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Pathological Conditions, Signs and Symptoms Commons

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Metachronous Eyelid Basal Cell Carcinoma On Opposite Eye And Lid: A Case Report, Danielle C. Kalberer OD, FAAO, Matthew A. DelMauro MD 2020 Northport Veterans Affairs Medical Center

Metachronous Eyelid Basal Cell Carcinoma On Opposite Eye And Lid: A Case Report, Danielle C. Kalberer Od, Faao, Matthew A. Delmauro Md

Optometric Clinical Practice

Background: Basal cell carcinoma (BCC) is the most common eyelid malignancy, accounting for approximately 90% of malignant eyelid lesions.1 Despite its high occurrence rates, it is frequently misdiagnosed as one of the benign “lumps and bumps” that can be present on the eyelid. In the present case, a patient with a past BCC on the right upper eyelid presented with a left lower eyelid lesion which persisted for months before the patient sought evaluation by an eyecare provider. This benign-looking lash-line lesion was the only external sign of the malignancy found on the deep surface of the eyelid and ...


Chronic Alcohol-Induced Neuroinflammation Involves Ccr2/5-Dependent Peripheral Macrophage Infiltration And Microglia Alterations, Patrick P. Lowe, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Abhishek Satishchandran, Istvan Furi, Yeonhee Cho, Benedek Gyongyosi, Donna Catalano, Eric Lefebvre, Laurent Fischer, Star Seyedkazemi, Dorothy P. Schafer, Gyongyi Szabo 2020 University of Massachusetts Medical School

Chronic Alcohol-Induced Neuroinflammation Involves Ccr2/5-Dependent Peripheral Macrophage Infiltration And Microglia Alterations, Patrick P. Lowe, Caroline Morel, Aditya Ambade, Arvin Iracheta-Vellve, Erica Kwiatkowski, Abhishek Satishchandran, Istvan Furi, Yeonhee Cho, Benedek Gyongyosi, Donna Catalano, Eric Lefebvre, Laurent Fischer, Star Seyedkazemi, Dorothy P. Schafer, Gyongyi Szabo

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of proinflammatory cytokines (including TNFalpha, IL-1beta, and CCL2) and microglial activation. We hypothesized chronic alcohol consumption results in peripheral immune cell infiltration to the CNS. Since chemotaxis through the CCL2-CCR2 signaling axis is critical for macrophage recruitment peripherally and centrally, we further hypothesized that blockade of CCL2 signaling using the dual CCR2/5 inhibitor cenicriviroc (CVC) would prevent alcohol-induced CNS infiltration of peripheral macrophages and alter the neuroinflammatory state in the brain after chronic alcohol consumption.

METHODS: C57BL ...


Tuberculosis Of The Flexor Carpi Radialis Muscle - A Case Report, Shah Fahad, Naveed Baloch, Nasir Ud Din 2020 Aga Khan University

Tuberculosis Of The Flexor Carpi Radialis Muscle - A Case Report, Shah Fahad, Naveed Baloch, Nasir Ud Din

Section of Orthopaedic Surgery

Tuberculosis involving almost any organ of the body is a major problem in developing countries. The most commonly affected site in tuberculosis is the lung. Of the extra pulmonary tuberculosis, musculoskeletal involvement accounts for 1-5% of the cases. Muscular involvement in tuberculosis is a rare manifestation of extra pulmonary tuberculosis. Unusual presentations often go undetected and are associated with a diagnostic and therapeutic delay. This case report presents tuberculosis of the flexor carpi radialis.


Sepsis Knowledge Among Adults Living In Tippecanoe County, Jessica Devine 2020 Purdue University

Sepsis Knowledge Among Adults Living In Tippecanoe County, Jessica Devine

The Journal of Purdue Undergraduate Research

No abstract provided.


