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Articles 1081 - 1110 of 235813

Full-Text Articles in Life Sciences

A New Twist: The Combination Of Sulbactam/Avibactam Enhances Sulbactam Activity Against Carbapenem-Resistant, Fernando Pasteran, Jose Cedano, Michelle Baez, Ezequiel Albornoz, Melina Rapoport, Jose Osteria, Sabrina Montaña, Casin Le, Grace Ra, Robert A Bonomo, Marcelo E Tolmasky, Mark D Adams, Alejandra Corso, Maria Soledad Ramirez May 2021

A New Twist: The Combination Of Sulbactam/Avibactam Enhances Sulbactam Activity Against Carbapenem-Resistant, Fernando Pasteran, Jose Cedano, Michelle Baez, Ezequiel Albornoz, Melina Rapoport, Jose Osteria, Sabrina Montaña, Casin Le, Grace Ra, Robert A Bonomo, Marcelo E Tolmasky, Mark D Adams, Alejandra Corso, Maria Soledad Ramirez

Faculty Research 2021

An increasing number of untreatable infections are recorded every year. Many studies have focused their efforts on developing new β-lactamase inhibitors to treat multi-drug resistant (MDR) isolates. In the present study, sulbactam/avibactam and sulbactam/relebactam combination were tested against 187 multi-drug resistant (MDR) Acinetobacter clinical isolates; both sulbactam/avibactam and sulbactam/relebactam restored sulbactam activity. A decrease ≥2 dilutions in sulbactam MICs was observed in 89% of the isolates when tested in combination with avibactam. Sulbactam/relebactam was able to restore sulbactam susceptibility in 40% of the isolates. In addition, the susceptibility testing using twenty-three A. baumannii AB5075 knockout ...


Antibiotic Resistance Gene Dissipation In Soil Microcosms Amended With Antibiotics And Swine Manure, Laura Alt, Alyssa N. Iverson, Michelle L. Soupir, Thomas B. Moorman, Adina Howe May 2021

Antibiotic Resistance Gene Dissipation In Soil Microcosms Amended With Antibiotics And Swine Manure, Laura Alt, Alyssa N. Iverson, Michelle L. Soupir, Thomas B. Moorman, Adina Howe

Agricultural and Biosystems Engineering Publications

The use of antibiotics in animal agriculture has exacerbated the presence of both antibiotic resistance genes (ARGs) and residual antibiotics excreted in animal manure. Field application of this manure is a common practice as its nutrient rich material can benefit crop growth. However, this practice can also introduce antibiotics and ARGs into non-agricultural settings. The integration of prairie buffer strips within and at the edge of crop fields is a potential management solution to reduce concentrations of ARGs commonly transported via water runoff and infiltration. To investigate the fate of ARGs in directly manured crop field soils and surrounding, impacted ...


Impact Of Angiogenic And Osteogenic Factors In The Presence Of Biodegradable Piezoelectric Films, Jayla Millender May 2021

Impact Of Angiogenic And Osteogenic Factors In The Presence Of Biodegradable Piezoelectric Films, Jayla Millender

Honors Scholar Theses

One of the most common causes of bone graft rejection is lack of a vascular network connecting the graft to the existing native tissue – allowing for nutrient flow. Under current grafting techniques, the existing blood vessel network in the patient slowly invades the implant in order to supply the injured site with its necessary nutrients. The purpose of this research is to determine if a synthetic bone graft with a stable microvascular network can be developed in vitro. I hypothesize that the use of indirect angiogenic factors such as sonic hedgehog homolog and hypoxia-inducible factor-1 in combination with the direct ...


Soybean Aphid Egg Hatch Complete, Ashley Dean, Erin W. Hodgson May 2021

Soybean Aphid Egg Hatch Complete, Ashley Dean, Erin W. Hodgson

Integrated Crop Management News

Iowa’s most significant soybean insect pest, soybean aphid, has host-alternating biology. Its primary host is buckthorn, an invasive shrub often found in hedgerows and roadside ditches, and its secondary host is soybean. For the majority of the year, soybean aphids exist as cold-hardy eggs on buckthorn branches near leaf buds. As spring temperatures increase, the eggs hatch and a few generations are produced on buckthorn before moving to soybean. In the summer, soybean aphid has multiple, overlapping generations on soybean. During the fall, soybean aphids return to buckthorn.


