Life Sciences Commons^™

Commentary On Blaser's "Antibiotic Use And Its Consequences For The Normal Microbiome", Fred C. Tenover

AMR Commentary

If you have not read this eye-opening commentary by Dr. Martin Blaser about the negative impact of the widespread use of antibiotics in children, you should. The goal of giving antibiotics to children usually is to treat an infection — an earache, a respiratory tract infection, or perhaps a potentially deadly bloodstream infection. Those antibiotics, however, will often kill more than just the bacteria that are causing the infection. Humans have large quantities of “good bacteria” in our intestinal tracts, on our skin, and elsewhere on our body that play an important role in keeping us healthy.

Prior To Termination, The Rye Cover Crop Increased The Soil Methane Sink, Shailesh Pandit, Graig W. Reicks, Janet Moriles Miller, Deepak R. Joshi, Sharon A. Clay, David E. Clay

Agronomy, Horticulture and Plant Science Faculty Publications

Even though the impact of cover crops on soil moisture has been well documented, little work has investigated the resulting impact on methane emissions. Therefore, the objective was to determine the influence of a dormant seeded rye (Secale cereale) cover crop on soil temperatures, soil moisture, inorganic N, and total CH₄-C emission in a well-drained frigid soil from the start of growth in April/May through corn's (Zea mays) V4 growth stage. In this study, soil moisture, temperature, CH₄-C, and N₂O-N fluxes were measured near-continuously. The rye cover crop: (1) reduced …

Skin Bacteriome Structure And Batrachochytrium Dendrobatidis Prevalence Differs Amongst Two Sympatric Salamanders In The San Francisco Bay Area., Aria Norwood, Jadyn Jamora, Micuel Madison, Jamiee Nguyen, Azan Yousaf, Katya Morales, Emily Vu, Obed Hernández-Gómez

Natural Sciences and Mathematics | Student Professional Publications

Microbial surveys are becoming an important component of wildlife health research, especially in cases where environmental change and infectious diseases are serious issues. Amongst amphibians, Batrachochytrium spp. have the potential to be fatal pathogens that can impact the population health of numerous species. We assessed the skin bacteriome, prevalence of Batrachochytrium dendrobatidis (Bd) and body conditions of two salamander genera with different life histories: the California slender salamander (Batrachoseps attenuatus) and members of the Pacific newt species complex (Taricha torosa and Taricha granulosa; Taricha sp.). We used 16S rRNA V4 amplicon sequencing to characterise the bacterial communities. Taricha sp. had …

Creek-Friendly Practices For Hoas, Plaster Creek Stewards

Print Materials

This booklet is intended to be a comprehensive guide to encourage Homeowner Associations (HOAs) in nurturing and safeguarding their local waterways. Within these pages the challenges facing our water ecosystems will be addressed, with particular focus being placed on the Plaster Creek Watershed in West Michigan. This booklet will also emphasize the role HOAs can play in fostering environmental stewardship and healthier, more resilient creek systems. This booklet contains practical strategies, from rain gardens to native plantings, that not only enhance the beauty of your HOA but extends care to downstream neighbors and the creek.

Fisheries Science Update - Pilbara Fishing Competition Science 2020 To 2024 - July 2025, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Science Updates

Key Points:

• Pilbara recreational fishing competitions are helping to track the sustainability of pelagic species like Spanish mackerel.
• Over 500 pelagic fish have been sampled at Pilbara fishing competitions over 5 years.
• This information goes towards DPIRD’s assessment of Spanish mackerel and monitoring the large pelagic resource in the North Coast Bioregion.