Bilateral Basal Ganglia Hemorrhage In A Patient With Confirmed Covid-19, Rrita Daci, Megan Kennelly, Annie Ferris, Muhammad U. Azeem, Mark D. Johnson, Farid Hamzei-Sichani, Adalia H. Jun-O'Connell, Sabareesh K. Natarajan 2020 University of Massachusetts Medical School

Bilateral Basal Ganglia Hemorrhage In A Patient With Confirmed Covid-19, Rrita Daci, Megan Kennelly, Annie Ferris, Muhammad U. Azeem, Mark D. Johnson, Farid Hamzei-Sichani, Adalia H. Jun-O'Connell, Sabareesh K. Natarajan

COVID-19 Publications by UMMS Authors

Bilateral basal ganglia hemorrhage is exceedingly rare. To our knowledge, our patient is the first reported case of a confirmed coronavirus disease 2019 (COVID-19) patient who had bilateral basal ganglia hemorrhage. In the absence of other risk factors for bilateral deep cerebral involvement, we suspect that COVID-19 may be contributing to these rare pathologies. Most published data represent a correlation between COVID-19 and neurologic complications, and more research is still needed to prove causation.


A Case Of Solitary Kidney With Duplex Collecting Systems And Renal Vascular Variants In An Adult Male Cadaver, Mehdi S. Salimy, Gabrielle A. Luiselli, Megan Yuen, Rose C. Healy, S. G. Shah, Eustathia Lela Giannaris, Manas Das, Alexandra E. Wink 2020 University of Massachusetts Medical School

A Case Of Solitary Kidney With Duplex Collecting Systems And Renal Vascular Variants In An Adult Male Cadaver, Mehdi S. Salimy, Gabrielle A. Luiselli, Megan Yuen, Rose C. Healy, S. G. Shah, Eustathia Lela Giannaris, Manas Das, Alexandra E. Wink

Open Access Publications by UMMS Authors

We describe a unique solitary kidney with duplex collecting system and vascular variation observed in an 86-year-old White male formaldehyde- and phenol-fixed cadaver during routine academic dissection. The left renal fossa was empty with an intact adrenal gland, and the right renal fossa contained a fused renal mass with apparent polarity between the superior and inferior regions and two renal pelves converging into a single ureter. There were three right renal arteries supplying the renal mass; the superior and middle arteries were noted to be postcaval and the inferior artery was precaval. There were also two right renal veins draining ...


Disease Activity And Patient-Reported Outcomes In Patients With Rheumatoid Arthritis And Sjogren's Syndrome Enrolled In A Large Observational Us Registry, Leslie R. Harrold, Ying Shan, Sabrina Rebello, Neil Kramer, Sean E. Connolly, Evo Alemao, Sheila Kelly, Joel M. Kremer, Elliot D. Rosenstein 2020 University of Massachusetts Medical School

Disease Activity And Patient-Reported Outcomes In Patients With Rheumatoid Arthritis And Sjogren's Syndrome Enrolled In A Large Observational Us Registry, Leslie R. Harrold, Ying Shan, Sabrina Rebello, Neil Kramer, Sean E. Connolly, Evo Alemao, Sheila Kelly, Joel M. Kremer, Elliot D. Rosenstein

Open Access Publications by UMMS Authors

The objective of this study was to compare rheumatoid arthritis (RA) disease activity and patient-reported outcomes (PROs) in a national sample of patients with RA with/without Sjogren's syndrome (SS). Adults with RA from a large observational US registry (Corrona RA) with known SS status between 22 April 2010 and 31 July 2018 and a visit 12 (+/- 3) months after index date were identified (n = 36,256/52,757). SS status: determined from a yes/no variable reported at enrolment into the Corrona RA registry and follow-up visits. Index date: date that SS status was recorded (yes/no). Patients ...


Sarcoid-Like Reaction In A Patient Recovering From Coronavirus Disease 19 Pneumonia, Sara Behbahani, Julia Baltz, Rebecca Droms, April C. Deng, Shinya U. Amano, Nikki A. Levin, Mary Callery O'Brien, Karen Wiss 2020 Rutgers University - Newark

Sarcoid-Like Reaction In A Patient Recovering From Coronavirus Disease 19 Pneumonia, Sara Behbahani, Julia Baltz, Rebecca Droms, April C. Deng, Shinya U. Amano, Nikki A. Levin, Mary Callery O'Brien, Karen Wiss

COVID-19 Publications by UMMS Authors

As coronavirus disease 2019 (COVID-19) cases continue to increase, so do the reported extrapulmonary manifestations of this disease. To date, described dermatologic manifestations of COVID-19 include pernio-like acral nodules, dengue fever–like petechiae, vesiculobullous eruptions, pityriasis rosea and viral-like exanthems, retiform purpura, and livedo reticularis.1 We describe a patient with new-onset, biopsy confirmed sarcoid-like reaction in the setting of COVID-19 pneumonia and postulate a role for this immunologic reaction in hastening disease recovery.


