Pharmacy and Pharmaceutical Sciences Commons^™

Appropriateness Of Ambulatory Antibiotic Prescribing In South Carolina, 2012–2017, Pamela Bailey, Majdi N. Al-Hasan, Julie Royer, Max Habicht, Julie Ann Justo, P. Brandon Bookstaver Pharm.D., Sharon Weissman, Hana R. Winders

Faculty Publications

This population-based cohort study examines the appropriateness of antibiotic prescribing in South Carolina via aggregated pharmacy claims data matched with diagnosis codes from medical claims. Inappropriate antibiotic prescribing decreased from 30.2% in 2012 to 22.6% in 2017 (P < 0.001) and was more common in adults >40 years old.

Voltammetric Analysis Of Pholcodine On Graphene-Modified Gnps/Pts With Green Assessment, Ekram Hany Mohamed, Nahla Abdel Shafy, Hadeer Elkhouly, Nehal Khoudary, Hany Darwish, Aswak Alanzi, Ibrahim Naguib

Pharmacy

Pholcodine, an anti-tussive medication widely used as an over-the-counter, OTC drug, has recently faced restrictions in several countries. This paper presents a sensitive electrochemical approach for pholcodine detection. The electrochemical method involved fabricating a graphene nanoplatelets electrode, incorporating polythiophene nanospheres polymer to promote electron transfer and increase the activated surface area. Characterization of the fabricated electrode was performed using transmission electron microscopy, ATR-Fourier-transform infrared spectroscopy, X-ray crystallography, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy. The electrochemical behavior of pholcodine with the fabricated electrode was investigated using cyclic voltammetry, chronoamperometry, square wave voltammetry (SWV), and differential pulse voltammetry (DPV). The developed …

Garcinia Pedunculata Roxb. Ex Buch.-Ham. Leaf Extract Ameliorates Diabetes In Streptozotocin Induced Diabetes In Rats, Kangkan Kalita, Techi Gello, Nilutpal Sharma Bora, Zothan Puia

Bulletin of Faculty of Pharmacy Cairo University

Although medicinal plants have been historically used for diabetes treatment throughout the world, few of them have been validated by scientific criteria. Diabetes mellitus is a metabolic disorder manifests as elevated blood glucose levels when the body cannot create sufficient amounts of insulin or utilize the insulin produced. This may be due to the free radicals present in the body. The antioxidants help to neutralize the free radicals by donating electron and thus protect from various oxidative stress diseases. The aim of this work is to evaluate the preliminary phytochemical screening, in vitro antioxidant study, in vitro and in vivo …

Bile Duct Ligation-Induced Cirrhosis Does Not Alter The Blood-Brain Barrier Permeability To Sucrose In Rats, Mohammad K. Miah, Ulrich Bickel, Reza Mehvar

Pharmacy Faculty Articles and Research

Contradictory results have been reported about the effects of liver diseases on the blood-brain barrier (BBB) permeability to markers. For instance, both an increase and no change in the BBB permeability to BBB markers sodium fluorescein and Evans blue have been reported in experimental cholestasis induced by bile duct ligation (BDL) in rats. These contradictory effects might be due to inherent limitations of these markers and/or methodological issues. Here, we investigated the time course of the impact of BDL in rats on BBB permeability using a recently developed stable isotope labeled marker [¹³C]sucrose, which is expected to be …

Computational Logp Calculations And Determination Of Lipophilicity Values Of Fluorinated Morphine Derivatives, Mirabella Romano, Allison Vu, Emily Chen

Student Scholar Symposium Abstracts and Posters

The addictive effect of opioids impacted 60 million people globally in 2023. This opioid crisis necessitates the development of opioid derivatives that maintain analgesic efficacy while minimizing addictive effects from opioid use. The present work focuses on morphine, a commonly prescribed opioid with high affinity to the mu-opioid receptor (MOR). Morphine binds non-selectively within both healthy and inflamed tissue. By modifying morphine’s structure through fluorination to counteract its non-selective binding, the drug’s pharmacological ability to provide effective pain relief comes with a lower risk of addiction. Specifically, the addition of fluorine to differing beta positions of the main binding site …

Brushing Up On Antibiotic Stewardship: Pharmacy Students Survey And Educate Dentists On Antibiotic Prescribing Guidelines And Practices, Niyaz Pordel, Kamaladdin Saei, Feifei Jia, Kaitlin Meyer, Lisa M. Avery

Doctoral External Publications

To evaluate dentists’ knowledge of ABX stewardship tools and to determine the likelihood of incorporating various antibiotic stewardship principles into practice after receiving a pharmacy school generated newsletter.

Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Among Novel Fda Approvals In 2023, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

Many newly approved immediate-release (IR) solid oral drugs are accompanied by broad "do-not-crush" warnings, often without specific explanations. Building on our recent publication of crushability analysis of novel drugs approved between 2020 and 2022, this research extends the assessment to the approvals of 2023. Our goal is to provide healthcare providers with timely recommendations for the safe manipulation of immediate-release tablets and capsules for patients who cannot swallow them whole.

Winter 2024 Edition, Southwestern Oklahoma State University

The Sig

GREETINGS FROM THE DEAN’S OFFICE
Southwestern Opens Doors to Opportunities Beyond Imagination

Homecoming Saturday on October26th was a wonderful day, and we are grateful to all the alumni, family, and friends who attended. Coming back to the COP to rekindle with classmates and faculty is always a special time, especially after many years. As each 50-year and 40-year graduate was recognized and shared a story or special thought with everyone, I was impressed by the common themes.

Anticoagulation Strategies After Left Ventricular Thrombus., Corey Uetrecht Pharmd, Jennifer Sposito Pharmd, Bcps, Bcccp, Kassandra Foellinger Pharmd, Bcps, Jamie Gaul Pharmd, Bcps, Sarah Ferrell Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting,

This medication use evaluation found that prescribing practices of DOAC and warfarin did not change after AHA guidance publication. Patients with HFrEF were more often discharged on warfarin, while those with Afib were more often discharged on DOACs. Those discharged on a DOAC had the highest incidence of LV thrombus resolution up to 6 months post-discharge. Physicians within Parkview Health do not routinely utilize a loading dose when discharging a patient on a DOAC.

Stepping Back: Evaluating Antipseudomonal Antibiotic Use In Diabetic Foot Infection., Hannah Davis Pharmd, Michele Walters Pharmd, Bcps, Aq-Id, Sarah Ferrell Pharmd, Bcpps, Jui Patel Pharmd, Bcps, Tiffany O'Keefe Pharmd, Bcgp

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that anti-pseudomonal (PsA) coverage is overutilized in diabetic foot infection (DFI), even when broad qualifying criteria are applied. The proposed criteria were poor predictors of PsA growth, which was present in a small number of cases. Patients who did grow PsA were somewhat more likely to have severe DFI, history of DFI, and 90-day history of admission or anti-PsA antibiotic use, but many patients without PsA growth also met these criteria.

Comparing Cardiometabolic Monitoring And Side Effect Management In A Pharmacist-Led Ambulatory Clozapine Clinic Versus Standard Care., Nicholas Buttermore Pharmd, Jenna Gilbert Pharmd, Bcpp, Naana Boachie Pharmd, Bcacp, Kenneth Wiley Pharmd, Bcacp, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that cardiometabolic monitoring rates were significantly higher in the pharmacist group compared to standard care, and that clozapine-related side effects were screened more frequently.

