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Articles 1 - 8 of 8
Full-Text Articles in Biomedical
Ac Electric Fields Manipulate And Concentrate Dna Molecules On Electrodes, Akila Wijesinghe, Dharmakeerthi Nawarathna
Ac Electric Fields Manipulate And Concentrate Dna Molecules On Electrodes, Akila Wijesinghe, Dharmakeerthi Nawarathna
Graduate Student Government Association Research Conference
Point-of-care (POC) electric field-based biosensors have emerged as a promising tool to detect early cancer biomarkers such as circulating tumor DNA (ctDNA), microRNA (miRNA), and proteins. To be effective in screening in clinical settings, these biosensors must be simple and easy to use. In this study, we have studied the manipulation of short DNA molecules suspended in a sessile drop to achieve this goal. Alternative current (AC) electric fields were used to polarize DNA molecules and produce dielectrophoretic (DEP) force on DNA molecules. DEP force is used to manipulate polarized DNA molecules towards the higher electric field gradients (toward the …
Dual Base Sige Is-Hbt For Use In Biosensing Applications, Liam Stephen Hayes
Dual Base Sige Is-Hbt For Use In Biosensing Applications, Liam Stephen Hayes
Master's Theses
The proposed research is for a novel SiGe-based Ion-Sensitive Dual Hetero-junction Bipolar Transistor (IS-HBT) to be used in both trans-dermal biological sensing as well as Lab-on-Chip (LOC) applications. The end goals for the device designed are two: For one, the research done for this work will be used to substantiate the claims made by Zafar et al. [1] that an HBT-style structure is better suited for biosensing application rather than a conventional Field Effect Transistor (FET) based geometries. Secondly, it provides the final element to be integrated along with a selectivity membrane, as well as with a reverse-iontophoresis system to …
On-Demand Electrically Induced Decomposition Of Thin-Film Nitrocellulose Membranes For Wearable Or Implantable Biosensor Systems, Benjamin M. Horstmann
On-Demand Electrically Induced Decomposition Of Thin-Film Nitrocellulose Membranes For Wearable Or Implantable Biosensor Systems, Benjamin M. Horstmann
Theses and Dissertations
Implantable or subcutaneous biosensors used for continuous health monitoring have a limited functional lifetime requiring frequent replacement and therefore may be highly discomforting to the patient and become costly. One possible solution to this problem is use of biosensor arrays where each individual reserve sensor can be activated on-demand when the previous one becomes inoperative due to biofouling or enzyme degradation. Each reserve biosensor in the array is housed in an individual Polydimethylsiloxane (PDMS) well and is protected from exposure to bodily fluids such as interstitial fluid ( ISF) by a thin-film nitrocellulose membrane. Controlled activation is achieved by decomposing …
Engineering Plasmonic Nanostructures For Light Management And Sensing, Sujan Phani Kumar Kasani
Engineering Plasmonic Nanostructures For Light Management And Sensing, Sujan Phani Kumar Kasani
Graduate Theses, Dissertations, and Problem Reports (ETD)
The two major global problems are to provide health safety and to meet energy demands for ever growing population on a large scale. The study of light interaction with nanostructures has shown a promising solution in improving the fields of bio-sensor and solar energy devices which addresses above mentioned two major global problems. Nanostructures have tunable physicochemical properties such as light absorption, electrical and thermal properties unlike bulk materials, which gives an advantage in applications like bio-sensing and energy harvesting devices. The development of nanofabrication techniques along with the discovery of Surface Enhanced Raman Scattering (SERS) and Plasmon Enhanced Fluorescence …
Reference Compensation For Localized Surface-Plasmon Resonance Sensors, Neha Nehru
Reference Compensation For Localized Surface-Plasmon Resonance Sensors, Neha Nehru
Theses and Dissertations--Electrical and Computer Engineering
Noble metal nanoparticles supporting localized surface plasmon resonances (LSPR) have been extensively investigated for label free detection of various biological and chemical interactions. When compared to other optical sensing techniques, LSPR sensors offer label-free detection of biomolecular interactions in localized sensing volume solutions. However, these sensors also suffer from a major disadvantage – LSPR sensors remain highly susceptible to interference because they respond to both solution refractive index change and non-specific binding as well as specific binding of the target analyte. These interactions can severely compromise the measurement of the target analyte in a complex unknown media and hence limit …
Multi-Mode Self-Referencing Surface Plasmon Resonance Sensors, Jing Guo
Multi-Mode Self-Referencing Surface Plasmon Resonance Sensors, Jing Guo
Theses and Dissertations--Electrical and Computer Engineering
Surface-plasmon-resonance (SPR) sensors are widely used in biological, chemical, medical, and environmental sensing. This dissertation describes the design and development of dual-mode, self-referencing SPR sensors supporting two surface-plasmon modes (long- and short-range) which can differentiate surface binding interactions from bulk index changes at a single sensing location. Dual-mode SPR sensors have been optimized for surface limit of detection (LOD). In a wavelength interrogated optical setup, both surface plasmons are simultaneously excited at the same location and incident angle but at different wavelengths. To improve the sensor performance, a new approach to dual-mode SPR sensing is presented that offers improved differentiation …
Field-Effect Amperometric Immuno-Detection Of Protein Biomarker, Jiapeng Wang, Siu-Tung Yau
Field-Effect Amperometric Immuno-Detection Of Protein Biomarker, Jiapeng Wang, Siu-Tung Yau
Electrical and Computer Engineering Faculty Publications
The field-effect enzymatic detection technique has been applied to the amperometric immunoassay of the cancer biomarker, carcinoma antigen 125 (CA 125). The detection adopted a reagentless approach, in which the analyte, CA 125, was immobilized on the detecting electrode, which was modified using carbon nanotubes, and the detection signal was obtained by measuring the reduction peak current of the enzyme that was used to label the antibody. A gating voltage was applied to the detecting electrode, inducing increase in the signal current and therefore providing amplification of the detection signal. The voltage-controlled signal amplification of the detection …
Preserved Enzymatic Activity Of Glucose Oxidase Immobilized On Unmodified Electrodes For Glucose Detection, Gang Wang, Ngee Mei Thai, Siu-Tung Yau
Preserved Enzymatic Activity Of Glucose Oxidase Immobilized On Unmodified Electrodes For Glucose Detection, Gang Wang, Ngee Mei Thai, Siu-Tung Yau
Electrical and Computer Engineering Faculty Publications
Glucose sensing electrodes have been realized by immobilizing glucose oxidase (GOx) on unmodified edge plane of highly oriented pyrolytic graphite (epHOPG) and the native oxide of heavily doped silicon (SiO2/Si). Both kinds of electrode show direct interfacial electron transfer due to the redox process of the immobilized GOx. The measured formal potential of the redox process agrees with that of the native enzyme, suggesting that the immobilized GOx has retained its enzymatic activity. The electron transfer rates of the GOx immobilized electrode are 2s−1 for GOx/epHOPG electrode and 7.9s−1 for GOx/SiO2/Si electrode, which …