Short-Term E-Cigarette Vapour Exposure Causes Vascular Oxidative Stress And Dysfunction: Evidence For A Close Connection To Brain Damage And A Key Role Of The Phagocytic Nadph Oxidase (Nox-2), Marin Kuntic, John F. Keaney Jr., Thomas Munzel 2020 University Medical Center, Mainz, Germany

Short-Term E-Cigarette Vapour Exposure Causes Vascular Oxidative Stress And Dysfunction: Evidence For A Close Connection To Brain Damage And A Key Role Of The Phagocytic Nadph Oxidase (Nox-2), Marin Kuntic, John F. Keaney Jr., Thomas Munzel

Open Access Publications by UMMS Authors

AIMS: Electronic (e)-cigarettes have been marketed as a 'healthy' alternative to traditional combustible cigarettes and as an effective method of smoking cessation. There are, however, a paucity of data to support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction and oxidative stress in the vasculature and the lungs. The mechanisms underlying these side effects remain unclear. Here, we investigated the effects of e-cigarette vapour on vascular function in smokers and experimental animals to determine the underlying mechanisms.

METHODS AND RESULTS: Acute e-cigarette smoking produced a marked impairment of endothelial function in chronic smokers determined by flow-mediated dilation ...


A Fatal Rectus Sheath Hematoma After A Myasthenia Crisis Case Report, Robert G. Michaud, Lesley B. Gordon 2020 Tufts University School of Medicine - Maine Track Program

A Fatal Rectus Sheath Hematoma After A Myasthenia Crisis Case Report, Robert G. Michaud, Lesley B. Gordon

Journal of Maine Medical Center

Introduction: Rectus sheath hematomas (RSH) generally occur due to damage to the inferior epigastric artery. They are rare causes of abdominal pain or acute blood loss anemia, but are an important diagnostic consideration because they can be cryptic and are potentially fatal.

Clinical Findings: An 85-year-old female who had been admitted to the hospital for 10 days with a myasthenia crisis was found to be abruptly hypotensive with a tender abdominal mass in the left lower quadrant subtly crossing midline. She was on prophylactic anticoagulation during her hospitalization.

Main diagnosis, therapeutics, interventions, and outcomes: The patient was initially stabilized with ...


Acute Kidney Injury, Mary Boadu 2020 Otterbein University

Acute Kidney Injury, Mary Boadu

Nursing Student Class Projects (Formerly MSN)

This poster presents up to date information regarding acute kidney injury (AKI) which often presents in patients in the intensive care unit (ICU). Most patients may not have identifiable symptoms therefore, advanced practice clinicians are charged with a great responsibility to diagnose, treat and follow-up with such patients. It is pertinent that clinicians recognize AKI early in an effort to prevent adverse consequences as seen in the progression of AKI to chronic kidney disease (CKD).


Effects Of Tobacco Cigarettes, E-Cigarettes, And Waterpipe Smoking On Endothelial Function And Clinical Outcomes, Thomas Munzel, Omar Hahad, Marin Kuntic, John F. Keaney Jr., John E. Deanfield, Andreas Daiber 2020 University Medical Center of the Johannes Gutenberg-University Mainz

Effects Of Tobacco Cigarettes, E-Cigarettes, And Waterpipe Smoking On Endothelial Function And Clinical Outcomes, Thomas Munzel, Omar Hahad, Marin Kuntic, John F. Keaney Jr., John E. Deanfield, Andreas Daiber

COVID-19 Publications by UMMS Authors

Tobacco smoking is a leading cause of non-communicable disease globally and is a major risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by the World Health Organizations (WHO) indicate that in the last two decades global tobacco use has significantly dropped, which was largely driven by decreased numbers of female smokers. Despite such advances, the use of e-cigarettes and waterpipes (shisha, hookah, narghile) is an emerging trend, especially among younger generations. There is growing body of evidence that e-cigarettes are not a harm-free alternative to tobacco cigarettes and there is considerable debate as to whether e-cigarettes ...