Pacific Rxtracts - December 2024, Pacific Rxtracts

Pacific RxTracts

Articles

• Attruby: A Promising Treatment for Transthyretin Amyloid Cardiomyopathy
• Triple Threat: GMRx2, An Emerging Low-Dose Triple Pill For Hypertension
• New Treatment for Hemophilia A or B
• Breaking the Placebo Barrier: FDA Review Challenges Effectiveness of Popular Decongestant
• Exploring Bempedoic Acid: Potential Benefits for Statin-Intolerant Patients and Liver Health
• The Flu Vaccine: Meeting You Where You Are
• Unique Application of Statins for Radiotherapy-Induced Cardiotoxicity
• One Shot, Two Solutions: How Semaglutide Combats Obesity and Knee Osteoarthritis

Tenecteplase For Acute Ischemic Stroke: Insights From A Large Community Teaching Hospital, Ithar Alsarraf, Jennifer Pilotto, Rebecca E. Baker, Emily Reich

Posters

Acute Ischemic Stroke (AIS) is a leading cause of disability and death in the United States, requiring urgent treatment1,2; earlier treatment improves patient outcomes.

Fibrinolytic agents including alteplase and tenecteplase (TNK) reduce long-term disability in AIS but are associated with hemorrhagic risks3,4.

As of January 2024, Corewell Health East hospitals updated their guidelines that TNK would be the first line agent in the treatment of AIS.

Alteplase is the only approved agent for AIS, but TNK shows similar effectiveness along with shorter preparation and administration time which may ultimately improve door-to-needle time2 .

Careful consideration of patient characteristics is important …

October / November / December 2024, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the October - November - December issue of Rural Rocks from the SWOSU College of Pharmacy.

Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven

Open Access Theses & Dissertations

Continuous overactivation of myofibroblasts leads to excessive deposition of profibrotic proteins, which in turn causes tissue stiffness and, ultimately, organ failure. One of those proteins, Cadherin-11 (CDH11), is reported to be overexpressed in the tissue of fibrotic skin, specifically on myofibroblasts. Similarly, chronic inflammation drives fibrosis progression in autoimmune-related illnesses like systemic sclerosis (SSc). Therefore, it is hypothesized that CDH11 could be a target for cell-specific delivery of antifibrotic therapies to fibrotic skin tissue. Here, a CDH11 peptide conjugated liposome loaded with Tofacitinib, a JAK inhibitor, was developed to understand the potential of targeted therapies to treat skin fibrosis. The …

Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

No abstract provided.

Dalbavancin Use At A Health System Network In Compliance With A Standard Plan Of Treatment For Infective Endocarditis And Osteomyelitis, Nicholas Lombardi, Anthoula Kritikos, Jacky Ye, Victor Cohen

Doctoral External Publications

Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and soft tissue infections caused by gram-positive microorganisms.

Used off-label in the management of infective endocarditis in IV drug users, as well as in osteomyelitis infections.

Extremely long half-life of greater than a week.

Potential cost-effective option for susceptible gram-positive infections and increased patient compliance.

Leading Biologics In Pharmacy Practice: The Role Of Pharmacists, Amerah Elshayeb, Emily Austin, Lipika Chablani

Doctoral External Publications

Evaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of biologics.

Impact Of Order Set Implementation On Institutional Management Of Clostridioides Difficile In Adult Patients, Nicole Henry, Olivia Campbell, Heather Daly, Katelyn Quartuccio, Melanie Lintala

Doctoral External Publications

In February 2022, the University of Rochester Medical Center (URMC) updated their practice guidelines, in accordance with the Infectious Diseases Society of America, to include fidaxomicin as the preferred agent in patients with initial (non-fulminant) or first recurrence of C. difficile infection (CDI).

Health system protocols were updated to include polymerase chain reaction (PCR) testing for patients with suspected CDI followed by confirmation via toxin enzyme immunoassay (EIA).

In the appropriate clinical context, PCR+/EIA+ test confirms active CDI and warrants antibiotic treatment.

PCR+/EIA- test indicates likely colonization and may preclude the need for treatment.

A CDI order set was implemented …

Local Chapters Of Ashp And Apha Partner With The Monroe County Sheriff’S Department To Host A Drug Take-Back Event In The Rochester Community, Mackenzie Bermingham, Michael Currier, Bailey Walker, Laura Witt, Shawn E. Fellows, Angela Nagel

Doctoral External Publications

Objection/Study Goals:

To provide a safe, environmentally responsible way to dispose of unused or expired medications and to raise awareness about the risks of medication misuse in the community.