Alpha-Synuclein Null Mutation Exacerbates The Phenotype Of A Model Of Menkes Disease In Female Mice, Meganne Casey, Dan Zou, Renee Reijo Pera Phd, Tiffany Hensley-Mcbain, Deborah E. Cabin

Touro College of Osteopathic Medicine (Great Falls) Publications and Research

Human SNCA, which encodes a-synuclein protein (SNCA), was the first gene linked to familial Parkinson's disease (PD). Since the discovery of the genetic link of SNCA to Parkinson's nearly three decades ago, many studies have investigated the normal function of SNCA protein. However, understanding of the normal function of SNCA is complicated by the lack of a reliable mammalian model of PD; indeed, mice with homozygous null mutations in the Snca gene live a normal lifespan and have only subtle synaptic deficits. Here, we report the first genetic modifier (a sensitized mutation) of a murine Snca null …

Covid-19-Related Beliefs And Dietary Behaviors Of American Undergraduate Students Vary By Race Via The Lens Of The Health Belief Model, Doreen Liou, Jong Min Lee

Department of Nutrition and Food Studies Scholarship and Creative Works

The COVID-19 pandemic caused immense physical disruptions, affecting young adults in the U.S. The Health Belief Model is a social psychological framework that predicts the likelihood of adopting health behavior. The purpose of this research is to investigate COVID-19-related health beliefs and dietary behaviors among undergraduate students during the pandemic. Using convenience sampling, a cross-sectional survey was completed by 304 individuals at a New Jersey state university. Survey data included the frequency of COVID-19 prevention behaviors (e.g., wearing an indoor mask, handwashing), and consumption of fruit and vegetables. The Health Belief Model constructs measured perceived susceptibility to COVID-19, severity, benefits, …

Protein Supplementation, Plasma Branched-Chain Amino Acids, And Insulin Resistance In Postmenopausal Women: An Ancillary Study From The Supplemental Protein To Outsmart Osteoporosis Now (Spoon) Trial, Jessica Dauz Bihuniak, Alessandra Byer, Christine A. Simpson, Rebecca R. Sullivan, Josephine M. Dudzik, Karl L. Insogna, Jeannette M. Beasley

Department of Nutrition and Food Studies Scholarship and Creative Works

Background/Objectives: Studies have reported an increased risk of type 2 diabetes among people with higher protein intake. Moreover, branched-chain amino acids (BCAA) are reported to be positively associated with insulin resistance (IR). However, it is not understood whether elevated levels of BCAA are causal to IR development, or if higher BCAA are a marker of IR. The objective of this study was to examine the effects of long-term protein and carbohydrate supplementation on plasma BCAA levels, and the relationship between plasma BCAA and IR in postmenopausal women. Methods: Stored samples and data from 84 postmenopausal women who participated in a …

Effect Of Traditional Versus Fenceline Weaning On Lamb Stress, Emma N. Sutton

Animal Science Undergraduate Honors Theses

Stress is a significant factor affecting the health, behavior, and performance of sheep in production settings. Most lambs go through artificial weaning, and this is a stressful time in a lamb’s life. Stress can negatively affect growth rates, feed efficiency, and susceptibility to illness and parasites. The traditional and most common method of weaning is the abrupt separation of lambs from their dams. An alternative method of weaning, fenceline weaning, has been found to reduce stress in cattle and may also reduce stress in sheep. The objectives of this study were to evaluate body weights, fecal egg counts, and behavior …

Using Rna Sequencing To Investigate The Causes Of Sex-Specific Aging In Drosophila Melanogaster, Anna W. Wheeler, Abigail R. Fox, Nicole C. Riddle

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Infralimbic Gabaergic Interneurons Show Opposing Activity During High And Low Fear States In Pavlovian Fear Model, Faith A. Brown, Noelle R. Potter, Rodrigo Campos-Cardoso, Kirstie A. Cummings

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Identification Of The Gd-Iga1 Autoantigen By New Monoclonal Finds Differential Nf-Kb Signaling, Hannah Adams, Taylor Person, Terri Rice, Colin Reily

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Investigating Whether The Loss Of Extracellular Progranulin Results In Ftd-Related Lysosomal Storage Pathology, Ryley B. Dykes, Asha Shareef, Jakub Hel, Mackenzie L. Love, Andrew E. Arrant

