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Musculoskeletal, Neural, and Ocular Physiology Commons

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Effects Of Heat Stress And Exercise On Shooting Performance, Patrick R. Lindecker 2019 University of Montana, Missoula

Effects Of Heat Stress And Exercise On Shooting Performance, Patrick R. Lindecker

Graduate Student Theses, Dissertations, & Professional Papers

Purpose: The purpose of this study was to evaluate the effects of exercise and acute heat stress on marksmanship performance measures of accuracy, precision, aim time, and distance travelled by the point of aim in trained US military veterans. Methods: Subjects (N=8) (height 184.1 ± 10.9 cm (SD), weight 92.1 ± 10.6 kg, 21.1 ± 8.9% body fat, VO2max 47.25 ± 7.36 mL/kg/min, age 26.8 ± 4.3 yrs.) completed one-hour of walking at 50% VO2max in a hot (35˚C, 30% maximal relative humidity) or cool (22˚C, 30% maximal ...


The Effect Of Arch Height On Variances In Gait Phases: A Kinematic Analysis, Mackenzie J. Haag 2019 University of Northern Iowa

The Effect Of Arch Height On Variances In Gait Phases: A Kinematic Analysis, Mackenzie J. Haag

Honors Program Theses

Millions of individuals suffer from pain or injury as a result of structural abnormalities of the medial longitudinal arch of the foot and/or improper footwear. A majority of the research on abnormalities of the medial longitudinal arch is focused on how the arch alters foot kinematics during gait but does not ask how abnormalities may contribute to deviations in knee kinematics as well. The purpose of this study was to determine the effect of foot arch types on deviations in healthy biomechanical gait in addition to the implications of orthotics in order to ultimately aid in the decrease of ...


Effects Of Age, Race, And Ethnicity On The Optic Nerve And Peripapillary Region Using Spectral-Domain Oct 3d Volume Scans, Linda Yi-Chieh Poon, Hussein Antar, Edem Tsikata, Rong Guo, Georgia Papadogeorgou, Madeline Freeman, Ziad Khoueir, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian John Que, Johannes F. de Boer, Teresa C. Chen 2018 Harvard Medical School

Effects Of Age, Race, And Ethnicity On The Optic Nerve And Peripapillary Region Using Spectral-Domain Oct 3d Volume Scans, Linda Yi-Chieh Poon, Hussein Antar, Edem Tsikata, Rong Guo, Georgia Papadogeorgou, Madeline Freeman, Ziad Khoueir, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian John Que, Johannes F. De Boer, Teresa C. Chen

Open Access Publications by UMMS Authors

Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects.

Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area.

Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 ...


Longitudinal Screening Detects Cognitive Stability And Behavioral Deterioration In Als Patients, Susan Woolley, Ray Goetz, Pam Factor-Litvak, Jennifer Murphy, Jonathan Hupf, Catherine Lomen-Hoerth, Howard Andrews, Daragh Heitzman, Richard Bedlack, Jonathan Katz, Richard Barohn, Eric Sorenson, Bjorn Oskarsson, Americo Fernandes Filho, Edward J. Kasarskis, Tahseen Mozaffar, Sharon Nations, Andrea Swenson, Agnes Koczon-Jaremko, Georgia Christodoulou, Hiroshi Mitsumoto 2018 Sutter Pacific Medical Foundation

Longitudinal Screening Detects Cognitive Stability And Behavioral Deterioration In Als Patients, Susan Woolley, Ray Goetz, Pam Factor-Litvak, Jennifer Murphy, Jonathan Hupf, Catherine Lomen-Hoerth, Howard Andrews, Daragh Heitzman, Richard Bedlack, Jonathan Katz, Richard Barohn, Eric Sorenson, Bjorn Oskarsson, Americo Fernandes Filho, Edward J. Kasarskis, Tahseen Mozaffar, Sharon Nations, Andrea Swenson, Agnes Koczon-Jaremko, Georgia Christodoulou, Hiroshi Mitsumoto

Neurology Faculty Publications

Objective. To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods. We analyzed data from 294 ALS participants, 134 of whom were studied serially. Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes. Change in cognitive/behavioral subgroups was assessed using one-way analyses of covariance. Results. Participants with follow-up data had fewer baseline behavior problems compared to ...


Developmental Dependence For Functional Eye Regrowth In Xenopus Laevis, Cindy X. Kha, Kelly Ai-Sun Tseng 2018 University of Nevada, Las Vegas

Developmental Dependence For Functional Eye Regrowth In Xenopus Laevis, Cindy X. Kha, Kelly Ai-Sun Tseng

Life Sciences Faculty Publications

A key challenge in designing tissue repair strategies is knowing whether and how developmental mechanisms are used for successful repair of mature/adult tissues. Although it is known that developmental components are used in repair, it remains mostly unclear which ones are required and whether they act similarly as during development. This issue is further complicated by the fact that it is difficult to assess the similarities and differences between development and the repair of mature tissues, since the two contexts are highly dissimilar. A potentially useful yet underutilized approach is to understand developmental regrowth (defined here as the ability ...


Fatigue Associated With Rheumatoid Arthritis In Young Adults, Sydney Van Alstyne 2018 DePaul University

Fatigue Associated With Rheumatoid Arthritis In Young Adults, Sydney Van Alstyne

Grace Peterson Nursing Research Colloquium

Background: Often, practitioners do not address their Rheumatoid Arthritis patients' fatigue and do not perceive it as a detriment to the patient's wellness. In actuality, fatigue has been determined to be proportionate to the other variables, such as pain and disease progression, of rheumatoid arthritis.

Objectives: to determine the cause(s) of fatigue in rheumatoid arthritis and determine how fatigue can be used in a clinical setting to determine disease progression and status in patients suffering from chronic illness.

Method: This integrative literature review was conducted using the keywords, “fatigue, rheumatoid arthritis, young adults, perception of fatigue” to search ...


Modulation Of Parathyroid Hormone 1 Receptor Signaling By Extracellular Nucleotides, Brandon Kim 2018 The University of Western Ontario

Modulation Of Parathyroid Hormone 1 Receptor Signaling By Extracellular Nucleotides, Brandon Kim

Electronic Thesis and Dissertation Repository

Parathyroid hormone (PTH) activates the PTH/PTH-related peptide receptor (PTH1R) on osteoblasts and other target cells. Mechanical stimulation of cells, including osteoblasts, causes release of nucleotides such as ATP into the extracellular fluid. In addition to its role as an energy source, ATP serves as an agonist at P2 receptors and an allosteric regulator of many proteins. We investigated the effects of concentrations of extracellular ATP, comparable to those that activate low affinity P2X7 receptors, on PTH1R signaling. Cyclic AMP levels were monitored in real-time using a bioluminescence reporter and β-arrestin recruitment to PTH1R was followed using a complementation-based luminescence ...


Interprofessional Opportunities In Sleep Practice, Kristen L. McHenry 2018 East Tennessee State University

Interprofessional Opportunities In Sleep Practice, Kristen L. Mchenry

Kristen L. McHenry

Interprofessional education has the potential to prepare health career students to be practice-ready and enter the workforce with a collaborative mindset. Respiratory care educators must adequately prepare students to work in this capacity. This emphasis on a team approach to patient-centered care has the ability to impact and improve health outcomes. Throughout the last decade, sleep medicine has experienced fluctuations. Sustainability of sleep labs who only perform diagnostic testing may prove challenging. The role of interprofessional practice in sleep medicine would be to overcome traditional roles (silos) so that multiple skilled practitioners could help identify and treat complex patient conditions ...


Physiological Differences Between Low Versus High Skeletal Muscle Hypertrophic Responders To Resistance Exercise Training: Current Perspectives And Future Research Directions, Michael D. Roberts, Cody T. Haun, Christopher B. Mobley, Petey W. Mumford, Matthew A. Romero, Paul A. Roberson, Christopher G. Vann, John J. McCarthy 2018 Auburn University

Physiological Differences Between Low Versus High Skeletal Muscle Hypertrophic Responders To Resistance Exercise Training: Current Perspectives And Future Research Directions, Michael D. Roberts, Cody T. Haun, Christopher B. Mobley, Petey W. Mumford, Matthew A. Romero, Paul A. Roberson, Christopher G. Vann, John J. Mccarthy

Physiology Faculty Publications

Numerous reports suggest there are low and high skeletal muscle hypertrophic responders following weeks to months of structured resistance exercise training (referred to as low and high responders herein). Specifically, divergent alterations in muscle fiber cross sectional area (fCSA), vastus lateralis thickness, and whole body lean tissue mass have been shown to occur in high versus low responders. Differential responses in ribosome biogenesis and subsequent protein synthetic rates during training seemingly explain some of this individual variation in humans, and mechanistic in vitro and rodent studies provide further evidence that ribosome biogenesis is critical for muscle hypertrophy. High responders may ...


Femoral Neck Stress In Older Adults During Stair Ascent And Descent, Chen Deng, Jason C. Gillette, Timothy R. Derrick 2018 Iowa State University

Femoral Neck Stress In Older Adults During Stair Ascent And Descent, Chen Deng, Jason C. Gillette, Timothy R. Derrick

Kinesiology Publications

A detailed understanding of the hip loading environment is needed to help prevent hip fractures, minimize hip pain, rehabilitate hip injuries, and design osteogenic exercises for the hip. The purpose of this study was to compare femoral neck stress during stair ascent and descent and to identify the contribution of muscles and reaction forces to the stress environment in mature adult subjects (n = 17; age: 50–65 y). Motion analysis and inverse dynamics were combined with musculoskeletal modeling and optimization, then used as input to an elliptical femoral neck cross-sectional model to estimate femoral neck stress. Peak stress values at ...


The Influence Of Visuospatial Intervention On Mathematical Ability, Tiffany Bui, Matthew Eclevia, Cody Shishido, Jessica Walker 2018 Chapman University

The Influence Of Visuospatial Intervention On Mathematical Ability, Tiffany Bui, Matthew Eclevia, Cody Shishido, Jessica Walker

Student Scholar Symposium Abstracts and Posters

The research proposal of this study intends to identify whether visuospatial interventions improve mathematical ability in college students. Visuospatial skills are important for identifying the distance between two objects, memory of images, and visualizing objects by mentally rotating them. The two important concepts relating to visuospatial ability are spatial relations and spatial visualizations. These are the abilities to mentally rotate two dimensional and three dimensional objects. Prior research has shown that visuospatial interventions are an effective tool for the improvement mathematical performance. This study is designed to see whether mathematical aptitude improves from pre-test to post-test after participation in visuospatial ...


Dystrophic Calcifications Point The Way-Unusual And Early Diagnostic Clue Of Conradi-Hünermann-Happle Syndrome, Kenneth Yu, Alexander T Reid, Stephanie J T Chen, Rajiv M Patel, Steven M Donn, Johann E Gudjonsson, Lori Lowe 2018 University of Iowa

Dystrophic Calcifications Point The Way-Unusual And Early Diagnostic Clue Of Conradi-Hünermann-Happle Syndrome, Kenneth Yu, Alexander T Reid, Stephanie J T Chen, Rajiv M Patel, Steven M Donn, Johann E Gudjonsson, Lori Lowe

Stead Family Department of Pediatrics Publications

No abstract provided.


Pre-Season Vitamin D And Iron Levels As A Predictor Of Musculoskeletal Injury In Division I Athletes, Mariellen Katherine Veach 2018 University of Arkansas, Fayetteville

Pre-Season Vitamin D And Iron Levels As A Predictor Of Musculoskeletal Injury In Division I Athletes, Mariellen Katherine Veach

Theses and Dissertations

Context: Pre-season testing that includes the analysis of micronutrient serum levels in the blood has become a routine part of pre-participation examinations in collegiate football. Objective: Assess the predictability of vitamin D and iron serum levels as indicators of future injury during a subsequent competitive season for lower extremity sprains, strains, and fractures. Additionally, determine the effectiveness of vitamin D supplementation on increasing serum 25(OH)D levels and preventing injury. Design: Cohort Study. Setting: National Collegiate Athletic Association Division I football program. Participants: Football athletes (n=349) who underwent pre-participation examinations and participated in at least one of three ...


Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin 2018 Liberty University

Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin

Senior Honors Theses

The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research ...


Bilateral Facial Spasm Following Guillain-Barré Syndrome, Zain Guduru, John Morgan, Kapil Sethi 2018 University of Kentucky

Bilateral Facial Spasm Following Guillain-Barré Syndrome, Zain Guduru, John Morgan, Kapil Sethi

Neurology Faculty Publications

Background: We report a patient who developed lower facial muscle spasm at rest and bilateral facial synkinesis several months after treatment of Guillain–Barré syndrome (GBS); this finding, to our knowledge, is hitherto unreported.

Phenomenology Shown: Bilateral synkinesis, facial muscles spasm at rest, bilateral postparalytic facial syndrome.

Educational Value: Aberrant regeneration of nerve fibers post GBS, resulting in facial muscles spasm at rest, bilateral synkinesis.


Functional Anatomy Of Palmar Musculature, Colin W. Moore 2018 The University of Western Ontario

Functional Anatomy Of Palmar Musculature, Colin W. Moore

Electronic Thesis and Dissertation Repository

The palmaris longus (PL) and palmaris brevis (PB) are upper limb muscles considered atavistic remnants of those found in animal species. Despite their use in surgical grafting and tendon transfer procedures, the functional role of the PL and PB have not been investigated comprehensively in vivo. Using a multi-modal experimental approach consisting of indwelling fine wire electromyography (EMG), ultrasonography and immunohistochemical muscle staining techniques, the function of the PL and PB in the hand was evaluated both in in vivo and in situ.

The purpose of Study 1 was to determine whether the PL provides synergistic contributions to thenar contractions ...


Effects Of Load Carriage And Surface Inclination On Linear And Non-Linear Postural Variability, Rahul Soangra, Hema Bhatt, Ehsan Rashedi 2018 Chapman University

Effects Of Load Carriage And Surface Inclination On Linear And Non-Linear Postural Variability, Rahul Soangra, Hema Bhatt, Ehsan Rashedi

Physical Therapy Faculty Articles and Research

Understanding of inclined-work-related risk of falls and developing novel practical engineering controls for reducing this risk of falls among hilly working population remains in high demand. Standing on sloped surfaces provides a unique environment for examining the biomechanics and neural control of standing. The present investigation examined the variability of postural signals when standing on inclined surfaces and with load carriages by linear and nonlinear analysis. The purpose of this study was to determine if the sloped surface deteriorated in postural stability among healthy individuals with two distinctive kinds of load carriage methods head versus posterior load carriage. We also ...


Acute Vitreoretinal Trauma And Inflammation After Traumatic Brain Injury In Mice, Lucy P Evans, Elizabeth A Newell, MaryAnn Mahajan, Stephen H Tsang, Polly J Ferguson, Jolonda Mahoney, Christopher D Hue, Edward W Vogel III, Barclay Morrison III, Ottavio Arancio, Russell Nichols, Alexander G. Bassuk, Vinit B. Mahajan 2018 University of Iowa

Acute Vitreoretinal Trauma And Inflammation After Traumatic Brain Injury In Mice, Lucy P Evans, Elizabeth A Newell, Maryann Mahajan, Stephen H Tsang, Polly J Ferguson, Jolonda Mahoney, Christopher D Hue, Edward W Vogel Iii, Barclay Morrison Iii, Ottavio Arancio, Russell Nichols, Alexander G. Bassuk, Vinit B. Mahajan

Stead Family Department of Pediatrics Publications

Objective: Limited attention has been given to ocular injuries associated with traumatic brain injury (TBI). The retina is an extension of the central nervous system and evaluation of ocular damage may offer a less-invasive approach to gauge TBI severity and response to treatment. We aim to characterize acute changes in the mouse eye after exposure to two different models of TBI to assess the utility of eye damage as a surrogate to brain injury.

Methods: A model of blast TBI (bTBI) using a shock tube was compared to a lateral fluid percussion injury model (LFPI) using fluid pressure applied directly ...


In-Home Delivery Of Constraint-Induced Movement Therapy Via Virtual Reality Gaming, Alexandra L. Borstad, Roger Crawfis, Kala Phillips, Linda Pax Lowes, David Maung, Ryan McPherson, Amelia Siles, Lise Worthen-Chaudhari, Lynne V. Gauthier 2018 College of St. Scholastica

In-Home Delivery Of Constraint-Induced Movement Therapy Via Virtual Reality Gaming, Alexandra L. Borstad, Roger Crawfis, Kala Phillips, Linda Pax Lowes, David Maung, Ryan Mcpherson, Amelia Siles, Lise Worthen-Chaudhari, Lynne V. Gauthier

Journal of Patient-Centered Research and Reviews

Purpose: People with chronic hemiparesis are frequently dissatisfied with the recovery of their hand and arm, yet many lack access to effective treatments. Constraint-induced movement therapy (CI therapy) effectively increases arm function and spontaneous use in persons with chronic hemiparesis. The purpose of this study was to determine the feasibility and measure safety and outcomes of an in-home model of delivering CI therapy using a custom, avatar-based virtual reality game.

Methods: Seventeen individuals with chronic hemiparesis participated in this pretest/posttest quasi-experimental design study. The 10-day intervention had three components: 1) high-repetition motor practice using virtual reality gaming; 2) constraint ...


The Effects Of Emerging Technology On Healthcare And The Difficulties Of Integration, Skyler J. Pavlish-Carpenter 2018 University of Central Florida

The Effects Of Emerging Technology On Healthcare And The Difficulties Of Integration, Skyler J. Pavlish-Carpenter

Honors Undergraduate Theses

Background: Disruptive technology describes technology that is significantly more advanced than previous iterations, such as: 3D printing, genetic manipulation, stem cell research, innovative surgical procedures, and computer-based charting software. These technologies often require extensive overhauls to implement into older systems and must overcome many difficult financial and societal complications before they can be widely used. In a field like healthcare that makes frequent advancements, these difficulties can mean that the technology will not be utilized to its full potential or implemented at all.

Objective: To determine the inhibiting factors that prevent disruptive technology from being implemented in conventional healthcare.

Methods ...


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