals, developed on research stations over a period of about 40 years, has been changed by a Commercial Chemical Company using newly developed herbicides to replace cultivation.
Structural Characterization Of Tick Cement Cones Collected From In Vivo And Artifical Membrane Blood-Fed Lone Star Ticks (Ambylomma Americanum), Rebekah Bullard, Paige Allen, Chien-Chung Chao, Jessica Douglas, Pradipta K. Das, Sarah E. Morgan, Wei-Mei Ching, Shahid Karim
Structural Characterization Of Tick Cement Cones Collected From In Vivo And Artifical Membrane Blood-Fed Lone Star Ticks (Ambylomma Americanum), Rebekah Bullard, Paige Allen, Chien-Chung Chao, Jessica Douglas, Pradipta K. Das, Sarah E. Morgan, Wei-Mei Ching, Shahid Karim
Faculty Publications
The Lone Star tick, Amblyomma americanum, is endemic to the southeastern United States and capable of transmitting pathogenic diseases and causing non-pathogenic conditions. To remain firmly attached to the host, the tick secretes a proteinaceous matrix termed the cement cone which hardens around the tick’s mouthparts to assist in the attachment of the tick as well as to protect the mouthparts from the host immune system. Cement cones collected from ticks on a host are commonly contaminated with host skin and hair making analysis of the cone difficult. To reduce the contamination found in the cement cone, we have adapted …
Understanding Tradeoffs Between Food And Predation Risks In A Specialist Mammalian Herbivore, Jamie L. Utz, Lisa A. Shipley, Janet L. Rachlow, Tamara Johnstone-Yellin, Meghan Camp, Jennifer Sorenson Forbey
Understanding Tradeoffs Between Food And Predation Risks In A Specialist Mammalian Herbivore, Jamie L. Utz, Lisa A. Shipley, Janet L. Rachlow, Tamara Johnstone-Yellin, Meghan Camp, Jennifer Sorenson Forbey
Biology Faculty Publications and Presentations
Understanding habitat use by animals requires understanding the simultaneous tradeoffs between food and predation risk within a landscape. Quantifying the synergy between patches that provide quality food and those that are safe from predators at a scale relevant to a foraging animal could better reveal the parameters that influence habitat selection. To understand more thoroughly how animals select habitat components, we investigated tradeoffs between diet quality and predation risk in a species endemic to sagebrush Artemisia spp. communities in North America, the pygmy rabbitBrachylagus idahoensis. This species is a rare example of a specialist herbivore that relies almost entirely …
American Society Of Parasitologists Newsletter, V. 38, No. 3, Late Summer 2016, Scott Lyell Gardner
American Society Of Parasitologists Newsletter, V. 38, No. 3, Late Summer 2016, Scott Lyell Gardner
American Society of Parasitologists: Newsletter
Newsletter issue of the American Society of Parasitologists.
High-Input Management Systems Effect On Soybean Seed Yield, Yield Components, And Economic Break-Even Probabilities, John M. Orlowski, Bryson J. Haverkamp, Randall G. Laurenz, David A. Marburger, Eric W. Wilson, Shaun N. Casteel, Shawn P. Conley, Seth L. Naeve, Emerson D. Nafziger, Kraig L. Roozeboom, William J. Ross, Kurt D. Thelen, Chad Lee
High-Input Management Systems Effect On Soybean Seed Yield, Yield Components, And Economic Break-Even Probabilities, John M. Orlowski, Bryson J. Haverkamp, Randall G. Laurenz, David A. Marburger, Eric W. Wilson, Shaun N. Casteel, Shawn P. Conley, Seth L. Naeve, Emerson D. Nafziger, Kraig L. Roozeboom, William J. Ross, Kurt D. Thelen, Chad Lee
Plant and Soil Sciences Faculty Publications
Elevated soybean [Glycine max (L.) Merr.] prices have spurred interest in maximizing soybean seed yield and has led growers to increase the number of inputs in their production systems. However, little information exists about the effects of high-input management on soybean yield and profitability. The purpose of this study was to investigate the effects of individual inputs, as well as combinations of inputs marketed to protect or increase soybean seed yield, yield components, and economic break-even probabilities. Studies were established in nine states and three soybean growing regions (North, Central, and South) between 2012 and 2014. In each site-year …
Molecular Underpinnings Of Diabetic Polyneuropathy, Jonathon Senefeld, Sandra K. Hunter
Molecular Underpinnings Of Diabetic Polyneuropathy, Jonathon Senefeld, Sandra K. Hunter
Exercise Science Faculty Research and Publications
No abstract provided.
