Biomedical Commons^™

Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić

Communications of the IIMA

Fuzzy inference systems have demonstrated considerable promise for EEG-based cognitive state monitoring in neurodegenerative conditions. However, two design decisions significantly influence system performance and clinical applicability: the choice of inference architecture (Takagi-Sugeno vs Mamdani) and the method of rule and membership function generation (manual expert-driven vs data-driven automated). This paper presents a comparative analysis of both dimensions in the context of an EEG-based Alzheimer’s disease monitoring system operating on the ds004504 OpenNeuro dataset (88 subjects: 36 AD, 23 FTD, 29 HC). A Takagi-Sugeno system, implemented as a hybrid FSM-Fuzzy architecture, is compared against a Mamdani equivalent across four axes: inference …

Early Detection Of Alzheimer’S Disease Using Federated Learning Based On Personalized Gans: A Data-Driven Approach, Iffat Fatima, Uzair Iqbal, Uzair Ishtiaq, Muhammad Burhan Ul Islam Khan

Makara Journal of Technology

Alzheimer’s disease (AD) is a complicated neurodegenerative disease marked by the slow worsening of memory and cognitive functions. Early detection is a key to effective disease management, but the creation of reliable machine learning models is not an easy task because medical data are limited, and there are strict privacy requirements, such as GDPR and HIPAA, that inhibit the creation of central databases. In this paper, a new privacy-saving model that combines personalized federated learning (PFL) with generative adversarial networks (GANs) is proposed to diagnose Alzheimer’s disease. Under the proposed method, the synthesis of data using GAN is conducted on …

Hardware-In-The-Loop Evaluation Of Sensor-Source Selection For Prosthetic Locomotion Intent Recognition, Victoria Asencio-Clemens

Master's Theses

Active lower-limb prostheses use intent-recognition systems to identify a user’s locomotion mode and select an appropriate control strategy, but sensor configurations that perform well offline may be unsuitable for resource-constrained embedded hardware. Existing sensor-selection methods generally prioritize classification accuracy without directly accounting for processing latency, memory usage, or other hardware-dependent requirements. To address this limitation, this thesis develops a hardware-in-the-loop source-selection framework for embedded classification of level walking, ramp ascent, ramp descent, stair ascent, and stair descent using multimodal biomechanical data from transtibial amputee participants. Subject-specific linear support vector machine classifiers were evaluated using trial-held-out validation, and candidate configurations from …

Explainable Machine Learning For Biomedical Diagnostics: Optical Imaging And Eeg Signal Analysis, Fozia Rajbdad

LSU Doctoral Dissertations

The growing convenience of complex biomedical data begins new roads for better disease detection and functional identification via artificial intelligence (AI). Nevertheless, conventional analysis methods often rely on basic metrics that drop sensitive biotic differences, and various AI systems are difficult to infer, limiting their clinical reliability and practical use. There is a growing need for explainable, physiologically relevant computational models that can extract key biomarkers from diverse biomedical data sources. This dissertation addresses this problem by obtaining explainable machine learning and deep learning procedures for studying biomedical signals and optical imaging data.

This dissertation is divided into two parts; …

The Neuropsychological Analysis Of The Effect Of Shame And Traumatic Memories In Paranoia: A Network Analysis, Anwesha Maitra

Clinical Psychology Dissertations

Paranoia is increasingly recognized as a multidimensional psychological phenomenon influenced by trauma-related distress, shame, maladaptive interpersonal experiences, and emotional functioning. Although these factors have been extensively associated with paranoia, their relationships with neurocognitive functioning, social cognition, and global functioning remain less well understood. The present study examined these relationships using traditional statistical analyses, network analysis, and machine-learning approaches in a non-clinical sample of 42 adults.