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Real-Time Dynamics Of Desmosomal Cadherin Behavior Via Time-Resolved Fluorescence Microscopy, Daniel Wang, Collin M. Ainslie, Anish Maskey, Caroline Tran, Ethan J. Taylor, Kannatassen Appavoo, Alexa L. Mattheyses

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Administration Of An Anti-Inflammatory Diet Plus Anti-Pd-1 Slows Renal Cancer Progression In Mice, Lucius Breazeale, Lyse Norian, Kimberlyn Bartlett

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Patient- Derived 3d Miniaturized Glioma Organotypic Slices (Migos) As A Model For Investigating Extracellular Matrix And Cellular Tumor Microenvironment Remodeling, Parth Kommidi, Dilani Patel, Melika Hashemi, Reid Hale, Andrea Comba

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Comparing Extenders For Cryopreservation Of Sperm From The Sea Urchin, Lytechinus Variegatus, Gus Roveri, Katie Gibbs

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Investigating The Effects Of Inflammatory Stress On Hematopoietic Stem And Progenitor Cells In Culture, Nicholas Stefanov, Caroline Ennis, Francesca Luca, Kharishni Lakshman, Paran Goel, Alana Franceski, Robert Welner

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

​​Site Fidelity Is Associated With The Social Experience Of Forked Fungus Beetles (Bolitotherus Cornutus), Joo Yeon Kim , '22, C. W. Wood, E. D. Brodie Iii, Vincent A. Formica

Biology Faculty Works

Consistently returning to or remaining within a specific location, a behavior known as site fidelity, is a useful metric for quantifying animal space use. When multiple individuals display similar site fidelity patterns, they are likely to interact, shaping the degree and quality of their social interactions. However, the link between the expression of site fidelity behavior and an individual’s social experience has not been thoroughly investigated. In this study we examined (1) how intrinsic individual properties (body size and sex) predicted variation in site fidelity and (2) whether site fidelity was linked to the social experience of individuals in wild …

Gis-Based Swat Modeling For Surface Runoff Assessment To Support Urban Flood Resilience In Central Java, Indonesia, Putri Amalia Sholichah Ms., Endah Sulistyawati, Susana Paulina Dewi

Smart City

Surface runoff significantly contributes to environmental hazards such as floods in Indonesia, including in Borobudur District. Based on watershed delineation, the administrative area of Borobudur District is predominantly located within the Sileng Subwatershed. The rehabilitation zones managed by PT Adaro Indonesia are located in several specific areas within this subwatershed. This study utilizes the SWAT (Soil and Water Assessment Tool) model integrated with GIS (Geographic Information System) to simulate surface runoff quantitaively in the Sileng subwatershed, part of the Progo watershed in Central Java Province. SWAT is applied in this research to simulate surface runoff in both watershed and …

Dynamic Microbiome Responses To Structurally Diverse Anthocyanin-Rich Foods In A Western Diet Context, Mohammed F. Almatani, Giovanni Rompato, Eliza C. Stewart, Marcus Hayden, Jeremy Case, Samuel Rice, Korry J. Hintze, Abby D. Benninghoff

Animal, Dairy, and Veterinary Science Student Research

Background/Objectives: Anthocyanin (ACN)-rich foods are known to influence the gut microbiota composition, but the temporal dynamics and structural specificity of these effects remain poorly understood. This study investigated how distinct ACN-rich fruit supplements impact the gut microbiome over time in the context of a Western-style diet. We hypothesized that ACN-induced microbial shifts would occur rapidly, differ by ACN source, and require continued intake to persist. Methods: C57BL/6J mice were fed the total Western diet (TWD) supplemented with freeze-dried powders from bilberry (BB), tart cherry (TC), chokeberry (CB), elderberry (EB), black currant (BC), or black raspberry (BRB) for 0, 1, 3, …

