Pharmacy and Pharmaceutical Sciences Commons^™

Knowledge And Attitudes Toward Over-The-Counter Medications Among Undergraduate Students At The University Of Mississippi, Anna S. Dawson

Honors Theses

This study examines and compares knowledge and attitudes towards over-the-counter (OTC) medications among undergraduate college students at the University of Mississippi. OTCs are purchased and administered without a prescription, making them an efficient, safe, and affordable method of healthcare. It is important to determine the attitudes college students have towards these drugs and if they are able to safely and correctly use them. Information gathered from this study can be used to guide future education on medication literacy and to gain insight into how college students use OTCs to medicate themselves. A Qualtrics survey was sent out to a random …

In Adults Older Than 18 Years With Obesity Living In Massachusetts, Can Engaging In A Weight Loss Program Help Them Lose Weight After Insurance Stops Covering Their Weight Loss Medications?, Angel Nagawa

Capstones

Executive summary

The Problem

Obesity rates continue to rise sharply across the United States. Weight loss medications have high compliance but face major insurance restrictions. Strict clinical criteria leave many patients without accessible treatment options.

The Proposed Solution

Launch structured, lifestyle-focused clinical weight loss programs. Provide an effective, accessible alternative to restricted pharmaceutical therapies.

Supporting Evidence

Evaluated data from three distinct randomized controlled trials. Findings confirm successful long-term weight management for program participants. Results prove effective control over serious obesity-related comorbidities.

Policy recommendation

Implement structured lifestyle programs as a primary, frontline intervention modality. Improve broad-scale patient health outcomes across clinical …

Phytochemical And In-Vitro Cytotoxic Analyses Of Flavonoid Species Isolated From Chromolaena Leivensis, Luke A. Bryant

Electronic Theses and Dissertations

As a leading cause of death worldwide, cancer and its treatments remain a primary source of interest among researchers. Modern studies are looking into bioselective cytotoxicity to create new chemotherapies that do not have the same harsh side effects as those we use today. Natural product research has a promising future for the development of such treatments. Specifically, polar flavonoids may be the key to a bioselective treatment. Such flavonoid species are native to plants, often within flower petals or within the body. A natural antioxidant, they are designed not to harm healthy cells. This study focuses on the plant …

Characterization Of Regulation Of Ace2 And Morphogenesis (Ram) Pathway Components In Aspergillus Fumigatus, Devi Naga Jyothi Bale

Theses and Dissertations (ETD)

Aspergillus fumigatus CotA is a conserved protein kinase and predicted orthologue of Cbk1, a terminal kinase of the Regulation of Ace2 and Morphogenesis (RAM) network. In our previous study, disruption of CotA resulted in carbon source dependent invasive growth with the mutant exhibiting preferential growth on glucose but severely impaired growth on alternate carbon sources. This pathway in other fungi has been implicated in the regulation of morphogenesis, stress responses, and virulence, but this study is the first one to characterize it in the pathogenic filamentous fungus.  In yeast, the RAM network includes the CotA ortholog, Cbk1, and associated proteins, …

Assessment Of Hypoglycemia Management In Acute Care Hospitals, Carley Warren, Christina Wing, Chenette Burks, Brooke Schmidt, Adam Hasse

HCA Healthcare Journal of Medicine

Background

Hypoglycemia is a common and potentially preventable complication among hospitalized patients, particularly those receiving insulin or other glucose-lowering therapies. Delayed recognition and inconsistent management can increase adverse outcomes. Although protocols exist, variability in treatment selection and timing may influence the likelihood of returning to normoglycemia. Understanding these patterns is critical to optimizing patient safety in acute care settings.

Methods

This retrospective review evaluated hypoglycemia management in adult inpatients across acute care hospitals within a large health system. Patients were included if they were aged 18 years or older, were hospitalized within the health system, and experienced a hypoglycemic event, …

Pharmacovigilance As An Act Of Awareness And Mindfulness, Mahima Silas, Hale Z. Toklu

HCA Healthcare Journal of Medicine

The term “pharmacovigilance” defines the activities related to the collection, detection, assessment, monitoring, and prevention of adverse reactions due to pharmaceuticals. While it is often framed as a technical and regulatory discipline, it can also be understood through a more reflective lens as a form of mindfulness practice. At its core, pharmacovigilance requires a way of thinking that closely mirrors mindfulness, including sustained attention, openness to uncertainty, and deep awareness of human experience. Viewing pharmacovigilance in this way reframes it not just as a safety mechanism, but as a thoughtful, patient-centered approach to medicine.

