Incorporation Of Egfr And Ron Receptors Into Nanodiscs,
2019
University of New Mexico
Incorporation Of Egfr And Ron Receptors Into Nanodiscs, Cristina Flores-Cadengo
Biomedical Engineering ETDs
Understanding the structure-function relationship of membrane receptors is essential to comprehend the crosstalk between key signaling pathways. Aberrant trans-activation between receptors can lead to tumorigenesis. Two of these receptors known to be involved in cancer development are receptor tyrosine kinases (RTKs), RON (Recepteur d'Origine Nantais) and EGFR (Epidermal Growth Factor Receptor). There has been evidence of heterodimerization and crosstalk between these two receptors based on co-immunoprecipitation, however the structural requirements behind these interactions remain unknown. Structural studies could provide insights into these RTKs’ modes of dimerization and structure-function relationship. However, structural studies of full-length membrane proteins are often difficult due …
Biomechanical Foot Guidance Linkage,
2019
Lincoln, NE
Biomechanical Foot Guidance Linkage, Carl Nelson, Cale J. Stolle, Judith M. Burnfield
Department of Mechanical and Materials Engineering: Faculty Publications
A gait replication apparatus can include a scalable mechanical mechanism configured to replicate different gaits . The scalable mechanical mechanism can include , for example , a four - bar linkage , a pantograph , a cam / Scotch - yoke mechanism , and so forth . In some embodiments , the mechanical mechanism includes a beam rotating about an axis passing proximate to its center , with a foot pedal slidably coupled with the beam , and a timing chain / belt or cable pulley - pair coupled with the foot pedal and looped about the beam . A …
Synthesis And Characterization Of Molybdenum Disulfide/Conducting Polymer Nanocomposite Materials For Supercapacitor Applications,
2019
University of South Florida
Synthesis And Characterization Of Molybdenum Disulfide/Conducting Polymer Nanocomposite Materials For Supercapacitor Applications, Turki S. Alamro
USF Tampa Graduate Theses and Dissertations
The needs for energy storage devices have kindled researchers desire to explore and synthesize nanocomposite materials. Storing energy efficiently, effectively and sustainably are the science and engineering communities’ highest priorities to develop electrochemical energy storage devices. Supercapacitors have become power solution not only because supercapacitors can bridge the gap between the traditional capacitors and rechargeable batteries but also because of many other advantages which include extraordinary electrochemical properties, wide working-temperature range, cost effective, safe operation and long/stable cycle life. They have higher current pules than batteries due to the mechanism of charging and discharging. Batteries charging and discharging via chemical …
Numerical Simulation Of Viscoelastic Flow In Micro/Nanochannels,
2019
Old Dominion University
Numerical Simulation Of Viscoelastic Flow In Micro/Nanochannels, Lanju Mei
Mechanical & Aerospace Engineering Theses & Dissertations
Micro/Nanofluidic devices often involve use of biological fluids or polymeric solutions that cannot be simply treated as Newtonian fluids. The numerical simulation for the complex fluids at micro/nanoscale presents a significant computational challenge, and the inclusion of electrokinetic body force further increases the complexity. Specifically, the well-known High Weissenberg Number Problem (HWNP) has become a challenge for the numerical simulation of viscoelastic fluid. This dissertation is aimed to develop a numerical tool to simulate the behavior of viscoelastic fluid in the micro/nanochannel. The most popular log-conformation reformulation to solve the HWNP is presented and implemented in a finite volume scheme. …
The Effect Of Defects And Surface Modification On Biomolecular Assembly And Transport,
2019
University of New Mexico - Main Campus
The Effect Of Defects And Surface Modification On Biomolecular Assembly And Transport, Haneen Martinez
Nanoscience and Microsystems ETDs
