Diagnosis And Evaluation Of Peripheral Neuropathies,
2013
Lehigh Valley Health Network
Diagnosis And Evaluation Of Peripheral Neuropathies, Jay D. Varrato Do
Neurology Update for the Non-Neurologist
No abstract provided.
Diagnosis And Treatment Options For Multiple Sclerosis,
2013
Lehigh Valley Health Network
Diagnosis And Treatment Options For Multiple Sclerosis, Gary Clauser Md
Neurology Update for the Non-Neurologist
No abstract provided.
Current Standards For Treatment Of Stroke: Management Of Acute Ischemic Stroke,
2013
Lehigh Valley Health Network
Current Standards For Treatment Of Stroke: Management Of Acute Ischemic Stroke, John E. Castaldo Md
Neurology Update for the Non-Neurologist
No abstract provided.
Diagnosis, Evaluation And Treatments For Dementia,
2013
Lehigh Valley Health Network
Diagnosis, Evaluation And Treatments For Dementia, John W. Margraf Md
Neurology Update for the Non-Neurologist
No abstract provided.
Treatment Options For Seizures: Practical Points In Epilepsy Management,
2013
Lehigh Valley Health Network
Treatment Options For Seizures: Practical Points In Epilepsy Management, Soraya E. Jiménez Md
Neurology Update for the Non-Neurologist
No abstract provided.
Diagnosis, Assessment And Evaluation For Seizures,
2013
Lehigh Valley Health Network
Diagnosis, Assessment And Evaluation For Seizures, John W. Margraf Md
Neurology Update for the Non-Neurologist
No abstract provided.
Special Populations And Considerations In Migraine Therapy,
2013
Lehigh Valley Health Network
Special Populations And Considerations In Migraine Therapy, Gary Clauser Md
Neurology Update for the Non-Neurologist
No abstract provided.
Migraine Diagnosis And Treatment,
2013
Lehigh Valley Health Network
Migraine Diagnosis And Treatment, Vitaliy Koss Md
Neurology Update for the Non-Neurologist
No abstract provided.
Defining The Need For Specific Neurological Studies,
2013
Lehigh Valley Health Network
Defining The Need For Specific Neurological Studies, John E. Castaldo Md
Neurology Update for the Non-Neurologist
No abstract provided.
Pope Benedict Xvi’S Resignation: A Witness To Aging, A Signal For A New Bioethics,
2013
University of San Diego
Pope Benedict Xvi’S Resignation: A Witness To Aging, A Signal For A New Bioethics, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘No Marine Deserted On The Battlefield’: Two Surviving Spouses Join Forces To Speed The Defeat Of Huntington's Disease,
2013
University of San Diego
‘No Marine Deserted On The Battlefield’: Two Surviving Spouses Join Forces To Speed The Defeat Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
When I Walk,
2013
California State University, Fullerton
When I Walk, Jeanette Reedy Solano
Journal of Religion & Film
This is a film review of When I Walk (2013) directed by Jason DaSilva.
Junior Seau, Super Sunday, And Our Most Important Natural Resource,
2013
University of San Diego
Junior Seau, Super Sunday, And Our Most Important Natural Resource, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Huntington's Disease And The Perils Of Adoption,
2013
University of San Diego
Huntington's Disease And The Perils Of Adoption, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Can Healthy Transplanted Tissue Be Used To Restore Motor Function In Patients With Parkinson's Disease?,
2013
Touro College
Can Healthy Transplanted Tissue Be Used To Restore Motor Function In Patients With Parkinson's Disease?, Aliza Erlbaum
The Science Journal of the Lander College of Arts and Sciences
Parkinson’s Disease is a condition that disrupts the lives the many people. The disease is characterized by a loss of dopamine producing neurons in the pars compacta of the substantia nigra of the ventral midbrain, and symptoms include a lack of motor control and rigidity in motion. Currently, there are many treatments available to treat patients with Parkinson’s disease. However, each treatment involves many adverse side effects that most wish to avoid. Science is discovering possible innovative, alternative options to treat Parkinson’s disease such as the transplantation of healthy dopaminergic neurons directly into the striatum of the patient. Methods include …
Preclinical Development Of Phytocannabinoid- And Endocannabinoid- Based Pharmacotherapies For The Treatment Of Ethanol-Induced Neurodegeneration,
2013
University of Kentucky
Preclinical Development Of Phytocannabinoid- And Endocannabinoid- Based Pharmacotherapies For The Treatment Of Ethanol-Induced Neurodegeneration, Daniel J. Liput
Theses and Dissertations--Pharmacy
