Parkinsonian Motor Impairment Predicts Personality Domains Related To Genetic Risk And Treatment Outcomes In Schizophrenia, 2017 University of Texas Rio Grande Valley
Parkinsonian Motor Impairment Predicts Personality Domains Related To Genetic Risk And Treatment Outcomes In Schizophrenia, Juan L. Molina, María Calvó, Eduardo Padilla, Mara Balda, Gabriela González Alemán, Néstor V. Florenzano, Gonzalo Guerrero, Danielle Kamis, Beatriz Molina Rangeon
School of Medicine Publications and Presentations
Identifying endophenotypes of schizophrenia is of critical importance and has profound implications on clinical practice. Here we propose an innovative approach to clarify the mechanims through which temperament and character deviance relates to risk for schizophrenia and predict long-term treatment outcomes. We recruited 61 antipsychotic naïve subjects with chronic schizophrenia, 99 unaffected relatives, and 68 healthy controls from rural communities in the Central Andes. Diagnosis was ascertained with the Schedules of Clinical Assessment in Neuropsychiatry; parkinsonian motor impairment was measured with the Unified Parkinson's Disease Rating Scale; mesencephalic parenchyma was evaluated with transcranial ultrasound; and personality traits were assessed ...
Retrospective Analysis Of Contact Sport Participation On Cognitive Function In Healthy Athletes, 2017 Humboldt State University
Retrospective Analysis Of Contact Sport Participation On Cognitive Function In Healthy Athletes, Lisa C. Martinez
HSU theses and projects
This study explored the effects of contact and limited contact sport participation on neurocognitive function in non-concussed collegiate and adolescent athletes over time. Athletes participating in contact and limited contact sports have an increased risk of sustaining neurocognitive injuries, known as subconcussive blows, compared to non-contact sport athletes. We hypothesized that athletes participating in contact and limited contact sports, would exhibit a deficit in neurocognitive function following multiple seasons of play when compared to athletes participating in non-contact sports. Using a mixed repeated measures MANOVA statistical design, we analyzed computerized neurocognitive baseline ImPACT composite scores (verbal memory, visual memory, visual ...
The Effect Of Acute Pain On Executive Function, 2017 Georgia Southern University
The Effect Of Acute Pain On Executive Function, Jenna M. Morogiello
Electronic Theses and Dissertations
Background: Executive functions are high-level cognitive processes that allow a person to successfully engage in an independent and self-fulfilling life. Previous literature indicates that acute pain can affect executive function, which may be due to a limited amount of shared neural resources of the brain.
Objective: The purpose of this study was to determine if acute pain affects executive function in recreationally active individuals who sustain a musculoskeletal injury.
Methodology: Twenty-four participants who presented with acute pain due to a musculoskeletal injury underwent a neuropsychological battery within 72 hours of injury and within two weeks from the initial testing session ...
Long-Term Quercetin Dietary Enrichment Partially Protects Dystrophic Skeletal Muscle, 2016 Iowa State University
Long-Term Quercetin Dietary Enrichment Partially Protects Dystrophic Skeletal Muscle, Hannah R. Spaulding, Christopher G. Ballmann, John C. Quindry, Joshua T. Selsby
Animal Science Publications
Duchenne muscular dystrophy (DMD) results from a genetic lesion in the dystrophin gene and leads to progressive muscle damage. PGC-1α pathway activation improves muscle function and decreases histopathological injury. We hypothesized that mild disease found in the limb muscles of mdx mice may be responsive to quercetin-mediated protection of dystrophic muscle via PGC-1α pathway activation. To test this hypothesis muscle function was measured in the soleus and EDL from 14 month old C57, mdx, and mdx mice treated with quercetin (mdxQ; 0.2% dietary enrichment) for 12 months. Quercetin reversed 50% of disease-related losses in specific tension and partially preserved ...
Interprofessional Opportunities In Sleep Practice, 2016 East Tennessee State University
Interprofessional Opportunities In Sleep Practice, Kristen L. Mchenry
ETSU Faculty Works
Interprofessional education has the potential to prepare health career students to be practice-ready and enter the workforce with a collaborative mindset. Respiratory care educators must adequately prepare students to work in this capacity. This emphasis on a team approach to patient-centered care has the ability to impact and improve health outcomes. Throughout the last decade, sleep medicine has experienced fluctuations. Sustainability of sleep labs who only perform diagnostic testing may prove challenging. The role of interprofessional practice in sleep medicine would be to overcome traditional roles (silos) so that multiple skilled practitioners could help identify and treat complex patient conditions ...
