Biomedical Commons^™

2d Face Database Diversification Based On 3d Face Modeling, Qun Wang, Jiang Li, Vijayan K. Asari, Mohammad A. Karim, Manuel Filipe Costa (Ed.)

Electrical & Computer Engineering Faculty Publications

Pose and illumination are identified as major problems in 2D face recognition (FR). It has been theoretically proven that the more diversified instances in the training phase, the more accurate and adaptable the FR system appears to be. Based on this common awareness, researchers have developed a large number of photographic face databases to meet the demand for data training purposes. In this paper, we propose a novel scheme for 2D face database diversification based on 3D face modeling and computer graphics techniques, which supplies augmented variances of pose and illumination. Based on the existing samples from identical individuals of …

Classification Algorithms For Genomic Microarray, Rakesh Choudary Malepati

UNLV Theses, Dissertations, Professional Papers, and Capstones

The advent of new technologies like DNA micro-arrays provides scientists the ability to gather important information such as the expression levels of almost all the genes within a cell. As the collected data is huge, it is always necessary to use analytical methods to extract important information which can be useful in biological and medical applications. One of such applications is presented in (Van‟t Veer LJ 2002), where the authors used the gene expression values obtained from micro-arrays of breast cancer cells to predict the outcome of the disease. The prediction is based on a supervised classification. While the idea …

A Monocular Marker-Free Gait Measurement System, Jane Courtney, Annraoi M. De Paor

Articles

This paper presents a new, user-friendly, portable motion capture and gait analysis system for capturing and analyzing human gait, designed as a telemedicine tool to monitor remotely the progress of patients through treatment. The system requires minimal user input and simple single-camera filming (which can be acquired from a basic webcam) making it very accessible to nontechnical, nonclinical personnel. This system can allow gait studies to acquire a much larger data set and allow trained gait analysts to focus their skills on the interpretation phase of gait analysis. The design uses a novel motion capture method derived from spatiotemporal segmentation …

Application Of Signal Advance Technology To Electrophysiology, Chris M. Hymel

Dissertations and Theses (Open Access)

Medical instrumentation used in diagnosis and treatment relies on the accurate detection and processing of various physiological events and signals. While signal detection technology has improved greatly in recent years, there remain inherent delays in signal detection/ processing. These delays may have significant negative clinical consequences during various pathophysiological events. Reducing or eliminating such delays would increase the ability to provide successful early intervention in certain disorders thereby increasing the efficacy of treatment.

In recent years, a physical phenomenon referred to as Negative Group Delay (NGD), demonstrated in simple electronic circuits, has been shown to temporally advance the detection of …

Simulation Of Temperature Distributions In Tissue Upon Laser Pulse Irradiation Including Water Mass Transfer, Deepthi Nagulapally

Electrical & Computer Engineering Theses & Dissertations

Lasers, due to their unique characteristics, have tremendous applications in the medical field. Generally all laser applications in hie-medicine involve the propagation of laser energy through tissue. Energy is deposited giving rise to many physical, hie-chemical, and mechanical effects. Among these are dynamical changes in the local temperature distributions within the tissue. Analysis of the temperature changes requires the creation of an appropriate optical transmission and heat flow model that incorporates user specified laser parameters. Here, a numerical simulation model was developed to study both steady state and time dependent temperature distributions due to pulsed laser radiation within user specified …

Intelligibility Of Electrolarynx Speech Using A Novel Actuator, Brian Madden, Mark Nolan, Ted Burke, James Condron, Eugene Coyle

Conference Papers

During voiced speech, the larynx provides quasi-periodic acoustic excitation of the vocal tract. Following a laryngectomy, some people speak using an electrolarynx which replaces the excitatory function of the absent larynx. Drawbacks of conventional electrolarynx designs include the buzzing monotonic sound emitted, the need for a free hand to operate the device, and difficulty experienced by many laryngectomees in adapting to its use. Despite these shortcomings, it remains the preferred method of speech rehabilitation for a substantial minority of laryngectomees. In most electrolarynxes, mechanical vibrations are produced by a linear electromechanical actuator, the armature of which percusses against a metal …

Circular Polarized Splatch Antenna, Cynthia Truong

Electrical Engineering

The Splatch Antenna combines excellent performance and cost-effectiveness into an antenna package that can be integrated. The goal of this project is to figure out how to connect two Splatch antennas to realize a Circular Polarized (CP) antenna. The advantage of CP versus linear polarization is that CP eliminates polarization mismatch losses caused by Faraday’s rotation.