Western Australia’S Agricultural R&D Ecosystem, Ross Kingwell

Farm Systems and Economics published reports

• Decades ago, the agricultural R&D ecosystem in Western Australia (WA) was fairly simple with few funders and some key providers of R&D services such as the Department of Agriculture, CSIRO and the University of Western Australia.
• Since then, the agricultural R&D ecosystem in WA has increased in complexity with more R&D providers and a greater injection of industry and private funding.
• These changes have occurred against a backdrop of the total investment in agricultural R&D declining as a share of agriculture’s gross value of production.
• State and federal governments have reduced their share of the total investment in agricultural R&D. …

Cdemapper: Enhancing National Institutes Of Health Common Data Element Use With Large Language Models, Yan Wang, Jimin Huang, Huan He, Vincent Zhang, Yujia Zhou, Xubing Hao, Pritham Ram, Lingfei Qian, Qianqian Xie, Ruey-Ling Weng, Fongci Lin, Yan Hu, Licong Cui, Xiaoqian Jiang, Hua Xu, Na Hong

Faculty, Staff and Student Publications

Objective: Common Data Elements (CDEs) standardize data collection and sharing across studies, enhancing data interoperability and improving research reproducibility. However, implementing CDEs presents challenges due to the broad range and variety of data elements. This study aims to develop a CDE mapping tool to bridge the gap between local data elements and National Institutes of Health (NIH) CDEs.

Methods: We propose CDEMapper, a large language model (LLM)-powered mapping tool designed to assist in mapping local data elements to NIH CDEs. CDEMapper has 3 core modules: (1) CDE indexing and embeddings. NIH CDEs were indexed and embedded to support semantic search; …

Evaluating Large Language Model Performance To Support The Diagnosis And Management Of Patients With Primary Immune Disorders, Nicholas L Rider, Yingya Li, Aaron T Chin, Daniel V Digiacomo, Cullen Dutmer, Jocelyn R Farmer, Kirk Roberts, Guergana Savova, Mei-Sing Ong

Faculty, Staff and Student Publications

Background: Generative artificial intelligence (GAI) is transforming health care in a variety of ways; however, the present utility of GAI for supporting clinicians who treat rare disease such as primary immune disorders (PIs) is not well studied. We evaluated the ability of 6 state-of-the-art large language models (LLMs) for providing clinical guidance about PIs.

Objective: To quantitatively and qualitatively measure the utility of current, open-source LLMs for diagnosing and providing helpful clinical decision support about PIs.

Methods: Five expert clinical immunologists each provided 5 real-world, anonymized PI case vignettes via multi-turn prompting to 6 LLMs (OpenAI GPT-4o, Llama-3.1-8B-Instruct, Llama-3.1-70B-Instruct, Mistral-7B-Instruct-v0.3, …

Wnt-Directed Cxcl12-Expressing Apical Papilla Progenitor Cells Drive Tooth Root Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Hiroaki Manabe, Angel Ka Yan Chu, Ramandeep Kaur, Meer Ali, Yuntao Yang, Chiaki Tsutsumi-Arai, Yuta Nakai, Yuki Matsushita, Nicha Tokavanich, W Jim Zheng, Joshua D Welch, Noriaki Ono, Wanida Ono

Faculty, Staff and Student Publications

The tooth root is a critical component of the tooth anchored to surrounding alveolar bones. Tooth root formation is driven by cells in the apical papilla (AP) that generate new dentin-forming odontoblasts at the root-forming front. Mesenchymal stem cells have been isolated from AP for regenerative use; however, how AP cells physiologically coordinate tooth root formation remains undefined. We find that CXCL12+ cells emerge in AP under hypoxic environments at the onset of tooth root formation. Using Cxcl12-creER-based cell-lineage analysis, we further find that CXCL12+ AP cells contribute not only to odontoblasts but also to cementum-forming cementoblasts of the elongating …

Studying The Population Dynamics Of Nslab And Their Influence On Spores During Cheese Ripening, Rakesh Kaushik, Sanjeev Anand