Morpholino-Mediated Knockdown Of Dux4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics, 2016 University of Massachusetts Medical School
Morpholino-Mediated Knockdown Of Dux4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics, Jennifer C. J. Chen, Oliver D. King, Yuanfan Zhang, Nicholas P. Clayton, Carrie Spencer, Bruce M. Wentworth, Charles P. Emerson Jr., Kathryn R. Wagner
Cell and Developmental Biology Publications
Derepression of DUX4 in skeletal muscle has emerged as a likely cause of pathology in facioscapulohumeral muscular dystrophy (FSHD). Here we report on the use of antisense phosphorodiamidate morpholino oligonucleotides to suppress DUX4 expression and function in FSHD myotubes and xenografts. The most effective was phosphorodiamidate morpholino oligonucleotide FM10, which targets the polyadenylation signal of DUX4. FM10 had no significant cell toxicity, and RNA-seq analyses of FSHD and control myotubes revealed that FM10 down-regulated many transcriptional targets of DUX4, without overt off-target effects. Electroporation of FM10 into FSHD patient muscle xenografts in mice also down-regulated DUX4 and DUX4 targets. These ...
Intraocular Bevacizumab In The Treatment Of Choroidal Metastases From Breast Cancer, 2016 University of Iowa
Intraocular Bevacizumab In The Treatment Of Choroidal Metastases From Breast Cancer, Kalyan Nadiminti, José Pablo Leone
Department of Internal Medicine Publications
No abstract provided.
Twelve Hours Of Heat Stress Induces Inflammatory Signaling In Porcine Skeletal Muscle, 2016 Iowa State University
Twelve Hours Of Heat Stress Induces Inflammatory Signaling In Porcine Skeletal Muscle, Shanthi Ganesan, Carme Reynolds, Katrin Hollinger, Sarah C. Pearce, Nicholas K. Gabler, Lance H. Baumgard, Robert P. Rhoads, Joshua T. Selsby
Animal Science Publications
Heat stress causes morbidity and mortality in humans and animals and threatens food security by limiting livestock productivity. Inflammatory signaling may contribute to heat stress-mediated skeletal muscle dysfunction. Previously we discovered increased circulating endotoxin and intramuscular oxidative stress and TNFα protein abundance but not inflammatory signaling following 24 and 72 hours of heat stress. Thus, the purpose of this investigation was to clarify the role of inflammatory signaling in heat stressed skeletal muscle. Crossbred gilts (n=8/group) were assigned to either thermal neutral (24° C), heat stress (37° C), or pair-fed thermal neutral (24° C) conditions for 12 hours ...
Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, 2016 Cedarville University
Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, Daniel A. Herring, Kyle D. Cherry, Hannah L. Stedge
The Research and Scholarship Symposium (2013-2019)
Introduction: Anterior cruciate ligament injuries occur over 200,000 times annually in the United States alone (Brophy, et al. 2009). This injury strains the healthcare system and affects the players, teams, parents, and the organization they are a part of. There have been, however, clinically researched risk factors that predispose athletes to ACL injury (Gignac, et al. 2015; Laible, et al. 2014). As a result, there is a clinical need for an effective screening tool to identify those athletes at risk for ACL injury. The Functional Movement Screen has been shown to be an effective screening tool for detecting athletes ...
Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, 2016 The University of Western Ontario
Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon
Electronic Thesis and Dissertation Repository
The purpose of this collection of studies was to further develop the knowledge of shoulder motion in order to better understand joint function through direct measurement of 3D scapulohumeral joint kinematics using a technique of high accuracy. Markerless, bi-planar fluoroscopic radiostereometric analysis using a generic shoulder model was developed in this thesis, reducing the amount of radiation exposure to subjects. The studies compared kinematic data of the scapulohumeral joint in six degrees of freedom with a precise, in-vivo measuring technique. Data were collected on young and older healthy individuals, individuals with a torn supraspinatus and post-surgical intervention.
Although this generic ...