Altered Photoreceptor Metabolism In Mouse Causes Late Stage Age-Related Macular Degeneration-Like Pathologies, Shun-Yun Cheng, Joris Cipi, Shan Ma, Brian P. Hafler, Rahul N. Kanadia, Richard S. Brush, Martin-Paul Agbaga, Claudio Punzo 2020 University of Massachusetts Medical School

Altered Photoreceptor Metabolism In Mouse Causes Late Stage Age-Related Macular Degeneration-Like Pathologies, Shun-Yun Cheng, Joris Cipi, Shan Ma, Brian P. Hafler, Rahul N. Kanadia, Richard S. Brush, Martin-Paul Agbaga, Claudio Punzo

Open Access Publications by UMMS Authors

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. While the histopathology of the different disease stages is well characterized, the cause underlying the progression, from the early drusen stage to the advanced macular degeneration stage that leads to blindness, remains unknown. Here, we show that photoreceptors (PRs) of diseased individuals display increased expression of two key glycolytic genes, suggestive of a glucose shortage during disease. Mimicking aspects of this metabolic profile in PRs of wild-type mice by activation of the mammalian target of rapamycin complex 1 (mTORC1) caused early drusen-like pathologies, as well as advanced ...


Body Mass Index And Treatment Survival In Patients With Ra Starting Treatment With Tnfalpha-Inhibitors: Long-Term Follow-Up In The Real-Life Meteor Registry, Sytske Anne Bergstra, Cornelia F. Allaart, David Vega-Morales, Marieke De Buck, Elizabeth Murphy, Karen I. Salomon-Escoto, Tom W. J. Huizinga 2020 Leiden University Medical Center

Body Mass Index And Treatment Survival In Patients With Ra Starting Treatment With Tnfalpha-Inhibitors: Long-Term Follow-Up In The Real-Life Meteor Registry, Sytske Anne Bergstra, Cornelia F. Allaart, David Vega-Morales, Marieke De Buck, Elizabeth Murphy, Karen I. Salomon-Escoto, Tom W. J. Huizinga

Open Access Publications by UMMS Authors

OBJECTIVES: To study whether there is an association between body mass index (BMI) category and survival of various tumour necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients in a real-life longitudinal international registry.

METHODS: Data from 5230 patients with RA starting treatment with any TNFi were selected from the METEOR registry. Patients were divided into six BMI categories: 3.7% underweight, BMI < 18.5 kg/m(2); 46% normal weight, BMI 18.5-25 kg/m(2); 32% pre-obesity, BMI 25-30 kg/m(2); 13% obesity class I, BMI 30-35 kg/m(2); 3.4% obesity class II, BMI 35-40 kg/m(2); and 1.6% obesity class III, BMI > 40 kg/m(2). Time on treatment in the different BMI categories was compared for all TNFi combined and for the infliximab, adalimumab and etanercept separately, using Kaplan-Meier curves and Cox regression analyses. Cox regression analyses were ...


Isolated Polymorphic Ventricular Tachycardia: An Unusual Presentation Of Acute Myocarditis, Natalie S. Shwaish 2020 Children's Mercy Hospital

Isolated Polymorphic Ventricular Tachycardia: An Unusual Presentation Of Acute Myocarditis, Natalie S. Shwaish

Research Days

No abstract provided.


Unusual Echocardiographic Findings Of Myocarditis Mimicking An Aortic Run-Off Lesion, Sarah Studyvin, Barbara A. Pahud, Christine Symes 2020 Children’s Mercy Hospital

Unusual Echocardiographic Findings Of Myocarditis Mimicking An Aortic Run-Off Lesion, Sarah Studyvin, Barbara A. Pahud, Christine Symes

Research Days

No abstract provided.