Only Women Report Increase In Pain Threshold Following Fatiguing Contractions Of The Upper Extremity, Kathy J. Lemley, Jonathon Senefeld, Sandra K. Hunter, Marie K. Hoeger Bement
Only Women Report Increase In Pain Threshold Following Fatiguing Contractions Of The Upper Extremity, Kathy J. Lemley, Jonathon Senefeld, Sandra K. Hunter, Marie K. Hoeger Bement
Physical Therapy Faculty Research and Publications
Purpose
The perception of pain in response to a noxious stimulus can be markedly reduced following an acute bout of exercise [exercise-induced hypoalgesia (EIH)]. Sex differences in EIH frequently occur after exercise but may be confounded by the sex differences in muscle fatigue. The purpose was to determine if sex differences in pain relief occur after an exercise protocol when muscle fatigue is similar for both young and older men and women.
Methods
Pain perception of 33 men (15 young) and 31 women (19 young) was measured using a pressure pain stimulus on the left index finger before and after …
Characterizing Active And Inactive Brown Adipose Tissue In Adult Humans Using Pet-Ct And Mr Imaging, Aliya Gifford, Theodore F. Towse, Ronald C. Walker, Malcolm J. Avison, E Brian Welch
Characterizing Active And Inactive Brown Adipose Tissue In Adult Humans Using Pet-Ct And Mr Imaging, Aliya Gifford, Theodore F. Towse, Ronald C. Walker, Malcolm J. Avison, E Brian Welch
Peer Reviewed Articles
Activated brown adipose tissue (BAT) plays an important role in thermogenesis and whole body metabolism in mammals. Positron emission tomography (PET)-computed tomography (CT) imaging has identified depots of BAT in adult humans, igniting scientific interest. The purpose of this study is to characterize both active and inactive supraclavicular BAT in adults and compare the values to those of subcutaneous white adipose tissue (WAT). We obtained [18F]fluorodeoxyglucose ([18F]FDG) PET-CT and magnetic resonance imaging (MRI) scans of 25 healthy adults. Unlike [18F]FDG PET, which can detect only active BAT, MRI is capable of detecting both active …
Upper Thermal Limits Of Freshwater Mussels (Bivalvia, Unionoida) In Ramped Temperature Exposures, Kathryn Rae Cottrell Martin
Upper Thermal Limits Of Freshwater Mussels (Bivalvia, Unionoida) In Ramped Temperature Exposures, Kathryn Rae Cottrell Martin
Graduate Theses/Dissertations
The purpose of this study was to determine the upper thermal limits of unionids. Three species of juvenile freshwater mussels were tested in lab experiments mimicking a diel pattern of temperature change (increasing 6 h, peak 2 h, and decreasing 8 h). The peak temperature fatal to half of the exposed population (LT50) was tested with respect to species, population, age, and seasonal acclimation. Mortality was monitored for 2 weeks after exposure. The smallest size classes were tested in a thermal cycler instrument, a novel application for testing mussels. LT50s for juveniles less than 3 weeks old were within 2-3°;C …
Determination Of Evolutionary History Of Big Bluestem Populations Through Chloroplast Dna Analysis, Tej Man Tamang
Determination Of Evolutionary History Of Big Bluestem Populations Through Chloroplast Dna Analysis, Tej Man Tamang
Master's Theses or Doctor of Nursing Practice
Andropogon gerardii Vitman (big bluestem) is one of the most dominant and widely distributed grasses of the North American prairie. It is widely used in restoration projects for the recovery of grassland ecosystems. A. gerardii demonstrates genetic and adaptive variation among populations across the prairie. With the objective to understand the evolutionary relationship between the A. gerardii populations, two noncoding chloroplast DNA (cpDNA) spacers (rpl32-trnL(UAG) and trnQ(UUG)-rps16) were studied. Similarly, genetic differentiation among the populations was also calculated based on the spacers. The trnQ(UUG)-rps16 spacer had more polymorphic sites than the rpl32-trnL(UAG) spacer. A phylogenetic tree based on combined cpDNA …
Encoding Of Saltatory Tactile Velocity In The Adult Orofacial Somatosensory System, Rebecca Custead
Encoding Of Saltatory Tactile Velocity In The Adult Orofacial Somatosensory System, Rebecca Custead
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Processing dynamic tactile inputs is a key function of somatosensory systems. Spatial velocity encoding mechanisms by the nervous system are important for skilled movement production and may play a role in recovery of motor function following neurological insult. Little is known about tactile velocity encoding in trigeminal networks associated with mechanosensory inputs to the face, or the consequences of movement.
