Life Sciences Commons^™

Aβ Vaccination In Combination With Behavioral Enrichment In Aged Beagles: Effects On Cognition, Aβ, And Microhemorrhages, Paulina R. Davis, Ginevra Giannini, Karin Rudolph, Nathaniel Calloway, Christopher M. Royer, Tina L. Beckett, M. Paul Murphy, Frederick Bresch, Dieter Pagani, Thomas Platt, Xiaohong Wang, Amy Skinner Donovan, Tiffany L. Sudduth, Wenjie Lou, Erin L. Abner, Richard J. Kryscio, Donna M. Wilcock, Edward G. Barrett, Elizabeth Head

Sanders-Brown Center on Aging Faculty Publications

Beta-amyloid (Aβ) immunotherapy is a promising intervention to slow Alzheimer’s disease (AD). Aging dogs naturally accumulate Aβ and show cognitive decline. An active vaccine against fibrillar Aβ 1–42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aβ. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aβ. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11–12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); (4) ENR and VAC (E/V) and treated for 20 months. …

Attack And Defense Movements Involved In The Interaction Of Spodoptera Frugiperda And Helicoverpa Zea (Lepidoptera: Noctuidae), José P. F. Bentivenha, Edson L. L. Baldin, Débora Goulart Montezano, Thomas E. Hunt, Silvana L. Vieira De Paula Moraes

Department of Entomology: Faculty Publications

The fall armyworm, Spodoptera frugiperda (J. E. Smith) and the corn earworm, Helicoverpa zea (Boddie) are among the main pests of maize. Both species exhibit cannibalistic behavior and quite often share the same feeding guild in maize (maize ears), which can result in several interspecific and intraspecific interactions. Paired interaction scenarios of intraspecific and interspecific larvae were assessed in arenas in the presence and absence of food to characterize movements resulting from interactions of these insects. There was a difference in the frequency of behavioral movements in all the interactions, except for S. frugiperda in the presence of food. …

The Fourteenth Amithao Thomson, 1878 (Coleoptera: Scarabaeidae: Cetoniinae: Gymnetini): A Remarkable New Species From Ecuador, Brett C. Ratcliffe

Department of Entomology: Faculty Publications

Anew species in the Neotropical genus Amithao Thomson, 1878 is described from Ecuador, with supporting illustrations and a diagnosis. A revised key to the 14 species in the genus is provided along with an annotated checklist.

Effects Of Neonicotinoid Imidacloprid Exposure On Bumble Bee (Hymenoptera: Apidae) Queen Survival And Nest Initiation, Judy Wu-Smart, Marla Spivak

Department of Entomology: Faculty Publications

Neonicotinoids are highly toxic to insects and may systemically translocate to nectar and pollen of plants where foraging bees may become exposed. Exposure to neonicotinoids can induce detrimental sublethal effects on individual and colonies of bees and may have long-term impacts, such as impaired foraging, reduced longevity, and reduced brood care or production. Less well-studied are the potential effects on queen bumble bees that may become exposed while foraging in the spring during colony initiation. This study assessed queen survival and nest founding in caged bumble bees [Bombus impatiens (Cresson) (Hymenoptera: Apidae)] after chronic (18-d) dietary exposure of imidacloprid …

Grains Research And Development Science Highlights 2015-17, Department Of Agriculture And Food Western Australia

All other publications

Western Australian grain production and industry value has quadrupled over the past 30 years, despite declining winter rainfall, more frost and high temperature events, acidifying soils and increasing input costs. Strong evidence links this productivity growth to R&D that has delivered genetically superior varieties, better agronomic practices and more reliable farming systems. Western Australian grain growers are innovators that rapidly adopt new technology which is increasingly sourced from a wider pool of national and global science, research and innovation. Continuing to push the productivity frontier is not only critical to grower’s profitability, it underpins the international competitiveness of our exports …