Evaluation Of Shortened Irinotecan Infusion Times And Adverse Effects Incidence For Gastrointestinal Medical Oncology Patients, Rachel N. Ochs, Daniel J. Donovan, Neha A. Betrabet, Wendy M. Covert

Advances in Cancer Education and Quality Improvement

Background: Irinotecan, a topoisomerase I inhibitor, is commonly used to treat gastrointestinal cancers. The infusion time of irinotecan is usually over 90 minutes; however, studies support the safety and feasibility of 30-minute infusions. A shortened infusion duration may improve patient quality of life, optimize infusion chair utilization, and reduce wait times. Faster infusion rates may increase the risk of acute cholinergic side effects, reported in up to 50% of patients (all grades). Current institutional practice in the gastrointestinal medical oncology (GIMO) clinic involves administering irinotecan over 90 minutes and using atropine as needed for reversing cholinergic symptoms. For patients who …

Implementation Of A Modified Trigger Tool For Adverse Drug Reaction Detection In Pediatric With Covid-19 In Indonesia, Nisa Maria, Avini Risda Khaerani, Indri Yuliani Hamdani, Annisa Lazuardi Larasati, Larasati Arrum Kusumawardani

Pharmaceutical Sciences and Research

Pediatric patients are vulnerable to adverse drug reactions (ADRs), necessitating prompt monitoring of treatment-related adverse events (AEs). This study analyzed ADRs in pediatric COVID-19 patients using a modified trigger tool to identify AEs, followed by causality analysis with the Naranjo Algorithm, and evaluated the tool’s performance. A cross-sectional, single-center retrospective study was conducted at a hospital in Indonesia from August 2020 to July 2021, using total sampling of pediatric patients aged one to≥24 hours with COVID-19. AEs were identified using 23 triggers (15 laboratory result, eight drug-administration). A total of 242 positive triggers were detected among 120 patients (mean two …

Innovative Development Of Synthetic Biology Industry From Perspective Of Deep Integration Of Four Chains, Qin Guo, Chao Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Future industries represent the development direction of technological innovation and emerging industries, and are the main path to accelerate the formation of new quality productivity. As an important subsector of the future industry, synthetic biology industry is becoming a new track and new format for new quality productivity, and various regions are making cutting-edge directions such as synthetic biology industry a hot topic for future industrial layout. Based on the analysis of typical cities such as Shenzhen, Beijing, Tianjin, Shanghai, Hangzhou, and Changzhou, the current integration of the Four Chains in the synthetic biology industry is facing a four-dimensional dilemma …

Ai-Driven Drug Innovation Research: Trends, Challenges, And Countermeasures, Tian Miao, Qi Zhou, Lianzheng Zhou, Weijun Xu, Siyuan Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence (AI) is profoundly transforming the innovation paradigm, industrial ecosystem, and business model of drug research and development. In recent years, the global AI-driven pharmaceutical market has grown rapidly. Major economies, multinational pharmaceutical enterprises, and technology giants are accelerating their strategic deployment. AI pharmaceutical industry has entered a critical stage of transitioning from proof-of-concept to commercial-application. China attaches great importance to the integrated development of AI and the biopharmaceutical industry, but it still faces challenges, including data scarcity, talent shortages, algorithmic black-boxes, regulatory lag, and weak foundations. This study proposes measures from the aspects of data supply, talent cultivation, …

Evaluating The Link Between Metabolic Syndrome And Cognitive Dysfunction In People Who Use Cannabis: A Critical Review Of Mechanistic Pathways, Evidence Quality, And Future Research Directions, Ghadah Alharbi, Ahmad H. Alhowail, Ashraf Mahmoud Emara

Saudi Toxicology Journal

Background: Cannabis is the most commonly used internationally controlled substance worldwide, with increasing rates of heavy use and cannabis use disorder (CUD) among adolescents and adults. While epidemiological evidence links cannabis exposure to both metabolic dysfunction and cognitive impairment, these outcomes have been examined predominantly in isolation. The mechanistic relationship between metabolic syndrome (MetS) and cannabis-related cognitive deficits remains poorly characterized. Objective: This review critically appraises the evidence linking cannabis use to metabolic dysfunction and cognitive impairment, proposes an integrative ``Cannabis–Metabolic–Cognitive Axis'' model, and identifies gaps limiting causal inference in the existing literature. Key Findings: Human studies frequently report lower …