Participants completed self-report measures assessing trauma-related distress, childhood interpersonal experiences, shame, paranoia, depressive symptoms, fear of negative evaluation, self-esteem, and hostile attribution bias, in addition to a comprehensive neurocognitive battery, an emotion recognition task, and …

Design And Parametric Testing Of A Transimpedance Amplifier For Low-Power Biomedical Applications, Stanlon Tan, William Chung, Brandon Wu

Electrical Engineering

This project developed and evaluated an optical sensing system for detecting changes associated with glucose concentration. The system combined a laser-diode, cuvette sample holder, photodiode, resistive-feedback transimpedance amplifier, high-resolution analog-to-digital converter, and microcontroller. Parametric testing evaluated the effects of input current and feedback resistance on transimpedance gain, output range, and linearity. Firmware was developed to configure the ADC, average repeated conversions, monitor measurement variation, convert raw digital counts into voltage using a source-meter calibration equation, and compare sample measurements with a water reference. A cuvette enclosure maintained alignment between the laser-diode, sample, and photodiode while reducing external optical interference. Testing …

Practical Multimodal Wearable Sensing For Functional Upper Extremity Primitive Classification With Application To Stroke Rehabilitation, Nicholas Weiss

Master's Theses

Stroke often causes long-term weakness and impaired motor control in the upper extremity (UE), making everyday tasks such as reaching, grasping, and moving objects more difficult. Restoring functional arm use is therefore a central goal of post-stroke rehabilitation. Measuring affected arm use continuously and objectively is important because isolated clinical assessments may not fully capture how the affected arm is used during therapy or daily life. Wearable sensors offer a promising approach for monitoring, but raw sensor signals are difficult to interpret directly. Functional movement primitives address this issue by describing UE behavior as smaller, task-agnostic movement units.

This thesis …

Dot Product Engine Based Neuromorphic Hardware For Continuous-Time Biomedical Signal Classification, Sanjeev Srinivasan

Master's Theses

Accurate diagnosis of pathological conditions from biomedical signals, such as electrocardiograms (ECGs) is often performed offline, making it time-consuming, costly, and inefficient, especially when abnormal patterns are rare and long-term monitoring generates large amounts of data. To address this, this work proposes a compact, scalable, and programmable neuromorphic system designed for real-time preliminary arrhythmia detection and classification using ECG signals, that can be extended to other biomedical signals. The proposed design processes ECG signals using a delta modulation-based spike encoder, followed by classification with a dot-product engine (DPE) based spiking neural network (SNN) processor and winner-take-all (WTA) circuit. The architecture …

Visualization And Marker-Less Tracking Of User-Defined Pre-Processed Mri Articulator Data Using Deep Learning, Michael De George

Student Theses

This thesis presents a comprehensive framework for the automated tracking and visualization of articulatory movements based on magnetic resonance imaging (MRI) data. A well-known data analysis tool for markerless pose estimation, known as DeepLabCut, is investigated for this purpose. The performance of this tool is enhanced through the design and implementation of a pre-processor. DeepLabCut is a markerless pose estimation toolbox based on deep learning, which overcomes the issue of making manual annotations frame-by-frame. Limitations from manually marking the MRI images are addressed by implementing transfer learning with convolutional neural networks to achieve accurate, user-defined articulator tracking without markers. Current …

Simultaneous Carrier, Cargo, And Functional Tracking Of Lipid Nanoparticles, Hannia Vanessa Balcorta Muñoz

Open Access Theses & Dissertations

Lipid nanoparticles (LNPs) have become effective delivery vehicles in nanomedicine, particularly for nucleic acid-based treatments. However, a major limitation remains in the field regarding the simultaneous monitoring of the nanoparticle carrier, its encapsulated payload, and the resulting functional protein production in both in vitro and in vivo systems. Furthermore, traditional lipophilic dyes employed for labeling LNPs frequently exhibit incompatibility with tissue-clearing methods, such as CLARITY, due to signal loss following lipid removal. This research developed and evaluated a new fluorescent labeling method using CM-DiI, a dye that reacts with thiols, for multimodal tracking of LNPs. CM-DiI was included in the …

Familybloom: Examining Ecologies Of Collaboration In Family-Centered Health Tracking, Lucas M. Silva, Aehong Min, Evropi Stefanidi, Franceli L. Cibrian, Jesus A. Beltran, Cassie Zeiler, Sabrina E. B. Schuck, Kimberley D. Lakes, Gillian R. Hayes, Daniel A. Epstein

