Open Access. Powered by Scholars. Published by Universities.®

Pathological Conditions, Signs and Symptoms Commons

Open Access. Powered by Scholars. Published by Universities.®

385 Full-Text Articles 1,450 Authors 73,086 Downloads 57 Institutions

All Articles in Pathological Conditions, Signs and Symptoms

Faceted Search

385 full-text articles. Page 4 of 18.

Stereotactic Body Radiation Therapy For Hepatocellular Carcinoma In Patients With Child-Pugh B Or C Cirrhosis, Peter L. Lee, Yunsheng Ma, Isabel Zacharias, Adel Bozorgzadeh, Sean Wilson, Kim Foley, Paul Rava, Mark Masciocchi, Linda Ding, Jacob R. Bledsoe, Thomas J. Fitzgerald, Shirin Sioshansi 2020 University of Massachusetts Medical School

Stereotactic Body Radiation Therapy For Hepatocellular Carcinoma In Patients With Child-Pugh B Or C Cirrhosis, Peter L. Lee, Yunsheng Ma, Isabel Zacharias, Adel Bozorgzadeh, Sean Wilson, Kim Foley, Paul Rava, Mark Masciocchi, Linda Ding, Jacob R. Bledsoe, Thomas J. Fitzgerald, Shirin Sioshansi

Radiology Publications

Purpose: Our purpose was to report outcomes in patients with Child-Pugh B or C (CP B/C) hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT).

Methods and Materials: Patients with HCC suitable for SBRT were prospectively enrolled in the study from 2012 to 2018. Outcomes in patients with CP B/C were analyzed. Cox proportional hazard models were used to compare survival outcomes between baseline CP score and post-SBRT CP score.

Results: Twenty-three patients with CP B/C with a total of 29 HCC tumors were treated with SBRT. Eighty-seven percent of patients were CP B8-C10. Median tumor ...


The Pathology Of Hepatic Cirrhosis: Analyzing Cytokine Signaling, Hepatocytes, And Collagen., Nicole Hamada 2020 Eastern Washington University

The Pathology Of Hepatic Cirrhosis: Analyzing Cytokine Signaling, Hepatocytes, And Collagen., Nicole Hamada

2020 Symposium Posters

Chronic cirrhosis takes the lives of approximately 41,000 individuals each year in the United States. This disease is a result of either chronic alcohol abuse, fatty liver, genetic disorders, and hepatitis. Liver disease leads to excessive fibro-genic scarring due to cytokine signaling, hepatocyte apoptosis, and replacement of collagen type III by collagen type I. The purpose of this study is to present a systematic review of the available evidence based on histological pathology slides and the literature surrounding Hepatic Cirrhosis. The research investigated is: to assess the role of the hepatocytes when a liver is cirrhotic, pathway of Hepatitis ...


Metastatic Spinal Cord Compression Mimicking Cauda Equina Syndrome Illustrating Importance Of Adequate Diagnostic Imaging, Jonathan L. Holt, Joseph Hill, Farzin Farhandnejad, Karyn Doddy, Se Won Lee 2020 HCA Healthcare

Metastatic Spinal Cord Compression Mimicking Cauda Equina Syndrome Illustrating Importance Of Adequate Diagnostic Imaging, Jonathan L. Holt, Joseph Hill, Farzin Farhandnejad, Karyn Doddy, Se Won Lee

Physical Medicine & Rehabilitation

See additional files.


Worsening Weakness After Posterior Cervical Decompression And Fusion; The Challenge In Diagnosis, Steven D. Kim, Joseph Hill, Farzin Farhandnejad, Karyn Doddy 2020 HCA Healthcare

Worsening Weakness After Posterior Cervical Decompression And Fusion; The Challenge In Diagnosis, Steven D. Kim, Joseph Hill, Farzin Farhandnejad, Karyn Doddy

Physical Medicine & Rehabilitation

See additional files.


Targeting Epigenetic Mechanisms To Alleviate Alcoholic Steatosis, Pranoti Mandrekar 2020 University of Massachusetts Medical School

Targeting Epigenetic Mechanisms To Alleviate Alcoholic Steatosis, Pranoti Mandrekar

Open Access Publications by UMMS Authors

Alcohol-related liver disease (ALD) is a major health concern and recent studies have reported nearly 1 million alcohol-related deaths from 1999 to 2017 in the United States.1 ALD is a spectrum of conditions that ranges from early steatosis or fatty liver to inflammation or alcoholic steatohepatitis progressing to fibrosis and cirrhosis. Approximately 8%–20% of alcoholic steatohepatitis patients develop cirrhosis and, in some, alcoholic steatohepatitis can present in the form of acute-on-chronic liver failure, termed alcoholic hepatitis, owing to excessive drinking episodes. Corticosteroids are the first line of therapy for ALD, however, only marginal short-term survival benefit in patients ...