Repurposing Potential Of Posaconazole And Grazoprevir As Inhibitors Of Sars-Cov-2 Helicase, Syed Hani Abidi, Nahlah Makki Almansour, Daulet Amerzhanov, Khaled S. Allemailem, Wardah Rafaqat, Mahmoud A A. Ibrahim, Philip La Fleur, Martin Lukac, Syed Ali May 2021

Repurposing Potential Of Posaconazole And Grazoprevir As Inhibitors Of Sars-Cov-2 Helicase, Syed Hani Abidi, Nahlah Makki Almansour, Daulet Amerzhanov, Khaled S. Allemailem, Wardah Rafaqat, Mahmoud A A. Ibrahim, Philip La Fleur, Martin Lukac, Syed Ali

Department of Biological & Biomedical Sciences

As the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic engulfs millions worldwide, the quest for vaccines or drugs against the virus continues. The helicase protein of SARS-CoV-2 represents an attractive target for drug discovery since inhibition of helicase activity can suppress viral replication. Using in silico approaches, we have identified drugs that interact with SARS-CoV-2 helicase based on the presence of amino acid arrangements matching binding sites of drugs in previously annotated protein structures. The drugs exhibiting an RMSD of ≤ 3.0 Å were further analyzed using molecular docking, molecular dynamics (MD) simulation, and post-MD analyses. Using these approaches, we ...


A Screen Of Fda-Approved Drugs Identifies Inhibitors Of Protein Tyrosine Phosphatase 4a3 (Ptp4a3 Or Prl-3), Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn May 2021

A Screen Of Fda-Approved Drugs Identifies Inhibitors Of Protein Tyrosine Phosphatase 4a3 (Ptp4a3 Or Prl-3), Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn

Molecular and Cellular Biochemistry Faculty Publications

Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, small molecule inhibitors of PRL-3 are lacking. Here, we screened 1443 FDA-approved drugs for their ability to inhibit the activity of the PRL phosphatase family. We identified five specific inhibitors for PRL-3 as well as one selective inhibitor of PRL-2. Additionally, we found nine drugs that broadly and significantly suppressed PRL activity. Two of these broad-spectrum PRL inhibitors, Salirasib and Candesartan, blocked PRL-3-induced migration in human embryonic kidney cells ...


Genome Sequence Of A Virulent African Swine Fever Virus Isolated In 2020 From A Domestic Pig In Northern Vietnam, Quang Lam Truong, Thi Lan Nguyen, Thi Hoa Nguyen, Jishu Shi, Hiep Lai Xuan Vu, Thi Lan Huong Lai, Van Giap Nguyen May 2021

Genome Sequence Of A Virulent African Swine Fever Virus Isolated In 2020 From A Domestic Pig In Northern Vietnam, Quang Lam Truong, Thi Lan Nguyen, Thi Hoa Nguyen, Jishu Shi, Hiep Lai Xuan Vu, Thi Lan Huong Lai, Van Giap Nguyen

Virology Papers

This study reports the genome sequence of an isolated African swine fever (ASF) virus (VNUA-ASFV-05L1/HaNam) obtained at the fourth passage on pulmonary alveolar macrophages. The virus was isolated during a typical acute ASF outbreak in pigs in a northern province of Vietnam in 2020.


Effect Of Nacl On Seed Germination And Seedling Growth Of Medicago Falcata L., Fengmei Qin, Hong Yan, Hongxiang Zhang, Daowei Zhou May 2021

Effect Of Nacl On Seed Germination And Seedling Growth Of Medicago Falcata L., Fengmei Qin, Hong Yan, Hongxiang Zhang, Daowei Zhou

International Grassland Congress Proceedings

No abstract provided.


Seedling Growth And Yield In Common Vetch At Different Seeding Density And Date, Pedro A. Martínez-Hernández, Eden Lopez‐Mendez, Ricardo Amendola‐Massiotti, Alfonso Hernandez‐Garay May 2021

Seedling Growth And Yield In Common Vetch At Different Seeding Density And Date, Pedro A. Martínez-Hernández, Eden Lopez‐Mendez, Ricardo Amendola‐Massiotti, Alfonso Hernandez‐Garay

International Grassland Congress Proceedings

No abstract provided.