Engineering Faculty Articles and Research

Family health informatics tools can help support well-being with shared data tracking. Prior work typically focused on shared data review, but often in specific moments, like bedtime, or centered on caregiving of children or elderly members. To investigate how tracking can support mutual health collaboration between family members pervasively across daily contexts, we designed and deployed FamilyBloom, a glanceable smartwatch and home display system for mood and goal tracking. Twelve families with both neurotypical and ADHD members used FamilyBloom for three months on average. Our findings reveal how family-centered tracking created collaboration opportunities and tensions across multiple ecological systems: individual …

Polymer Microstructures For Advanced Biomanufacturing, Tongyao Wu

LSU Doctoral Dissertations

With the continued growth of the biopharmaceutical industry, the demand for scalable, robust, and resource-efficient platforms for large-scale mammalian cell culture is amplified. Recent developments in microfluidic technology, such as precise control of the microenvironment, showed the potential to improve the performance of cell culture systems. However, constrained by scalability and operational efficiency, applying such approaches to large-scale cell culture and biopharmaceutical production presents challenges. This dissertation addresses these challenges through three independent but conceptually related technological developments. First, a roll-to-roll (R2R) fabrication process was developed for the scalable production of hollow microcarriers (HMCs). HMCs provide three-dimensional microenvironments suitable for …

Optimized Resnet-18 Architecture For Multi-Class Oral Diseases Classification, Ahmed Ahmed

Karbala International Journal of Modern Science

In recent years, the classification of oral diseases has gained significant attention due to its influence on public health and the necessity for early and accurate diagnosis. Traditional diagnosis depends on manual clinical assessment, which can be slow and subjective. An optimized and subsequently quantized model is required to provide a faster and more consistent diagnostic support tool. This paper proposes an optimized ResNet-18 architecture for the classification of six oral diseases. The optimization process is based on removing the Rectified Linear Unit (ReLU), Batch Normalization (BN), and convolutional layers from the base ResNet-18 blocks that contain 128 filters. This …

Design And Validation Of A Low-Cost Wearable Electromyography (Emg) System For Monitoring Exercise-Induced Changes In Muscle Activity, Ingrid E. Halverson

Dissertations, Master's Theses and Master's Reports

Wearable technologies have expanded opportunities for monitoring athletic performance, but many existing systems remain costly and confined to laboratory or medical settings. This thesis presents the design, development, and evaluation of a low-cost, wearable EMG platform for monitoring neuromuscular activity during exercise. A wireless device incorporating a surface EMG sensor, an ESP32 microcontroller, and Wi-Fi transmission was developed to acquire muscle activation data. Signal processing techniques, including filtering, root-mean-square (RMS), mean frequency (MNF), and median frequency (MDF) analyses, were used to evaluate changes in muscle activation. Experimental testing demonstrated reliable wireless data acquisition and successful capture of physiological changes before …

C. Difficile Detection Method For First Responder Glove Application, Alli N. Senedak

Williams Honors College, Honors Research Projects

Clostridioides Difficile (C. diff) is a Anaerobic Gram-positive bacillus that is capable of spore formation, making it difficult to control its spread and duration in clinical environments. This phenomenon can provide danger to first responders, healthcare workers, and patients. The goal of this project is to create a biosensor capable of detecting C. diff in a clinical setting that can be applied to a glove apparatus. The project will involve the use of C. diff aptamers activated on the surface of an electrode. Once surface activation has been verified via surface analysis, the electrodes will be exposed to C. diff …

Healthcare Digital Twins: A Methodological Literature Review On Integrating Iot And Ai For Personalized Medicine And Predictive Care, Sara Shahnazinia, Mahsa Tavasoli, Abdolhossein Sarrafzadeh, Ali Karimoddini