Oral Insulin Nanoparticles In Animal Models Of Diabetes: A Systematic Review Of Recent Studies, Dhea Rahmania, Shaum Shiyan, Yulianto Kusnadi, Subandrate Subandrate, Juliana Palungan, Ayeshah Augusta Rosdah

Pharmaceutical Sciences and Research

Oral insulin has long been explored as a potential alternative to injectable insulin therapy. However, the development remains challenging due to enzymatic degradation in the gastrointestinal tract and limited intestinal absorption. Nanoparticle-based delivery systems have also been proposed as a strategy to protect insulin and improve uptake after oral administration. Therefore, this systematic review aimed to summarize recent preclinical studies investigating oral insulin nanoparticles in diabetic animal models and examine the reported pharmacological outcomes. Relevant studies were identified through database searches in PubMed, SpringerLink, and ScienceDirect using predefined keywords related to oral insulin, nanoparticles, diabetes, and animal models. Articles published …

Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao

Pharmacy Faculty Articles and Research

Emerging tools for spatial analysis, systems biology, and synthetic biology offer opportunities to observe, dissect, and perturb cancer mechanisms, to design strategies for the prevention of oncogenesis, and to identify therapies that lead to durable tumor control. Here, we summarize perspectives from the virtual Innovation Lab on “Synthetic and Systems Approaches to Interrogate Spatiotemporal Processes in Cancer” (S3) hosted by the National Institutes of Health (NIH), which assembled interdisciplinary experts to discuss cancer spatial organization and dynamic cellular interactions and how they can be addressed by leveraging novel synthetic and systems biology approaches. These discussions focused especially on cancer initiation, …

A Seven-Year Reflection On Confidence Building And The Evolving Needs Of Pharmacy Residency Applicants, Hindu Rao, Neeloufar Fakourfar

Pharmacy Faculty Articles and Research

Purpose

Description

Lc-Hrms Identification And In Silico Anti-Elastase Analysis Of Cynometra Cauliflora Leaf Bioactive Fractions, Winni Nur Auli, Otniel Prima Saputra Purba, Afifah Khoirunisa, Anjar Hermadi Saputro, Syahrizal Nasution

Chimica et Natura Acta

The development of natural cosmetic raw materials as anti-aging agents is one area of research that receives significant attention. Secondary metabolites and extracts from plants have been widely studied and found to possess anti-aging activity. Previous research yielded results showing very strong antioxidant activity of the extract and fractions of namnam leaves. This study aims to analyze the metabolite from the strongest fraction from antioxidant activity and analyze the interaction of flavonoid metabolites with elastase enzymes in silico. Metabolite analysis was performed using LC-HRMS. The molecular docking study was conducted on protein code 5A09 using Autodock Tools 1.4.7. The skin …

Developing A Cell-Based High-Throughput Screening (Hts) Assay For Antibody-Mediated Amyloid-Beta Clearance, Tran Vo '27, Lucille Whyman, June Javens-Wolfe

Annual Student Research Poster Session

Antibody therapeutics targeting amyloid-beta (Aβ), such as Aducanumab and Lecanemab, are among the first Alzheimer's disease treatments to show clinical potential, with efficacy thought to depend partly on Fc receptor-mediated immune clearance of Aβ plaques. Testing new antibody variants in mouse models is slow and expensive, so TREAT-AD's ADHTS core develops cell-based assays to screen candidates earlier. This project lays the groundwork for a scalable, cell-based high-throughput screening assay of antibody-mediated Aβ clearance. We purified Fc-competent and Fc-silenced Aducanumab, confirmed its specificity for full-length Aβ, and established a live-imaging assay of Aβ uptake in microglia. Assay optimization is ongoing.

October 2026, Swosu Rural Health Center

RURAL ROCKS

SWOSU Rural Health Center Highlights Innovation at Oklahoma Rural Health Conference

Rural Health. Community Strength

Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation | HAIs | CDC

Epic shifts focus to cybersecurity while AI, interoperability agenda still on track, company says

UnitedHealthcare, Cigna, Centene sign on to CertifyOS' new provider credentialing model

Hospitals' use of AI coding tools cost BCBSA plans $942M more for similar care: analysis

Why Prime Therapeutics is betting on bridging the gaps between medical, pharmacy benefits

HRSA names 10 drugmakers for revised 340B rebate pilot ahead of 2027 launch

HRSA …

Pharmacy Access Is Out Of Reach For One In Six South Carolinians, Bryan L. Love Pharm.D., Tessa J. Hastings Phd, Abby Davies

CORE Research Briefs

A cross-sectional geospatial analysis mapped active South Carolina community pharmacies and used 2020 Census tract data to estimate the population residing within and beyond five-mile pharmacy service areas. About one in six South Carolinians lives more than five miles from an active community pharmacy, with limited access disproportionately affecting rural communities.