Cave Millipedes Of The United States. Xiv. Revalidation Of The Genus Speorthus Chamberlin, 1952 (Diplopoda, Polydesmida, Macrosternodesmidae), With A Description Of A New Species From Texas And Remarks On The Families Polydesmidae And Macrosternodesmidae In North America, William A. Shear, James M. Reddell

Insecta Mundi

The genus Speorthus Chamberlin is revalidated for S. tuganbius Chamberlin and S. reyesi, new species (Diplopoda, Polydesmida, Macrosternodesmidae). The families Polydesmidae and Macrosternodesmidae (as they occur in North America) are briefly discussed, and their component North American genera listed. The validity of Macrosternodesmidae is reaffirmed; the family is predominantly North American. Nearctodesminae, new status, is formally designated as a subfamily of Macrosternodesmidae. The superfamily Trichopolydesmoidea is synonymized with the superfamily Polydesmoidea, new combination.

Una Nueva Especie De Eraina Clarke (Lepidoptera: Autostichidae) De Chile Central, Francisco Urra

Insecta Mundi

Se describe una nueva especie de Autostichidae, Eraina beechei nov. sp., a partir de ejemplares recolectados en la precordillera andina de la Provincia de Ñuble, Región del Biobío. Se presentan caracteres de diagnóstico para la especie; se entregan fotografías del adulto, ilustraciones de las estructuras genitales del macho y de la hembra, y una clave para la determinación de las especies del género Eraina.

Morphological Revision Of The Western Palaearctic Species Of The Genus Copris Geoffroy, 1762 With Three Foretibial External Teeth (Coleoptera: Scarabaeoidea: Scarabaeidae), Stefano Ziani

Insecta Mundi

This revision concerns a small group of Western Palaearctic Copris species (Coleoptera: Scarabaeoidea: Scarabaeidae) distinguished by having three lateral teeth on the foretibae. According to the literature, this group consists of four taxa: Copris armeniacus Faldermann, 1835, C. felschei Reitter, 1892, C. pueli Mollandin de Boissy, 1905 and C. umbilicatus Abeille de Perrin, 1901. Copris armeniacus is herein deemed a species inquirenda, and C. felschei, for which a neotype is designated, is deemed valid. Copris umbilicatus is recorded for the first time from Turkey. A key to all species of the genus Copris known from the Western Palaearctic …

Key To The Korean Species Of Armored Scale Insects (Hemiptera: Diaspididae), Soo-Jung Suh

Insecta Mundi

A list of all 80 species of armored scale insects (Hemiptera: Diaspididae) in 30 genera that have been identified or documented in Korea, along with a dichotomous key to separate them, is provided.

Species Groups Of Traumatomutilla André (Hymenoptera: Mutillidae), Kevin A. Williams, Pedro R. Bartholomay, Márcio Luiz De Oliveira

Insecta Mundi

Females of Traumatomutilla André (Hymenoptera: Mutillidae) are organized into 14 species groups; 136 of the 138 Traumatomutilla taxa known from females were studied. Of these species groups, only the inermis species group was adequately established and diagnosed in the literature (Casal 1969). The remaining newly established species groups are as follows: americana, auriculata, bellica, bifurca, diabolica, gemella, indica, integella, juvenilis, quadrinotata, tabapua, trochanterata, and vitelligera. Diagnoses and lists of included species are provided for each species group. Eighty-three new country records are provided for 49 species.

The Plecoptera Of Panama. I. The Stonefly Fauna Of Mount Totumas Cloud Forest And Biological Reserve, Including A New Country Record, Brian J. Armitage, Bill P. Stark

Insecta Mundi

The Republic of Panama currently has 21 recorded species of stoneflies, all in the genus Anacroneuria (Plecoptera: Perlidae). Herein, we record five species of this genus from the Mount Totumas Cloud Forest and Biological Reserve, in the upper reaches of the Río Chiriquí Viejo watershed. One of these species, A. plutonis (Banks), represents a new country record for Panama. These results are part of an ongoing effort to characterize the aquatic insect fauna of Panama, and to evaluate that country’s major watersheds.