Storage Of Seeds From Tropical Legumes Used In Cuban Livestock Production Systems, Marlen Navarro, Arístides Pérez, Yolanda González, Juan Carlos Lezcano May 2021

Storage Of Seeds From Tropical Legumes Used In Cuban Livestock Production Systems, Marlen Navarro, Arístides Pérez, Yolanda González, Juan Carlos Lezcano

International Grassland Congress Proceedings

No abstract provided.


Studies On Attachment Behavior Of Germinating Surface‐Sown Mengnong Sainfoin And Astragalus Adsurgens Seeds, Yanjie Mi, Fengling Shi, Cuiping Gao, Ning Lu May 2021

Studies On Attachment Behavior Of Germinating Surface‐Sown Mengnong Sainfoin And Astragalus Adsurgens Seeds, Yanjie Mi, Fengling Shi, Cuiping Gao, Ning Lu

International Grassland Congress Proceedings

No abstract provided.


North Central Extension Risk Management Education Center, Christine Lockert, Bradley D. Lubben May 2021

North Central Extension Risk Management Education Center, Christine Lockert, Bradley D. Lubben

Cornhusker Economics

Farmers and ranchers face many risks and challenges in production agriculture on a daily basis. Changing market fundamentals, farm policy reforms, and crop insurance program developments defined the risk environment that led to the authorization of agricultural risk management education as part of the Agricultural Risk Protection Act of 2000. The education efforts have been designed to help producers manage the full range of production, marketing, financial, legal, and human risks that are all part of agriculture.


Reeling In New Antibiotics: Synthesis And Antimicrobial Susceptibility Testing Of Zinc-Binding Clavanins From Styela Clava (Sea Squirt), Eduardo Badillo-Colberg May 2021

Reeling In New Antibiotics: Synthesis And Antimicrobial Susceptibility Testing Of Zinc-Binding Clavanins From Styela Clava (Sea Squirt), Eduardo Badillo-Colberg

Honors Scholar Theses

Clavanins have been a quite rarely studied antimicrobial peptide (AMP) family. Though the data in the few studies published on the matter and in theoretical experimental data presented by the Wang lab in their peptide library creation [14], in that the members of this family could potentially be quite effective novel antimicrobial candidates. Among those that have been targets of studies, Clavanin A has been at the forefront of this endeavor of finding effective novel antimicrobial peptides[14]. In these aforementioned studies, Clavanin A has been shown to be quite effective against many different bacterial strains, which begs the question ...


Syrup Hedera Helix Extract Poisoning In Dog: A Clinical Report, Erdem Gülersoy, Murat Kaan Durgut, Süleyman Serhat İyigün, Mutlu Sevinç May 2021

Syrup Hedera Helix Extract Poisoning In Dog: A Clinical Report, Erdem Gülersoy, Murat Kaan Durgut, Süleyman Serhat İyigün, Mutlu Sevinç

Revista de Medicina Veterinaria

En este informe clínico se describe un cuadro de gastroenteritis desarrollada por un golden retriever de 1 año que pesaba 24 kg, como resultado del uso aleatorio y sin receta de un extracto de jarabe de Hedera helix, que es solo para uso por humano. El diagnóstico se realizó después de que se descartaron otros factores que podrían causar gastroenteritis. Se observó una mejora en los hallazgos clínicos como resultado del tratamiento de apoyo. Ya se ha reconocido ampliamente que las saponinas triterpénicas, que son compuestos biológicos activos de Hedera helix, causan gastroenteritis en perros, y se considera que el ...


Nest Site Selection And Nesting Behavior Of The Mud Turtle Kinosternon Scorpiodes (Testudines, Kinosternidae) In Palo Verde National Park, Costa Rica: Implications For Management, José M. Mora, Franklin E. Castañeda May 2021

Nest Site Selection And Nesting Behavior Of The Mud Turtle Kinosternon Scorpiodes (Testudines, Kinosternidae) In Palo Verde National Park, Costa Rica: Implications For Management, José M. Mora, Franklin E. Castañeda

Biology Faculty Publications and Presentations

Habitat selection is the process whereby individuals preferentially use, or occupy, a non-random set of available habitats. At the same time, nest site selection is defined as the placement of eggs by females at sites differing from random sites within a delimited area. We located 59 nests of the mud turtle Kinosternon scorpioides in Palo Verde National Park (PVNP) in Northwestern Costa Rica. We compared eight microhabitat variables at nest sites against those at random sites. Females significantly placed their eggs at sites with more understory, leaf litter cover, and greater leaf litter depth than in random sites. Additionally, females ...


