Flexor Dysfunction Following Unilateral Transient Ischemic Brain Injury Is Associated With Impaired Locomotor Rhythmicity, 2018 West Virginia University
Flexor Dysfunction Following Unilateral Transient Ischemic Brain Injury Is Associated With Impaired Locomotor Rhythmicity, Kiril Tuntevski
Graduate Theses, Dissertations, and Problem Reports
Functional motor deficits in hemiplegia after stroke are predominately associated with flexor muscle impairments in animal models of ischemic brain injury, as well as in clinical findings. Rehabilitative interventions often employ various means of retraining a maladapted central pattern generator for locomotion. Yet, holistic modeling of the central pattern generator, as well as applications of such studies, are currently scarce. Most modeling studies rely on cellular neural models of the intrinsic spinal connectivity governing ipsilateral flexor-extensor, as well as contralateral coupling inherent in the spinal cord. Models that attempt to capture the general behavior of motor neuronal populations, as well ...
Examining Upper Extremity Injuries In Male Baseball Players Between The Ages Of 14 To 22 Years Old, 2018 University of Montana, Missoula
Examining Upper Extremity Injuries In Male Baseball Players Between The Ages Of 14 To 22 Years Old, James T. Yancy
Graduate Student Theses, Dissertations, & Professional Papers
Yancy, James T. (J.T.), MAT., May 2018 AthleticTraining
Examining Upper Extremity Injuries In Male Baseball Players Between The Ages Of 14 To 22 Years Old
Chairperson: Melanie McGrath
The number of upper extremity injuries is increasing in advanced baseball (14 to 22 years old) at an alarming rate. The length of seasons, multiple leagues and the velocity of throwing in overhead sports are the most common causes of elbow and shoulder injuries. In addition, biomechanical variables also influence the risk of injury. Any alteration in range of motion (ROM) directly impacts the biomechanics of overhead activities, such as pitching ...
Changes In The Utilization Of Osteoporosis Drugs After The 2010 Fda Bisphosphonate Drug Safety Communication, 2017 King Saud University
Changes In The Utilization Of Osteoporosis Drugs After The 2010 Fda Bisphosphonate Drug Safety Communication, Bander Balkhi, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio
Pharmacy Faculty Articles and Research
In October 2010, the US Food and Drug Administration (FDA) issued a safety communication regarding the risks of atypical fractures of the femur, with bisphosphonates drugs. This study evaluated the impact of the bisphosphonates FDA safety communication on the utilization of osteoporosis medications in Medicaid programs.
Osteoporosis drugs utilization data from the July 2006 to June 2014 were extracted from the national Summary Files from the Medicaid State Drug Utilization Data maintained by the Centers for Medicare & Medicaid Services (CMS). We performed an interrupted time series analyses to evaluate trends in utilization of osteoporosis drugs before and after ...
Elevated Blood Pressure Is Associated With Higher Prevalence Of Low Visual Acuity Among Adolescent Males In Northeast China, 2017 University of Massachusetts Medical School
Elevated Blood Pressure Is Associated With Higher Prevalence Of Low Visual Acuity Among Adolescent Males In Northeast China, Miaomiao Zhao, Wei Wang, Han Yu, Yunsheng Ma, Liqiang Zheng, Lijuan Zhang, Guiping Wu, Yingxian Sun, Jue Li
Open Access Publications by UMMS Authors
The purpose of this study is to track the trends of low visual acuity (VA) from 2005 to 2014, and to investigate its associations with systemic blood pressure (BP) components among adolescents in Northeast China. A total of 55320 students of Han nationality aged 13 to 18 years were included. There has been a significant increase in the prevalence of low VA, with 31.3% in 2005, 40.2% in 2010 and 43.4% in 2014. In multivariable-adjusted logistic regression models, each 1-mm Hg increment in systolic BP (SBP) was associated with 0.8% (95% confidence interval [CI]: 0.1-1 ...
