Comparison Of Efficacy Between Thai Herbal Anti-Hemorrhoid Formula And Micronized Purified Flavonoid Fraction In Patients With Internal Hemorrhoids, Darunee Rattanawongsamathakul, Varut Lohsiriwat, Suksalin Booranasubkajorn, Angkana Apichartvorakit, Pravit Akarasereenont

Journal of Health Research

Background: Hemorrhoids are a common anorectal condition. In Thai traditional medicine, the Bantaoridsidwangthawan formula (BRF) has been used to treat hemorrhoids. We aimed to evaluate the clinical efficacy and satisfaction of BRF versus Micronized purified flavonoid fraction (MPFF) in patients with internal hemorrhoids grades 1 and 2.

Methods: This was a single-blind, randomized control noninferiority trial. Twenty-seven participants were randomly assigned to BRF (n=13) or MPFF (n=14). The BRF group received 5 pills 3 times daily for 14 days. The MPFF group received 2 tablets 3 times daily for 4 days, and then 2 tablets 2 times daily …

Design, Synthesis, And Nmr-Guided Characterization Of A Targeted Covalent Inhibitor-Like Molecule Against Ivyp1 From P. Aeruginosa, Samuel Taylor Moore

Master's Theses

Multi-drug resistance poses a serious threat to future generations and historical antibiotic pipelines; consequently, the medical and economic burdens associated with treating multidrug-resistant bacteria are substantiated. In this context, P. aeruginosa (PA) emerges as one of the most significant healthcare challenges, being a leading cause of resistance-associated mortality worldwide. Despite modern efforts to combat these poor outcomes, drug-resistant cases continue to rise, and the need for novel antibiotic treatment is apparent. To this end, we investigated relevant resistance mechanisms and past antibiotic targets within PA, and in doing so, we identified relationships between peptidoglycan biology and a periplasmic protein, Inhibitor …

Personalized And Culturally Tailored Features Of Mobile Apps For Gestational Diabetes Mellitus And Their Impact On Patient Self-Management: Scoping Review, Catherine Jones, Yi Cui, Ruth Jeminiwa, Elina Bajracharya, Katie Chang, Tony Ma

College of Pharmacy Faculty Papers

BACKGROUND: Gestational diabetes mellitus (GDM) is an increasingly common high-risk pregnancy condition requiring intensive daily self-management, placing the burden of care directly on the patient. Understanding personal and cultural differences among patients is critical for delivering optimal support for GDM self-management, particularly in high-risk populations. Although mobile apps for GDM self-management are being used, limited research has been done on the personalized and culturally tailored features of these apps and their impact on patient self-management.

OBJECTIVE: This scoping review aims to explore the extent to which published studies report the integration and effectiveness of personalized and culturally tailored features in …

A Conjugate Of An Egfr-Binding Peptide And Doxorubicin Shows Selective Toxicity To Triple-Negative Breast Cancer Cells, Phi-Phung Than, Shih-Jing Yao, Emad Althagafi, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Selective targeting of cancer cells via overexpressed cell-surface receptors is a promising strategy to enhance chemotherapy efficacy and minimize off-target side effects. In this study, we designed peptide 31 (YHWYGYTPERVI) to target the overexpressed epidermal growth factor receptor (EGFR) in triple-negative breast cancer (TNBC) cells. Peptide 31 is internalized by TNBC cells through EGFR-mediated endocytosis and shares sequence and structural similarities with human EGF (hEGF), a natural EGFR ligand. Unlike hEGF, peptide 31 does not induce cell migration in TNBC cells. A novel conjugate of peptide 31 with doxorubicin (Dox) retains selectivity for TNBC cells and exhibits significant toxicity comparable …

Identifying Barriers To Effective Clinical Decision Support Use In Preventing Medical Errors: The Pharmacy’S Perspective, Jonathan Stoliker, Monika Baranek, Megan Park

Annual Research Symposium

The purpose of this research is to understand the perceptions of pharmacy personnel in community and hospital settings concerning their workflows, the Clinical Decision Support (CDS) alerts they interact with, and how their interpretation of these alerts influences patient care. This research aims to begin to investigate pharmacy personnel-voiced factors that influence high rates of alert dismissal. The project also aims to qualify what design factors contribute to more effective CDS Alerts from the pharmacy’s perspective.

Appropriateness Of Ambulatory Antibiotic Prescribing In South Carolina, 2012–2017, Pamela Bailey, Majdi N. Al-Hasan, Julie Royer, Max Habicht, Julie Ann Justo, P. Brandon Bookstaver Pharm.D., Sharon Weissman, Hana R. Winders

Faculty Publications

This population-based cohort study examines the appropriateness of antibiotic prescribing in South Carolina via aggregated pharmacy claims data matched with diagnosis codes from medical claims. Inappropriate antibiotic prescribing decreased from 30.2% in 2012 to 22.6% in 2017 (P < 0.001) and was more common in adults >40 years old.