Diverse Landscapes Beneath Pine Island Glacier Influence Ice Flow, Robert G. Bingham, David G. Vaughan, Edward C. King, Damon Davies, Stephen L. Cornford, Andrew M. Smith, Robert J. Arthern, Alex M. Brisbourne, Rydt, Jan De Rydt, Alastair G. C. Graham, Matteo Spagnolo, Oliver J. Marsh, David E. Shean

Marine Science Faculty Publications

The retreating Pine Island Glacier (PIG), West Antarctica, presently contributes ~5–10% of global sea-level rise. PIG’s retreat rate has increased in recent decades with associated thinning migrating upstream into tributaries feeding the main glacier trunk. To project future change requires modelling that includes robust parameterisation of basal traction, the resistance to ice flow at the bed. However, most ice-sheet models estimate basal traction from satellite-derived surface velocity, without a priori knowledge of the key processes from which it is derived, namely friction at the ice-bed interface and form drag, and the resistance to ice flow that arises as ice deforms …

Major Advance Of South Georgia Glaciers During The Antarctic Cold Reversal Following Extensive Sub-Antarctic Glaciation, Alastair G. C. Graham, Gerhard Kuhn, Ove Meisel, Claus-Dieter Hillenbrand, Dominic A. Hodgson, Werner Ehrmann, Lukas Wacker, Paul Wintersteller, Santos Ferreira, Dos Santos Ferreira, Miriam Römer, Duanne White, Gerhard Bohrmann

Marine Science Faculty Publications

The history of glaciations on Southern Hemisphere sub-polar islands is unclear. Debate surrounds the extent and timing of the last glacial advance and termination on sub-Antarctic South Georgia in particular. Here, using sea-floor geophysical data and marine sediment cores, we resolve the record of glaciation offshore of South Georgia through the transition from the Last Glacial Maximum to Holocene. We show a sea-bed landform imprint of a shelf-wide last glacial advance and progressive deglaciation. Renewed glacier resurgence in the fjords between c. 15,170 and 13,340 yr ago coincided with a period of cooler, wetter climate known as the Antarctic Cold …

Limited Grounding-Line Advance Onto The West Antarctic Continental Shelf In The Easternmost Amundsen Sea Embayment During The Last Glacial Period, Johann P. Klages, Gerhard Kuhn, Claus-Dieter Hillenbrand, James A. Smith, Alastair G. C. Graham, Frank O. Nitsche, Thomas Frederichs, Patrycja E. Jernas, Karsten Gohl, Lukas Wacker

Marine Science Faculty Publications

Precise knowledge about the extent of the West Antarctic Ice Sheet (WAIS) at the Last Glacial Maximum (LGM; c. 26.5–19 cal. ka BP) is important in order to 1) improve paleo-ice sheet reconstructions, 2) provide a robust empirical framework for calibrating paleo-ice sheet models, and 3) locate potential shelf refugia for Antarctic benthos during the last glacial period. However, reliable reconstructions are still lacking for many WAIS sectors, particularly for key areas on the outer continental shelf, where the LGM-ice sheet is assumed to have terminated. In many areas of the outer continental shelf around Antarctica, direct geological data for …

Stable And Radiocarbon Isotopic Composition Of Dissolved Organic Matter In The Gulf Of Mexico, B. D. Walker, E. R. M. Druffel, J. Kolasinski, B. J. Roberts, X. Xu, B. E. Rosenheim

Marine Science Faculty Publications

Dissolved organic carbon (DOC) is of primary importance to marine ecosystems and the global carbon cycle. Stable carbon (δ¹³C) and radiocarbon (Δ¹⁴C) isotopic measurements are powerful tools for evaluating DOC sources and cycling. However, the isotopic signature of DOC in the Gulf of Mexico (GOM) remains almost completely unknown. Here we present the first DOC Δ¹⁴C and δ¹³C depth profiles from the GOM. Our results suggest the Mississippi River exports large amounts of DOC with an anthropogenic “bomb” Δ¹⁴C signature. Riverine DOC is removed and recycled offshore, and some marine …

