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Articles 116581 - 116610 of 255893

Full-Text Articles in Life Sciences

Erk3 As A Braf-Regulated Tumor Suppressor Is A New Potential Cancer Target In Melanoma, Minyi Chen Jan 2017

Erk3 As A Braf-Regulated Tumor Suppressor Is A New Potential Cancer Target In Melanoma, Minyi Chen

Browse all Theses and Dissertations

Melanoma is the highest mortality rate skin cancer and the sixth most common cancer in the U.S..[1, 2] Arising from melanocytes, melanoma is known for frequent mutation of BRAF to its constitutive activation state BRAFV600E, thus over-activating its downstream MAPK targets ERK1/2 and contributing to melanoma progression.[3, 4, 5] ERK3, a less studied MAPK family protein which contributes to promoting lung, breast, cervical, head and neck (HNC) cancer metastasis, has also shown a correlation with upregulation of BRAF.[6, 7, 8, 9] However, the BRAF-ERK3 regulatory mechanism and the function of ERK3 in melanoma are still unclear. Here, we first elucidate …

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Urinary Metabolomics To Detect Polycystic Kidney Disease At Early Stage, Amnah Mahmoud Obidan Jan 2017

Urinary Metabolomics To Detect Polycystic Kidney Disease At Early Stage, Amnah Mahmoud Obidan

Browse all Theses and Dissertations

Urinary metabolomics abilities in detection of biological effects (i.e., toxicity, disease) is compounded by high background variability. Previously, we showed mild kidney dysfunction was detectable under the stress imposed by furosemide (diuretic). Here we tested whether furosemide (FUR) can enhance the sensitivity to detect autosomal dominant polycystic kidney disease (ADPKD) at an early stage. ADPKD is one of the most common inherited renal disorders and is characterized by the growth of numerous cysts in the kidneys. Urinary metabolomics analyses, using nuclear magnetic resonance (NMR) spectroscopy, were conducted in control (WT) and diseased mice (RC) at 7 and 24 weeks of …

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Intercellular Adhesion Molecule-1 Augments Myoblast Adhesion And Fusion Through Homophilic Trans-Interactions, Francis X. Pizza, Ryan A. Martin, Evan M. Springer, Maxwell S. Leffler, Bryce R. Woelmer, Issac J. Recker, Douglas W. Leaman Jan 2017

Intercellular Adhesion Molecule-1 Augments Myoblast Adhesion And Fusion Through Homophilic Trans-Interactions, Francis X. Pizza, Ryan A. Martin, Evan M. Springer, Maxwell S. Leffler, Bryce R. Woelmer, Issac J. Recker, Douglas W. Leaman

Biological Sciences Faculty Publications

The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments the adhesive and fusogenic properties of myogenic cells. Hypotheses were tested using cultured myoblasts and fibroblasts, which do not constitutively express ICAM-1, and myoblasts and fibroblasts forced to express full length ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1. ICAM-1 mediated myoblast adhesion and fusion were quantified using novel assays and cell mixing experiments. We report that ICAM-1 augments myoblast adhesion to myoblasts and myotubes through homophilic trans-interactions. Such adhesive interactions enhanced levels of active Rac in adherent and …

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The Difference Between Two Implants And No Implants In Nebraska Steers, Bailie Boyce Jan 2017

The Difference Between Two Implants And No Implants In Nebraska Steers, Bailie Boyce

Undergraduate Research Journal

A small-pelleted implant placed under the skin on the back of the ear of a calf can help increase average daily gains (ADG) by 10-20% when compared to non-implanted calves (Payne 2012). As a result of increased feed efficiency from the implant(s), less feed is needed, which in return decreases the costs of production by 5-10% (Payne 2012). Implants can influence weight gain in cattle, resulting in an overall increase in beef supply for producers. Implants work by slowly dissolving under the skin to release a small amount of artificial hormones daily anywhere from 60 to 120 days. They are …