Angiogenic Therapy In A Fibrotic Murine Model Of Duchenne Muscular Dystrophy, 2016 The University of Western Ontario
Angiogenic Therapy In A Fibrotic Murine Model Of Duchenne Muscular Dystrophy, Kelly M. Gutpell
Electronic Thesis and Dissertation Repository
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disorder that affects approximately 1 in 5000 males. Vascular-targeted therapy has been proposed as a treatment for DMD to reduce ischemia and enhance endogenous repair. Additionally, a more vascularized environment may enhance regenerative approaches currently under investigation. Vascular endothelial growth factor (VEGF) and angiopoietin-1 (ANG1) are two of the most studied pro-angiogenic factors for this approach. To date, little is known regarding the effect of these pro-angiogenic factors on muscle function and whether they may exacerbate fibrosis in a relevant murine model of DMD. The first aim of this thesis was to ...
Musculoskeletal Disorders In The Nursing Profession: A Case Study, 2016 Embry-Riddle Aeronautical University - Daytona Beach
Musculoskeletal Disorders In The Nursing Profession: A Case Study, Kaitlin A. Kee-Dayton
Human Factors and Applied Psychology Student Conference
Musculoskeletal Disorders in the Nursing Profession: A Case Study
Beth Blickensderfer, Ph.D.
Embry-Riddle Aeronautical University
Daytona Beach, FL
This ergonomics assessment focused on a female Licensed Practical Nurse (LPN) and her life inside and outside of her job. In particular, this case study assessed how working as a nurse may affect the human body in terms of Musculoskeletal Disorders (MSDs). The researcher first conducted an in-depth interview with the nurse about her workplace layout, typical daily work schedule, work habits, physical challenges, MSD injuries she has sustained, and the workplace environment/organizational culture. Next, the researcher conducted ...
Single Nucleotide Polymorphisms In Cldn14 And Smoc1 Affecting Bone Mineral Density Influence Other Musculoskeletal Traits, 2016 George Washington University
Single Nucleotide Polymorphisms In Cldn14 And Smoc1 Affecting Bone Mineral Density Influence Other Musculoskeletal Traits, Christopher Payette, Courtney Sprouse, Cara Goerlich, Heather A. Gordish-Dressman, Thomas Lynch, Heather Flynn, Leticia M. Ryan, Eric P. Hoffman, Monica J. Hubal, Paul D. Thompson, Theodore J. Angelopoulos, Paul M. Gordon, Niall M. Moyna, Linda S. Pescatello, Paul S. Visich, Robert F. Zoeller, Laura L. Tosi
GW Research Days 2016 - 2020
Background: A recent genome-wide association study (GWAS) identified novel genes influencing bone mineral density (BMD). This three stage GWAS identified two novel loci: rs227425 in the SPARC-Related Modular Calcium Binding 1 gene (SMOC1) was significantly associated with BMD and rs170183 in the claudin 14 (CLDN14) gene was significantly associated with BMD in females.
Objective: The purpose of this study was to determine if two novel single nucleotide polymorphisms (SNPs) known to affect BMD are associated with other musculoskeletal traits.
Methods/Design :The Bone Health Cohort consists of 150 African-American participants enrolled at Children’s National Health System as part of ...
The Effects Of Advanced Age On Primary Total Knee Arthroplasty: A Meta-Analysis And Systematic Review, Ethan F Kuperman, Marin Schweizer, Parijat Joy, Xiaomei Gu, Michele M Fang
Department of Internal Medicine Publications
BACKGROUND: Total knee arthroplasty is an effective treatment when nonsurgical treatments fail, but it is associated with risk of complications which may be increased in advanced age. The purpose of this study was to quantify age-related differences in perioperative morbidity and mortality after total knee arthroplasty through systematic review of existing literature.
METHODS: PubMed, the Cochrane database of systematic reviews, Scopus, and clinicaltrials.gov, were queried for relevant studies that compared primary total knee arthroplasty outcomes of mortality, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE) and functional status, of geriatric patients (>75 years old) with a younger ...
An Ultrasonographic Analysis Of The Structures Of The Subacromial Space, As They Relate To The Postures Of Upper String Musicians, Elliot V. Smithson
Theses, Dissertations and Capstones
Background: The leading source of general population shoulder pain is subacromial impingement syndrome (SAIS) which can contribute to rotator cuff disease (RCD). 1 It has been reported that up to 12% of musicians end their musical career due to musculoskeletal injury.2 SAIS is a common source of shoulder pain in the bowing arm of upper string musicians.3 However, the mechanisms leading to shoulder pain in upper string musicians are not well known.