Nanoscale transport using the kinesin-microtubule (MT) biomolecular system has been successfully used in a wide range of nanotechnological applications including self-assembly, nanofluidic transport, and biosensing. Most of these applications use the ‘gliding motility geometry’, in which surface-adhered kinesin motors attach and propel MT filaments across the surface, a process driven by ATP hydrolysis. It has been demonstrated that active assembly facilitated by these biomolecular motors results in complex, non-equilibrium nanostructures currently unattainable through conventional self-assembly methods. In particular, MTs functionalized with biotin assemble into rings and spools upon introduction of streptavidin and/or streptavidin-coated nanoparticles. Upon closer examination of these structures …
Electrochemical Modification Of Granular Activated Carbon And Carbon Nanofibers To Determine Effect On Adsorption,
2019
Air Force Institute of Technology
Electrochemical Modification Of Granular Activated Carbon And Carbon Nanofibers To Determine Effect On Adsorption, Jose E. Martinez Sanchez
Theses and Dissertations
Granular activated carbon and carbon nanofiber samples were tested as is and electrochemically modified to determine the effect on adsorption. An electrochemical cell was used to modify the carbon samples. The samples were then used in bench bottle tests with 2,4-dinitrotoluene (DNT), brilliant blue (BB) dye, and methylene blue (MB) dye solutions and sampled over time intervals. An ultraviolet–visible spectrophotometer was used to analyze the results of the bottle bench tests. The results indicated that electrochemically modified coal-based carbons’ adsorption were improved 25% over the adsorption of the as is carbon samples prior to modification. The electrochemical modification increased adsorption …
Nanoparticle Synthesis For Glucose-Loaded Mesoporous Silica And Sucrose Hydrolysis Strategies For Bioanalyte Detection Applications Using A Personal Glucose Meter,
2019
University of South Florida
Nanoparticle Synthesis For Glucose-Loaded Mesoporous Silica And Sucrose Hydrolysis Strategies For Bioanalyte Detection Applications Using A Personal Glucose Meter, Xiomar Emauel Bustos Perez
USF Tampa Graduate Theses and Dissertations
Point-of-care (POC) tests are a reliable, portable, easy to use, and more affordable alternative to regular laboratory diagnostic tests. They bypass the necessity of expensive equipment, human labor, and technical expertise. The personal glucose meter (PGM) is a POC device that measures glucose levels in blood. Lately, the PGM have been used as a tool to detect other bioanalytes in different applications. There are two analytes which POC detection would be beneficial for patients: creatinine and tacrolimus. Creatinine is used to calculate glomerular filtration rate, a measurement of kidneys function that can help to diagnose kidney failure, and other nephropathies. …
Axitinib Loaded Plga Nanoparticles For Age-Related Macular Degeneration,
2019
University of South Florida
Axitinib Loaded Plga Nanoparticles For Age-Related Macular Degeneration, Priya P. Narvekar
USF Tampa Graduate Theses and Dissertations
Despite of all the research going on for the treatment of ocular diseases, age-related macular degeneration (AMD) remains one of the serious vision threatening disease worldwide. Choroidal neovascularization, a pathophysiological characteristic of wet AMD, is the growth of anomalous blood vessels in the eye choroidal layer. Neovascularization is a key factor in AMD and thus anti-angiogenic therapy is beneficial in reducing the development of new abnormal blood vessels to prevent progression of AMD. Axitinib, multi-receptor tyrosine kinase inhibitor, is a small molecule that works by blocking vascular endothelial growth factor receptors (VEGFR) and platelet derived growth factor receptors (PDGFR) responsible …
Removal Of Synthetic Azo Dye Using Bimetallic Nickel-Iron Nanoparticles,
2019
University of Arkansas, Fayetteville
Removal Of Synthetic Azo Dye Using Bimetallic Nickel-Iron Nanoparticles, Shelby L. Foster, Katie Estoque, Michael Voecks, Nikki Rentz, Lauren F. Greenlee
Chemical Engineering Faculty Publications and Presentations