Voltammetric Analysis Of Pholcodine On Graphene-Modified Gnps/Pts With Green Assessment, Ekram Hany Mohamed, Nahla Abdel Shafy, Hadeer Elkhouly, Nehal Khoudary, Hany Darwish, Aswak Alanzi, Ibrahim Naguib

Pharmacy

Pholcodine, an anti-tussive medication widely used as an over-the-counter, OTC drug, has recently faced restrictions in several countries. This paper presents a sensitive electrochemical approach for pholcodine detection. The electrochemical method involved fabricating a graphene nanoplatelets electrode, incorporating polythiophene nanospheres polymer to promote electron transfer and increase the activated surface area. Characterization of the fabricated electrode was performed using transmission electron microscopy, ATR-Fourier-transform infrared spectroscopy, X-ray crystallography, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy. The electrochemical behavior of pholcodine with the fabricated electrode was investigated using cyclic voltammetry, chronoamperometry, square wave voltammetry (SWV), and differential pulse voltammetry (DPV). The developed …

Garcinia Pedunculata Roxb. Ex Buch.-Ham. Leaf Extract Ameliorates Diabetes In Streptozotocin Induced Diabetes In Rats, Kangkan Kalita, Techi Gello, Nilutpal Sharma Bora, Zothan Puia

Bulletin of Faculty of Pharmacy Cairo University

Although medicinal plants have been historically used for diabetes treatment throughout the world, few of them have been validated by scientific criteria. Diabetes mellitus is a metabolic disorder manifests as elevated blood glucose levels when the body cannot create sufficient amounts of insulin or utilize the insulin produced. This may be due to the free radicals present in the body. The antioxidants help to neutralize the free radicals by donating electron and thus protect from various oxidative stress diseases. The aim of this work is to evaluate the preliminary phytochemical screening, in vitro antioxidant study, in vitro and in vivo …

Computational Logp Calculations And Determination Of Lipophilicity Values Of Fluorinated Morphine Derivatives, Mirabella Romano, Allison Vu, Emily Chen

Student Scholar Symposium Abstracts and Posters

The addictive effect of opioids impacted 60 million people globally in 2023. This opioid crisis necessitates the development of opioid derivatives that maintain analgesic efficacy while minimizing addictive effects from opioid use. The present work focuses on morphine, a commonly prescribed opioid with high affinity to the mu-opioid receptor (MOR). Morphine binds non-selectively within both healthy and inflamed tissue. By modifying morphine’s structure through fluorination to counteract its non-selective binding, the drug’s pharmacological ability to provide effective pain relief comes with a lower risk of addiction. Specifically, the addition of fluorine to differing beta positions of the main binding site …

Bile Duct Ligation-Induced Cirrhosis Does Not Alter The Blood-Brain Barrier Permeability To Sucrose In Rats, Mohammad K. Miah, Ulrich Bickel, Reza Mehvar

Pharmacy Faculty Articles and Research

Contradictory results have been reported about the effects of liver diseases on the blood-brain barrier (BBB) permeability to markers. For instance, both an increase and no change in the BBB permeability to BBB markers sodium fluorescein and Evans blue have been reported in experimental cholestasis induced by bile duct ligation (BDL) in rats. These contradictory effects might be due to inherent limitations of these markers and/or methodological issues. Here, we investigated the time course of the impact of BDL in rats on BBB permeability using a recently developed stable isotope labeled marker [¹³C]sucrose, which is expected to be …

Brushing Up On Antibiotic Stewardship: Pharmacy Students Survey And Educate Dentists On Antibiotic Prescribing Guidelines And Practices, Niyaz Pordel, Kamaladdin Saei, Feifei Jia, Kaitlin Meyer, Lisa M. Avery

Doctoral External Publications

To evaluate dentists’ knowledge of ABX stewardship tools and to determine the likelihood of incorporating various antibiotic stewardship principles into practice after receiving a pharmacy school generated newsletter.

Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Among Novel Fda Approvals In 2023, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

Many newly approved immediate-release (IR) solid oral drugs are accompanied by broad "do-not-crush" warnings, often without specific explanations. Building on our recent publication of crushability analysis of novel drugs approved between 2020 and 2022, this research extends the assessment to the approvals of 2023. Our goal is to provide healthcare providers with timely recommendations for the safe manipulation of immediate-release tablets and capsules for patients who cannot swallow them whole.