Purpose: The purpose of this study was to characterize aspects of the subacromial space anatomy while in standard playing positions of upper string musicians, specifically measurements ...
Does Aerobic Exercise During Pregnancy Prevent Cesarean Sections?, 2016 Philadelphia College of Osteopathic Medicine
Does Aerobic Exercise During Pregnancy Prevent Cesarean Sections?, Kait Lassen
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not aerobic exercise in pregnant women prevents cesarean sections (“C-sections”).
STUDY DESIGN: Review of two English articles and one English/Portuguese article, two of which were randomized control trials (RCTs) and one was a prospective study, all published after 2011.
DATA SOURCES: Two RCTs and one prospective study found via PubMed and Cochrane Database.
OUTCOMES MEASURED: The main clinical outcome in all studies measured the incidence of C-section as compared to vaginal delivery. The outcomes were measured by method of delivery which was categorized as either vaginally ...
Pelvic Floor Muscle Training In Management Of Postpartum Pelvic Floor Dysfunctions: A Literature Review, 2016 University of Central Florida
Pelvic Floor Muscle Training In Management Of Postpartum Pelvic Floor Dysfunctions: A Literature Review, Rebecca S. Tanner
Honors Undergraduate Theses
Women can face a wide range of pelvic floor dysfunctions following pregnancy, ranging from urinary incontinence to pelvic pain. Unfortunately, these problems are not routinely checked for in postpartum check-ups and women do not always bring it to the physician’s attention. Strengthening of the pelvic floor muscles may be able to help women prevent these disorders and improve these women’s lifestyles.
The purpose of this thesis was to review and analyze different trials to determine if different pelvic floor dysfunctions (urinary incontinence, sexual dysfunction, and pelvic girdle pain) can be treated using pelvic floor muscle training in the ...
Il-15 Mediates Mitochondrial Activity Through A Ppar𝛿-Dependent-Ppar𝛼-Independent Mechanism In Skeletal Muscle Cells, Shantaé M. Thornton, James E. Krolopp, Marcia J. Abbott
Health Sciences and Kinesiology Faculty Articles
Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed “myokines,” has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPAR𝛼 and/or PPAR𝛿 as targets of IL-15 signaling. C2C12 SKM cells were differentiated for 6 days and treated every other day with IL-15 (100 ng/mL), a PPAR𝛼 inhibitor (GW-6471 ...
Therapy Options For Winged Scapula Patients: A Literature Review, 2016 University of Central Florida
Therapy Options For Winged Scapula Patients: A Literature Review, Samantha L. Normand
Honors Undergraduate Theses
Winged scapula is a condition characterized by lateral or medial protrusion of the scapula caused by nerve damage leading to muscular paralysis. The purpose of this systematic review of literature is to evaluate the current research literature related to the effectiveness of therapy options for winged scapula. Eleven peer reviewed English language research articles published from 1998 to present were included for evaluation. Study results revealed positive therapeutic outcomes for physical therapy and scapular bracing. Results also showed positive outcomes for the use of transcutaneous electrical nerve stimulation and acupuncture for the treatment of nerve related conditions similar to winged ...
Characterization Of Inhibitor Of Differentiation (Id) Proteins In Human Cornea, 2016 Harry S. Truman Memorial Veterans' Hospital
Characterization Of Inhibitor Of Differentiation (Id) Proteins In Human Cornea, Rajiv R. Mohan, Brandie R. Morgan, Govinduraj Anumanthan, Ajay Sharma, Shyam S. Chaurasia, Frank G. Rieger
Pharmacy Faculty Articles and Research
Inhibitor of differentiation (Id) proteins are DNA-binding transcription factors involved in cellular proliferation, migration, inflammation, angiogenesis and fibrosis. However, their expression and role in the cornea is unknown. The present study was undertaken to characterize the expression of Id proteins and their interactions with the pro-fibrotic cytokine Transforming Growth Factor β1 (TGFβ1) and anti-fibrotic cytokine, bone morphogenic protein 7 (BMP7) in human cornea. Human donor corneas procured from Eye Bank were used. Id proteins were localized in human corneal sections using immunofluorescence. Primary cultures of human corneal fibroblasts (HCF) were established and treated with either TGFβ1 (5 ng/ml) or ...