Endocarditis Infecciosa En Canino Con Diagnóstico Previo De Síndrome Vestibular Periférico Secundario A Probable Otitis Media-Interna: Reporte De Caso, María Andrea Guzmán Solano, Pedro Vargas-Pinto, César Augusto Cabrejo Saavedra May 2021

Endocarditis Infecciosa En Canino Con Diagnóstico Previo De Síndrome Vestibular Periférico Secundario A Probable Otitis Media-Interna: Reporte De Caso, María Andrea Guzmán Solano, Pedro Vargas-Pinto, César Augusto Cabrejo Saavedra

Revista de Medicina Veterinaria

La endocarditis infecciosa es un proceso patológico de baja incidencia en la clínica diaria; su principal etiología son los agentes bacterianos, los cuales colonizan con mayor prevalencia de válvula mitral y aortica. En este artículo se presenta el estudio de un perro con diagnóstico previo de síndrome vestibular periférico secundario a probable otitis media-interna. Se presenta con un soplo de aparición súbita, claudicaciones intermitentes, inapetencia, depresión y fiebre, por lo cual se hace la valoración ecocardiográfica, donde se evidencia engrosamiento valvular mitral, acompañado de estructuras hiperecoicas en el borde libre que corresponden a lesiones vegetativas. Por medio de los criterios ...


The Spread Of Batrachochytrium Dendrobatidis And Its Effect On The Global Amphibian Ecosystem, Mars Pinkelman May 2021

The Spread Of Batrachochytrium Dendrobatidis And Its Effect On The Global Amphibian Ecosystem, Mars Pinkelman

COD Library Student Research and Award Symposium

The Spread of Batrachochytrium Dendrobatidis and its Effect on the Global Amphibian Ecosystem, discusses the deadly amphibian pathogen Batrachochytrium Dendrobatidis. My work aimed to answer the question, "How did the spread of batrachochytrium dendrobatidis, affect amphibian populations from its discovery in 1993 to modern day, and how could it affect biodiversity in the future?" It first covers a brief history of the disease and its discovery as well as the impacts it has on individual hosts. I then discuss the effects that the parasitic fungus has on biodiversity, concluding with ways for individuals and communities to mitigate the impacts that ...


The Effects Of Covid-19 On Heart Function, Samiha Syed May 2021

The Effects Of Covid-19 On Heart Function, Samiha Syed

COD Library Student Research and Award Symposium

Student will investigate the heart function of heart patients who suffer from COVID-19 from a biological and physics-based lens and identify innovative treatment options to alleviate symptoms and blood flow. Students will seek faculty advising one-on-one with Dr. Purcell and additional, from other faculty members in the biology and physics departments at the College of DuPage. Student will also research ways to study heart function in the classroom and develop a model for further study.

Faculty Sponsor: Susan Purcell


Perspectives On Covid, Glenn Bass May 2021

Perspectives On Covid, Glenn Bass

CULTURE & CRISIS: Reconciling Constitutionalism & Federalism in a Time of Crisis

The purpose of this paper is to delve further into the topic of Culture & Crisis: Reconciling Constitutionalism & Federalism in a Time of Crisis through Liberty University’s Helms School of Government & Journal of Statesmanship & Public Policy. The United States of America is currently under siege by the COVID-19 virus. This virus has steadily killed hundreds of individuals and consequently nearly shutdown the American socio-economic system. Through a constitutional government and federal principles, the executive functions have been able to address this time of crisis. However, there are different views referencing exactly how to address the needs of our nation during this time of crisis. This threat to public health is perceived differently by the Republican and Democratic parties. Democrats have been viewed as trying to present the severity of the situation, in terms of health, finances, and safety. The Republicans are viewed as presenting information that does not demonstrate such a severity of the situation; however, they do understand the perceived threats which have invoked several governmental functions (e.g., relief funds, unemployment insurance). These views can be skewed, as Republicans and Democrats, as they live in different counties which have been impacted differently by the COVID-19 virus. Tensions have been on the rise due to this phenomenon which can be handled efficiently through the execution of deliberative constitutionalism. These issues and more will be discussed further.