Bimetallic nanoparticles comprised of iron (Fe) and nickel (Ni) were investigated for the removal of an azo dye contaminant in water. Morphology (core shell and alloy) and metal molar ratio (Ni2Fe10, Ni5Fe10, and Ni10Fe10) were tested as key nanoparticle properties. The shelf life of the nanoparticles was tested over a 3-week period, and the effect of initial nanoparticle concentration on dye removal was evaluated. The highest initial nanoparticle concentration (1000 mg/L) showed consistent Orange G removal and the greatest extent of dye removal, as compared to the other tested concentrations (i.e., 750 mg/L, 500 mg/L, and 250 mg/L) for the …
Soft , Multilayered Electronics For Wearable Devices And Methods To Produce The Same,
2019
University of Nebraska - Lincoln
Soft , Multilayered Electronics For Wearable Devices And Methods To Produce The Same, Carmel Majidi, Michael D. Bartlett, Eric J. Markvicka
Department of Mechanical and Materials Engineering: Faculty Publications
Disclosed herein is an efficient fabrication approach to create highly customizable wearable electronics through rapid laser machining and adhesion - controlled soft materials assembly . Well - aligned , multi - layered materials can be created from 2D and 3D elements that stretch and bend while seamlessly integrating with rigid components such as micro chip integrated circuits ( IC ) , discrete electrical components , and interconnects . These techniques are applied using commercially available materials . These materials and methods enable custom wearable electronics while offering versatility in design and functionality for a variety of bio - monitor ing …
Analysis Of Dynamic Behaviour Of A Tensioned Carbon Nanotube In Thermal And Pressurized Environments,
2019
University of Lagos
Analysis Of Dynamic Behaviour Of A Tensioned Carbon Nanotube In Thermal And Pressurized Environments, Ahmed Yinusa, Gbeminiyi Sobamowo
Karbala International Journal of Modern Science
In this paper, the dynamic behaviour of a tensioned single-walled carbon nanotubes (SWCNT) in thermal and pressurized environments is investigated analytically. With the applications of Bernoulli-Euler and thermal elasticity mechanics theories, the governing equation of motion are developed and solved using Laplace and Fourier transforms. The results of the close form solution in this work are in excellent agreements with past results in literature. From the parametric studies, it is established that as the magnitude of the pressure distribution at the surface increases, the deflection associated with the nanotube increases at any mode of vibration. However, a corresponding increase in …
Å-Indentation For Non-Destructive Elastic Moduli Measurements Of Supported Ultra-Hard Ultra-Thin Films And Nanostructures,
2019
New York University
Å-Indentation For Non-Destructive Elastic Moduli Measurements Of Supported Ultra-Hard Ultra-Thin Films And Nanostructures, Filippo Cellini, Yang Gao, Elisa Riedo
Publications and Research
During conventional nanoindentation measurements, the indentation depths are usually larger than 1–10 nm, which hinders the ability to study ultra-thin films (<10 >nm) and supported atomically thin two-dimensional (2D) materials. Here, we discuss the development of modulated Å-indentation to achieve sub-Å indentations depths during force-indentation measurements while also imaging materials with nanoscale resolution. Modulated nanoindentation (MoNI) was originally invented to measure the radial elasticity of multi-walled nanotubes. w, by using extremely small amplitude oscillations (<<1 Å) at high frequency, and stiff cantilevers, we show how modulated nano/Å-indentation (MoNI/ÅI) enables non-destructive measurements of the contact stiffness and indentation modulus of ultra-thin ultra-stiff films, including CVD diamond films (~1000 GPa stiffness), as well as the transverse modulus of 2D materials. Our analysis demonstrates that in presence of a standard laboratory noise floor, the signal to noise ratio of MoNI/ÅI implemented with a commercial atomic force microscope (AFM) is such that a dynamic range of 80 dB –– achievable with commercial Lock-in amplifiers –– is sufficient to observe superior indentation curves, having indentation depths as small as 0.3 Å, resolution in indentation <0.05 Å, and in normal load <0.5 nN. Being implemented on a standard AFM, this method has the potential for a broad applicability.