Effect Of Different Collegiate Sports On Cortical Bone In The Tibia, 2017 South Dakota State University
Effect Of Different Collegiate Sports On Cortical Bone In The Tibia, L. A. Weidauer, M. M. Eilers, T. L. Binkley, M. D. Vukovich, B. L. Specker
Objectives: The purpose of this study was to determine the effect of sports participation on cortical bone in the tibia. Methods: 53 female collegiate athletes (25 cross-country, 16 soccer, and 12 volleyball) and 20 inactive controls had the left distal 20% tibia scanned by pQCT. Cortical volumetric BMD (vBMD) was measured within the cortical shell at the anterior, posterior, medial, and lateral regions and standard deviations were calculated. Results: Total vBMD was greater in the control group (1161±5 mg/mm3) than each of the sports (p<0.05). Soccer players (1147±5 mg/mm3) had greater vBMD than volleyball players (1136±7 mg/mm3) (p<0.05), but similar to cross-country runners (1145±5 mg/mm3). Cortical thickness was greatest in soccer players (4.1±0.1 mm), while cross-country and control subjects (3.8±0.1 mm) had greater thickness than volleyball players (3.4±0.1 mm)(p<0.05). Periosteal circumference was greater in volleyball players (71±1.4 mm) than soccer, cross-country, and control subjects (68±0.9, 69±0.8, and 66±1 mm, respectively; all, p<0.05). vBMD variation within the cortical shell was greater among control subjects (70±6 mg/cm3) than each of the athlete groups, with soccer players having lower variation than cross country runners (within-in person SD 36±6 mg/cm3 and 54±5 mg/cm3 respectively; p<0.05). Conclusion: These results indicate bone geometry and distribution within the cortical shell of ...0.05).>
Interactions Of Primary Insult Biomechanics And Secondary Cascades In Spinal Cord Injury: Implications For Therapy, 2017 University of Kentucky
Interactions Of Primary Insult Biomechanics And Secondary Cascades In Spinal Cord Injury: Implications For Therapy, Michael B. Orr, John C. Gensel
Spinal Cord and Brain Injury Research Center Faculty Publications
No abstract provided.
A Graphene-Based Flexible Pressure Sensor With Applications To Plantar Pressure Measurement And Gait Analysis, Cunguang Lou, Shuo Wang, Tie Liang, Chenyao Pang, Lei Huang, Mingtao Run, Xiuling Liu
Open Access Publications by UMMS Authors
In the present study, we propose and develop a flexible pressure sensor based on the piezoresistive effect of multilayer graphene films on polyester textile. The pressure response results from the deformation of graphene conductive network structure and the changes in resistance. Here, we show that the graphene pressure sensor can achieve a sensitivity value of 0.012 kPa - 1 , the measurement range can be as high as 800 kPa, and the response time can reach to 50 ms. Subsequently, a stable in-shoe wireless plantar pressure measurement system is developed and dynamic pressure distribution is acquired in real-time. Overall, the graphene ...
Pannexins 1 And 3 In Skeletal Health And Osteoarthritis, 2017 The University of Western Ontario
Pannexins 1 And 3 In Skeletal Health And Osteoarthritis, Paxton M. Moon
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA) is a disease that gradually robs affected individuals of their mobility and places a substantial burden on health care systems and economies. OA results from pathological changes in bone, cartilage, synovium and supporting structures which are all essential to joint function. Cartilage degeneration, a hallmarking feature of OA, is an irreversible and untreatable consequence of these changes. Though the mechanisms underlying the initiation of cartilage breakdown remain unclear, joint injury and aging are risk factors. Pannexins (PANXs), a novel family of channel forming glycoproteins, have been suggested as important mediators of early OA. Therefore, my thesis tested the ...
Impacts Of Exercise On Functional Ability Of Recovering Gbs Patients: An Integrative Literature Review, Yasmin Sheriff
Grace Peterson Nursing Research Colloquium
This integrative literature review aimed to investigate the impacts exercise has on functional ability of GBS patients in recovery.
Task Condition And Pupillometry, 2017 Worcester Polytechnic Institute
Task Condition And Pupillometry, Mina Shojaeizadeh, Worcester Polytechnic Institute, John Rochford, Ping Chen
Eunice Kennedy Shriver Center Publications
While eye tracking is gaining popularity in IS research, pupillometry is relatively less explored in IS eye tracking studies. Research however suggests that pupillometry may serve as an excellent unobtrusive measure to study user information processing behavior. The Adaptive decision making theory asserts that task demand affects information processing behavior. Grounded in this theory, we argue that users’ pupillary responses will be different under different task conditions (task demand). We tested our assertion via an eye tracking laboratory experiment. Our results show that pupillary responses were significantly different under different task conditions.
