Life Sciences Commons^™

Defining Lipedema’S Molecular Hallmarks By Multi-Omics Approach For Disease Prediction In Women, Leon G Straub, Jan-Bernd Funcke, Nolwenn Joffin, Chanmin Joung, Sara Al-Ghadban, Shangang Zhao, Qingzhang Zhu, Ilja L Kruglikov, Yi Zhu, Paul R Langlais, Ruth Gordillo, Karen L Herbst, Philipp E Scherer

Children’s Nutrition Research Center Staff Publications

Lipedema is a chronic disease in females characterized by pathologic subcutaneous adipose tissue expansion and hitherto remains without druggable targets. In this observational study, we investigated the molecular hallmarks of lipedema using an unbiased multi-omics approach. We found adipokine dysregulation in lipedema patients participating in a cross-sectional clinical study (ClinicalTrial.gov, NCT02838277), pointing towards the adipocyte as a key player. Analyses of newly generated transcriptomic (SRA, PRJNA940039) and proteomic (ProteomeXchange, PXD058489) datasets of early- and late-stage lipedema samples revealed a local downregulation of factors involved in inflammation. Concomitantly, factors involved in cellular respiration, oxidative phosphorylation, as well as in mitochondrial …

Scientific Note: Garden Loosestrife (Lysimachia Vulgaris, Primulaceae), An Emerging Invasive Plant Species Of Riparian Corridors In The Mid-Atlantic Region, Christopher T. Martine, Amy L. Jewitt, Claire M. Ciafre, Kaitlin G. Henry, Elizabeth H. Williams, Pj Newhart, Melody P. Sain

Faculty Journal Articles

Lysimachia vulgaris (garden loosestrife, Primulaceae) is an herbaceous perennial native to Europe that has been identified as an aggressive invasive species in parts of North America. The status of the species in the Mid-Atlantic region of the US, however, is poorly determined. Using recent field observations (from iNaturalist, iMapInvasives, and EDDMapS records) we here report localized incursions of L. vulgaris in the Susquehanna River Valley of central Pennsylvania, along with notes on its ecology, threats to native plant communities, and broader distribution in the state.

The Impact Of Respiratory Muscle Training On Respiratory Function In Patients With Neuromuscular Disease: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Nancy Y. Ortiz-Garcia, Diego Eduardo Rueda-Capristran, Ajay Kumar, Domenica Alejandra Herrera, Angie Carolina Alonso-Ramírez, Diana Othón-Martínez, Jonathan Reyes-Rivera, Frances Marie Mejia, Jonathan David Martinez-Illan, Carla Isabella Miret Durazo

School of Medicine Publications

Background: Neuromuscular diseases (NMDs) can impair respiratory muscle function, leading to increased morbidity and mortality. Respiratory muscle training (RMT) is widely used to manage these respiratory complications, but its efficacy across different NMDs remains unclear. This systematic review and meta-analysis evaluated the impact of physiotherapy interventions, specifically RMT, on respiratory muscle function in NMD patients.

Methods: A systematic search of multiple databases, including MEDLINE, EMBASE, Web of Science, Cochrane, CRS-Web, PEDro, LILACS, ICTPR, the China National Knowledge Infrastructure database, and ClinicalTrials.gov, was conducted up to February 2025. Randomized controlled trials (RCTs) and cohort studies evaluating RMT's effect on lung volumes …

Feasibility Of Applying Bacillus Amyloliquefaciens-Derived Solid State Fermentation Products Into The Hatch Cabinet Environment As A Method To Mitigate The Microbial Bloom During The Hatching Phase Authors, Mitchell C. Rowland, Lucas E. Graham, Callie Selby, Aaron J. Forga, Billy M. Hargis, Christine N. Voung, Graham Danielle

Poultry Science Faculty Publications and Presentations

Formaldehyde has been used to control microbial contamination in commercial hatch cabinets. The purpose of the present study was to investigate the effects of spray application of Bacillus amyloliquefaciens solid state fermentation products on the microbial load in the hatch cabinet, pioneer colonization of the gastrointestinal tract (GIT), and early performance compared to formaldehyde fumigation. An environmental challenge model was used to simulate the microbial bloom to compare the application of two B. amyloliquefaciens strains (MCR002, MCR009) to formaldehyde fumigation. Groups included 1) non-challenged control (NC), 2) challenged with pathogen mix (PM) containing Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus …

Evaluation Of The Incremental Effect Of Fasting Length On Ph, Select Cecal Microbial Groups, Cecal Volatile Fatty Acid Concentrations, And Secretory Iga Excretion In Roosters, B.W. Parsons, M.R. Bedford, C.L. Wyatt

Poultry Science Faculty Publications and Presentations

Two experiments were conducted to evaluate the effect of incremental fasting time on the gastrointestinal tract in chickens. Adult White Leghorn roosters with intact ceca were provided a nutrient-adequate corn-soybean meal diet ad libitum for 3 weeks. Prior to initiation of the experimental phase, ad libitum feed intake was recorded for 8 h and immediately after the fasting period commenced. In Experiment 1, roosters were fasted for either 0, 3, 6, 9, 12, 16, or 24 h. At each time point birds were euthanized and pH in the crop, gizzard, and ceca were recorded and cecal contents were collected to …

Effectiveness Of A Telephone-Delivered Walk With Ease Program On Arthritis-Related Symptoms, Function, And Activity: A Randomized Trial, Christine Pellegrini Ph.D., Sara Wilcox Phd, Yesil Kim, Scott Jamieson, Katherine Devivo, Daniel Heidtke

Faculty Publications

Objective

Walk With Ease (WWE) is a six-week arthritis-appropriate evidence-based physical activity program traditionally offered in a face-to-face format. Because many populations encounter participation barriers to in-person programs, WWE was modified for telephone delivery (WWE-T). The short- and long-term effects of this program on physical activity and arthritis-related outcomes were examined.

Methods

Participants (n = 267) with arthritis were randomized to WWE-T or a wait list control. WWE-T participants received two telephone calls per week (one group and one individual call) for six weeks. Group calls focused on arthritis education and social support. Individual calls focused on problem-solving and goal …

Vertical Hydrokinetic Turbine, Miki Harding, Ben E. Mertz

Rose-Hulman Undergraduate Research Publications

No abstract provided.

Bibliometric Analysis Of Congenital Toxoplasmosis: A Ten-Year (2013-2023) Review Of Research Publications, Festus Mulakoli, Horatius Musembi, Ann Kimani

School of Nursing & Midwifery, East Africa

Background:Toxoplasma gondii, an obligate intracellular protozoan, infects more than one-third of the global population and causes toxoplasmosis, which can lead to severe fetal complications in pregnant women. The global prevalence of latent toxoplasmosis in pregnant women is 33.8%, with regional variations and risk factors, including the consumption of undercooked meat, exposure to cat feces, and consumption of contaminated water. Pregnant women lack sufficient awareness of these risk factors, necessitating enhanced education, regular screening, and counseling during antenatal care for early detection and management.

Aim: This study performed a comprehensive bibliometric analysis of research on congenital toxoplasmosis published between 2013 …

Un(Der)Explored Links Between Plant Diversity And Particulate And Mineral-Associated Organic Matter In Soil, Šárka Angst, Gerrit Angst, Kevin E. Mueller, Markus Lange, Nico Eisenhauer

Biological, Geological, and Environmental Faculty Publications

Plant diversity can alter soil carbon stocks, but the effects are difficult to predict due to the multitude of mechanisms involved. We propose that these mechanisms and their outcomes can be better understood by testing how plant diversity affects particulate organic matter (POM) and mineral-associated organic matter (MAOM) depending on whether MAOM storage is "saturated" and the total soil organic matter pool is limited by plant inputs. Such context-dependency of plant-diversity effects on POM, MAOM, and total soil organic matter helps explain inconsistencies in plant-diversity-soil-carbon relationships across studies. Further illumination of this context-dependency is required to better predict consequences of …

Purification Of Uranium Tetrafluoride Using Ammonium Bifluoride, Kyle R. Foster, Juliano Schorne-Pinto, Ronald E. Booth, Annabelle Husek, Mina Aziziha, Hunter B. Tisdale, Bernie W.N. Fitzpatrick, Hans Conrad Zur Loye, Markus H.A. Piro, Theodore M. Besmann

Faculty Publications

A method of purification for UF₄ utilizing NH₄HF₂ was investigated to remove oxygen and hydrate impurities from the salt. The original salt exhibited a melting point at 915–920 °C, which corresponds to the eutectic temperature of the UF4-UO2 system, showing clear signs of oxygen contamination. To purify the salt, an air-tight reaction vessel inside an argon glovebox was used to react UF4/NH4HF2 mixtures at elevated temperatures under a continuous flow of inert gas. The process yielded a significantly purer UF4 salt as confirmed via inert gas fusion, X-ray diffraction, differential scanning calorimetry and inductively coupled plasma-optical …

Full Issue, Volume 13, Number 1, Donna J. Peterson, Scott Cummings, Elizabeth Gregory North

Journal of Human Sciences and Extension

No abstract provided.