Sharksrx Newsletter Fall 2026, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Network Pharmacology Of A Decaffeinated Green Coffee–Turmeric Combination: Potential Therapeutic Activity Against Hypertension And Diabetes Mellitus, Feri Eko Hermanto, Mohammad Saifur Rohman, Victor Alvianoes Guterez Hose, Mifetika Lukitasari, Dwi Adi Nugroho, Nashi Widodo, Inggita Kusumastuty

Makara Journal of Science

Decaffeinated green coffee and turmeric are recognized for their protective effects against hypertension (HTN) and diabetes mellitus (DM). Combining them into a functional drink, green coffee and turmeric (GCT), offers potential health benefits for managing these conditions. This study explored the bioactivity of GCT in HTN and DM through network biology, identifying intersecting protein targets and their roles in inflammation and glucose metabolism. Key proteins identified were AKT1, CCL2, CXCL8, IL-1β, and IL18. Molecular docking revealed that GCT compounds, particularly Cafestol, Chlorogenic Acid, Kahweol, Curcumin, and Desmethoxycurcumin, interacted strongly with AKT1 at its allosteric site, potentially inhibiting its activity. However, …

From Advisory To Action: The Case For Preserving Paccarb In The Fight Against Antimicrobial Resistance, Leila S. Hojat, Muhammad Dhanani, Amy Y. Kang, Salome O. Chitavi, Robert A. Weinstein, Edward Stenehjem

Pharmacy Faculty Articles and Research

The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) was established to advise the government on strategies to mitigate antimicrobial resistance (AMR) and its increasing threat to public health and national security. Its members included experts from diverse disciplines such as healthcare, veterinary medicine, industry, public health, and agriculture who were positioned to interface with key stakeholders and the public in an aspirational multidisciplinary approach to combating AMR. The council was successful in elevating AMR as a national priority and played a crucial role in watershed events for antimicrobial stewardship (AS) such as the development of the second National Action …

Copper Nanoparticles And Their Future In Drug Delivery And Anticancer Therapy, Keykavous Parang, Rajesh Vadlapatla, Cassia Charles, Kimberly Tang, Trang Nguyen, Amir Nasrolahi Shirazi, Ajoy Koomer

Pharmacy Faculty Articles and Research

Copper nanoparticles (CuNPs) have attracted growing attention in nanomedicine owing to their distinctive physicochemical, optical, and biological properties. Their large surface area, tunable size, ease of surface modification, and low cost make them attractive candidates for drug delivery, where they can both improve delivery efficiency and enable stimuli-responsive release. CuNPs also possess intrinsic antimicrobial, anticancer, anti-inflammatory, and photothermal activities, further broadening their biomedical utility. In this review, we synthesize recent advances in the synthesis, characterization, surface functionalization, and biomedical application of CuNPs, comparing chemical, physical, and green synthetic routes and their effects on stability, biocompatibility, and therapeutic efficacy. We examine …

Pharmacist-Led Initiative To Increase Naloxone Prescribing For Patients On High-Dose Opioids In A General Internal Medicine Clinic, Christine E. Leduc, Hyun J. Lee, Polly D. Fraga

The Lahey Journal

Abstract

Introduction:

Opioid overdose is a pressing public health concern in the United States. In 2022, prescription opioids were involved in 15% of all opioid deaths.1 Despite CDC recommendations for prescribing naloxone to high-risk patients, primary care physicians prescribe only 1.5 naloxone prescriptions per 100 prescriptions of high-dose opioids.2,3 Strategies are needed for healthcare institutions to expand naloxone access and mitigate opioid-related harm. This pilot study assesses the impact of a pharmacist-led quality improvement patient outreach initiative on increasing naloxone prescribing for adult patients taking ≥ 50 MME per day of prescription opioids as recommended by current CDC guidelines.