Parasite Microbiome Project: Systematic Investigation Of Microbiome Dynamics Within And Across Parasite-Host Interactions, Nolwenn M. Dheilly, Daniel Bolnick, Seth Bordenstein, Paul J. Brindley, Cédric Figuères, Edward C. Holmes, Joaquín Martínez Martínez, Anna J. Phillips, Robert Poulin, Karyna Rosario

Marine Science Faculty Publications

Understanding how microbiomes affect host resistance, parasite virulence, and parasite-associated diseases requires a collaborative effort between parasitologists, microbial ecologists, virologists, and immunologists. We hereby propose the Parasite Microbiome Project to bring together researchers with complementary expertise and to study the role of microbes in host-parasite interactions. Data from the Parasite Microbiome Project will help identify the mechanisms driving microbiome variation in parasites and infected hosts and how that variation is associated with the ecology and evolution of parasites and their disease outcomes. This is a call to arms to prevent fragmented research endeavors, encourage best practices in experimental approaches, and …

Forage News [2017-01], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• 2016 Long-Term Summary of Kentucky Forage Variety Trials
• Purchase Improved Clovers for Frost Seeding NOW
• Roundup-Ready Alfalfa Variety Differences
• Understanding and Improving Fermentation in Alfalfa and Grass Baleage

Peripheral Huntingtin Silencing Does Not Ameliorate Central Signs Of Disease In The B6.Httq111/+ Mouse Model Of Huntington's Disease., Sydney R Coffey, Robert M Bragg, Shawn Minnig, Seth A Ament, Jeffrey P Cantle, Anne Glickenhaus, Daniel Shelnut, José M Carrillo, Dominic D Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C Frank Bennett, Nathan D Price, Holly B Kordasiewicz, Jeffrey B Carroll

Articles, Abstracts, and Reports

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease whose predominant neuropathological signature is the selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant protein (huntingtin) is found in virtually every cell so far studied, and, consequently, phenotypes are observed in a wide range of organ systems both inside and outside the central nervous system. We, and others, have suggested that peripheral dysfunction could contribute to the rate of progression of striatal phenotypes of HD. To test this hypothesis, we lowered levels of huntingtin by treating mice with antisense oligonucleotides (ASOs) targeting the murine …

Differences In Behavioral And Physiological Variables Measured With Precision Dairy Monitoring Technologies Associated With Postpartum Diseases, I Ching Tsai

Theses and Dissertations--Animal and Food Sciences

The transition period is defined as the three weeks before and three weeks after the cow calves. Transition cow diseases are considered production diseases. Precision dairy monitoring (PDM) technologies measure physiological, behavioral, and production indicators on individual animals to improve management strategies and farm performance. The objective of the first study was to assess how hypocalcemia, hyperketonemia, and metritis affected variables measured by PDM technologies. The objective of the second study was to use variables from multiple commercially available PDM to examine alert performance generated from different analyses.

An Examination Of Milk Quality Effects On Milk Yield And Dairy Production Economics In The Southeastern United States, Derek T. Nolan

Theses and Dissertations--Animal and Food Sciences

Mastitis is one of the most costly diseases to dairy producers around the world with milk yield loss being the biggest contributor to economic losses. The objective of first study of this thesis was to determine the impacts of high somatic cell counts on milk yield loss. To accomplish this, over one million cow data records were collected from Southeastern US dairy herds. The objective of the second study was to determine optimum treatment cost of clinical mastitis by combining two economic modeling approaches used in animal health economics. The last objective of this thesis was to determine how much …