Excessive ethanol consumption, characteristic of alcohol use disorders (AUDs), is associated with widespread neurodegeneration and cognitive and behavioral impairments that may contribute to the chronic and relapsing nature of alcoholism. Therefore, identifying novel targets that can afford neuroprotection will undoubtedly aid current treatment strategies for AUDs. The cannabinoids have been shown to provide neuroprotection in a variety of preclinical models of neurodegeneration; however minimal data is available regarding the use of cannabinoid-based pharmacotherapies for treating ethanol-induced neurodegeneration. Therefore, the current dissertation examined the overarching hypothesis: the cannabinoids are a therapeutic strategy to afford neuroprotection in the context of ethanol-induced neurodegeneration. …
Investigating Therapeutic Options For Lafora Disease Using Structural Biology And Translational Methods,
2013
University of Kentucky
Investigating Therapeutic Options For Lafora Disease Using Structural Biology And Translational Methods, Amanda R. Sherwood
Theses and Dissertations--Molecular and Cellular Biochemistry
Lafora disease (LD) is a rare yet invariably fatal form of epilepsy characterized by progressive degeneration of the central nervous and motor systems and accumulation of insoluble glucans within cells. LD results from mutation of either the phosphatase laforin, an enzyme that dephosphorylates cellular glycogen, or the E3 ubiquitin ligase malin, the binding partner of laforin. Currently, there are no therapeutic options for LD, or reported methods by which the specific activity of glucan phosphatases such as laforin can be easily measured. To facilitate our translational studies, we developed an assay with which the glucan phosphatase activity of laforin as …
Aβ Alters The Dna Methylation Status Of Cell-Fate Genes In An Alzheimer’S Disease Model,
2013
Liberty University
Aβ Alters The Dna Methylation Status Of Cell-Fate Genes In An Alzheimer’S Disease Model, Gary D. Isaacs, Noor Taher, Courtney Mckenzie, Rebecca Garrett, Matthew Baker, Nena Fox
Faculty Publications and Presentations
Alzheimer’s disease (AD) is characterized by neurofibrillary tangles and extracellular amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding the role of Aβ in the pathogenesis of this neurodegenerative disease. While several studies have focused on the mutations associated with AD, our understanding of the epigenetic contributions to the disease remains less clear. To that end, we determined the changes in DNA methylation in differentiated human neurons with and without Aβ treatment. We isolated the DNA from neurons treated with Aβ or vehicle, and digested the two samples with either a methylation-sensitive (HpaII) or a methylation-insensitive (MspI) restriction endonuclease. …
Chlamydia Pneumoniae Infection Of Neuronal Cells Induces Changes In Calcium-Associated Gene Expression Consistent With Alzheimer’S Disease,
2013
Philadelphia College of Osteopathic Medicine
Chlamydia Pneumoniae Infection Of Neuronal Cells Induces Changes In Calcium-Associated Gene Expression Consistent With Alzheimer’S Disease, Christopher Andrew Cappellini, Ahmad B. Cader, Keith G. Williams, Juliana Zoga, Susan T. Hingley
Scholarly Posters
Background and Significance: Previous studies have shown that cells infected with Chlamydia pneumoniae (Cpn) exhibit altered gene expression consistent with that observed in Alzheimer’s disease (AD). Furthermore, AD neurodegeneration has been linked to dysregulation of intracellular calcium and calcium-related processes. Therefore, we hypothesize that one mechanism by which pathogenesis evolves in AD is through infection-induced changes in expression of calcium-related genes. Objectives: To determine if infection of neuronal cells with Cpn alters expression of calciumrelated genes associated with neurodegeneration. Methods: SK-N-MC neuronal cells were infected with Cpn (AR39 strain; MOI=1) for 3 to 72 hours, then calcium-related genes were screened …
Analysis Of Autophagy And Inflammasome Regulation In Neuronal Cells And Monocytes Infected With Chlamydia Pneumoniae: Implications For Alzheimer’S Disease,
2013
Philadelphia College of Osteopathic Medicine
Analysis Of Autophagy And Inflammasome Regulation In Neuronal Cells And Monocytes Infected With Chlamydia Pneumoniae: Implications For Alzheimer’S Disease, Brian J. Balin, Christine J. Hammond, Juliana Zoga, Ahmad B. Cader, Annette K. Slutter, Jonathan M. Anzman, Ian Kohler, Susan T. Hingley, Denah M. Appelt
Scholarly Posters
Objectives: Our laboratory has been studying the role of infection with the obligate intracellular bacterium Chlamydia pneumoniae in sporadic late-onset Alzheimer disease (LOAD). This infection may be a trigger for the pathology observed in LOAD as a function of initiating changes in gene regulation following entry of the organism into the brain. As such, we are analyzing how this infection can promote changes in autophagy and inflammasome gene regulation as both have been shown to be altered in LOAD. Methods: Human SKNMC neuronal cells and THP1 monocytes were infected in vitro for 24-72 hrs with a laboratory strain of Chlamydia …