Combining Molecular And Imaging Biomarkers To Enhance Maldi Biomarker Analysis, Ayyappa Chowdary Vadlamudi

Electrical & Computer Engineering Theses & Dissertations

This thesis presents a three-step method to predict prostate cancer (PCa) regions on biopsy tissue samples based on high confident, low resolution PCa regions marked by a pathologist. First, a prediction model is designed to predict PCa regions using matrix-assisted laser desorption mass spectrometry (MALDI-MS) tissue imaging data from one prostate tissue slice. Second, a texture analysis technique is applied to a high magnification optical image for the same purpose from an adjacent tissue slice. Finally, those two results are fused to obtain the PCa regions that will assist MALDI imaging biomarker analysis. Experiments show that the texture analysis based …

Human Osteoblast Proliferation In Culture Following A Nanosecond Pulsed Electric Field (Nspef), Leonard Joseph Carinci Jr.

Biological Sciences Theses & Dissertations

Osteoblasts are mononucleate bone forming cells responsible for the deposition of new bone. Application of mechanical stress on bone reveals its ability to produce and release electric potentials across the cell membrane called piezoelectricity. The electric potentials produced in response to mechanical stress may have a direct correlation on osseous cells and the signaling pathways that regulate proliferation. Nanosecond pulsed electric fields (nsPEFs) are high intensity, ultrashort pulses which have the ability to maintain the integrity of the cell membrane by avoiding traditional electroporation. We delivered 8 nsPEFs (0.5 Hz) of a 25 kV/cm or 35 kV/cm electric field strength …

Theory Of ‘Selectivity’ Of Label-Free Nanobiosensors – A Geometro-Physical Perspective, Pradeep R. Nair, Muhammad A. Alam

Birck and NCN Publications

Modern label-free biosensors are generally far more sensitive and require orders of magnitude less incubation time compared to their classical counterparts. However, a more important characteristic regarding the viability of this technology for applications in Genomics/Proteomics is defined by the ‘Selectivity’, i.e., the ability to concurrently and uniquely detect multiple target biomolecules in the presence of interfering species. Currently, there is no theory of Selectivity that allows optimization of competing factors and there are few experiments to probe this problem systematically. In this article, we use the elementary considerations of surface exclusion, diffusion limited transport, and void distribution function to …

Scaffold Based In-Vitro Osteodistraction For Bone Tissue Engineering, Cesar Adrian Terrazas

Open Access Theses & Dissertations

Engineering of hard tissues such as bone is a challenge because of the limited ability of the body to heal large defects. Current treatment options, such as employing bone sections from the patient or a deceased donor have been utilized for some time now with various degrees of success. However, these methods still exhibit many limitations such as limited supply and the possibility of transmission of disease.

To address the many limitations of bone grafts, synthetic engineered substitutes have been developed and widely researched for nearly three decades. Generally termed scaffolds, these are matrices that serve the purpose of temporary …

Categorization Of Functional Impairments In Human Locomotion Using The Methods Of The Fusion Of Multiple Sensors And Computational Intelligence, Huiying Yu

Open Access Theses & Dissertations

The main aim of this dissertation work was to develop an intelligent system to monitor, quantify and differentiate variances in human gait with high reliability and efficiency using the fusion of multiple sensor data and the methods of fuzzy inferential logic.

Gait disorders are heterogeneous and produce disabilities that vary substantially from individual to individual. The recognition, quantification and analysis of gait dysfunction is complex and, requires the integration of large amounts of data across multiple domains (kinetic, kinematic and electromyographic). Current systems for gait analysis generally require space and complex imaging equipment, as well as prolonged processing time, rendering …

Synthesis And Manufacture Of Photocrosslinkable Poly(Caprolactone)-Based 3d Scaffolds For Tissue Engineering Applications, Nathan Jonathan Castro

Open Access Theses & Dissertations

It is known that the body can efficiently repair hard tissue (bone) micro fractures by suturing the defect through the deposition of minerals resulting in an area that is stronger post-injury. Larger defects, however, generally cause more trouble since the body is incapable of repairing them. Bone defects can occur as a result of congenital abnormalities, trauma, or disease. Traditional methods for addressing these defects have involved the use of acellular cadaverous bone or autologous bone. Both contain innate problems associated with them; the former method can result in disease transmission, as well as very low integration with the host …

Multidisciplinary Collaborative Model For Complex, Angel Ernesto Delgado

Open Access Theses & Dissertations

Nowadays, most devices with advanced technology require the development of embedded systems with mechanical and electrical components as well as software including more than one discipline. These are devices that are usually complex in terms of composition and functionality and that design must follow a methodology in order to successfully design and launch a device of this nature. Hence, the assembly of a multidisciplinary engineering group is required to carry out such complex devices and develop a fully functional product. The group may also need an expert on the field that can provide guidance and knowledge where needed. This is …

Fabrication Of Miniature Drug Screening Platform Using Low Cost Bioprinting Technology, Jorge Ivan Rodriguez