High resolution functional magnetic resonance imaging (fMRI) was used to investigate the neural substrates of velocity encoding in the human orofacial somatosensory system during unilateral saltatory pneumotactile inputs to perioral hairy skin in 20 healthy adults. A custom multichannel, scalable …
Soybean Tolerance To Soybean Aphid (Aphis Glycines Matsumura) Herbivory, Lia Marchi Werle
Soybean Tolerance To Soybean Aphid (Aphis Glycines Matsumura) Herbivory, Lia Marchi Werle
Department of Entomology: Dissertations, Theses, and Student Research
This research examined the soybean aphid tolerant soybean KS4202 and its possible role in soybean aphid management. Studies documented the stage at which the tolerance response was initially expressed, quantified the relationship between cumulative aphid-days (CADs) and yield loss, and determined economic injury levels (EILs) for the soybean aphid tolerant KS4202 soybean. At high aphid infestation levels, aphids negatively impacted yield for KS4202 and K03-4686 (susceptible) plants that were infested at V1 stage; however, KS4202 expressed tolerance to the soybean aphid at low aphid infestation levels. No significant differences in the yield parameters were detected for KS4202 when infested at …
Mechanism Of Triglyceride Lowering Action Of Akkermansia Muciniphila And Fenugreek In A Genetic Induced Hyperlipidemia, Jing Shen
Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research
Hyperlipidemia is a condition of abnormally elevated levels of lipids and/or lipoproteins in the blood circulation. It is usually accompanied with obesity, type 2 diabetes, insulin resistance, hypertension and non-alcoholic fatty liver diseases (NAFLD) and has become a great threat to human health. New therapeutic strategies are needed for the prevention and treatment of both genetic intervention-induced hyperlipidemia and environmentally induced hyperlipidemia. In this study, we determined the therapeutic effects of a diseaseprotecting gut bacteria, Akkermansia muciniphila, and an annual legume, fenugreek, on hypertriglyceridemia induced by genetic depletion of cAMP responsive binding protein H (CREBH KO) in mice. We found …
A Dynamic Run-Profile Energy-Aware Approach For Scheduling Computationally Intensive Bioinformatics Applications, Sachin Pawaskar, Hesham Ali
A Dynamic Run-Profile Energy-Aware Approach For Scheduling Computationally Intensive Bioinformatics Applications, Sachin Pawaskar, Hesham Ali
Computer Science Faculty Proceedings & Presentations
High Performance Computing (HPC) resources are housed in large datacenters, which consume exorbitant amounts of energy and are quickly demanding attention from businesses as they result in high operating costs. On the other hand HPC environments have been very useful to researchers in many emerging areas in life sciences such as Bioinformatics and Medical Informatics. In an earlier work, we introduced a dynamic model for energy aware scheduling (EAS) in a HPC environment; the model is domain agnostic and incorporates both the deadline parameter as well as energy parameters for computationally intensive applications. Our proposed EAS model incorporates 2-phases. In …
Funciones Sensoriales En Niños Menores De 3 Años Diagnosticados Con Trastorno Del Espectro Autista (Tea) / Sensory Processing In Toddlers Diagnosed With Autism Spectrum Disorder (Asd), Juliana Gutiérrez, Megan Chang, Erna Imperatore Blanche
Funciones Sensoriales En Niños Menores De 3 Años Diagnosticados Con Trastorno Del Espectro Autista (Tea) / Sensory Processing In Toddlers Diagnosed With Autism Spectrum Disorder (Asd), Juliana Gutiérrez, Megan Chang, Erna Imperatore Blanche
Faculty Research, Scholarly, and Creative Activity
Spanish: Las dificultades de procesamiento sensorial en niños con Trastorno del Espectro Autista (TEA) están ampliamente descritos en la literatura principalmente mediante el uso de encuestas a padres y observaciones. Con menor frecuencia se han descrito las dificultades de procesamiento sensorial en niños menores de 3 años de edad que han sido posteriormente diagnosticados con TEA. Este studio retrospectivo está basado en 84 niños (28 diagnosticados con TEA, 28 con retraso en el desarrollo, y 28 niños con desarrollo típico) entre 18 y 36 meses de edad que asistieron a un programa de intervención temprana y cuyos padres completaron el …