A Rare Cause Of Pneumoperitoneum, Robert Zusman, George Michael, Anna E. Augustin, My Myers, Dudith Pierre-Victor 2020 HCA Healthcare

A Rare Cause Of Pneumoperitoneum, Robert Zusman, George Michael, Anna E. Augustin, My Myers, Dudith Pierre-Victor

West Florida Division Virtual Research Day

Pneumoperitoneum is most commonly associated with a perforated viscus. When free air is seen on imaging, the most common course of action is an emergent exploratory laparotomy. However, pneumoperitoneum may not always be indicative of a perforated bowel. In the case described below, we will discuss a patient who developed acute peritonitis and pneumoperitoneum after undergoing chest compressions during cardiopulmonary resuscitation (CPR) and positive pressure mechanical ventilation.


Diaphragmatic Paralysis: A Presentation Of Spontaneous Chest Pain And Shortness Of Breath, Donna Dorriz, Hilary Lois, Candace Wise, Brady Dehart 2020 HCA Healthcare

Diaphragmatic Paralysis: A Presentation Of Spontaneous Chest Pain And Shortness Of Breath, Donna Dorriz, Hilary Lois, Candace Wise, Brady Dehart

Capital Division Virtual Research Day 2020

Chest pain accounts for approximately 7.6 million annual visits to emergency departments (ED) in the United States and can include a broad differential1. The workup warranted includes extensive testing with the goal of demonstrating a reassuring cardiopulmonary status. When preliminary chest pain workup is negative, the subtle features of common primary symptoms can provide insight into other less common etiologies. This case looks to highlight the rare presentation of a relatively healthy middle age male with complaint of chest pain and shortness of breath, worsened with exertion and supine position. When standard cardiopulmonary workup was negative, further specialty testing ...


Giant Splenic Artery Pseudoaneurysm Rupture Presenting As Hemorrhagic Shock, Jaya Sanapati, Parth R. Desai, Locke W. Barber, Johnathan Frunzi, Timothy Lee 2020 HCA Healthcare

Giant Splenic Artery Pseudoaneurysm Rupture Presenting As Hemorrhagic Shock, Jaya Sanapati, Parth R. Desai, Locke W. Barber, Johnathan Frunzi, Timothy Lee

West Florida Division Virtual Research Day

A 56-year-old Asian male was brought to the emergency department by first responders after he developed severe, sudden-onset headache and chest pain at his home. Past medical history was insignificant. On arrival to the emergency department, the patient was in respiratory distress. Vital signs revealed temperature of 36.0°C, blood pressure of 71/44, heart rate of 90 beats per minute, respiratory rate of 18 breaths per minute, and oxygen saturation of 95% with delivery of oxygen at 2 liters per minute via nasal cannula. Examination of the abdomen revealed diffuse tenderness. Laboratory findings and arterial blood gas analysis ...


Pain Care In The Department Of Veterans Affairs: Understanding How A Cultural Shift In Pain Care Impacts Provider Decisions And Collaboration, Kristin M. Mattocks, Marc I. Rosen, John Sellinger, Tu Ngo, Brad Brummett, Diana M. Higgins, Thomas E. Reznik, Paul Holtzheimer, Alicia M. Semiatin, Todd Stapley, Steve Martino 2020 University of Massachusetts Medical School

Pain Care In The Department Of Veterans Affairs: Understanding How A Cultural Shift In Pain Care Impacts Provider Decisions And Collaboration, Kristin M. Mattocks, Marc I. Rosen, John Sellinger, Tu Ngo, Brad Brummett, Diana M. Higgins, Thomas E. Reznik, Paul Holtzheimer, Alicia M. Semiatin, Todd Stapley, Steve Martino

Open Access Publications by UMMS Authors

OBJECTIVE: Over the past decade, the Department of Veterans Affairs (VA) has experienced a sizeable shift in its approach to pain. The VA's 2009 Pain Management Directive introduced the Stepped Care Model, which emphasizes an interdisciplinary approach to pain management involving pain referrals and management from primary to specialty care providers. Additionally, the Opioid Safety Initiative and 2017 VA/Department of Defense (DoD) clinical guidelines on opioid prescribing set a new standard for reducing opioid use in the VA. These shifts in pain care have led to new pain management strategies that rely on multidisciplinary teams and nonpharmacologic pain ...


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