Common Sources, Perceived Communication Efficacy And Sufficiency Of Cervical Cancer Information, Education And Communication Materials For Women With Hiv/Aids In Rural Kenya, Scholastic Musakali Adeli, Elkanah Orang'o, Violet Naanyu, Ann Mwangi, Peter Itsura, Barry Rosen, Patrick Loehrer

Obstetrics and Gynaecology, East Africa

Introduction: Cervical cancer is the greatest cause of cancer-related death among women in Sub-Saharan Africa, with particularly high incidence and mortality rates in rural regions. In Kenya, Women with HIV/AIDS (WLHA) are at a greater risk of developing cervical cancer though screening rate remains low. Information, education and communication (IEC) materials play a crucial role in raising awareness, promoting screening, and supporting early detection and treatment; however, little is known about the accessibility, content, and perceived effectiveness of these materials from the perspective of WLHA.

Methods: The objective of this study was to determine the common sources, perceived communication efficacy …

Redundant Functions Of Mir156-Targeted Squamosa Promoter Binding Protein-Like Transcription Factors In Promoting Cauline Leaf Identity, Darren Manuela, Liren Du, Qi Zhang, Yifei Liao, Tieqiang Hu, Jim P. Fouracre, Mingli Xu

Faculty Publications

No abstract provided.

Crystal Growth, Thermal, Optical, Magnetic And Electrochemical Properties Of Mo2Ta2O11, Md Abdullah Al Muhit, Alevtina A. Maksimova, Sean C. Wechsler, Habiba Binte Kashem, Gopabandhu Panigrahi, Gregory Morrison, Morgan Stefik, Hans Conrad Zur Loye

Faculty Publications

Single crystals of the transition metal oxide Mo2Ta2O11 were grown for the first time using molten flux synthesis. The compound crystalizes in the trigonal space group R 3‾m (no. 166) with lattice parameters a = b = 5.6267(1) Å and c = 25.1424(6) Å and a unit cell volume of 689.36(3) ų. The structure of Mo2Ta2O11 is composed of alternating layers of TaO6 octahedra and MoO4 tetrahedra connected via corner-sharing. CaH2 was used to achieve a partial low temperature reduction of Mo2Ta2O11. The electrochemical lithiation of polycrystalline Mo2Ta2O11 was also investigated for the first time. Mo2Ta2O11 underwent a …

Academic Wellness In Health Professional Students: The Intersection Between Dietary Attitudes And Behaviors, Sleep Quality, And Mental Health, Kenya Shereece Moore

Theses and Dissertations

Academic success is strongly influenced by student well-being, with nutrition, sleep, and mental health emerging as critical and interconnected components. Health profession students often face significant mental and physical demands, as they navigate their educational training, which can challenge their ability to maintain healthy behaviors and access necessary support. Although these students are often trained to recognize, treat, and promote wellness in others, they may struggle to prioritize or seek care for themselves. This work aims to explore the health behaviors and care-seeking patterns of health profession students, with a focus on dietary habits, sleep, and barriers to mental health …

Biocomputing Approach To Modeling And Modulating Calcium Signaling, Sehee Sun

School of Computing: Dissertations, Theses, and Student Research

Biocomputing is an emerging field that seeks to perform computational tasks using biological substrates and processes. Unlike conventional computing systems based on silicon hardware, biocomputing leverages the parallelism, energy efficiency, and complex dynamics of living systems. Among various cellular mechanisms, calcium (Ca2+) signaling stands out as a central regulator of diverse biological functions, offering a promising basis for programmable logic and control in living cells.

