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Articles 1 - 7 of 7
Full-Text Articles in Biomedical
Development Of 3d Human Cardiovascular And Cancer Tissue Model Within A Self-Driven Microfluidic Platform For Preclinical Drug Screening, Aibhlin Alexis Esparza
Development Of 3d Human Cardiovascular And Cancer Tissue Model Within A Self-Driven Microfluidic Platform For Preclinical Drug Screening, Aibhlin Alexis Esparza
Open Access Theses & Dissertations
According to the American Heart Association and World Health Organization, cardiovascular diseases (CVDs) are the leading cause of death worldwide. Monolayer cell culture (2D) and animal models are conventional methods to study CVDs, however, they limit researcherâ??s ability to simulate the human cardiovascular cellular microenvironments and accurate predication of pharmaceutical drug responses. Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), biomaterials, and microfluidic technologies can be combined to create a controlled, reproducible 3D platform to study physiologically-relevant cellular responses to biochemical and physical changes in the microenvironment. My dissertation work demonstrates the development of novel self-driven microfluidic devices designed with …
Development Of A 3d Printed Conductive Biopolymer For Cardiac Tissue Engineering, Britanny Lizeth Stark
Development Of A 3d Printed Conductive Biopolymer For Cardiac Tissue Engineering, Britanny Lizeth Stark
Open Access Theses & Dissertations
Cardiovascular disease (CVD) is the leading cause of death in the US, with approximately 859,000 deaths each year. The major contributor to CVD is Acute Myocardial Infarction (AMI), which causes the death of approximately 25% of the cardiomyocytes present in the left ventricle of the heart. After AMI, the adult human heart has a very limited regenerative capacity. Moreover, the electrical propagation of the myocardium is severely disrupted, making the heart more susceptible to failure and patient death. However, current pharmacological treatments do not address the loss of cardiomyocytes and the disruption of electrical propagation in the heart. Tissue engineering …
3d Printing Of High Viscosity Fluids And Its Application In 3d Printing Of Prosthetic Teeth., Abhilash Aditya
3d Printing Of High Viscosity Fluids And Its Application In 3d Printing Of Prosthetic Teeth., Abhilash Aditya
Open Access Theses & Dissertations
The advancement in technology has brought forward non-conventional manufacturing methods that are efficient and advantageous for specific applications. 3D printing is one such outcome, whose applications stretch from biomedical applications to daily products. 3D printing is a rapidly growing technology, and innovative research developments have proven versatility in creating physical objects. Simplification and constant improvement in Fused Deposition Modeling (FDM) operation result from decades of research. However, 3D printing is material-specific and contributes to shortcomings in the technology. The build-material dictates the extrusion parameters, including the material discharge rate and head speed for a continuous flow. Customization being the prime …
Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin
Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin
Honors Projects
A 3D printed hand and arm prosthetic was created from the idea of adding bionic elements while keeping the cost low. It was designed based on existing models, desired functions, and materials available. A tilt sensor keeps the hand level, two motors move the wrist in two different directions, a limit switch signals the fingers to open and close, and another motor helps open and close the fingers. All sensors and motors were built on a circuit board, programmed using an Arduino, and powered by a battery. Other supporting materials include metal brackets, screws, guitar strings, elastic bands, small clamps, …
Developmental Steps For A Functional Three-Dimensional Cell Culture System For The Study Of Asymmetrical Division Of Neural Stem Cells, Martina Zamponi
Developmental Steps For A Functional Three-Dimensional Cell Culture System For The Study Of Asymmetrical Division Of Neural Stem Cells, Martina Zamponi
Biomedical Engineering Theses & Dissertations
Stem cells are a cell type present during and following development, which possess self- renewal properties, as well as the ability to differentiate into specific cells. Asymmetrical division is the cellular process that allows stem cells to produce one differentiated and one un-differentiated daughter cell during the same mitotic event. Insights in the molecular mechanisms of such process are minimal, due to the absence of effective methods for its targeted study. Currently, traditional methods of investigation include monolayer cell culture and animal models. The first poses structural limitations to the accurate representation of human tissue and cell structures, while animal …
3d Printed Pcu/Uhmwpe Polymeric Blends For Artificial Knee Meniscus, Raissa Araujo Borges
3d Printed Pcu/Uhmwpe Polymeric Blends For Artificial Knee Meniscus, Raissa Araujo Borges
Graduate Theses and Dissertations
3D printing was used to fabricate porous artificial knee meniscus material from biocompatible polymeric blends of polycarbonate-urethane (PCU) and ultra-high-molecular-weight polyethylene (UHMWPE) to enable “weep” lubrication that mimics the native meniscus. 3D printed and molded pure PCU, as well as molded PCU and UHMWPE, were used for comparison. Preliminary printing was done to evaluate the impact of process parameters on the results. The samples were subject to a variety of rotational oscillating friction and wear tests under simulated body fluid and loading conditions to replicate the natural motion of the knee. Results show that 3D printed PCU samples yielded a …
On Demand 3d Printed Hybrid Scaffolds For Tissue Engineering Applications, Ivan D. Hernandez
On Demand 3d Printed Hybrid Scaffolds For Tissue Engineering Applications, Ivan D. Hernandez
Open Access Theses & Dissertations
A composite 3D printed polymer scaffold with inbuilt porosity and filled with a hydrogel can provide an ideal support system for cell growth, proliferation, and vascularization. Therefore, a hybrid system of 3D printed polycaprolactone (PCL) scaffold and a hydroxyapatite-based hydrogel was developed for application in the reconstruction of bone defects, which are inherently difficult to repair without any guided therapies. In the present study, a 3D printed gyroid structure of PCL allowed the loading of a higher amount of hydrogel as compared to conventionally used 3D printed mesh structure of the same volume and strut thickness. The hydrogel was composed …