Activation Of Aryl Hydrocarbon Receptor Signaling In Human Trophoblasts Alters Markers Of Growth And Differentiation, Asmaa Alsousi May 2021

Activation Of Aryl Hydrocarbon Receptor Signaling In Human Trophoblasts Alters Markers Of Growth And Differentiation, Asmaa Alsousi

Research Days

Background: It is estimated that 1.7% of pregnant women smoke during their pregnancy globally, with the highest levels observed in Europe at 8.1%, and lowest in Africa at 0.8. The association of maternal cigarette smoking with increased risk of poor birth outcomes such as preterm birth, congenital anomalies, and neonatal mortality is well-established. In addition, evidence suggests that intrauterine exposure to maternal smoking impacts the risk of developing diseases later in life; however, we still do not understand the exact mechanism(s) leading to these outcomes. Once components of cigarette smoke (CS) cross the placenta and enter ...


Novel Hsp40/J-Domain Protein Inhibitors To Deplete Misfolded Mutant P53, Shigeto Nishikawa May 2021

Novel Hsp40/J-Domain Protein Inhibitors To Deplete Misfolded Mutant P53, Shigeto Nishikawa

Research Days

Background: Accumulation of oncogenic mutant p53 (mutp53) greatly contributes to cancer progression. Heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), has been implicated in stabilization of misfolded forms of mutp53. Specifically, we demonstrate that DNAJA1, a member of HSP40/JDPs, binds to and stabilizes misfolded mutp53, while knockdown of DNAJA1 results in CHIP ubiquitin ligase-mediated degradation of misfolded mutp53 and inhibition of tumor growth. Since no HSP40/JDPs inhibitors are currently available in clinics, these findings prompted us to identify inhibitors for DNAJA1 or HSP40/JDPs.

Objectives/Goal: The goal of this study is to identify and ...


A Tissue Specific Transcriptomic, Proteomic And Phospho-Proteomic Atlas Of The Translational Machinery Of Arabidopsis Thaliana, Abdullah Salim May 2021

A Tissue Specific Transcriptomic, Proteomic And Phospho-Proteomic Atlas Of The Translational Machinery Of Arabidopsis Thaliana, Abdullah Salim

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Gene expression encompasses the flow of genetic information from DNA to mRNA (transcription) and from mRNA to protein (translation) along with the regulatory mechanisms underlying these processes. Omics technologies offer a powerful toolset with which to study gene expression at each of these stages. A recently published dataset integrating transcriptomic, proteomic and phospho-proteomic measurements from 30 Arabidopsis thaliana tissues provides a unique resource to explore gene expression.1 The translational machinery (the ribosome, and its initiation, elongation, and termination factors) are a core component in gene expression. Defects in translation can be lethal or lead to major developmental defects and ...


Heterosis And Combining Ability Of Morphological And Forage Quality Predictors Of Silage Corn Incentral Valley Of Mexico, B. Alarcon‐Zuniga, A. Bata‐Valverde, A. Betanzos‐Betanzos, M. Meneses‐Mayo, M. Crosby‐Galvan May 2021

Heterosis And Combining Ability Of Morphological And Forage Quality Predictors Of Silage Corn Incentral Valley Of Mexico, B. Alarcon‐Zuniga, A. Bata‐Valverde, A. Betanzos‐Betanzos, M. Meneses‐Mayo, M. Crosby‐Galvan

International Grassland Congress Proceedings

No abstract provided.


Leaf Growth Dynamics And Forage Quality In Temperate And Tropical Grasses, Mónica G. Agnusdei, F. Nennin, Oscar Norberto Di Marco, M. S. Aello May 2021

Leaf Growth Dynamics And Forage Quality In Temperate And Tropical Grasses, Mónica G. Agnusdei, F. Nennin, Oscar Norberto Di Marco, M. S. Aello

International Grassland Congress Proceedings

No abstract provided.