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Nitrogen Pulses And Competition Between Native And Invasive Plant Species, Nicolas Matallana, Mandy L. Slate, Ragan M. Callaway Jan 2017

Nitrogen Pulses And Competition Between Native And Invasive Plant Species, Nicolas Matallana, Mandy L. Slate, Ragan M. Callaway

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Variation in the timing and size of resource fluctuations can influence how plants grow, allocate biomass, and reproduce. Resources are sometimes made available in relatively continuous, reliable pulses while other times they are temporally separated and unpredictable. Native and invasive plant species are thought to respond differently to resource fluctuations, or pulses, which can influence competitive outcomes. The “Fluctuating Resource Hypothesis” predicts that resource fluctuations benefit invasive species more than native species, potentially because many invaders are highly effective at rapidly capturing resources. In a field setting, we examined the effects of varying nitrogen pulses on competition between exotic invasive …

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Genetic Analysis Of Serf Gene Function In Drosophila Melanogaster And Its Contribution To A Fly Model Of Spinal Muscular Atrophy, Swagata Ghosh Jan 2017

Genetic Analysis Of Serf Gene Function In Drosophila Melanogaster And Its Contribution To A Fly Model Of Spinal Muscular Atrophy, Swagata Ghosh

Theses and Dissertations--Biology

The Serf gene is evolutionarily highly conserved but its biological function is not known in any organism. In human, SERF1/H4F5 was first identified as a modifier of the disease Spinal Muscular Atrophy (SMA). SMA is caused by mutations in the Survival Motor Neuron 1(SMN1) gene leading to diminished levels of the Smn protein. More than 90% of patients with the most severe form of SMA have deletions that remove SERF1 as well as mutaions within SMN1. Hence, loss of Serf activity is hypothesized to exacerbate SMA disease progression. The primary motivation of this thesis was to test …

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An Observational Study Of Ticks On The 30 Acre Lake Trail At Turnbull National Wildlife Refuge, Robert E. Shadix Jr. Jan 2017

An Observational Study Of Ticks On The 30 Acre Lake Trail At Turnbull National Wildlife Refuge, Robert E. Shadix Jr.

EWU Masters Thesis Collection

Ticks are known carriers of bacterial pathogens that cause diseases in humans and other mammals. Hosts (mice, chipmunks, rabbits, deer, and elk) must be in the tick’s questing range to fulfill the life cycle. The questing range depends on the life stage of the tick, vegetation, and host accessibility. Mammal densities directly affect the number of questing ticks observed in the environment. The 30 Acre Lake Trail site was selected for this study due to the high density of Dermacentor species ticks observed in past studies and the only known site of Rickettsia rickettsii pathogen isolated from ticks on the …

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Instructions For Authors, Discovery Editors Jan 2017

Instructions For Authors, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

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Effects Of Labeling And Consumer Health Trends On Preferred Ground Beef Color Characteristics, Fat Content And Palatability In Simulated Retail Display, Fred W. Pohlman Ii, Fred Pohlman, Nicholas B. Anthony, Famous Yang Jan 2017

Effects Of Labeling And Consumer Health Trends On Preferred Ground Beef Color Characteristics, Fat Content And Palatability In Simulated Retail Display, Fred W. Pohlman Ii, Fred Pohlman, Nicholas B. Anthony, Famous Yang

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Nutritional concerns have impacted the protein market, decreasing red meat consumption as well as prompting the advent of lean and extra lean ground beef. However, such lean blends of ground beef may suffer in palatability. This study seeks to bridge the gap between perceived health and palatability. Participants were asked to identify the relative importance of characteristics commonly used in purchasing ground beef and select a preferred package of ground beef from labeled and unlabeled sections consisting of 4%, 10%, 20%, and 27% fat content. Instrumental color data and their main drivers were also collected. Participants then completed a blind …

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Bumpers College Students In Action, Discovery Editors Jan 2017

Bumpers College Students In Action, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