Gastrointestinal Sensor Implantation System,
2019
Lincoln , NE
Gastrointestinal Sensor Implantation System, Benjamin Terry, Weston Lewis, Wanchuan Xie, Pengbo Li, Alfred Tsubaki
Department of Mechanical and Materials Engineering: Faculty Publications
A gastrointestinal ( GI ) sensor deployment device is dis closed . In implementations , the sensor deployment device includes an orally - administrable capsule with a tissue cap ture device removably coupled to the orally - administrable capsule . The tissue capture device includes a plurality of fasteners for connecting the tissue capture device to GI tissue within a body . A biometric sensor is coupled to the tissue capture device for continuous or periodic monitoring of the GI tract of the body at the GI tissue attachment location . A chamber within the orally - administrable capsule is …
Interactions Between Dislocations And Three-Dimensional Annealing Twins In Face Centered Cubic Metals,
2019
University of Nebraska–Lincoln
Interactions Between Dislocations And Three-Dimensional Annealing Twins In Face Centered Cubic Metals, Yanxiang Liang, Xiaofang Yang, Mingyu Gong, Guisen Liu, Qing Liu, Jian Wang
Department of Mechanical and Materials Engineering: Faculty Publications
Annealing twins often form in metals with a face centered cubic structure during thermal and mechanical processing. Here, we conducted molecular dynamic (MD) simulations for copper and aluminum to study the interaction processes between {1 1 1}1/2 <1 1 0> dislocations and a three-dimensional annealing twin. Twin boundaries are characterized with Σ3{1 1 1} coherent twin boundaries (CTBs) and Σ3{1 1 2} incoherent twin boundaries (ITBs). MD results revealed that dislocation-ITB interactions affect slip transmission for a dislocation crossing CTBs, facilitating the nucleation of Lomer dislocation.
Recent Developments In Surface/Interface Modulation And Structure-Performance Relationship Of Cathode Catalysts For Li-Air Batteries,
2019
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China;
Recent Developments In Surface/Interface Modulation And Structure-Performance Relationship Of Cathode Catalysts For Li-Air Batteries, Rui Gao, Jun-Kai Wang, Zhong-Bo Hu, Xiang-Feng Liu
Journal of Electrochemistry
Lithium-air battery has been considered to be one of the most promising secondary battery systems because of its high energy density. However, the sluggish kinetics of the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) on the cathode, and the high overpotential, poor cycle stability and low rate capacity have severely blocked the development and application of Li-air battery. One of the effective strategies to alleviate these issues is to develop cathode catalysts for Li-air batteries. The design and development of bifunctional cathode catalysts with high activity and efficiency on both ORR and OER is highly desired for Li-air …
Development Of A Counter-Flow Thermal Gradient Microfluidic Device,
2019
Louisiana Tech University
Development Of A Counter-Flow Thermal Gradient Microfluidic Device, Shayan Davani
Doctoral Dissertations
This work presents a novel counter-flow design for thermal stabilization of microfluidic thermal reactors. In these reactors, precise control of temperature of the liquid sample is achieved by moving the liquid sample through the thermal zones established ideally through the conduction in the solid material of the device. The goal here is to establish a linear thermal distribution when there is no flow and to minimize the temperature change at flow condition. External convection as well as internal flowinduced effects influence the prescribed thermal distribution. The counter-flow thermal gradient device developed in this study is capable of both stabilizing the …
Optimization Of Processing Parameters Of Nanocomposite Film For Fresh Sliced Okra Packaging,
2019
Kwara State University, Malete, Nigeria
Optimization Of Processing Parameters Of Nanocomposite Film For Fresh Sliced Okra Packaging, Adeshina Fadeyibi Phd, Zinash Delebo Osunde Phd, Professor, Mohammed Gana Yisa Professor
Journal of Applied Packaging Research