Winter 2024 Edition, Southwestern Oklahoma State University

The Sig

GREETINGS FROM THE DEAN’S OFFICE
Southwestern Opens Doors to Opportunities Beyond Imagination

Homecoming Saturday on October26th was a wonderful day, and we are grateful to all the alumni, family, and friends who attended. Coming back to the COP to rekindle with classmates and faculty is always a special time, especially after many years. As each 50-year and 40-year graduate was recognized and shared a story or special thought with everyone, I was impressed by the common themes.

The Benefits Of Telehealth Among Disadvantaged Communities, Anoosh Arshad

Honor’s College Freeman Research Journal

This study aims to understand how the widespread integration of telehealth services affects underserved communities, helping reduce health disparities in this group. Telemedicine includes various technologies and applications, supported by extensive research, public health, administrative, and patient-care benefits, to adapt to different fields. It involves clinical applications that focus on patient care, like making health decisions, and nonclinical applications like arranging board meetings. Telehealth is a health platform that uses communication technologies that allow doctors and patients to meet online through video and telephone visits, ensuring that patients receive high-quality care. It increases access to healthcare by removing geographical and …

How Low Can We Go: Evaluation Of A Pharmacist-Led Weight Loss Management Program, Kelly Rubi, Elaina Rosario, Sara Panella, Jacqualine Igwe, Maria Pulido, Faaria Quadri

Nursing & Health Sciences Research Journal

Background: Obesity is a major health challenge that is associated with several health risks, including diabetes and hypertension. The purpose of this project was to evaluate the impact of clinical pharmacists on the therapy optimization of GLP-1 receptor agonists (GLP-1RAs) in a weight management program. Methods: This project evaluated a quality improvement initiative through a retrospective chart review that included patients who were treated with semaglutide or liraglutide between October 2022 and July 2023, with body mass indices (BMI) of 27 kg/m2 or greater with at least one weight-related comorbidity or a BMI greater than or equal to 30 kg/m2. …

Anticoagulation Strategies After Left Ventricular Thrombus., Corey Uetrecht Pharmd, Jennifer Sposito Pharmd, Bcps, Bcccp, Kassandra Foellinger Pharmd, Bcps, Jamie Gaul Pharmd, Bcps, Sarah Ferrell Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting,

This medication use evaluation found that prescribing practices of DOAC and warfarin did not change after AHA guidance publication. Patients with HFrEF were more often discharged on warfarin, while those with Afib were more often discharged on DOACs. Those discharged on a DOAC had the highest incidence of LV thrombus resolution up to 6 months post-discharge. Physicians within Parkview Health do not routinely utilize a loading dose when discharging a patient on a DOAC.

Comparing Cardiometabolic Monitoring And Side Effect Management In A Pharmacist-Led Ambulatory Clozapine Clinic Versus Standard Care., Nicholas Buttermore Pharmd, Jenna Gilbert Pharmd, Bcpp, Naana Boachie Pharmd, Bcacp, Kenneth Wiley Pharmd, Bcacp, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that cardiometabolic monitoring rates were significantly higher in the pharmacist group compared to standard care, and that clozapine-related side effects were screened more frequently.

Anti-Inflammatory Potential Of Black Cumin Seed Oil And Its Nanoemulsion Formulation Against Lipopolysaccharide-Induced Liver Injury In Mice, Shady Swidan, Hesham Hafez, Rehab Hosni, Hatem Amin

Pharmacy

Original Article

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice

Haffez, Hesham^1,2,✉; Hosni, Rehab³; Swidan, Shady A.⁴; Amin, Hatem K.^1,5

Author Information

¹Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Helwan, 11795, Cairo, Egypt

²Center of Scientific Excellence “Helwan Structural Biology Research”, Helwan University, Helwan, 11795, Cairo, Egypt

³El Sisi Comprehensive Clinic, General Authority for Health Insurance-Giza, Haram, 12556, Giza, Egypt

⁴Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk, 11837, Cairo, …

Tenecteplase For Acute Ischemic Stroke: Insights From A Large Community Teaching Hospital, Ithar Alsarraf, Jennifer Pilotto, Rebecca E. Baker, Emily Reich

Posters

Acute Ischemic Stroke (AIS) is a leading cause of disability and death in the United States, requiring urgent treatment1,2; earlier treatment improves patient outcomes.

Fibrinolytic agents including alteplase and tenecteplase (TNK) reduce long-term disability in AIS but are associated with hemorrhagic risks3,4.

As of January 2024, Corewell Health East hospitals updated their guidelines that TNK would be the first line agent in the treatment of AIS.

Alteplase is the only approved agent for AIS, but TNK shows similar effectiveness along with shorter preparation and administration time which may ultimately improve door-to-needle time2 .

Careful consideration of patient characteristics is important …

Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

No abstract provided.