Molecularly Imprinted Polymers Synthesized As Adsorbents For Ergot Alkaloids: Characterization And In Vitro And Ex Vivo Assessment Of Effects On Ergot Alkaloid Bioavailability, Manoj B. Kudupoje

Theses and Dissertations--Animal and Food Sciences

Alkaloid toxicities negatively impact livestock health and production and are of serious economic concern to animal industries. To date, few strategies have been developed to evaluate alkaloid levels in feed or to counteract alkaloid toxicities. The present research evaluated the applicability of imprinting technology to synthesize polymers that have potential to interact with ergot alkaloids and therefore reduce their bioavailability in the GIT. The studies also evaluated applicability of synthesized polymers for use in the ruminal environment using an in vitro ruminal fermentation model, and for the ability to ameliorate vasoconstriction using ex vivo myographic evaluations.

In the first experiment, …

Variation In Arthropod Hydration Across Us Cities With Distinct Climate, Kevin E. Mccluney, Justin D. Burdine, Steven D. Frank

Biological Sciences Faculty Publications

Increasing evidence suggests that altered environmental conditions within cities (e.g. temperature) can have strong effects on the biology and ecology of animals. Moreover, multiple abiotic (e.g. soil moisture, distributions of water bodies) and biotic factors (e.g. plant and animal communities) may be more similar among cities in distinct climate regions as compared to outside cities. But the mechanisms behind these patterns are unclear. We suggest that animal physiological condition responds to urbanization and may become more similar with urbanization among cities. As a first attempt at assessing this possibility, we measured hydration (water content) of field-collected arthropods, across variation in …

The Application Of Half-Life In Clinical Decision Making: Comparison Of The Pharmacokinetics Of Extended-Release Topiramate (Usl255) And Immediate-Release Topiramate, Barry E. Gidal, Annie M. Clark, Bob Anders, Frank Gilliam

Neuroscience Faculty Publications

Objective: For extended-release drugs with multi-compartment kinetics, such as topiramate, effective half-life (t_1/2eff) may be a more clinically relevant parameter than elimination half-life (t_1/2z). Using topiramate as a real-life example, the objective was to compare these half-life values for immediate- and extended-release topiramate (TPM-IR and USL255, respectively) to understand how drug pharmacokinetics may impact drug dosing recommendations.

Methods: The t_1/2z and t_1/2eff for USL255 and TPM-IR were compared using data from a phase I study (N = 36) of 200 mg USL255 administered once daily (QD) or TPM-IR twice daily (BID); effect of sampling duration …

Ictv Virus Taxonomy Profile: Circoviridae, Mya Breitbart, Eric Delwart, Karyna Rosario, Joaquim Segales, Arvind Varsani

Marine Science Faculty Publications

The family Circoviridae comprises viruses with small, circular, single-stranded DNA (ssDNA) genomes, including the smallest known animal viruses. Members of this family are classified into two genera, Circovirus and Cyclovirus, which are distinguished by the position of the origin of replication relative to the coding regions and the length of the intergenic regions. Within each genus, the species demarcation threshold is 80 % genome-wide nucleotide sequence identity. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Circoviridae, which is available at www.ictv.global/report/circoviridae.

Diverse And Highly Recombinant Anelloviruses Associated With Weddell Seals In Antarctica, Elizabeth Fahsbender, Jennifer M. Burns, Stacy Kim, Simona Kraberger, Greg Frankfurter, Mya Breitbart

Marine Science Faculty Publications

The viruses circulating among Antarctic wildlife remain largely unknown. In an effort to identify viruses associated withWeddell seals (Leptonychotes weddellii) inhabiting the Ross Sea, vaginal and nasal swabs, and faecal samples were collectedbetween November 2014 and February 2015. In addition, a Weddell seal kidney and South Polar skua (Stercorariusmaccormicki) faeces were opportunistically sampled. Using high throughput sequencing, we identified and recovered 152anellovirus genomes that share 63–70% genome-wide identities with other pinniped anelloviruses. Genome-wide pairwisecomparisons coupled with phylogenetic analysis revealed two novel anellovirus species, tentatively named torque tenoLeptonychotes weddellii virus (TTLwV) -1 and -2. TTLwV-1 (n¼133, genomes encompassing 40 genotypes) is …