Nanocomposite film can be regarded as an active packaging material which is capable of curtailing microbial growth and keeping food for an extended life. In this research, the optimum processing parameters of cassava starch-zinc nanocomposite film was determined for packaging fresh-sliced okra. Samples of the films, with thickness ranging between 15– 17µm, were developed from the blends of 24g of cassava starch, 0–2 % zinc nanoparticles (NP) and 45–55 % glycerol in 600 ml distilled water. The ideal film was determined by optimizing the film processing parameters using Box-Behnken Design in Surface Response Methodology. It was subsequently used to package …
Electrical Properties And Electromagnetic Interference Shielding Effectiveness Of Interlayered Systems Composed By Carbon Nanotube Filled Carbon Nanofiber Mats And Polymer Composites,
2019
The University of Texas Rio Grande Valley
Electrical Properties And Electromagnetic Interference Shielding Effectiveness Of Interlayered Systems Composed By Carbon Nanotube Filled Carbon Nanofiber Mats And Polymer Composites, Claudia A. Ramirez-Herrera, Homero Gonzalez, Felipe De La Torre, Laura Benitez, Jose G. Cabanas-Moreno, Karen Lozano
Mechanical Engineering Faculty Publications
The demand for multifunctional requirements in aerospace, military, automobile, sports, and energy applications has encouraged the investigation of new composite materials. This study focuses on the development of multiwall carbon nanotube (MWCNT) filled polypropylene composites and carbon nanofiber composite mats. The developed systems were then used to prepare interlayered composites that exhibited improved electrical conductivity and electromagnetic interference (EMI) shielding efficiency. MWCNT-carbon nanofiber composite mats were developed by centrifugally spinning mixtures of MWCNT suspended in aqueous poly(vinyl alcohol) solutions. The developed nanofibers were then dehydrated under sulfuric acid vapors and then heat treated. Interlayered samples were fabricated using a nanoreinforced …
Deep Learning Segmentation Of Coronary Calcified Plaque From Intravascular Optical Coherence Tomography (Ivoct) Images With Application To Finite Element Modeling Of Stent Deployment,
2019
Case Western Reserve University
Deep Learning Segmentation Of Coronary Calcified Plaque From Intravascular Optical Coherence Tomography (Ivoct) Images With Application To Finite Element Modeling Of Stent Deployment, Yazan Gharaibeh, Pengfei Dong, David Prabhu, Chaitanya Kolluru, Juhwan Lee, Vlad Zimin, Hozhabr Mozafari, Hiram Bizzera, Linxia Gu, David Wilson
Department of Mechanical and Materials Engineering: Faculty Publications
Because coronary artery calcified plaques can hinder or eliminate stent deployment, interventional cardiologists need a better way to plan interventions, which might include one of the many methods for calcification modification (e.g., atherectomy). We are imaging calcifications with intravascular optical coherence tomography (IVOCT), which is the lone intravascular imaging technique with the ability to image the extent of a calcification, and using results to build vessel-specific finite element models for stent deployment. We applied methods to a large set of image data (>45 lesions and > 2,600 image frames) of calcified plaques, manually segmented by experts into calcified, lumen and …
Strength And Plasticity Of Amorphous Silicon Oxycarbide,
2019
University of Nebraska-Lincoln
Strength And Plasticity Of Amorphous Silicon Oxycarbide, Kaisheng Ming, Chao Gu, Qing Su, Yongqiang Wang, Arezoo Zare, Don A. Lucca, Michael Nastasi, Jian Wang
Department of Mechanical and Materials Engineering: Faculty Publications
Amorphous SiOC films were synthesized by magnetron sputtering at room temperature with/without radio frequency (RF) bias and further improved in terms of mechanical properties by ion irradiation. As-deposited SiOC films without RF bias exhibit catastrophic failure at a low stress and strain, which is ascribed to microstructural heterogeneities associated with the formation of voids during deposition, as evidenced by transmission electron microscopy. Ion irradiation unifies microstructure accompanied with eliminating the voids, resulting in a simultaneously increase in strength and plasticity (ultimate strength of 5–7 GPa and the strain to shear instability of over 20%). Homogeneous microstructures are demonstrated to ensure …