Dairy Science and Food Science Faculty Publications: 2022 to Present

Cheese ripening involves microbial changes, with starter lactic acid bacteria (SLAB) initiat- ing fermentation and nonstarter lactic acid bacteria (NSLAB) driving flavor and texture development. However, heat-resistant spores of Clostridium and Bacillus can survive pas- teurization and cause spoilage during ripening. This study evaluated NSLAB dynamics in the presence of spores during cheese ripening. Cheddar cheese samples at pilot-scale level (110 L) with four treatments, namely control, with spores of B. licheniformis (T1), with spores of Cl. tyrobutyricum (T2), and both spores (T3) at 2.0 Log10 CFU/mL, were ripened at 7 ◦C for six months. SLAB declined from 8.0 to …

Alfred Russel Wallace Notes 37. What About Wallace On Vaccination . . . ?, Charles H. Smith

Faculty/Staff Personal Papers

Best known for his natural history studies on evolution and biogeography, Alfred Russel Wallace (1823−1913) had a significant second career as a social critic. One of his most controversial stances was his position on (smallpox) vaccination. Anti-vaxxers of the present frequently bring up his name as a resource for their side, but the situation is not so easily reducible to that.

Effect Of Rainfall Reduction And Competition On The Phenology Of The Mediterranean Forage Perennial Legume Bituminaria Bituminosa Var. Albomarginata Cv. Lanza, Jesus Fernandez-Habas, Daniel Real, Tom Vanwalleghem, Jose Ramon Leal-Murillo, Jesus Fernandez-Rebollo

Grain and Other Field Crops Research Articles

Tedera (Bituminaria bituminosa (L.) C.H. Stirt.) is a Mediterranean drought-tolerant species that shows potential as a forage perennial legume for Mediterranean livestock systems. This three-year study investigated the phenology of the newly developed variety of tedera (Lanza) in response to an annual 24% rainfall reduction and competition compared to alfalfa (Medicago sativa L.) in a typical Mediterranean environment of the Iberian Peninsula. Tedera showed early phenology for the reproductive stages from inflorescence emergence to ripening compared to alfalfa, with a long flowering period from early April to mid-May, overlapping with mature fruits. In general, tedera responded to a …

Utilizing Pharmacogenomics To Improve Students' Self-Perception On The Interprofessional Competencies Of Roles And Responsibilities, And Teams And Teamwork, Amanda Brown, Moom R. Roosan, Robert Goldsteen, Scott D. Ochs, Reza Taheri

Pharmacy Faculty Articles and Research

Introduction

Pharmacogenomics (PGx) is an emerging discipline with the potential to revolutionize personalized medicine, but its successful implementation requires interprofessional collaboration. To address this need, a virtual interprofessional education (IPE) session was designed for student pharmacists and medical students to engage in a case-based learning experience.

Objective

The primary objective was to develop and implement an IPE activity focused on a patient case requiring PGx-guided dual antiplatelet therapy and to assess students' perceptions of two Interprofessional Education Collaborative (IPEC) Version 3 Core Competencies. A secondary objective was to identify key lessons from the session.

Methods

Pharmacist and physician faculty collaboratively …

A Child With Severe Pneumonia Cannot Feed, Causing Malnutrition: Exploring Health Worker And Caregiver Perspectives And Practices For Mitigating Malnutrition Among Children With Severe Pneumonia, A Case Of Uganda, Damalie Nalwanga, Robert Opoka, Andrew Sentoogo Ssemata, Lawrence Kakooza, Andrew Kiggwe, Victor Musiime, Sarah Kiguli

Paediatrics and Child Health, East Africa

Background: Severe pneumonia remains the leading cause of morbidity and mortality among children worldwide. Severe pneumonia causes death during hospitalization, and survivors are prone to malnutrition after discharge from the hospital. The World Health Organization and United Nations International Children’s Fund recommend ‘continued’ feeding following a severe pneumonia illness without specific recommendations on nutritional support. This recommendation could influence health workers’ and caregivers’ nutritional practices. This study aimed to explore the perspectives and practices of health workers and caregivers for mitigating malnutrition among children with severe pneumonia.

Methods: We conducted a cross-sectional qualitative study between June and November 2021 among …