Genome Sequence Of Euphorbia Mosaic Virus From Passionfruit And Euphorbia Heterophylla In Florida, J. E. Polston, M. A. Londoño, A. L. Cohen, M. Padilla-Rodriguez, K. Rosario, Mya Breitbart

Marine Science Faculty Publications

Euphorbia mosaic virus (EuMV) was found in a symptomatic passionfruit (Passiflora edulis) plant from Homestead, Florida, USA, as well as in the symptomatic weed Euphorbia heterophylla. This is the first identification of EuMV in Florida and the United States and the first report of a natural infection of passionfruit by EuMV.

Virus Taxonomy In The Age Of Metagenomics, Peter Simmonds, Mike Adams, Mária Benkő, Mya Breitbart, J. Rodney Brister, Eric Carstens

Marine Science Faculty Publications

The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the …

Interpreting The Role Of Ph On Stable Isotopes In Large Benthic Foraminifera, L. L. Robbins, P. O. Knorr, J. G. Wynn, Pamela Hallock, P. J. Harries

Marine Science Faculty Publications

Large benthic foraminifera (LBF) are prolific producers of calcium carbonate sediments in shallow, tropical environments that are being influenced by ocean acidification (OA). Two LBF species, Amphistegina gibbosa (Order Rotaliida) with low-Mg calcite tests and Archaias angulatus (Order Miliolida) with high-Mg calcite tests, were studied to assess the effects of pH 7.6 on oxygen and carbon isotopic fractionation between test calcite and ambient seawater. The δ 18O and δ 13C values of terminal chambers and of whole adult tests of both species after 6 weeks were not significantly different between pH treatments of 8.0 and 7.6. However, tests of juveniles …

Challenges In Methane Column Retrievals From Aviris-Ng Imagery Over Spectrally Cluttered Surfaces: A Sensitivity Analysis, Minwei Zhang, Ira Leifer, Chuanmin Hu

Marine Science Faculty Publications

A comparison between efforts to detect methane anomalies by a simple band ratio approach from the Airborne Visual Infrared Imaging Spectrometer-Classic (AVIRIS-C) data for the Kern Front oil field, Central California, and the Coal Oil Point marine hydrocarbon seep field, offshore southern California, was conducted. The detection succeeded for the marine source and failed for the terrestrial source, despite these sources being of comparable strength. Scene differences were investigated in higher spectral and spatial resolution collected by the AVIRIS-C successor instrument, AVIRIS Next Generation (AVIRIS-NG), by a sensitivity study. Sensitivity to factors including water vapor, aerosol, planetary boundary layer (PBL) …

Cloud And Sun-Glint Statistics Derived From Goes And Modis Observations Over The Intra-Americas Sea For Geo-Cape Mission Planning, Lian Feng, Chuanmin Hu, Brian B. Barnes, Antonio Mannino, Andrew K. Heidinger, Kathleen Strabala, Laura T. Iraci

Marine Science Faculty Publications

Knowledge of cloud cover, frequency, and duration is not only important to study cloud dynamics, but also critical in determining when and where to take ocean measurements from geostationary orbits such as the Geostationary Coastal and Air Pollution Events (GEO-CAPE) mission due to the challenges in achieving complete hemispheric coverage of coastal oceans, estuaries, and inland waters at hourly frequency. Using GOES hourly measurements at 4 km nadir resolution between 2006 and 2011, the number of cloud-free hourly observations per day (N_cf) for solar zenith angle θ_o < 80° was estimated for each 0.1° location of the Intra-Americas Sea. The number of Sun-glint-affected hourly observations per day (N_sg) was also calculated based on the …