Neonatal-Derived Il-17 Producing Dermal Gammadelta T Cells Are Required To Prevent Spontaneous Atopic Dermatitis, Nicholas A. Spidale, Nidhi Malhotra, Michela Frascoli, Katelyn E. Sylvia, Bing Miu, Coral Freeman, Brian D. Stadinski, Eric Huseby, Joonso Kang 2020 University of Massachusetts Medical School

Neonatal-Derived Il-17 Producing Dermal Gammadelta T Cells Are Required To Prevent Spontaneous Atopic Dermatitis, Nicholas A. Spidale, Nidhi Malhotra, Michela Frascoli, Katelyn E. Sylvia, Bing Miu, Coral Freeman, Brian D. Stadinski, Eric Huseby, Joonso Kang

Open Access Publications by UMMS Authors

Atopic Dermatitis (AD) is a T cell-mediated chronic skin disease and is associated with altered skin barrier integrity. Infants with mutations in genes involved in tissue barrier fitness are predisposed towards inflammatory diseases, but most do not develop or sustain the diseases, suggesting that there exist regulatory immune mechanisms to prevent aberrant inflammation. The absence of one single murine dermal cell type, the innate neonatal-derived IL-17 producing gammadelta T (Tgammadelta17) cells, from birth resulted in spontaneous, highly penetrant AD with many of the major hallmarks of human AD. In Tgammadelta17 cell-deficient mice, basal keratinocyte transcriptome was altered months in advance ...


Spinal Cord Ischemia Following Endovascular Repair Of Infrarenal Abdominal Aortic Aneurysm: A Rare Complication, Abdelrahman Attili MD, Alberto Gonzalez 2020 HCA healthcare

Spinal Cord Ischemia Following Endovascular Repair Of Infrarenal Abdominal Aortic Aneurysm: A Rare Complication, Abdelrahman Attili Md, Alberto Gonzalez

General Surgery

Introduction:

Paralysis secondary to spinal cord ischemia following Endovascular repair of infrarenal abdominal aortic aneurysm is extremely rare complication, the reported incidence in the literature is 0.21%.

Case report:

Our patient is an 85-year old female patient who presented to the emergency department with abdominal pain radiating to the back. Abdominal examination showed mild epigastric tenderness. Laboratory work up was within the normal limits, and she had Computed Tomography Angiography of the abdomen and pelvis which showed impending rupture of 5.8 cm abdominal aortic aneurysm. The anatomic configuration of the AAA fulfilled the requirements for EVAR.

The patient ...


Bradycardia In The Setting Of Gastric Sarcoidosis, Kameron Black MPH, Michelle Levine DO, Rage Geringer MD, Gregory Hicks MD, Oliwier Dziadkowiec 2020 HCA Healthcare

Bradycardia In The Setting Of Gastric Sarcoidosis, Kameron Black Mph, Michelle Levine Do, Rage Geringer Md, Gregory Hicks Md, Oliwier Dziadkowiec

Internal Medicine

No abstract provided.


How Deep Is Too Deep?, Dietrich Schlueter MD, Asma Jamil MD, Ibrahim Talab, Samia Faiz, Scott Kubomoto MD 2020 HCA Healthcare

How Deep Is Too Deep?, Dietrich Schlueter Md, Asma Jamil Md, Ibrahim Talab, Samia Faiz, Scott Kubomoto Md

Internal Medicine

No abstract provided.


Flexor Tenotomy For The Treatment Of Hallux Ulcers, Nathalia Esmeral, Val E. Haddon, Chase G. Dahl, Erin Lewis, David Khakshoor 2020 HCA Healthcare

Flexor Tenotomy For The Treatment Of Hallux Ulcers, Nathalia Esmeral, Val E. Haddon, Chase G. Dahl, Erin Lewis, David Khakshoor

Podiatry

Aims: To assess and evaluate the relationship between flexor tenotomies in a clinical setting and the time course for healing neuropathic, diabetic and structural deformity hallux ulcers.

Methods: This retrospective study analyzes the medical files of 1,471 patients treated for digital foot ulcers by flexor tenotomies between September 2011 and January 2019. For the intent of this particular research, focus was preserved towards the effect of flexor tenotomy on healing time to address hallux ulcers. A total of 97 patients between the ages of 41 and 86 years old underwent flexor tenotomy for the treatment of hallux ulcers with ...