Large Deletions At The Shox Locus In The Pseudoautosomal Region Are Associated With Skeletal Atavism In Shetland Ponies, Nima Rafati, Lisa S. Andersson, Sofia Mikko, Chungang Feng, Terje Raudsepp, Jessica Pettersson, Jan Janecka, Ove Wattle, Adam Ameur, Gunilla Thyreen, John E. Eberth, John Huddleston, Maika Malig, Ernest Bailey, Evan E. Eichler, Göran Dalin, Bhanu Chowdary, Leif Andersson, Gabriella Lindgren, Carl-Johan Rubin
Large Deletions At The Shox Locus In The Pseudoautosomal Region Are Associated With Skeletal Atavism In Shetland Ponies, Nima Rafati, Lisa S. Andersson, Sofia Mikko, Chungang Feng, Terje Raudsepp, Jessica Pettersson, Jan Janecka, Ove Wattle, Adam Ameur, Gunilla Thyreen, John E. Eberth, John Huddleston, Maika Malig, Ernest Bailey, Evan E. Eichler, Göran Dalin, Bhanu Chowdary, Leif Andersson, Gabriella Lindgren, Carl-Johan Rubin
Maxwell H. Gluck Equine Research Center Faculty Publications
Skeletal atavism in Shetland ponies is a heritable disorder characterized by abnormal growth of the ulna and fibula that extend the carpal and tarsal joints, respectively. This causes abnormal skeletal structure and impaired movements, and affected foals are usually killed. In order to identify the causal mutation we subjected six confirmed Swedish cases and a DNA pool consisting of 21 control individuals to whole genome resequencing. We screened for polymorphisms where the cases and the control pool were fixed for opposite alleles and observed this signature for only 25 SNPs, most of which were scattered on genome assembly unassigned scaffolds. …
Computational Modeling Of Facial Response For Detecting Differential Traits In Autism Spectrum Disorders, Manar D. Samad
Computational Modeling Of Facial Response For Detecting Differential Traits In Autism Spectrum Disorders, Manar D. Samad
Electrical & Computer Engineering Theses & Dissertations
This dissertation proposes novel computational modeling and computer vision methods for the analysis and discovery of differential traits in subjects with Autism Spectrum Disorders (ASD) using video and three-dimensional (3D) images of face and facial expressions. ASD is a neurodevelopmental disorder that impairs an individual’s nonverbal communication skills. This work studies ASD from the pathophysiology of facial expressions which may manifest atypical responses in the face. State-of-the-art psychophysical studies mostly employ na¨ıve human raters to visually score atypical facial responses of individuals with ASD, which may be subjective, tedious, and error prone. A few quantitative studies use intrusive sensors on …
Microbubble Generation By Piezoelectric Transducers For Biomedical Studies, Mohammed Alkhazal
Microbubble Generation By Piezoelectric Transducers For Biomedical Studies, Mohammed Alkhazal
Electrical & Computer Engineering Theses & Dissertations
Bubbles induced by blast waves or shocks are speculated as the major cause of damage in biological cells in mild traumatic brain injuries (TBI). Microbubble collapse was found to induce noticeable cell detachment from the cell substrate, changes in focal adhesion, and biomechanics. To better understand the bubble mechanism, a system needs to be constructed which allows clear differentiation on the impact of bubbles from that of shocks. Such a generator needs to be low profile in order to place under a microscope. A piezoelectric transducer system was designed to meet the need. The system uses either a flat or …
Machine Learning Methods For Medical And Biological Image Computing, Rongjian Li
Machine Learning Methods For Medical And Biological Image Computing, Rongjian Li
Computer Science Theses & Dissertations
Medical and biological imaging technologies provide valuable visualization information of structure and function for an organ from the level of individual molecules to the whole object. Brain is the most complex organ in body, and it increasingly attracts intense research attentions with the rapid development of medical and bio-logical imaging technologies. A massive amount of high-dimensional brain imaging data being generated makes the design of computational methods for efficient analysis on those images highly demanded. The current study of computational methods using hand-crafted features does not scale with the increasing number of brain images, hindering the pace of scientific discoveries …
Impacts Of Mowing Treatments On Smooth Bromegrass (Bromus Inermis) Belowground Bud Bank, L. Xu, J. Young, A. Boe, J. R. Hendrickson, N. H. Troelstrup Jr.
