Biomedical Commons^™

A System For Monitoring Pressures And Spinal Curvature In Spinally Injured People Immobilised On A Spinal Raft, Ruairí De Fréin, Eoin Flinn, Ted Burke

Articles

We present a system designed to study the pressure at various ‘hot spots’ on the back of the body and the deformation of the spine experienced by a patient when strapped to a spinal board, and the potential alleviation of both by the addition of an inflatable “spinal raft” (or other similar device). In measuring pressure we devised a system of air-filled sacks interfaced with a PC. Each sack, placed under a particular key point on the body, is inflated until its faces just begin to separate and a switch thereby opens. The pressure reading is then captured and displayed …

Using Optimization To Calibrate Models Of Intracranial Pressure Dynamics To Patients With Intracranial Hypertension, Wayne W. Wakeland, A. Bulbul, Mateo Aboy, James Mcnames, Brahm Goldstein

Complex Systems Faculty Publications and Presentations

Aim: Automatically calibrate ICP Dynamic model to a specific patients.

Method: Use optimization algorithm to estimate parameter values (ICP, compliances, resistances) that minimize the squared error in predicted ICP.

Results: Estimated parameter values are plausible and improve predicted ICP. Optimization time for 18 minute episode = 2.5 min. for 1 parameter, 10 to 200 min. for multiple simultaneous parameters (too long).

A Comparison Of System Dynamics And Agent-Based Simulationapplied To The Study Of Cellular Receptor Dynamics, Wayne W. Wakeland, Edward J. Gallaher, Louis Macovsky, C. Athena Aktipis

Complex Systems Faculty Publications and Presentations

Cellular receptor dynamics are often analyzed using differential equations, making system dynamics (SD) a candidate methodology. In some cases it may be useful to model the phenomena at the biomolecular level, especially when concentrations and reaction probabilities are low and might lead to unexpected behavior modes. In such cases, agent-based simulation (ABS) may be useful. We show the application of both SD and ABS to simulate non-equilibrium ligand-receptor dynamics over a broad range of concentrations, where the probability of interaction varies from low to very low. Both approaches offer much to the researcher and are complementary. We did not find …

Calibrating An Intracranial Pressure Dynamics Model With Clinical Data - A Progress Report, Wayne W. Wakeland, James Mcnames, Brahm Goldstein

Complex Systems Faculty Publications and Presentations

We describe the calibration of a computer model of intracranial pressure (ICP) dynamics to correspond with annotated clinical data taken from a patient being treated for elevated ICP due to a traumatic brain injury. The research protocol employed during treatment includes adjusting the elevation of the head of the bed, adjusting the ventilator settings to induce mild hyperventilation and hypoventilation, and adjusting the height of the cerebrospinal fluid drainage system. The model behavior corresponds to the experimental data quite well in the case of the changing the head of the bed, but less well in the case of changing the …

Stimulation Of Capacitative Calcium Entry In Hl-60 Cells By Nanosecond Pulsed Electric Fields, Jody A. White, Peter F. Blackmore, Karl H. Schoenbach, Stephen J. Beebe

Bioelectrics Publications

Nanosecond pulsed electric fields (nsPEFs) are hypothesized to affect intracellular structures in living cells providing a new means to modulate cell signal transduction mechanisms. The effects of nsPEFs on the release of internal calcium and activation of calcium influx in HL-60 cells were investigated by using real time fluorescent microscopy with Fluo-3 and fluorometry with Fura-2. nsPEFs induced an increase in intracellular calcium levels that was seen in all cells. With pulses of 60 ns duration and electric fields between 4 and 15 kV/cm, intracellular calcium increased 200-700 nM, respectively, above basal levels (similar to100 nM), while the uptake of …

Developing Software For Wound Measurement, Savo Kordic

Theses : Honours

Chronic wounds such as leg ulcers, pressure ulcers and diabetic ulcers affect many thousands of people in Australia. In addition to the costs of these wounds in terms of human suffering, loss of income and resources, there are costs related to the treatment of ulcers. Thus, there is a genuine need to develop an accurate and a fully objective application for wound measurement. The aim of this project was to create software for the measurement of wounds. In achieving this goal, several issues were addressed: an accurate measurement method capable of detecting small changes in an open wound surface area, …