Use Of Pefloxacin As A Surrogate Marker To Detect Ciprofloxacin Susceptibility In Salmonella Enterica Serotypes Typhi And Paratyphi A, Safia Moin, Mohammad Zeeshan, Sidra Laiq, Ahmed Raheem, Afia Zafar 2020 Aga Khan University

Use Of Pefloxacin As A Surrogate Marker To Detect Ciprofloxacin Susceptibility In Salmonella Enterica Serotypes Typhi And Paratyphi A, Safia Moin, Mohammad Zeeshan, Sidra Laiq, Ahmed Raheem, Afia Zafar

Department of Pathology and Laboratory Medicine

Objective: To determine the use of pefloxacin as a surrogate marker to detect fluoroquinolone (ciprofloxacin) susceptibility against Salmonella enterica serotypes Typhi and Paratyphi A.
Methods: The prospective, descriptive cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from September 2016 to March 2018, and comprised Salmonella Typhi and Paratyphi A isolates of blood cultures. Disk susceptibility tests and broth microdilution to test minimum inhibitory concentration were performed as per standard guidelines. Data was analysed using SPSS 21.
Results: Of the 138 isolates, 91(66%) were intermediate resistant to ciprofloxacin but were resistant to pefloxacin, 42(30%) were resistant ...


Assessing Morphology Of Iprgcs After Traumatic Brain Injury, Brian Foresi, Matt Smith 2020 The University of Akron

Assessing Morphology Of Iprgcs After Traumatic Brain Injury, Brian Foresi, Matt Smith

Williams Honors College, Honors Research Projects

ipRGCs are retinal ganglion cells that project to visual processing centers of the brain for nonimage forming visual functions. The relation of ipRGCs to tramatic brain injury (TBI) is emerging as data has been published describing ipRGC functional changes in TBI affected military veterans. Major symptomologies of concussions, a mild form of TBI, also overlap with the function governed by sites in the brain with major ipRGC projection percentages. Assesing if a morphological change is occuring in the ipRGCs after a TBI could support the idea of a pathological mechanism of the injury. This study could also indicate further relevance ...


The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine 2020 Virginia Commonwealth University

The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine

Theses and Dissertations

Patients with severe lung pathologies, such as Acute Respiratory Distress Syndrome (ARDS), often require mechanical ventilation as a clinical intervention; however, this procedure frequently exacerbates the original pulmonary issue and produces an exaggerated inflammatory response that potentially leads to sepsis, multisystem organ failure, and mortality. This acute lung injury (ALI) condition has been termed Ventilator-Induced Lung Injury (VILI). Alveolar overdistension, cyclic atelectasis, and biotrauma are the primary injury mechanisms in VILI that lead to the loss of alveolar barrier integrity and pulmonary inflammation. Stress and strains during mechanical ventilation are believed to initiate alveolar epithelial mechanotransduction signaling mechanisms that contribute ...


Retinal Changes Associated With Alzheimer's Disease, Brianna Stevens 2020 Iowa State University

Retinal Changes Associated With Alzheimer's Disease, Brianna Stevens

Creative Components

The retina has emerged as a potential biomarker for the diagnosis of Alzheimer's Disease because decreased retinal thickness is evident in patients with known AD. This presentation proposes a research study that includes participants over the age of 65, with or without a diagnosis of AD. Participants' retinas would be imaged with optical coherence tomography, a quick and non-invasive imaging modality that produces high-resolution 3D images.


The Importance Of Early Detection For Alzheimer's Disease, Mariah McKenzie 2020 Eastern Kentucky University

The Importance Of Early Detection For Alzheimer's Disease, Mariah Mckenzie

Kentucky Journal of Undergraduate Scholarship

More Americans are suffering from late diagnoses of Alzheimer’s disease (AD) in the U.S. each year. Therefore, there is a need for more access toward early detection of this disease to sustain optimal quality of life and treatments for individuals. AD is one of the leading causes of deaths and with the lack of funds for research, individuals diagnosed with AD is expected to continue to increase. Medicare, Medicaid, and National Institute of Health services are providing funds for the current issues; however, it is not enough. There are many forms of poor access to services for individuals ...


Physical Activity–Induced Neuroprotection In Parkinson’S Disease Is Mediated By Neurotrophic Factors, Hunter Twedt 2020 Iowa State University

Physical Activity–Induced Neuroprotection In Parkinson’S Disease Is Mediated By Neurotrophic Factors, Hunter Twedt

Creative Components

Parkinson’s disease (PD) is a progressive neurological movement disorder manifested by motor and non-motor disturbances that are brought about by degeneration of dopaminergic (DAergic) neurons in the substantia nigra (SN), causing a decline in dopamine (DA) levels in the striatum. Pharmacological and surgical treatment of PD are often ineffective, cause severe side effects, and the benefits seen decrease with disease progression; therefore, there is a need to seek new therapies. Physical activity (PA), which includes exercise, is able to improve many systems in the body, including motor and cognitive function, and may serve as a viable option for remedy ...