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Marketing Tips For Small-Scale, Local Honey Bee Keepers In Northwest Arkansas, Samuel L. Goll, Michael P. Popp, Jennie S. Popp, Donald C. Steinkraus Jan 2017

Marketing Tips For Small-Scale, Local Honey Bee Keepers In Northwest Arkansas, Samuel L. Goll, Michael P. Popp, Jennie S. Popp, Donald C. Steinkraus

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

The objective of this thesis was to gain market information for beekeepers regarding different honey bee products and to provide information about economic feasibility when produced on a small, local scale. Since cost-of-production information about operating an apiary is widely available, the focus of this work was on gaining marketing knowledge. One of the objectives of the surveys was to develop a better sense of what potential resellers of honey bee products considered locally produced. Another objective was to determine preferences for honey bee product packaging as well as bee pollination services. Using that feedback, a marketing plan for different …

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Development Of A Rapid Detection And Quantification Method For Yeasts And Molds In Dairy Products, Brandon Nguyen Jan 2017

Development Of A Rapid Detection And Quantification Method For Yeasts And Molds In Dairy Products, Brandon Nguyen

Department of Food Science and Technology: Dissertations, Theses, and Student Research

A rapid quantitative PCR (qPCR) method was developed for the detection and quantification of fungi that are potentially present in dairy commodities. Genes of interest that were considered and used in the method development were the following: 18S rRNA, actin, beta-tubulin, and elongation factor 1-alpha. The following organisms were screened in this method development: Galactomyces candidus, Debaryomyces hansenii, Yarrowia lipolytica, Penicillium roqueforti, Penicillium verrocosum and Cladosporium cladosporioides. The developed method has a standard curve based on the organism, Galactomyces candidus, and the primers based on the elongation factor 1-alpha gene. Using this yeast and …

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Survivorship And Growth Among Three Developmental Stages Of Black Mangrove (Avicennia Germinans) Seedlings In Southernmost Texas, Frank W. Judd, Kenneth R. Sunny, Robert I. Lonard, Ruben A. Mazariegos Jan 2017

Survivorship And Growth Among Three Developmental Stages Of Black Mangrove (Avicennia Germinans) Seedlings In Southernmost Texas, Frank W. Judd, Kenneth R. Sunny, Robert I. Lonard, Ruben A. Mazariegos

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Black mangrove is useful for shoreline stabilization in Texas and Mexico but there is insufficient information regarding propagule survivorship and seedling growth. We compared survivorship and growth of three develop-mental groups of black mangrove seedlings planted on three dredge spoil islands in the Lower Laguna Madre of Texas, to better understand optimum planting strategy. Each spoil island had 100 seedlings without emergent radicles, 100 seedlings with emergent radicles, and 75 head-started seedlings. Survivorship of seedlings with and with-out emergent radicles was low, (0-16%). Survivorship of head-started seedlings was higher, (60 – 62.7%). Varia-tion in survivorship among developmental categories was significant …

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Virtual Screening For Novel 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors: A Shape-Based Search Approach, Prasan Tangyuenyongwatana, Wandee Gritsanapan Jan 2017

Virtual Screening For Novel 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors: A Shape-Based Search Approach, Prasan Tangyuenyongwatana, Wandee Gritsanapan

The Thai Journal of Pharmaceutical Sciences

A virtual screening study with ArgusLab 4.0.1 was performed on 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), the second enzyme in the methyl erythritol phosphate pathway in isoprenoids production which is present in malarial parasite Plasmodium .

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Chemical Compositions And Repellent Activity Of Eucalyptus Tereticornis And Eucalyptus Deglupta Essential Oils Against Culex Quinquefasciatus Mosquito, Rini Pujiarti, Rini Pujiarti Jan 2017

Chemical Compositions And Repellent Activity Of Eucalyptus Tereticornis And Eucalyptus Deglupta Essential Oils Against Culex Quinquefasciatus Mosquito, Rini Pujiarti, Rini Pujiarti

The Thai Journal of Pharmaceutical Sciences

Eucalyptus oils have distinctive smell that not preferably by mosquito and able to repellent mosquito. This research was evaluated chemical compositions and repellent activity of Eucalyptus tereticornis and Eucalyptus deglupta oils against C. quinquefasc.