Open Access Theses & Dissertations

In the pharmaceutical industry, new chemicals and substances are being tested to find appropriate compounds or mix for treating a specific disease. The demand for screening large compound collections against and increasing number of therapeutic targets has stimulated technology development in the areas of assay automation and miniaturization. Current methods for evaluating the reactions of cells use a volume in the range of microliters. We have developed a new and low-cost deposition method to fabricate miniature drug screening platform that can realistically and inexpensively evaluate biochemical reactions up to 4 substances per trial in a picoliter-scale volume. This paper describes …

Computer-Aided Detection Of Sleep Apnea And Sleep Stage Classification Using Hrv And Eeg Signals, Edson F. Estrada

Open Access Theses & Dissertations

Sleep is a circadian rhythm essential for human life. Many events occur in the body during this state. In the past, significant efforts have been made to provide clinicians with reliable and less intrusive tools to automatically classify the sleep stages and detect apnea events. A few systems are available in the market to accomplish this task. However, sleep specialists may not have full confidence and trust in such systems due to issues related to their accuracy, sensitivity and specificity. The main objective of this work is to explore possible relationships among sleep stages and apneic events and improve on …

Prediction Of Brain Tumor Progression Using A Machine Learning Technique, Yuzhong Shen, Debrup Banerjee, Jiang Li, Adam Chandler, Yufei Shen, Frederic D. Mckenzie, Jihong Wang, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)

Electrical & Computer Engineering Faculty Publications

A machine learning technique is presented for assessing brain tumor progression by exploring six patients' complete MRI records scanned during their visits in the past two years. There are ten MRI series, including diffusion tensor image (DTI), for each visit. After registering all series to the corresponding DTI scan at the first visit, annotated normal and tumor regions were overlaid. Intensity value of each pixel inside the annotated regions were then extracted across all of the ten MRI series to compose a 10 dimensional vector. Each feature vector falls into one of three categories:normal, tumor, and normal but progressed to …

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …

Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …

Galvanic Vestibular Stimulation Applied To Flight Training, Joel D. Hanson

Master's Theses

Between 1994 and 2003 spatial disorientation resulted in at least 202 aircraft

accidents, 184 of them resulting in fatalities. Galvanic Vestibular Stimulation (GVS)

provides a cost effective and safe way to simulate spatial disorientation and

potentially test pilot’s vestibular system prior to aircraft operation. This experiment

investigates the use of GVS as an indicator of motion sensitivity and explores the

effects of GVS on flight simulation performance. Bilateral bipolar rectangular pulse

electrical stimulations were given to subjects via skin-mounted electrodes placed over

each mastoid process to stimulate the vestibular system with roll and yaw sensations.

Two studies were conducted in …

Focusing Electromagnetic Radiation In Dielectric Media, Mark A. Migliaccio Jr.

Electrical & Computer Engineering Theses & Dissertations

Bioelectrics and microwave imaging requires an ultra-wideband (UWB) antenna to deliver intense, short electromagnetic pulses into biological targets for the purpose of therapy and imaging. Two antennas with different focal distances, predicted by a two­ dimensional model, have been designed for focusing electromagnetic radiation in the near field.

Focusing is achieved through the use of prolate spheroidal reflector antennas with a conical wave launcher submerged in water. For an ultra-wideband feed signal, with a rise time of 200 picoseconds, the maximum electric field was found to be close to the edge of the reflector, a result that differs from the …

Ekg Tracking For Augmented Standardized Patient Virtual Pathology Stethoscope Heart Auscultation, Sujith Surendran

Electrical & Computer Engineering Theses & Dissertations

In recent years, a lot of research has focused on improving the clinical skills of medical students and medical practitioners using standardized patients. Standardized patients (SP's) are used by the medical students and physicians in place of mannequins for a more realistic experience. SP's are real people trained to simulate specific illnesses and conditions to a high degree of accuracy which makes it difficult for the medical students to distinguish them from real patients. This research will enhance the capabilities of the standardized patients by providing a non-invasive, natural, harmless and realistic appearing tracking method for placing virtual pathologies using …

Towards Supervised Autonomous Task Completion Using An In Vivo Surgical Robot, Jason J. Dumpert

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Laparoscopy is a minimally invasive alternative to traditional abdominal surgery. Unlike traditional surgery, a laparoscopic procedure can be completed using small incisions. The use of these small incision results in reduced pain to the patient, shorter recovery times, and less trauma to skin, muscle and other tissues. However, these benefits to the patient are offset by the increased difficulty to the surgeon performing the procedure. These difficulties include reduced dexterity, reduced perception, and longer procedure times. The use of small in vivo robotic devices in minimally invasive surgery is one possible solution to these problems. The movement of these devices …

An Electrooculogram-Based Binary Saccade Sequence Classification (Bssc) Technique For Augmentative Communication And Control, Johnalan Keegan, Ted Burke, James Condron