Chronic Recurrent Priapism: A High Flow State Secondary To An Arteriovenous Fistula Of The Corpus Cavernosum, Catherine M. Fiore, Melissa L. Pellegrino, Meghna C. Trivedi 2020 University of Massachusetts Medical School

Chronic Recurrent Priapism: A High Flow State Secondary To An Arteriovenous Fistula Of The Corpus Cavernosum, Catherine M. Fiore, Melissa L. Pellegrino, Meghna C. Trivedi

Open Access Publications by UMMS Authors

Priapism is clinically defined as an erect penis for more than 4h unrelated to sexual stimulation. There are two main types of priapism-high flow and low flow, based on the pathophysiology. In this case report we will mainly focus on high flow, non-ischemic priapism, which is the less common form. High flow priapism occurs secondary to congenital malformation or from the development of arteriovenous malformation from genital trauma. This case highlights the importance of differentiation and recognition of posttraumatic high flow priapism and unveils the role of selective internal pudendal artery angiography and embolization in its management.


The Efficacy Of Yoga As An Adjunctive Therapy To Standard Multidisciplinary Care In The Treatment Of Female Patients Presenting With Cognitive Eating Disorder Symptoms, Cassidy Nagle 2020 Arcadia University

The Efficacy Of Yoga As An Adjunctive Therapy To Standard Multidisciplinary Care In The Treatment Of Female Patients Presenting With Cognitive Eating Disorder Symptoms, Cassidy Nagle

Capstone Showcase

Introduction: Current treatment of patients exhibiting cognitive eating disorder symptoms is standard multidisciplinary care (SMDC) involving behavioral therapy, medical management and dietetics. Because these symptoms often persist or relapse despite treatment, research has begun to explore adjunctive therapies like yoga for this population. This review will explore seven studies in order to analyze the effect of yoga (I) on cognitive eating disorder symptoms (O) in teenage and adult females (P) when added to SMDC compared to symptom reduction with SMDC alone (C).

Methods: A literature search was conducted in PubMed, Academic Search Ultimate and Google Scholar starting November 2018. Seven ...


Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer 2020 Arcadia University

Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer

Capstone Showcase

ABSTRACT

Introduction: Anterior Cruciate Ligament (ACL) injuries are an upsetting setback for many athletes that require a long and costly recovery process. The injury rates are four times greater in women than men. Preventative measures that help to prevent ACL injuries are limited to stretching and strengthening. Therefore, this review aims to investigate if oral contraceptive [I] usage provides a possible new avenue for prevention of ACL injury [O] in young female athletes (ages 18-30) [P] compared to those that do not take oral contraceptives [C].

Methods: A literature review was performed though PubMed, Google Scholar, SCOPUS Database, and ClinicalKey ...


Effectiveness Of Integrative Medicine Group Visits In Chronic Pain And Depressive Symptoms: A Randomized Controlled Trial, Paula Gardiner, Man Luo, Salvatore D'Amico, Katherine Gergen-Barnett, Laura F. White, Robert Saper, Suzanne Mitchell, Jane M. Liebschutz 2019 University of Massachusetts Medical School

Effectiveness Of Integrative Medicine Group Visits In Chronic Pain And Depressive Symptoms: A Randomized Controlled Trial, Paula Gardiner, Man Luo, Salvatore D'Amico, Katherine Gergen-Barnett, Laura F. White, Robert Saper, Suzanne Mitchell, Jane M. Liebschutz

Open Access Publications by UMMS Authors

BACKGROUND: Current treatment options for chronic pain and depression are largely medication-based, which may cause adverse side effects. Integrative Medical Group Visits (IMGV) combines mindfulness techniques, evidence based integrative medicine, and medical group visits, and is a promising adjunct to medications, especially for diverse underserved patients who have limited access to non-pharmacological therapies.

OBJECTIVE: Determine the effectiveness of IMGV compared to a Primary Care Provider (PCP) visit in patients with chronic pain and depression.

DESIGN: 9-week single-blind randomized control trial with a 12-week maintenance phase (intervention-medical groups; control-primary care provider visit).

SETTING: Academic tertiary safety-net hospital and 2 affiliated federally-qualified ...


Digital Commons powered by bepress