Electrical & Computer Engineering Faculty Publications

Digital Twin (DT) technology has the potential to revolutionize healthcare delivery and enhance patient outcomes through personalized and precision medicine, simulation models for operations and interventions, and drug discovery. However, successful implementation of DTs in Internet of Things (IoT) and artificial intelligence (AI) healthcare is contingent upon addressing key challenges such as privacy, ethics, and robust data security. This paper presents a methodological literature review of DT applications in healthcare, systematically analyzing the current state of research, key enabling technologies, and implementation challenges. The review summarizes DT categorization approaches (application-based, technology-based, and real-time function-based); delineates core DT components such as …

Beyond The Square Pulse: Waveform Shape, Eeg Correlates, And The Pursuit Of Natural Sensation In Tens, Jason Whitson

Honors Undergraduate Theses

This study investigates the relationship between electrical stimulus characteristics of shape and charge on evoked sensations and electroencephalogram (EEG) data during multi-waveform transcutaneous electrical nerve stimulation (TENS) of the median nerve. Neuromodulation methods have traditionally had little control over the location and quality of their associated evoked sensation (e.g., electric, vibration, touch). This experiment utilized five unique stimulus waveforms during TENS stimulation. EEG data were collected concurrently to provide an introductory objective measure of the neural responses underlying these sensory changes. Eleven participants completed three tasks (thresholding, super-threshold stimulation, two-alternative forced choice) using a two-electrode TENS approach. Stimulus waveforms were …

Consensus And Controversies Of International Guidelines For The Diagnosis, Surveillance, And Management Of Fetal Growth Restriction: An Updated Comparison, Daniele Diane Mascio, Suneet P. Chauhan, Tullio Ghi, Asma Khalil, Juliana G. Martins, Sara Sorrenti, Tamara Stampalija, Fabrizio Zullo, Francesc Figueras

Department of Obstetrics & Gynecology Faculty Publications

OBJECTIVE: To compare areas of consensus and disagreements across contemporary international and national guidelines on the diagnosis, surveillance, and management of fetal growth restriction (FGR).

DATA SOURCES: Electronic searches of MEDLINE from database inception up to March 2026 using MeSH terms and keywords related to FGR and guidelines. STUDY ELIGIBILITY CRITERIA: Critical, structured comparison of national or international guidelines on FGR published since 2010. Final inclusion required unanimous agreement from all authors.

STUDY APPRAISAL AND SYNTHESIS METHODS: Pre-specified extraction across domains: definition; prediction/prevention; surveillance tools and frequency; delivery timing and mode; and labor induction methods. Dual data …

Federated And Explainable Spiking Neural Networks For Fair And Privacy-Preserving Nail Disease Diagnostics, Ch Pavani Reddy, Krishnanaik Vankdoth

Mansoura Engineering Journal

Automated nail disease diagnostics provide a non-invasive pathway for identifying underlying systemic health conditions; however, conventional centralized deep learning approaches often raise concerns related to privacy, fairness, and interpretability. Although the original NeuroNail-SNN framework demonstrated an energy-efficient and edge-ready diagnostic solution, its broader clinical adoption remained limited by unresolved trust, transparency, and ethical considerations. In this study, we propose the Federated and Explainable NeuroNail-SNN, which extends the original spiking neural architecture by integrating federated learning (FL), explainable artificial intelligence (XAI), fairness evaluation, and uncertainty quantification within a unified framework. Federated learning enables decentralized model training across hospitals and mobile clinics …

Design And Development Of Biomimetic Hydrogel Interfaces For Enhanced Bioelectrical Signal Acquisition, Daniela Nikoloska

UNLV Theses, Dissertations, Professional Papers, and Capstones

Every second, human skin processes over one million sensory signals while maintaining properties such as electrical conductivity, mechanical adaptability, and regenerative capability that surpass all synthetic materials. Contemporary bioelectronic devices prove inadequate when contacting skin surfaces due to poor adhesion and electrical contact issues that prevent effective sensing. Despite advancements in wearable and bioelectronic technologies, current devices face major drawbacks when interfacing with human skin, particularly in maintaining firm adhesion, conformability, and low-noise electrical signal acquisition.

This research focuses on the development of a biomimetic hydrogel-based interface for bioelectronic sensing. Specifically, a hybrid hydrogel system composed of polydopamine (PDA)- doped …