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Time-Kill Study Of The In Vitro Antimicrobial Activity Of Tedizolid Against Methicillin-Resistant Staphylococcus Aureus, Tanawat Nunart, Tanitta Chatsuwan, Wanchai Treyaprasert Jan 2017

Time-Kill Study Of The In Vitro Antimicrobial Activity Of Tedizolid Against Methicillin-Resistant Staphylococcus Aureus, Tanawat Nunart, Tanitta Chatsuwan, Wanchai Treyaprasert

The Thai Journal of Pharmaceutical Sciences

To evaluate the in vitro antimicrobial activity of tedizolid against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) by time-kill curve experiments. Four bacterial strains were used in methicillin susceptibility tests, including M.

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Effects Of Family Pharmacy Intervention On Clinical Outcomes In Primary Care Settings In Thailand, Wiwat Thavornwattanayong, Namfon Sribundit Jan 2017

Effects Of Family Pharmacy Intervention On Clinical Outcomes In Primary Care Settings In Thailand, Wiwat Thavornwattanayong, Namfon Sribundit

The Thai Journal of Pharmaceutical Sciences

Background Despite pharmaceutical care had positive effect on improving patient health, currently data fact sheet illustrate slightly increasing of uncontrolled diabetes and uncontrolled hypertension among Thai elderly. Family pharmacist applied more ef..

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Vanillin Increases Stem Cell Signal And Cell Adhesion In Keratinocytes, Supak Taboonpong, Chayanin Kiratipaiboon, Preeyaporn Plaimee Phiboonchaiyanan, Premjit Junthongjin, Pornlert Trithossadech, Pithi Chanvorachote Jan 2017

Vanillin Increases Stem Cell Signal And Cell Adhesion In Keratinocytes, Supak Taboonpong, Chayanin Kiratipaiboon, Preeyaporn Plaimee Phiboonchaiyanan, Premjit Junthongjin, Pornlert Trithossadech, Pithi Chanvorachote

The Thai Journal of Pharmaceutical Sciences

Keratinocyte stem cells residing in the basal layer of the epidermis are thought to function in the process of the epidermis renewal and maintain the barrier property of the skin. This study has explored for the first time that vanillin, a natural compou.

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Effect Of Different Production Variables On The Physical Properties Of Pellets Prepared By Extrusion-Spheronization Using A Multivariate Analysis, John Rojas Jan 2017

Effect Of Different Production Variables On The Physical Properties Of Pellets Prepared By Extrusion-Spheronization Using A Multivariate Analysis, John Rojas

The Thai Journal of Pharmaceutical Sciences

The spheronization process has been widely used in recent years in multiparticulate oral formulations because it is a simple and rapid technology. It offers advantages over other dosage forms such as tablets due to the more uniform and predictable transp.

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Docking, Synthesis, And Cytotoxic Activity Of N-4-Methoxybenzoyl-N’-(4-Fluorophenyl)Thiourea On Hela Cell Line, Anindi Lupita Nasyanka Jan 2017

Docking, Synthesis, And Cytotoxic Activity Of N-4-Methoxybenzoyl-N’-(4-Fluorophenyl)Thiourea On Hela Cell Line, Anindi Lupita Nasyanka

The Thai Journal of Pharmaceutical Sciences

Tiourea derivatives such as phenylthiourea, benzoyltiourea, tenovin, and many more have been reported as anticancer agent. In this study, we have done some initial step (docking, synthesis, and cytotoxic assay) to develop one of thiourea derivatives, N-4.