The Effect Of Ensiling Rice Straw With Or Without Bacterial Inoculants On Fermentation Quality, Chemical Composition And Nutritive Value, Chuncheng Xu, Yimin Cai, Lujia Han, Xian Liu, Zengling Yang, Norio Yoshida May 2021

The Effect Of Ensiling Rice Straw With Or Without Bacterial Inoculants On Fermentation Quality, Chemical Composition And Nutritive Value, Chuncheng Xu, Yimin Cai, Lujia Han, Xian Liu, Zengling Yang, Norio Yoshida

International Grassland Congress Proceedings

No abstract provided.


Soil Macroinvertebrates Responses To Wildfires In The Blue Ridge Mountains, Usa, Madeline Olliff May 2021

Soil Macroinvertebrates Responses To Wildfires In The Blue Ridge Mountains, Usa, Madeline Olliff

Biology Theses

Fire has been a prevalent disturbance on Earth for millions of years. Around the globe there are several regions that have become fire adapted, including the Southeastern United States. There have been few studies examining the effects of wildland fires on soil macroinvertebrates in the Blue Ridge Mountains, in spite of the importance of these animals to soil processes and their contributions to the biodiversity of these ecosystems. During the fall of 2016, the Southeastern USA experienced numerous, large wildfires. These fires offered an opportunity to study the effects of wildland fire on soil macroinvertebrates. We sampled sites from three ...


Tuning Polymorphs And Morphology Of Microbially Induced Calcium Carbonate: Controlling Factors And Underlying Mechanisms, Maryam Khanjani, David J. Westenberg, Aditya Kumar, Hongyan Ma May 2021

Tuning Polymorphs And Morphology Of Microbially Induced Calcium Carbonate: Controlling Factors And Underlying Mechanisms, Maryam Khanjani, David J. Westenberg, Aditya Kumar, Hongyan Ma

Biological Sciences Faculty Research & Creative Works

Microbially precipitated calcium carbonate (CaCO3) has drawn broad attention due to its potential applications in various areas, for example, biocementation, medicine, and soil reinforcement. Sporosarcina pasteurii (S. pasteurii), formerly known as Bacillus pasteurii, has been investigated for CaCO3 biomineralization due to its high ureolytic activity. A high degree of supersaturation with respect to the presence of bacterial cell wall, extracellular polymeric substances, and organic byproducts of bacterial activity plays an important role in the formation and stabilization of CaCO3 polymorphs. Although microbially induced CaCO3 and its polymorphs have been investigated broadly, the mechanisms of polymorph selection ...


Begin Scouting For Black Cutworm In Corn, Ashley Dean, Erin W. Hodgson May 2021

Begin Scouting For Black Cutworm In Corn, Ashley Dean, Erin W. Hodgson

Integrated Crop Management News

Black cutworm (BCW) is a migratory pest that arrives in Iowa with spring storms each year. It is sporadic and unpredictable, making it essential to scout to determine whether BCW larvae are present in a field and management is required. Since much of the corn planting around the state is complete and many fields have emerged, now is a good time to begin scouting for larvae.


Adjusting Weed Management Plans After The Dry Start, Bob Hartzler May 2021

Adjusting Weed Management Plans After The Dry Start, Bob Hartzler

Integrated Crop Management News

Performance of preemergence herbicides in many areas of the state may be less effective than normal due to limited rain following application. Although weed emergence following planting was reduced by dry soils and cool temperatures, it is likely that most fields will have some weeds that emerged during this period. Systematic scouting of fields, beginning shortly after crop emergence, will be essential to determine how best to manage weeds throughout the remainder of the season.


Expression And Purification Of N-Terminally Acetylated Microtubule Binding Protein Tau, Abigail Fleurima May 2021

Expression And Purification Of N-Terminally Acetylated Microtubule Binding Protein Tau, Abigail Fleurima

Honors Projects Overview

The microtubule-associated protein Tau (MAPT) plays a critical role in many neurodegenerative diseases. Tau functions to stabilize microtubule structures that are essential for transport within the neuron, and transport disruption leads to loss of neuronal function. Tau binding is regulated by phosphorylation with the help of kinases that add phosphate groups which block microtubule binding sites, and phosphatases that remove phosphate groups and expose the microtubule-binding regions. Tau can be found in hyper-phosphorylated states, which causes Tau to self-assemble into aggregates and prevent microtubule binding. It's clear that post-translational modifications (PTMs) of Tau play a key role in the ...