This thesis introduces a novel framework for modeling and modulating Ca2+ dynamics using biologically inspired Boolean logic circuits. Specifically, we propose the Ca2+ Boolean Logic (CaBL) model, in which Ca2+ fluxes and interactions are abstracted …

Attitudes Towards Insects: An Attempt To Change Negative Attitudes To Neutral Or Positive, Christina Chapman

Department of Entomology: Distance Master of Science Projects

Purpose and Summary

The purpose of this project was to examine whether negative attitudes towards insects could be changed in children after learning about them in a safe and enjoyable environment. At the start of this project, I was a science teacher in an urban middle school, where most students were neither fond of nor interested in insects. This experience shaped my project: I wanted to change attitudes from negative to positive, transforming “eww gross, kill it!” into “let it live; it has a job to do.” Through my studies in the entomology program, my belief that insects are highly …

The Loss Of Opa1 Accelerates Intervertebral Disc Degeneration And Osteoarthritis In Aged Mice, Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige Boneski, Hiromi Sesaki, Ruteja Barve, John Collins, Makarand Risbud

Department of Orthopaedic Surgery Faculty Papers

Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a mitochondrial fusion protein, in their homeostasis. OPA1 knockdown in NP cells altered mitochondrial size and cristae shape and increased the oxygen consumption rate. OPA1 governed the morphology of multiple organelles, including peroxisomes, early endosomes and cis-Golgi and loss resulted in the dysregulation of autophagy. Metabolic profiling and

Native Seed Scoop, 2025 Summer Edition, University Of Northern Iowa. Tallgrass Prairie Center.

Native Seed Scoop

Contents:

--- Upcoming Events
--- TPC at 2025 National Native Seed Conference
--- Regional and National Partnerships
--- 2025 Iowa Native Seed Meeting
--- New Species in Production
--- A Scoop of Science

Soil Health In Nebraska: Exploring Practitioners' Needs And Insights From A Long-Term Organic Farm, Ingrids Isabel Mata Vigil

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Soil health is foundational to sustainable agriculture, environmental resilience, and long-term food security. Yet, the adoption of soil health assessments remains limited, often perceived as too technical, costly, or difficult to implement in real-world contexts. To better understand these challenges, the first chapter presents findings from a statewide survey of 41 soil health practitioners in Nebraska, including farmers, extension educators, NRCS staff, and conservation professionals. Respondents highlighted the need for simpler, more accessible, and context-specific tools for soil health assessment that help practitioners make informed decisions aligned with their management goals. Complementing these insights, the second chapter includes an independent, …

Field Responses Of Glossina Pallidipes And Glossina Fuscipes Fuscipes Tsetse Flies To Novel Repellent Blend And Waterbuck Repellent Compounds In Kenya, Benson M. Wachira, Richard Echodu, Johnson O. Ouma, Imna I. Malele, Daniel Gamba, Michael Okal, Kennedy O. Ogolla, Clement Mangwiro, Robert Opiro, Deusdedit J. Malulu, Bernard Ochieng, Raymond E. Mdachi, Paul O. Mireji

All Peer-Reviewed Publications

Control of tsetse flies constitutes a cornerstone of trypanosomiasis control and elimination efforts in Africa. The use of eco-friendly odor-based bait technologies has been identified as a safer method for control of tsetse flies. These technologies are significantly augmented by development of effective repellents that reduce contact between trypanosome-infected tsetse flies and their vertebrate hosts. Waterbuck Repellent Compounds (WRC) and Novel Repellent Blend (NRB) are recently developed tsetse fly repellent formulations. Information on relative efficacy of these formulations against major tsetse fly vectors of trypanosomiasis in Kenya is limited. Such information can inform choices of repellent technology for optimal control …

Fisheries Research Report No. 352: Boat-Based Recreational Fishing In Western Australia 2023/24, Karina L. Ryan, Eva K. Lai, Claire B. Smallwood, Alissa Tate

Fisheries Research Reports

The integrated survey of boat-based recreational fishing includes three components: off-site phone surveys (encompassing an initial screening survey, a longitudinal phone-diary survey, and post-enumeration surveys), on-site boat ramp surveys and remote camera surveys. The recent phone-diary survey from September 2023 to August 2024 (inclusive) provides comparisons with previous surveys in 2020/21 (September 2020 to August 2021), 2017/18 (September 2017 to August 2018), 2015/16 (September 2015 to August 2016), 2013/14 (May 2013 to April 2014) and 2011/12 (March 2011 to February 2012).