Impacts Of Mowing Treatments On Smooth Bromegrass (Bromus Inermis) Belowground Bud Bank, L. Xu, J. Young, A. Boe, J. R. Hendrickson, N. H. Troelstrup Jr.
Natural Resource Management Faculty Publications
Introduced in the 1880s for improving forage production and controlling soil erosion, smooth bromegrass (Bromus inermis Leyss) has invaded and is threating numerous native prairie ecosystems and wildlife habitats in the Northern Great Plains. Land managers of the mixed-grass prairie ecosystems currently spend significant resources attempting to control invasive species and restore native grasslands with various management strategies including grazing, prescribed burning, herbicide application and seeding native species. Unfortunately, many studies have showed that such management efforts have minimal short-term effects. Without sustained effort, persistence and resurgence of smooth bromegrass is inevitable.
Heterochrony Of Cranial Bones In Amniota And The Phylogenetic Placement Of Testudines, Kathleen Sagarin
Heterochrony Of Cranial Bones In Amniota And The Phylogenetic Placement Of Testudines, Kathleen Sagarin
Masters Theses
The study of developmental systems may help to resolve the disagreement between morphological data and molecular data when it comes to the placement of Testudines among Amniota. Among other unique morphological adaptations, turtles possess an anapsid (unfenestrated) condition of the temporal region of the skull. If turtles are descended from diapsids, as molecular data suggests, this implies a rapid transformation of the temporal region from the diapsid condition to the anapsid condition. This study specifically addressed temporal bone heterochony among amniotes using the methods of Continuous Analysis (Germain and Laurin 2009) and Parsimov-based Genetic Inference (Harrison and Larsson 2008) to …
Communiqué: College Of Humanities, Arts & Sciences Alumni Magazine,Volume 5, Summer 2016, University Of Northern Iowa. College Of Humanities, Arts, And Sciences.
Communiqué: College Of Humanities, Arts & Sciences Alumni Magazine,Volume 5, Summer 2016, University Of Northern Iowa. College Of Humanities, Arts, And Sciences.
Communiqué: College of Humanities, Arts & Sciences Alumni Magazine
Contents:
-- Dean's Message
-- Candid: Fortepan Iowa
-- News in Short
-- Art + Science = "Big Bang"
-- Frontline Philosophy: Herrera
-- Pressing Forward: North American Review
-- CHAS Applause
-- Book Nook
-- Away in the Alpine
-- Printing Press
-- Nepal
-- Expanding Horizons
-- Donor Feature: Gary Sholten
-- National Science Foundation Funding
-- Metal Casting Center Moves
-- Transitions
-- Yager Awards
-- Students in the News
-- Coding Against Cancer
-- Dean's Fund Donor Listing
-- Alumni News
Plant Growth Promotion By Bradyrhizobium Japonicum Under Heavy Metal Stress, M. Seneviratne, S. Gunaratne, T. Bandara, L. Weerasundara, Nishanta Rajakaruna, G. Seneviratne, M. Vithanage
Plant Growth Promotion By Bradyrhizobium Japonicum Under Heavy Metal Stress, M. Seneviratne, S. Gunaratne, T. Bandara, L. Weerasundara, Nishanta Rajakaruna, G. Seneviratne, M. Vithanage
Biological Sciences
The increase in usage of heavy metals in different industrial activities causes their existence in effluents. Excessive concentrations of these heavy metals pollute soil and water. Heavy metals cause toxicities and other harmful effects not only in humans and animals but also in plants and soil microorganisms. Heavy metals disrupt many biochemical and physiological activities in bacteria, including growth, development, enzyme and hormone production. Indole acetic acid (IAA) is one of the most important hormones in plants, which is secreted by both bacteria and plants. The present study assessed the effects of Ni, Pb and Cu on the growth of …
Phamdb: A Web-Based Application For Building Phamerator Databases, James G. Lamine, Randall J. Dejong, Serita M. Nelesen
Phamdb: A Web-Based Application For Building Phamerator Databases, James G. Lamine, Randall J. Dejong, Serita M. Nelesen
University Faculty Publications and Creative Works
PhamDB is a web application which creates databases of bacteriophage genes, grouped by gene similarity. It is backwards compatible with the existing Phamerator desktop software while providing an improved database creation workflow. Key features include a graphical user interface, validation of uploaded GenBank files, and abilities to import phages from existing databases, modify existing databases and queue multiple jobs. Availability and implementation: Source code and installation instructions for Linux, Windows and Mac OSX are freely available at https://github.com/jglamine/phage. PhamDB is also distributed as a docker image which can be managed via Kitematic. This docker image contains the application and all …
Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar
Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar
USF Tampa Graduate Theses and Dissertations
Proteins represent major constituent of the extracellular matrix which plays an important role in the formation, maintenance and remodeling of tissues, this project focuses on adsorption of two specific serum proteins fibronectin (FN) and vitronectin (VTN) responsible for mediating cell matrix interaction through integrin binding, tripeptide Arg-Gly-Asp (RGD) sequence found in these protein features are recognized by αβV3 integrin which ultimately helps in clot formation.