Acute Heat Stress Activated Inflammatory Signaling In Porcine Oxidative Skeletal Muscle, 2017 Iowa State University
Acute Heat Stress Activated Inflammatory Signaling In Porcine Oxidative Skeletal Muscle, Shanthi Ganesan, Olga Volodina, Sarah C. Pearce, Nicholas K. Gabler, Lance H. Baumgard, Robert P. Rhoads, Joshua T. Selsby
Animal Science Publications
Despite well‐studied clinical manifestations, intracellular mechanisms of prolonged hyperthermic injury remain unclear, especially in skeletal muscle. Given muscle's large potential to impact systemic inflammation and metabolism, the response of muscle cells to heat‐mediated injury warrants further investigation. We have previously reported increased activation of NF‐κB signaling and increased NF‐κB and AP‐1‐driven transcripts in oxidative skeletal muscle following 12 h of heat stress. The purpose of this investigation was to examine early heat stress‐induced inflammatory signaling in skeletal muscle. We hypothesized that heat stress would increase NF‐κB and AP ...
Markerless Kinematics Of Pediatric Manual Wheelchair Mobility, 2017 Marquette University
Markerless Kinematics Of Pediatric Manual Wheelchair Mobility, Jacob Robert Rammer
Dissertations (1934 -)
Pediatric manual wheelchair users face substantial risk of orthopaedic injury to the upper extremities, particularly the shoulders, during transition to wheelchair use and during growth and development. Propulsion strategy can influence mobility efficiency, activity participation, and quality of life. The current forefront of wheelchair biomechanics research includes translating findings from adult to pediatric populations, improving the quality and efficiency of care under constrained clinical funding, and understanding injury mechanisms and risk factors. Typically, clinicians evaluate wheelchair mobility using marker-based motion capture and instrumentation systems that are precise and accurate but also time-consuming, inconvenient, and expensive for repeated assessments. There is ...
Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity Of The Core Nucleus Accumbens Direct And Indirect Pathways, 2017 University of Massachusetts Medical School
Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity Of The Core Nucleus Accumbens Direct And Indirect Pathways, Xincai Ji, Sucharita Saha, Jenya Kolpakova, Melissa Guildford, Andrew R. Tapper, Gilles E. Martin
University of Massachusetts Medical School Faculty Publications
Binge alcohol drinking, a behavior characterized by rapid repeated alcohol intake, is most prevalent in young adults and is a risk factor for excessive alcohol consumption and alcohol dependence. Although the alteration of synaptic plasticity is thought to contribute to this behavior, there is currently little evidence that this is the case. We used drinking in the dark (DID) as a model of binge alcohol drinking to assess its effects on spike timing-dependent plasticity (STDP) in medium spiny neurons (MSNs) of the core nucleus accumbens (NAc) by combining patch-clamp recordings with calcium imaging and optogenetics. After 2 weeks of daily ...
Inhibiting Axon Degeneration In A Mouse Model Of Acute Brain Injury Through Deletion Of Sarm1, 2017 University of Massachusetts Medical School
Inhibiting Axon Degeneration In A Mouse Model Of Acute Brain Injury Through Deletion Of Sarm1, Nils Henninger
GSBS Dissertations and Theses
Traumatic brain injury (TBI) is a leading cause of disability worldwide. Annually, 150 to 200/1,000,000 people become disabled as a result of brain trauma. Axonal degeneration is a critical, early event following TBI of all severities but whether axon degeneration is a driver of TBI remains unclear. Molecular pathways underlying the pathology of TBI have not been defined and there is no efficacious treatment for TBI.
Despite this significant societal impact, surprisingly little is known about the molecular mechanisms that actively drive axon degeneration in any context and particularly following TBI. Although severe brain injury may cause ...
Efficacy Of Electromyography And The Dead Bug Exercise, 2017 Chapman University
Efficacy Of Electromyography And The Dead Bug Exercise, Taylor M. Scavo, Rachel C. Cooklin, Erika N. Faria, Madeline L. Johnson, Eric Sternlicht
Student Scholar Symposium Abstracts and Posters
The Dead Bug exercise is performed in physical therapy clinics to restore lumbar spine stability and core strength in patients with lower back pain (LBP). The aim of this study was to evaluate the efficacy of using electromyography (EMG) feedback to enhance proper mechanics during the Dead Bug exercise. Sixteen healthy, college age students volunteered as subjects for the study. Subjects performed the Dead Bug (Fig. 1a.) with and without visual EMG cues and were given instructions on how to execute the exercise. Data was recorded using a BTS FREEEMG Analyzer and signal processed and data analyzed using the BTS ...
Trunk And Respiratory Motor Control In Typically Developing Children And Its Implications In Children With Chronic Spinal Cord Injury., Goutam Singh
Electronic Theses and Dissertations
Independent sitting is a major milestone and is also a prerequisite for optimal performance of activities of daily living (ADLs). Development of sitting posture control is a dynamic process involving control of degrees of freedom of head and trunk. Traditionally, trunk has been modeled as a single unit (segment). However, recent studies have suggested that it is made up multiple spinal units, controlled by a combination of trunk muscles. During typical development, posture control of trunk is different for different trunk segments. This motor development of trunk control is a complex process due to constant interaction between the nervous system ...
The Immediate Cardiovascular Response To Joint Mobilization Of The Neck - A Randomized, Placebo-Controlled Trial In Pain-Free Adults, Emmanuel Yung, Cheongeun Oh, Michael Wong, Jason K. Grimes, Erica M. Barton, Muhammad I. Ali, David A. Cameron
All PTHMS Faculty Publications
Background: Some normotensive patients can have a spike in resting systolic blood pressure (SBP) in response to acute neck pain. Applying the typical dosage of mobilization may potentially result in a sympatho-excitatory response, further increasing resting SBP. Therefore, there is a need to explore other dosage regimens that could result in a decrease in SBP.
Objectives: To compare the blood pressure (BP) and heart rate (HR) response of pain-free, normotensive adults when receiving unilateral posterior-to-anterior mobilization (PA) applied to the neck versus its corresponding placebo (PA-P).
Study design: Double-Blind, Randomized Clinical Trial.
Short-Term Heat Stress Alters Redox Balance In Porcine Skeletal Muscle, 2017 Iowa State University
Short-Term Heat Stress Alters Redox Balance In Porcine Skeletal Muscle, Olga Volodina, Shanthi Ganesan, Sarah C. Pearce, Nicholas K. Gabler, Lance H. Baumgard, Robert P. Rhoads, Joshua T. Selsby
Animal Science Publications
Heat stress contributes to higher morbidity and mortality in humans and animals and is an agricultural economic challenge because it reduces livestock productivity. Redox balance and associated mitochondrial responses appear to play a central role in heat stress‐induced skeletal muscle pathology. We have previously reported increased oxidative stress and mitochondrial content in oxidative muscle following 12 h of heat stress. The purposes of this investigation were to characterize heat stress‐induced oxidative stress and changes in mitochondrial content and biogenic signaling in oxidative skeletal muscle. Crossbred gilts were randomly assigned to either thermal neutral (21°C; n = 8, control ...
Osteoblast-Derived Fgf9 Regulates Skeletal Homeostasis, 2017 University of California - San Francisco
Osteoblast-Derived Fgf9 Regulates Skeletal Homeostasis, Liping Wang, Theresa M. Roth, Marcia J. Abbott, Linh Ho, Lalita Wattanachanya, Robert A. Nissenson
Health Sciences and Kinesiology Faculty Articles
FGF9 has complex and important roles in skeletal development and repair. We have previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein signaling and therefore the present study was done to determine whether OB-derived FGF9 was important in skeletal homeostasis. To directly test this idea, we deleted functional expression of Fgf9 gene in OBs using a 2.3 kb collagen type I promoter-driven Cre transgenic mouse line (Fgf9OB −/−). Both Fgf9 knockout (Fgf9OB −/−) and the Fgf9 floxed littermates (Fgf9fl/fl) mice were fully backcrossed and maintained in an FBV/N background. Three month old ...
What Outcomes Are Important For Gout Patients? In-Depth Qualitative Research Into The Gout Patient Experience To Determine Optimal Endpoints For Evaluating Therapeutic Interventions, 2017 Adelphi Values
What Outcomes Are Important For Gout Patients? In-Depth Qualitative Research Into The Gout Patient Experience To Determine Optimal Endpoints For Evaluating Therapeutic Interventions, Sophi Tatlock, Katja Rudell, Charlotte Panter, Rob Arbuckle, Leslie R. Harrold, William J. Taylor, Tara Symonds
University of Massachusetts Medical School Faculty Publications
BACKGROUND AND OBJECTIVES: Characterized by sudden onset of severe joint pain, swelling, redness, and tenderness to touch, gout 'flare ups' have a substantial impact on quality of life (QoL). This research employed a patient-centered approach to explore the symptoms and impacts of gout, and assess the content validity of existing patient-reported outcomes (PROs).
METHODS: Qualitative interviews were conducted with 30 US gout patients (non-tophaceous: n = 20, tophaceous: n = 10) and five expert rheumatologists. Each interview included both concept elicitation (CE) questioning to learn about the patient experience and cognitive debriefing to assess the content validity of three PRO instruments (HAQ-DI ...