Conference Papers

In the field of assistive technology, the electroocu-logram (EOG) can be used as a channel of communication and the basis of a man-machine interface. For many people with severe motor disabilities, simple actions such as changing the TV channel require assistance. This paper describes a method of detecting saccadic eye movements and the use of a saccade sequence classification algorithm to facilitate communication and control. Saccades are fast eye movements that occurs when a person's gaze jumps from one fixation point to another. The classification is based on pre-defined sequences of saccades, guided by a static visual template (e.g. a …

Brain Tumor Progression Assessment Using Multiple Mri Volumes, Yufei Shen

Electrical & Computer Engineering Theses & Dissertations

Predicting and assessing tumor progression is important in brain tumor treatment. We attempt to use machine learning techniques to achieve consistency in assessing brain tumor progression. This thesis presents a prediction method of brain tumor progression by exploring a large MR database, which contains two patients ' complete records covering all their visits in the past two years. All ten MRI series, namely, apparent diffusion coefficient (ADC) , diffusion tensor imaging (DTI) , fractional anisotropy (FA), fluid attenuated inversion recovery (FLAIR), max eigenvalue (MAX), mid eigenvalue (MID), min eigenvalue (MIN) , post-contrast T₁-weighted, T₁- weighted, and …

Effects Of Low-Temperature Atmospheric Pressure Plasma On Streptococcus Mutans, Margaret Farrer Lemaster

Dental Hygiene Theses & Dissertations

The recent emergence of low temperature atmospheric pressure plasma (LTAPP) technology has led researchers to explore biomedical applications. The present study set out to determine if LTAPP has the ability to inactivate dental caries causing bacteria, specifically Streptococcus mutans. Methods: A total of 90 samples were processed. Seventy-two samples of S. mutans at 1: 100 dilution in BHI broth were exposed to LTAPP for various time intervals (60, 120, 180, 300 seconds). Eighteen control samples were plated but not exposed to LTAPP. Samples were plated on Mi tis salivarius (MS) agar and incubated 48 hours at 37° C. Colony …

Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang

Electrical & Computer Engineering Theses & Dissertations

Prostate cancer is the second most common type of cancer among men in the U.S. [1]. Traditionally, prostate cancer diagnosis is made by the analysis of prostate-specific antigen (PSA) levels and histopathological images of biopsy samples under microscopes. Proteomic biomarkers can improve upon these methods. MALDI molecular spectra imaging is used to visualize protein/peptide concentrations across biopsy samples to search for biomarker candidates. Unfortunately, traditional processing methods require histopathological examination on one slice of a biopsy sample while the adjacent slice is subjected to the tissue destroying desorption and ionization processes of MALDI. The highest confidence tumor regions gained from …

A Hybrid Biofuel Cell Based On Electrooxidation Of Glucose Using Ultra-Small Silicon Nanoparticles, Yongki Choi, Gang Wang, Munir H. Nayfeh, Siu-Tung Yau

Electrical and Computer Engineering Faculty Publications

The ultra-small silicon nanoparticle was shown to be an electrocatalyst for the electrooxidation of glucose. The oxidation appeared to be a first order reaction which involves the transfer of 1 electron. The oxidation potential showed a low onset of −0.4V vs. Ag/AgCl (−0.62V vs. RHE). The particle was used as the anode catalyst of a prototype hybrid biofuel cell, which operated on glucose and hydrogen peroxide. The output power of the hybrid cell showed a dependence on the enzymes used as the cathode catalyst. The power density was optimized to 3.7μW/cm² when horseradish peroxidase was …

Lifetime Estimation Of Wireless Body Area Sensor Network For Patient Health Monitoring, Frank Agyei-Ntim

Electronic Theses and Dissertations

Wireless Body Area Sensor Networks (WBASN) is an emerging technology which utilizes wireless sensors to implement real-time wearable health monitoring of patients to enhance independent living. These sensors can be worn externally to monitor multiple bio-parameters (such as blood oxygen saturation (SpO2), blood pressure and heart activity) of multiple patients at a central location in the hospital.

In health monitoring, the loss of critical or emergency information is a serious issue so there is a concern for quality of service which needs to be addressed. It is important to have an estimate of the time the first node will fail …

Time-Frequency Analysis Of Intracardiac Electrogram, Erik Brockman

Master's Theses

The Cardiac Rhythm Management Division of St. Jude Medical specializes in the development of implantable cardioverter defibrillators that improve the quality of life for patients diagnosed with a variety of cardiac arrhythmias, especially for patients prone to sudden cardiac death. With the goal to improve detection of cardiac arrhythmias, this study explored the value in time-frequency analysis of intracardiac electrogram in four steps. The first two steps characterized, in the frequency domain, the waveforms that construct the cardiac cycle. The third step developed a new algorithm that putatively provides the least computationally expensive way to identifying cardiac waveforms in the …