Hyflex Teaching Application In Beverage Npd, Catherine (Rena) Barry-Ryan

Case studies: Digital Education

The post-graduate module (Level 9) in Beverage Product Development (FOOD8003) is delivered to a wide range of students including mature, international and those working full-time. This hyflex module was delivered in Semester 2 of their year-long courses, where students were well settled in TU Dublin, had gained technological ability and were familiar with the VLE (Brightspace) and its online classroom (Bongo). Each week the module progresses a step in the new product development process and therefore attendance and engagement in weekly activities were essential. The student could choose to attend face-to- face or online each week, while getting the same …

Evaluating Target Proteins Of Dock7 Function In Dmd Skeletal Muscle, Maya H. Garner, Katherine G. English, Muthukumar Karupassamy, Matthew S. Alexander

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Exogenous Ketones Reduce Inflammation And Pathology In The Tgf344-Ad Rat Model, Amaya Rogers, Pheven Yohannes, Juan P. Carcamo, Preetham Gundlapally, Amaya Coker, Macy A. Seijo, Caesar M. Hernandez

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences
• Engineering
• Physical & Applied Sciences

Use Of High-Throughput Phenomics With And Without Fungicide As A Wheat Breeding Tool, Gerardo Ivan Rivera Collazo

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Wheat (Triticum aestivum) is an important food staple for many countries around the world and current consumption and production data demonstrate a production deficit. Breeders are challenged to help close this gap in production by selecting better cultivars with improved yields. Several methods aim to accelerate the breeding process to reduce the time required for releasing an elite variety. One of the main breeding bottlenecks is the lack of fast and reliable phenotypic data acquisition that could dissect physiological and morphological plant data. High-throughput remote sensing could have the potential to reduce this bottleneck by streamlining data acquisition, …

Catching A Fever: A Comparison Of Vachellia Xanthophloea Populations In The Limpopo And Luvuvhu River Floodplains Of The Makuleke Contractual Park, Kianie B. David

School of Natural Resources: Dissertations, Theses, and Student Research

This study investigates patterns of stand structure regeneration, growth characteristics, and coarse woody debris (CWD) patterns in Vachellia xanthophloea (fever tree) stands within the Makuleke Contractual Park (MCP), a semi-arid savanna system in northern Kruger National Park (KNP), South Africa. Fieldwork was conducted across two stand types: a monospecific fever tree stand in Rietbok Vlei and a mixed-species stand in the Western Nhlangaluwe Floodplain where fever tree is established with Faidherbia albida (ana tree). Data were collected from 20 total 1/4-acre (1,011 m²) circular plots between both stands in 2024 and 2025, including seedling root collar diameter (RCD), …

Bioenergy Crop Production: Implications For Grassland Bird Communities In Southwestern Nebraska, Grace E. Schuster

School of Natural Resources: Dissertations, Theses, and Student Research

Biofuel and bioenergy systems are components of most climate stabilization pathways to reduce greenhouse gas emissions and limit global warming. Currently, corn (Zea mays) is the predominant feedstock used for bioenergy production in the United States. However, widespread production of this monoculture crop has resulted in many negative environmental impacts. The most notorious impact has been the loss of grassland habitat due to agriculture expansion which has had detrimental effects on wildlife that depend on grassland habitat. One such group, grassland birds, has faced steeper, more consistent, and more widespread declines than any other avian guild. Therefore, strategies …

Lingnan Gardeners Newsletter (No. 75) = 彩園通訊 (第75期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University

Lingnan Gardeners Newsletter 嶺南彩園通訊

No abstract provided.

Urbanization And Earthquake Resilience In The Kathmandu Valley, Alex Nation

Nepal: Geoscience in the Himalaya

The Kathmandu Valley is the fastest growing city in South Asia and is developing in a haphazard manner, subsequently creating an unnecessary earthquake risk. Few papers have been published regarding the development of Kathmandu and its surroundings as a whole and relating it to earthquakes. This study conducted visits to some cities in the valley and analyzed the infrastructure, architecture and engineering, as well as city layout. It was discovered that zoning is completely absent in the region and planning attempts are unable to keep up with the rate of expansion. Further awareness, enforcement of codes, and zoning is needed …