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Enhancement Of Solubility And Dissolution Rate Of Quercetin With Solid Dispersion System Formation Using Hpmc Matrix, Dwi Setyawan Jan 2017

Enhancement Of Solubility And Dissolution Rate Of Quercetin With Solid Dispersion System Formation Using Hpmc Matrix, Dwi Setyawan

The Thai Journal of Pharmaceutical Sciences

Purpose : The aim of the present study was to obtain raw quercetin materials using solid dispersion system with better solubility and dissolution rate than pure quercetin. Methods: The solid dispersion of Quercetin-HPMC was prepared by solvent method. Su.

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Gold Nanoparticle-Colocasia Gigantean Conjugates For Enhancing Cytotoxic Effect Against A375 Melanoma Cell Line, Amornpun Sereemaspun Jan 2017

Gold Nanoparticle-Colocasia Gigantean Conjugates For Enhancing Cytotoxic Effect Against A375 Melanoma Cell Line, Amornpun Sereemaspun

The Thai Journal of Pharmaceutical Sciences

Herbs are a prototype of traditional medicine for primary health care. Their knowledge is the basis of many modern medicinal discoveries. With the new invention of nanomaterials for biomedical applications, gold nanoparticles (AuNPs) have been proven to .

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Determination Of Ethionamide In Pharmaceutical By Spectrophotometry Via Oxidation Reaction With Potassium Iodate, Nagib A.S. Qarah, Kanakapura Basavaiah Jan 2017

Determination Of Ethionamide In Pharmaceutical By Spectrophotometry Via Oxidation Reaction With Potassium Iodate, Nagib A.S. Qarah, Kanakapura Basavaiah

The Thai Journal of Pharmaceutical Sciences

Two new spectrophotometric methods are described for the determination of ethionamide (ETM) in pure and tablet forms. Method A is based on the oxidation of ETM by KIO3 in H2SO4 medium, and the in situ generated iodine is extracted into chloroform and mea.

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In Vitro Antimicrobial Activity Of Antidesma Bunius Extracts On Oral Pathogenic Bacteria, Panicha Pongnaratorn, Prakasit Kuacharan, Vayura Kotsuno, Naruwat Pakdee, Pranee Sriraj, Jintana Sattayasai Jan 2017

In Vitro Antimicrobial Activity Of Antidesma Bunius Extracts On Oral Pathogenic Bacteria, Panicha Pongnaratorn, Prakasit Kuacharan, Vayura Kotsuno, Naruwat Pakdee, Pranee Sriraj, Jintana Sattayasai

The Thai Journal of Pharmaceutical Sciences

High antioxidant content of Antidesma bunius may lead to many beneficial pharmaceutical properties such as an anti-bacterial, anti-inflammatory and somatic cell decelerations, as well as cancer prevention. This study aimed at quantifying total phenolic c.

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Analytical Method Development And Validation For Iron And Ascorbic Acid In Ferrous Bisglyciante Effervescent Tablets By Colorimetry And Rp-Hplc., Vasantharaju Sg Jan 2017

Analytical Method Development And Validation For Iron And Ascorbic Acid In Ferrous Bisglyciante Effervescent Tablets By Colorimetry And Rp-Hplc., Vasantharaju Sg

The Thai Journal of Pharmaceutical Sciences

A sensitive colorimetric and reverse phase high performance liquid chromatographic method was developed for estimation of total iron and ascorbic acid in ferrous bisglycinate effervescent tablets. A colorimetric method was developed for total iron us...

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The Reform Of Drug Patent System In Thailand, Wanna Sriviriyanupap Jan 2017

The Reform Of Drug Patent System In Thailand, Wanna Sriviriyanupap

The Thai Journal of Pharmaceutical Sciences

Drug patent system has a direct impact on the health care cost and the access of the drugs of people. Previously, the drug patent system in Thailand encounters the problems both efficiency and quality of patent approval. This study aims to analyze the pr.