Methods: …

Surgical And Transcatheter Pulmonary Valve Replacement In Patients With Congenital Heart Disease, Who Have A History Of Right Ventricular Outflow Tract Remodeling, Indonesia: A Model-Based Economic Evaluation, Andi Nurul Annisa, Puree Anantachoti, Radityo Prakoso, Dafsah A. Juzar, Osot Nerapusee

The Thai Journal of Pharmaceutical Sciences

Background: Patients with congenital heart disease who have previously undergone right ventricular outflow tract (RVOT) surgery frequently require repeat valve replacement later in life. While transcatheter pulmonary valve replacement (TPVR) offers less invasive reintervention compared with surgery, its high device cost raises concerns about affordability under Indonesia’s National Health Insurance Program (Jaminan Kesehatan Nasional).
Objectives: To compare the cost-effectiveness of surgical pulmonary valve replacement (SPVR) versus TPVR in post-RVOT surgery patients, and to estimate the TPVR price threshold for cost-effectiveness from a societal perspective.
Methods: A Markov model simulated a hypothetical cohort of 15-year-old patients with prior RVOT surgery over …

Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara

The Thai Journal of Pharmaceutical Sciences

Background: Diphtheria remains endemic in parts of Thailand and continues to threaten unvaccinated populations. To strengthen vaccine self-sufficiency, the Government Pharmaceutical Organization has developed in-house diphtheria–tetanus–pertussis (DTP) and diphtheria– tetanus (dT) vaccines. Potency testing of diphtheria toxoid is traditionally performed in guinea pigs; however, limitations in animal availability, cost, and logistics have prompted evaluation of alternative models.
Objectives: To compare diphtheria toxoid potency estimates of in-houseproduced DTP and dT vaccines using guinea pigs and mice, followed by a Vero cell-based toxin neutralization assay, and to assess the suitability of mice as an alternative model for potency testing.
Materials and Methods: …

Development Of Micellar Sprays Containing Rhinacanthus Nasutus Extract For Dandruff Management, Suwipa Ungphaiboon Associate Professor, Sutasinee Ardhanwanich, Ketsuda Wongsuwan, Salwa Yanya, Nattanit Aekwattanaphol

The Thai Journal of Pharmaceutical Sciences

Background: Dandruff is a common scalp disorder associated with altered sebum secretion and microbial imbalance, particularly between Cutibacterium and Staphylococcus, which correlates with disease severity.
Objectives: This study aimed to develop and optimize a multifunctional leave-on hair and scalp spray with anti-dandruff, nourishing, and protective properties.
Materials and Methods: Micelles containing Rhinacanthus nasutus extract were prepared using eco-friendly methods, including film hydration and direct solubilization. The formulations were optimized and evaluated for physicochemical properties, drug release, and antibacterial activity.
Results: The optimized micellar spray (BP), prepared through direct solubilization in citrate buffer, exhibited a mean particle size of 192.45 …

Modified Etoposide Loaded Graphene Oxide Nanoparticles: In-Depth Physical And Biological Evaluation For Lung Cancer Treatment, Umesh Kumar Atneriya, Jitendra Sainy

The Thai Journal of Pharmaceutical Sciences

Background: Lung cancer is approximately 25% of all death cases in any cancer and the death beats the number of deaths reported by colorectal cancer, breast cancer, and prostate cancer combined.
Objectives: This present study was carried out with an objective to investigate the possibility of graphitic carbon toward making a multifunctional anti-lung cancer nano-platform targeting etoposide (ETS) as a model drug.
Materials and Methods: First, the synthesis of graphene oxide (GO) was made by the Hummer method based on graphite flakes and further modified with folic acid (FA) and polyethylene glycol to make FA/GO/ETS. The formation of FA/GO/ETS was …

Acute Liver Injury Likely Induced By Alpha Lipoic Acid Contained In Dietary Supplement, Simona Maksimyan, Jonathan V. Reyes, Kasim Kazbay, Farah K. Gazi

Journal of Community Hospital Internal Medicine Perspectives

The rise in use of herbal and dietary supplements, which are regulated as food rather than as drugs by the Food and Drug Association, poses the risk of unknown and potentially severe side effects. We describe the case of acute liver injury, characterized by significant elevation in AST and ALT, likely induced by the consumption of an over-the-counter supplement containing alpha lipoic acid (ALA). Our patient trusted in a “natural” alternative to Western medicine for management of neuropathy, which was ultimately detrimental to her liver. An immediate and sustained improvement in liver enzyme levels was noted with discontinuation of the …

Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …