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Articles 1 - 30 of 278

Full-Text Articles in Musculoskeletal, Neural, and Ocular Physiology

Roles And Regulation Of Satellite Cells In Skeletal Muscle Regeneration, Sydney M. Vlasman Jun 2021

Roles And Regulation Of Satellite Cells In Skeletal Muscle Regeneration, Sydney M. Vlasman

University Honors Theses

Skeletal muscle has an innate ability to self-regenerate in response to certain stimuli. In the case of trauma, muscle resident stem cells are required to meet the regenerative needs of the tissue. These resident stem cells, called satellite cells (SCs), are crucial in the regenerative process following injury; understanding the major factors which regulate satellite cell activity can provide valuable insight for regenerative medicine. The ability to implement and properly activate satellite cells has immense potential in the treatment of conditions including trauma, degenerative disorders, and age-related sarcopenia. This review will discuss the current understanding of satellite cell-mediated regeneration and ...


Differential Effect Of Proinflammatory Cytokines On Corneal And Conjunctival Epithelial Cell Mucins And Glycocalyx, Kiumars Shamloo, Priya Mistry, Ashley Barbarino, Christopher Ross, Vishal Jhanji Jun 2021

Differential Effect Of Proinflammatory Cytokines On Corneal And Conjunctival Epithelial Cell Mucins And Glycocalyx, Kiumars Shamloo, Priya Mistry, Ashley Barbarino, Christopher Ross, Vishal Jhanji

Pharmacy Faculty Articles and Research

Purpose: Ocular surface mucins and glycocalyx are critical for providing ocular hydration as well lubrication and repelling pathogens or allergens. Elevated levels of tear proinflammatory cytokines in dry eye may have detrimental effect on mucins and glycocalyx. The present study tested the effect of proinflammatory cytokines IL-6, TNF-α, and IFN-γ on membrane-tethered mucins expression, glycocalyx, and viability of ocular surface epithelial cells.

Methods: Stratified cultures of human corneal and conjunctival epithelial cells were exposed to different concentrations of IL-6, TNF-α, and IFN-γ for 24 hours. The mucins gene and protein expressions were quantified by real-time polymerase chain reaction (PCR) and ...


Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), Madison Marcom May 2021

Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), Madison Marcom

Electronic Theses and Dissertations

Sarcopenia is a disease of muscle wasting primarily seen in older adults. Although this term was first coined over three decades ago, there is a lack of consensus on a definition, screening criteria, and treatment protocol for sarcopenia. The primary purpose of this study is to determine whether registered dietitian nutritionists (RDNs) in the United States (U.S.) screen for sarcopenia. Study participants were recruited through a randomized email list and included RDNs throughout the U.S. Respondents completed a survey questioning knowledge of sarcopenia, screening tools and company protocols in place, and the need and desire for sarcopenia education ...


The Effect Of Chronic Alcohol Consumption On Exercise-Induced Muscle Damage In Young Men, Emma Hamilton, Grant Hilliard Apr 2021

The Effect Of Chronic Alcohol Consumption On Exercise-Induced Muscle Damage In Young Men, Emma Hamilton, Grant Hilliard

Honors Theses

PURPOSE: To investigate the effects of chronic alcohol consumption on exercise-induced muscle damage of the knee extensors in young men. METHODS: Twenty-one males (age 21.9 ± 1.1 yr; weight 183.4 ± 27.6 lbs; height 174.0 ± 13.1 cm) performed 100 maximal eccentric contractions at 30°/sec of the knee extensors using their non-dominant leg. The isometric and isokinetic muscle strengths (60°/sec and 180°/sec) were measured pre-exercise and immediately, 24 h, 48 h, 72 h, 96 h, and 120 h post-exercise. Muscle soreness and plasma creatine kinase (CK) activity were measured pre-exercise and 24 h, 48 ...


Disrupted Glucose Homeostasis And Skeletal Muscle-Specific Glucose Uptake In An Exocyst Knockout Mouse Model, Brent A. Fujimoto, Madison Young, Nicole Nakamura, Herena Ha, Lamar Carter, Matthew W. Pitts, Daniel Torres, Hye Lim Noh, Sujin Suk, Jason K. Kim, Noemi Polgar Feb 2021

Disrupted Glucose Homeostasis And Skeletal Muscle-Specific Glucose Uptake In An Exocyst Knockout Mouse Model, Brent A. Fujimoto, Madison Young, Nicole Nakamura, Herena Ha, Lamar Carter, Matthew W. Pitts, Daniel Torres, Hye Lim Noh, Sujin Suk, Jason K. Kim, Noemi Polgar

Open Access Publications by UMMS Authors

Skeletal muscle is responsible for the majority of glucose disposal following meals, and this is achieved by insulin-mediated trafficking of glucose transporter type 4 (GLUT4) to the cell membrane. The eight-protein exocyst trafficking complex facilitates targeted docking of membrane-bound vesicles, a process underlying the regulated delivery of fuel transporters. We previously demonstrated the role of exocyst subunit EXOC5 in insulin-stimulated GLUT4 exocytosis and glucose uptake in cultured rat skeletal myoblasts. However, the in vivo role of EXOC5 in skeletal muscle remains unclear. Using mice with inducible, skeletal muscle-specific knockout of exocyst subunit EXOC5 (Exoc5-SMKO), we examined how muscle-specific disruption of ...


Physiology, Rem Sleep, Joshua Feriante, John F. Araujo Feb 2021

Physiology, Rem Sleep, Joshua Feriante, John F. Araujo

Open Access Publications by UMMS Authors

Sleep is a reversible state of disconnection from the environment, including reduced consciousness, skeletal muscle mobility, and metabolism. All forms of sensory responses are markedly decreased to varying degrees depending on the sleep cycle stage. Although this phenomenon is observed in all species that have been studied and occupies a significant fraction of the human lifespan, the purpose and function of sleep remain poorly understood.

Sleep is measured primarily by polysomnography (PSG) which is considered the gold standard for diagnosing sleep disorders.. PSG reveals that sleep architecture has several distinct stages that vacillate between the non-rapid eye movement (NREM) stages ...


Hospital-Acquired Venous Thromboembolism Or Bleeding Following Total Joint Arthroplasty: A Systematic Review And Meta-Analysis For The Association Of The Gene Polymorphism., Michael Debeau Feb 2021

Hospital-Acquired Venous Thromboembolism Or Bleeding Following Total Joint Arthroplasty: A Systematic Review And Meta-Analysis For The Association Of The Gene Polymorphism., Michael Debeau

Medical Student Research Symposium

This review seeks to understand the current existing literature on genetic polymorphisms to VTE following orthopedic surgery. Using PRISMA guidelines, 234 studies were retrieved from PubMed and Cochrane. The eligibility assessment yielded 16 studies including a systematic review. A STREGA and STROBE quality assessment found these studies to have high methodological quality. A significant association was found between the PAI-1 4G/4G genotype and resistance to anticoagulation therapy (OR = 2.692; 95% CI = 1.302 - 4.702). Moreover, the MTHFR C677T and A1298C polymorphisms significantly increased the incidence of VTE in patients that are compound heterozygotes (OR = 2.89; 95 ...


Measuring Femoral Neck Loads In Healthy Young And Older Adults During Stair Ascent And Descent, Chen Deng, Jason C. Gillette, Timothy R. Derrick Jan 2021

Measuring Femoral Neck Loads In Healthy Young And Older Adults During Stair Ascent And Descent, Chen Deng, Jason C. Gillette, Timothy R. Derrick

Kinesiology Publications

Understanding the hip loading environment for daily activities is useful for hip fracture prevention, rehabilitation, and the design of osteogenic exercises. Seventeen older adults (50–70 yrs) and twenty young adults (18–30 yrs) were recruited. A rigid body model combined with a musculoskeletal model was used to estimate lower extremity loading. An elliptical cross-section model of the femoral neck was used to estimate femoral neck stress during stair ascent and descent. Two peaks were identified in the stress curves, corresponding to the peaks in the vertical ground reaction force. During stair ascent, significantly higher tension on the superior femoral ...


The Effects Of E-Vapor On The Pathogenesis Of Rheumatoid Arthritis Mouse Models And Potential Implications For Future Generations, Christiana Daas Oct 2020

The Effects Of E-Vapor On The Pathogenesis Of Rheumatoid Arthritis Mouse Models And Potential Implications For Future Generations, Christiana Daas

Selected Honors Theses

Rheumatoid arthritis is the most prevalent autoimmune disease. Rheumatoid arthritis (RA) has no cure, and the direct cause of the disease is still unknown. The two leading hypotheses concerning its etiology are based on the effects of HLA-DRB1 gene expression, and cigarette smoke. Conjunctively, the use of vaping devices amongst adolescents has increased significantly since introduced in 2007. There is no long-term data on the effects of e-vapor and its aerosols on bodily health. Cigarette smoke is the most noteworthy environmental factor contributing to RA therefore the question is raised as to whether or not vaping relates to rheumatoid arthritis ...


The Bromodomains Of The Mammalian Swi/Snf (Mswi/Snf) Atpases Brahma (Brm) And Brahma Related Gene 1 (Brg1) Promote Chromatin Interaction And Are Critical For Skeletal Muscle Differentiation [Preprint], Anthony N. Imbalzano, Hanna Witwicka, Tapan Sharma Sep 2020

The Bromodomains Of The Mammalian Swi/Snf (Mswi/Snf) Atpases Brahma (Brm) And Brahma Related Gene 1 (Brg1) Promote Chromatin Interaction And Are Critical For Skeletal Muscle Differentiation [Preprint], Anthony N. Imbalzano, Hanna Witwicka, Tapan Sharma

University of Massachusetts Medical School Faculty Publications

Skeletal muscle differentiation induces changes in the epigenome of myoblasts as they proceed towards a myogenic phenotype. mSWI/SNF chromatin remodeling enzymes coordinate with lineage-determining transcription factors and are key regulators of differentiation. Three mSWI/SNF proteins, the mutually exclusive ATPases, BRG1 and BRM, and the BAF180 protein (Polybromo1, PBRM1) contain bromodomains belonging to the same structural subfamily. Bromodomains bind to acetylated lysines on histone N-terminal tails and on other proteins. Pharmacological inhibition of mSWI/SNF bromodomain function using the selective inhibitor PFI-3 reduced differentiation, decreased expression of myogenic genes, and increased the expression of cell cycle-related genes and the ...


Loss Of Supervillin Causes Myopathy With Myofibrillar Disorganization And Autophagic Vacuoles, Carola Hedberg-Oldfors, Elizabeth J. Luna, Anders Oldfors, Cordula Knopp Aug 2020

Loss Of Supervillin Causes Myopathy With Myofibrillar Disorganization And Autophagic Vacuoles, Carola Hedberg-Oldfors, Elizabeth J. Luna, Anders Oldfors, Cordula Knopp

Open Access Publications by UMMS Authors

The muscle specific isoform of the supervillin protein (SV2), encoded by the SVIL gene, is a large sarcolemmal myosin II- and F-actin-binding protein. Supervillin (SV2) binds and co-localizes with costameric dystrophin and binds nebulin, potentially attaching the sarcolemma to myofibrillar Z-lines. Despite its important role in muscle cell physiology suggested by various in vitro studies, there are so far no reports of any human disease caused by SVIL mutations. We here report four patients from two unrelated, consanguineous families with a childhood/adolescence onset of a myopathy associated with homozygous loss-of-function mutations in SVIL. Wide neck, anteverted shoulders and prominent ...


Rem Rebound Effect, Joshua Feriante, Shantanu Singh Jul 2020

Rem Rebound Effect, Joshua Feriante, Shantanu Singh

Open Access Publications by UMMS Authors

Sleep is a state consisting of several different stages of reversible disconnection from the environment with accompanying reduced consciousness, atonia, and metabolic changes. These stages are primarily divided into rapid-eye-movement (REM) sleep, which is characterized by classic ocular saccadic movement and fast-wave EEG patterns reminiscent of wakefulness, and non-rapid-eye movement (NREM) which can be subdivided further into three stages each distinguished by distinct EEG wave patterns. Normally an individual will progress through a predictable cycle of stages beginning with wakefulness, then through each stage of NREM sleep before quickly reversing through the stages to enter REM sleep.

The maintenance of ...


Evaluation Of Resident Palpation Skills In Foot And Ankle Anatomic Structures Using Bedside Ultrasound, Se Won Lee, Phuong U. Le, Craig Van Dien, Mike Hansen, Timothy Tiu Jul 2020

Evaluation Of Resident Palpation Skills In Foot And Ankle Anatomic Structures Using Bedside Ultrasound, Se Won Lee, Phuong U. Le, Craig Van Dien, Mike Hansen, Timothy Tiu

HCA Healthcare Journal of Medicine

Objective: The objective is to determine the accuracy of foot and ankle joint and soft tissue structure palpation in Physical Medicine and Rehabilitation (PM&R) residents using ultrasonography (US) verification.

Methods: PM&R residents were tested in an outpatient musculoskeletal (MSK) clinic on palpated foot and ankle anatomic structures in a human model. Once the presumed structures were localized, residents marked a 1 cm size circle on the overlying skin with a ink marker. The accuracy of the circle over the joint line and soft tissue structures was verified using US.

Results: The overall palpation accuracy for 22 joint line ...


Injury Prevention Among Professional Ballet Dancers – A Qualitative Study, Elizabeth Balyakina, Nathan J. Hershberger, Sajid A. Surve, Rita M. Patterson Jun 2020

Injury Prevention Among Professional Ballet Dancers – A Qualitative Study, Elizabeth Balyakina, Nathan J. Hershberger, Sajid A. Surve, Rita M. Patterson

Neuromusculoskeletal

Rationale: The physical stress placed on ballet dancers’ bodies during their professional career predisposes them to injury. Qualitative research can be used to examine ways to support current strategies that dancers use to stay healthy and to inform further research in areas where dancers may be most prone to injury.

Purpose: To examine therapies and strategies dancers use to keep healthy and to treat injury.

Educational Objectives:

At the end of the presentation, the participants will be able to:

  1. Describe the most common strategies dancers use to stay healthy
  2. Formulate an understanding of how professional dancers manage injury
  3. Identify the ...


A Decline In Walking Speed Is Associated With Incident Knee Replacement In Adults With And At Risk For Knee Osteoarthritis, Matthew S. Harkey, Kate L. Lapane, Shao-Hsien Liu, Grace H. Lo, Timothy E. Mcalindon, Jeffrey B. Driban Jun 2020

A Decline In Walking Speed Is Associated With Incident Knee Replacement In Adults With And At Risk For Knee Osteoarthritis, Matthew S. Harkey, Kate L. Lapane, Shao-Hsien Liu, Grace H. Lo, Timothy E. Mcalindon, Jeffrey B. Driban

University of Massachusetts Medical School Faculty Publications

OBJECTIVE: To determine if a one-year change in walking speed is associated with receiving an incident knee replacement during the following year in adults with and at risk for knee osteoarthritis (OA).

METHODS: Using data from the Osteoarthritis Initiative, we determined a one-year change in 20- meter walk speed from three observation periods (i.e., 0-12, 12-24, and 24-36 month). We operationally defined one-year change in walking speed as either: 1) decline: < -0.1 m/s change, 2) no change: between -0.1 and 0.1 m/s change, 3) increase: > 0.1 m/s change. Incident knee replacement was defined using each subsequent one-year period (i.e., 12-24, 24- 36, and 36-48 month). Combining data from the three ...


The Myosin Interacting-Heads Motif Present In Live Tarantula Muscle Explains Tetanic And Posttetanic Phosphorylation Mechanisms, Raul Padron, Weikang Ma, Sebastian Duno-Miranda, Natalia Koubassova, Kyounghwan Lee, Antonio Pinto, Lorenzo Alamo, Pura Bolanos, Andrey Tsaturyan, Thomas Irving, Roger W. Craig Jun 2020

The Myosin Interacting-Heads Motif Present In Live Tarantula Muscle Explains Tetanic And Posttetanic Phosphorylation Mechanisms, Raul Padron, Weikang Ma, Sebastian Duno-Miranda, Natalia Koubassova, Kyounghwan Lee, Antonio Pinto, Lorenzo Alamo, Pura Bolanos, Andrey Tsaturyan, Thomas Irving, Roger W. Craig

Radiology Publications

Striated muscle contraction involves sliding of actin thin filaments along myosin thick filaments, controlled by calcium through thin filament activation. In relaxed muscle, the two heads of myosin interact with each other on the filament surface to form the interacting-heads motif (IHM). A key question is how both heads are released from the surface to approach actin and produce force. We used time-resolved synchrotron X-ray diffraction to study tarantula muscle before and after tetani. The patterns showed that the IHM is present in live relaxed muscle. Tetanic contraction produced only a very small backbone elongation, implying that mechanosensing-proposed in vertebrate ...


Racial/Ethnic Disparities In Physical Function Before And After Total Knee Arthroplasty Among Women In The United States, Alyson M. Cavanaugh, Mitchell J. Rauh, Caroline A. Thompson, John Alcaraz, William M. Mihalko, Chloe E. Bird, Giselle Corbie-Smith, Milagros C. Rosal, Wenjun Li, Aladdin H. Shadyab, Todd Gilmer, Andrea Z. Lacroix May 2020

Racial/Ethnic Disparities In Physical Function Before And After Total Knee Arthroplasty Among Women In The United States, Alyson M. Cavanaugh, Mitchell J. Rauh, Caroline A. Thompson, John Alcaraz, William M. Mihalko, Chloe E. Bird, Giselle Corbie-Smith, Milagros C. Rosal, Wenjun Li, Aladdin H. Shadyab, Todd Gilmer, Andrea Z. Lacroix

Open Access Publications by UMMS Authors

Importance: Although racial/ethnic differences in functional outcomes after total knee arthroplasty (TKA) exist, whether such differences are associated with differences in presurgical physical function (PF) has not been thoroughly investigated.

Objective: To examine trajectories of PF by race/ethnicity before and after TKA among older women.

Design, Setting, and Participants: This cohort study was conducted among the prospective Women's Health Initiative with linked Medicare claims data. A total of 10325 community-dwelling women throughout the United States with Medicare fee-for-service underwent primary TKA between October 1, 1993, and December 31, 2014, and were followed up through March 31, 2017 ...


Giving Credence To The Experience Of X-Linked Hypophosphatemia In Adulthood: An Interprofessional Mixed-Methods Study, Melissa Hughes, Carolyn Macica, Catherine Meriano, Maya Doyle Apr 2020

Giving Credence To The Experience Of X-Linked Hypophosphatemia In Adulthood: An Interprofessional Mixed-Methods Study, Melissa Hughes, Carolyn Macica, Catherine Meriano, Maya Doyle

Journal of Patient-Centered Research and Reviews

Purpose: X-linked hypophosphatemia (XLH) is a rare X-linked dominant metabolic bone disease, often diagnosed in childhood but causing increasing physical debilitation and pain in adulthood. Physical comorbidities of XLH in adulthood include pervasive and early-onset degenerative arthritis, mineralizing enthesophytes and osteophytes, osteomalacia and pseudofracture, dental abscesses, and hearing loss.

Methods: This mixed-methods analysis included physical findings, diagnostic imaging, occupational and physical therapy assessments, and semi-structured interviews by social work to understand the functional outcomes and lived experience of XLH in adulthood, through connections between qualitative data obtained by social work and occupational therapy with the quantitative findings from other disciplines ...


A Comparison Of Power Variables For Two Loading Methods In Weighted Vertical Jumps, Jonathan Tanguay Apr 2020

A Comparison Of Power Variables For Two Loading Methods In Weighted Vertical Jumps, Jonathan Tanguay

Master's Theses

Training exercises to develop muscular strength and power, such as the weighted jump squat, commonly utilize barbells and dumbbells to increase resistance. Strength coaches often measure improvements in peak force, peak power, and rate of force development to determine effectiveness of a training program. The purpose of this study was to determine if equipment selection (barbells vs. dumbbells) affects peak force, peak power, and/or rate of force development in weighted jump squats. Thirteen physically active, college-aged males (age: 21.6 ± 2.0 years, height: 182.8 ± 9.7 cm, body mass: 87.2 ± 9.0 kg, lean mass: 72 ...


Perceived Effectiveness Of Stem Cell Injections In Adults With Joint Injuries, Delaney Marie Merrill Apr 2020

Perceived Effectiveness Of Stem Cell Injections In Adults With Joint Injuries, Delaney Marie Merrill

Senior Theses

Introduction: Osteoarthritis plagues around 27 million Americans. Stem cell injections are a new method of treatment that could potentially cure this by regenerating cartilage in joints. Purpose: The purpose of this study is to examine the perceived effectiveness of stem cells at regenerating cartilage in joints, specifically the knees, hips, and shoulders. Methods: Participants were recruited via social media, forums, and from healthcare clinics that offer stem cell treatments. They were asked to complete a survey focusing primarily on the treatment protocol and how the injured joint felt post-stem cell injection. Frequencies were calculated to describe problematic joints, treatment history ...


Role Of Atp1a1 In Skeletal Muscle Growth And Metabolism, Laura C. Kutz Jan 2020

Role Of Atp1a1 In Skeletal Muscle Growth And Metabolism, Laura C. Kutz

Theses, Dissertations and Capstones

Skeletal muscle comprises approximately 30% of total body mass, and loss of muscle mass and dysfunctional muscle metabolism are implicated in multiple disease states, including type 2 diabetes, heart failure, and septic shock. As such, understanding the mechanisms of skeletal muscle growth and atrophy, including pharmaceutical targets that may prove safe and effective, is therefore an important goal of current research on skeletal muscle physiology. One potential target in skeletal muscle development and function that has not been fully explored is the Na/KATPase (NKA), especially the α1 isoform. This isoform has a unique signaling function that has previously been ...


Systematic Literature Review Of Cognitive Behavioral Treatments For Patients With Classical, Secondary, And Idiopathic Trigeminal Neuralgia, Linnea B. Herzog Jan 2020

Systematic Literature Review Of Cognitive Behavioral Treatments For Patients With Classical, Secondary, And Idiopathic Trigeminal Neuralgia, Linnea B. Herzog

Honors Undergraduate Theses

Trigeminal neuralgia is a painful neuralgia with a complicated pathology that is not clearly understood. Due to the ambiguity of the condition, patients often have to search for medical providers that specialize in trigeminal neuralgia, and even with the guidance of a specialist, some patients do not respond well to treatment.1 Despite the uncertainty surrounding the specifics of the disease, there are treatments available that can provide some level of pain relief for patients suffering from this disorder. When a patient does not respond well to medical therapy, surgery can be the next appropriate step in patient care management ...


Artificial Reverse Shoulder Arthroplasty Joint Project, Michael Rosen, Bailei Hoyng Jan 2020

Artificial Reverse Shoulder Arthroplasty Joint Project, Michael Rosen, Bailei Hoyng

Williams Honors College, Honors Research Projects

This proposed project will be developing an artificial reverse shoulder arthroplasty joint that focuses on improvements to the Zimmer Biomet Comprehensive Reverse System by freating a unique feature, or features, to the humeral component that focuses on the prevention of dislocation by not limiting the range of motion of men from ages 45 to 65 years.

The development of the this project will utilize the Food and Drug Administration (FDA) medical device design process. This project will involve a total of four Biomedical Engineering students from the University of Akron. Two students, Michael and Bailei, are in the Honors college ...


Analyzing The Effects Of Opioids On Cortical Pore Networks In Rabbit Tibiae And Femora, Kassidy Wilson Jan 2020

Analyzing The Effects Of Opioids On Cortical Pore Networks In Rabbit Tibiae And Femora, Kassidy Wilson

Williams Honors College, Honors Research Projects

The following project was approved by the Institutional Animal Care and Use Committee (IACUC) (Protocol number #18-11-12 ARC). This study was completed as a subset of Dr. Andronowski's overarching lab project. Femora and tibiae were procured from New Zealand White rabbits to study the prolonged effects of opioid use in bone remodeling. This specific project analyzed the effects of opioids on the pore networks and the pore orientation.


Impact Of A Multimodal Exercise Program On Tibial Bone Health In Adolescents With Development Coordination Disorder: An Examination Of Feasibility And Potential Efficacy, Jocelyn L. Tan, Aris Siafarikas, Timo Rantalainen, Nicolas H. Hart, Fleur Mcintyre, Beth Hands, Paola Chivers Jan 2020

Impact Of A Multimodal Exercise Program On Tibial Bone Health In Adolescents With Development Coordination Disorder: An Examination Of Feasibility And Potential Efficacy, Jocelyn L. Tan, Aris Siafarikas, Timo Rantalainen, Nicolas H. Hart, Fleur Mcintyre, Beth Hands, Paola Chivers

ECU Publications Post 2013

© 2020, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved. Objectives: Developmental coordination disorder (DCD) compromises bone health purportedly due to lower levels of physical activity. The potential of an exercise intervention to improve bone health parameters in adolescents with DCD has not previously been studied. This study thus aimed to determine the impact of a multimodal exercise intervention on bone health in this population at-risk of secondary osteoporosis. Methods: Twenty-eight adolescents (17 male, 11 female) aged between 12-17 years (Mage =14.1) with DCD participated in a twice weekly, 13-week generalised multimodal exercise intervention. Peripheral quantitative computed tomography ...


Muscular And Physical Response To An Agility And Repeated Sprint Tests According To The Level Of Competition In Futsal Players, Jorge García-Unanue, José Luis Felipe, David Bishop, Enrique Colino, Esther Ubago-Guisado, Jorge López-Fernández, Enrique Hernando, Leonor Gallardo, Javier Sánchez-Sánchez Jan 2020

Muscular And Physical Response To An Agility And Repeated Sprint Tests According To The Level Of Competition In Futsal Players, Jorge García-Unanue, José Luis Felipe, David Bishop, Enrique Colino, Esther Ubago-Guisado, Jorge López-Fernández, Enrique Hernando, Leonor Gallardo, Javier Sánchez-Sánchez

ECU Publications Post 2013

© Copyright © 2020 García-Unanue, Felipe, Bishop, Colino, Ubago-Guisado, López-Fernández, Hernando, Gallardo and Sánchez-Sánchez. The aim of this study was to evaluate the neuromuscular response to an agility and repeated sprint ability (RSA) test according to the level of competition in futsal players. A total of 33 players from two elite teams and one amateur team participated in the study. The participants completed an agility t-test, a 30 m-speed test, and a RSA test. A countermovement jump (CMJ) test and a tensiomyography test of the rectus femoris (RF) and biceps femoris (BF) of both legs were carried out before and after the ...


Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer Jan 2020

Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer

Capstone Showcase

ABSTRACT

Introduction: Anterior Cruciate Ligament (ACL) injuries are an upsetting setback for many athletes that require a long and costly recovery process. The injury rates are four times greater in women than men. Preventative measures that help to prevent ACL injuries are limited to stretching and strengthening. Therefore, this review aims to investigate if oral contraceptive [I] usage provides a possible new avenue for prevention of ACL injury [O] in young female athletes (ages 18-30) [P] compared to those that do not take oral contraceptives [C].

Methods: A literature review was performed though PubMed, Google Scholar, SCOPUS Database, and ClinicalKey ...


An Analysis Of Abdominal Stability Following Hyperthermic Exercise In Euhydrated And Dehydrated Conditions, Carli Ceckanowicz Dec 2019

An Analysis Of Abdominal Stability Following Hyperthermic Exercise In Euhydrated And Dehydrated Conditions, Carli Ceckanowicz

Honors Scholar Theses

Core stability is essential for maintaining safety and optimizing performance during exercise and sport. The purpose of this study is to analyze how heat and hydration status (euhydrated USG<1.025 or dehydrated USG>1.025) can impair trunk stability in males and females (in both follicular and luteal phases) using the Trunk Stability Test (TST). Participants complete three blocks of 30 minutes of hyperthermic (35±1.299 oC and 49.418±5.0329% relative humidity) treadmill exercise. Exercise intensity is equivalent to 15 minutes at either 11W/kg or 7W/kg and the following 15 minutes at either 7W/kg or 4W/kg ...


Gait Speed And Mood, Cognition, And Quality Of Life In Older Adults With Atrial Fibrillation, Francesca Marino, Darleen M. Lessard, Jane S. Saczynski, David D. Mcmanus, Luke G. Silverman-Lloyd, Christopher M. Benson, Michael J. Blaha, Molly E. Waring Nov 2019

Gait Speed And Mood, Cognition, And Quality Of Life In Older Adults With Atrial Fibrillation, Francesca Marino, Darleen M. Lessard, Jane S. Saczynski, David D. Mcmanus, Luke G. Silverman-Lloyd, Christopher M. Benson, Michael J. Blaha, Molly E. Waring

Open Access Publications by UMMS Authors

Background: Low gait speed has been linked with impaired mood, cognition, and quality of life (QOL) in older adults. We examined whether low gait speed was associated with impaired mood, cognition, and QOL among older adults with atrial fibrillation (AF).

Methods and Results: Participants (n=1185) had a diagnosis of AF, aged > /=65 years, CHA2DS2VASc > /=2 and had no contraindications to anticoagulation. Participants completed a 15-foot walk test, and low gait speed was categorized using cutoffs from the Fried Frailty Index. Participants self-reported measures of depressive symptoms (Patient Health Questionnaire 9 > /=10), anxiety symptoms (Generalized Anxiety Disorder 7 > /=10), cognitive ...


Nutraceutical And Pharmaceutical Cocktails Did Not Improve Muscle Function Or Reduce Histological Damage In D2-Mdx Mice, Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer, John C. Quindry, Joshua T. Selsby Oct 2019

Nutraceutical And Pharmaceutical Cocktails Did Not Improve Muscle Function Or Reduce Histological Damage In D2-Mdx Mice, Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer, John C. Quindry, Joshua T. Selsby

Animal Science Publications

Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy. Lisinopril (Lis) protects skeletal muscle and improves cardiac function in dystrophin-deficient mice, therefore it was included in this study to evaluate the effects of lisinopril used with quercetin and NR. Our purpose was to determine the extent to which Q, NR ...