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Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Hepatic Phase Ii Drug-Metabolizing Enzymes In Rats, Pitchayapa Seeka, Nuansri Niwattisaiwong, Mayuree H. Tantisira, Songpol Chevapat, Kridsada Anuntawuttikul, Khemchat Apipalakul, Somsong Lawanprasert Jan 2017

Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Hepatic Phase Ii Drug-Metabolizing Enzymes In Rats, Pitchayapa Seeka, Nuansri Niwattisaiwong, Mayuree H. Tantisira, Songpol Chevapat, Kridsada Anuntawuttikul, Khemchat Apipalakul, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

The standardized extract of C. asiatica ECa233 (ECa 233) was shown to possess neuroprotective and wound healing effects. The purpose of this study was to investigate effects ECa 233 on the activities of phase II drug metabolizing enzymes including UDP-gl.

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Application Of Ion-Pair Complexation Reaction For The Spectrophotometric Determination Of Clarithromycin In Pharmaceutical Formulations, Sameer A. M. Abdulrahman Jan 2017

Application Of Ion-Pair Complexation Reaction For The Spectrophotometric Determination Of Clarithromycin In Pharmaceutical Formulations, Sameer A. M. Abdulrahman

The Thai Journal of Pharmaceutical Sciences

Two simple, rapid, sensitive, selective and extraction-free spectrophotometric methods have been developed for the determination of clarithromycin (CLR) both in pure form and in pharmaceutical formulations. The developed methods are based on ion-pair com.

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High-Performance Thin-Layer Chromatography Analysis Of (E)-4-(3?,4?-Dimethoxyphenyl)But-3-En-1-Ol (Compound D) In Zingiber Cassumunar Roxb Rhizome Extract: An Application On Genetic Differentiation, Prasan Tangyuenyongwatana, Piyarat Parinyapong Chareonsap, Wandee Gritsanapan Jan 2017

High-Performance Thin-Layer Chromatography Analysis Of (E)-4-(3?,4?-Dimethoxyphenyl)But-3-En-1-Ol (Compound D) In Zingiber Cassumunar Roxb Rhizome Extract: An Application On Genetic Differentiation, Prasan Tangyuenyongwatana, Piyarat Parinyapong Chareonsap, Wandee Gritsanapan

The Thai Journal of Pharmaceutical Sciences

Objectives: This study focused on developing high performance thin-layer chromatography (HPTLC) quantitative analysis method for compound D, a major anti-inflammatory compound in Zingiber cassumunar extract. In addition, the amplified fragment length pol.

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Hepatoprotective And Hepatoregenerative Therapeutic Effects Of Polyherbal Medicine Heparmin Tm On Rattus Norvegicus Wistar With Liver Fibrosis, Diana Lyrawati, Amalia Ghassani Muslimah, Dewi Laksmita, Dian Indrawati Santoso, Erlien Lindawati Poernomo, Karina Larasati, Lina Zahrotus Sajidah, Oktavia Rahayu Adianingsih, Rosida Dewi Agusningtyas, Mudjiwijono Handaru Eko, Bogi Pratomo Wibowo Jan 2017

Hepatoprotective And Hepatoregenerative Therapeutic Effects Of Polyherbal Medicine Heparmin Tm On Rattus Norvegicus Wistar With Liver Fibrosis, Diana Lyrawati, Amalia Ghassani Muslimah, Dewi Laksmita, Dian Indrawati Santoso, Erlien Lindawati Poernomo, Karina Larasati, Lina Zahrotus Sajidah, Oktavia Rahayu Adianingsih, Rosida Dewi Agusningtyas, Mudjiwijono Handaru Eko, Bogi Pratomo Wibowo

The Thai Journal of Pharmaceutical Sciences

Chronic injury severely impairs liver regeneration through excess inflammation, scarring and epithelial abnormalities, since injured cells may shift response from pro-regeneration into pro-fibrosis which leads to cirrhosis and total liver failure. An Ind.

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