Distribution Of Genomic Variation In The Usda Soybean Germplasm Collection And Relationship With Phenotypic Variation, Nonoy Batiller Bandillo
Distribution Of Genomic Variation In The Usda Soybean Germplasm Collection And Relationship With Phenotypic Variation, Nonoy Batiller Bandillo
Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research
The USDA Soybean Germplasm Collection harbors a large stock of genetic diversity with potential to accelerate soybean cultivar development. The extent and nature of favorable alleles contained in the collection are not well known nor is the distribution of genetic variation and how it relates to phenotypic variation. The genotyping of the entire USDA Soybean Germplasm Collection marked the beginning of a systematic exploration of genetic diversity for genetic research and breeding. In this research, we conducted the first comprehensive analysis of population structure on the collection of ~14,400 soybean accessions [Glycine max (L.) Merr. and G. soja Siebold …
Bioaugmentation And Correlating Anaerobic Digester Microbial Community To Process Function, Kaushik Venkiteshwaran
Bioaugmentation And Correlating Anaerobic Digester Microbial Community To Process Function, Kaushik Venkiteshwaran
Dissertations (1934 -)
This dissertation describes two research projects on anaerobic digestion (AD) that investigated the relationship between microbial community structure and digester function. Both archaeal and bacterial communities were characterized using high-throughput (Illumina) sequencing technology with universal 16S rRNA gene primers. In the first project, bioaugmentation using a methanogenic, aerotolerant propionate enrichment culture was investigated as a possible method to increase digester methane production. Nine anaerobic digesters, seeded with different biomass, were operated identically and their quasi steady state function was compared. Before bioaugmentation, different seed biomass resulted in different quasi steady state function, with digesters clustering into high, medium or low …
A Computational Framework For Learning From Complex Data: Formulations, Algorithms, And Applications, Wenlu Zhang
A Computational Framework For Learning From Complex Data: Formulations, Algorithms, And Applications, Wenlu Zhang
Computer Science Theses & Dissertations
Many real-world processes are dynamically changing over time. As a consequence, the observed complex data generated by these processes also evolve smoothly. For example, in computational biology, the expression data matrices are evolving, since gene expression controls are deployed sequentially during development in many biological processes. Investigations into the spatial and temporal gene expression dynamics are essential for understanding the regulatory biology governing development. In this dissertation, I mainly focus on two types of complex data: genome-wide spatial gene expression patterns in the model organism fruit fly and Allen Brain Atlas mouse brain data. I provide a framework to explore …
Machine Learning Methods For Brain Image Analysis, Ahmed Fakhry
Machine Learning Methods For Brain Image Analysis, Ahmed Fakhry
Computer Science Theses & Dissertations
Understanding how the brain functions and quantifying compound interactions between complex synaptic networks inside the brain remain some of the most challenging problems in neuroscience. Lack or abundance of data, shortage of manpower along with heterogeneity of data following from various species all served as an added complexity to the already perplexing problem. The ability to process vast amount of brain data need to be performed automatically, yet with an accuracy close to manual human-level performance. These automated methods essentially need to generalize well to be able to accommodate data from different species. Also, novel approaches and techniques are becoming …
Selfish Mutations: The Genetic Basis Of The Paternal Age Effect, Eoin C. Whelan
Selfish Mutations: The Genetic Basis Of The Paternal Age Effect, Eoin C. Whelan
Biological Sciences Theses & Dissertations
As the mean age of childrearing grows, the effect of parental age on genetic disease and child health becomes ever more important. A number of autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: substitutions that grant spermatogonial stem cells (SSCs) a selective advantage in the testes of the father but have a deleterious effect in offspring.
I present a mathematical model to analyse the normal function of the stem cell compartment, which provides a framework for SSC renewal and accommodates differences between animal systems. In order to model the SSC mutation accumulation, a Markov chain …