Nervous System Diseases Commons^™

The Affects Of Music Therapy On Management Of Pain And Anxiety During Burn Dressing Changes, Kush S. Patel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not music therapy improves pain management and anxiety during burn dressing changes.

STUDY DESIGN: Review of three English languages primary randomized controlled trial studies published from 1992-2010.

DATA SOURCES: Three randomized controlled trials studying the affects of music therapy during burn dressing changes were found using PubMed, OVID and Cochrane databases.

OUTCOMES MEASURED: Outcomes measured were level of pain and anxiety experienced by the patients. The severities of these symptoms were measured using a numeric scale system. An analyses of anxiety was measured …

Is Dexamethasone Epidural Injection Effective In Relieving Radicular Pain In An Adult Population?, Christine M. Unger

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not dexamethasone epidural injections are effective in treating radicular pain in an adult population.

STUDY DESIGN: Review of three randomized controlled trials, two of which were published in 2012 and one in 2010, all English language.

DATA SOURCES: Three randomized controlled trials comparing dexamethasone epidural injections to saline injections. All articles were found using PubMed, Medline, and OVID.

OUTCOMES MEASURED: Researchers measured pain associated with radicular pain using the Short McGill Pain Questionnaire, Numeric Pain Scale, and Oswestry Disability Index.

RESULTS: All …

Does Treatment With Amantadine Increase The Rate Of Improvement Of Cognitive Function In Patients Suffering From Traumatic Brain Injury?, Matthew Voit

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: To determine, “Does treatment with amantadine improve the rate of cognitive function in patients with Traumatic Brain Injury?”

STUDY DESIGN: Review of three English language randomized controlled trials from 1999-2012

DATA SOURCES: Three randomized, placebo-controlled, double blind cross-over trials comparing amantadine to placebo were found using Pub-Med and Cochrane Databases.

OUTCOMES MEASURED: The trials measured the effects of amantadine on command-following, object recognition, functional object use, intelligible verbalization, reliable yes-or-no communication, sustained attention, orientation, attention, memory, executive flexibility, and behavior and used the following assessment tools: Neurobehavioral Rating Scale and DRS (Disability Rating Scale).

RESULTS …

Is Melatonin An Effective Treatment For Sleep Problems In Autism?, Andrew J. Winkler

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not melatonin is an effective treatment for sleep problems in Autism.

STUDY DESIGN: Review of three English language, randomized controlled blinded trials published within peer-reviewed journals from 2006-2010 evaluating the efficacy of Melatonin as an oral sleep supplement in diagnosed autistic children.

DATA SOURCES: A double blind, randomized, placebo-controlled, crossover trial; a randomized controlled crossover trial; and a randomized controlled trial found using Cochrane, PubMed, and DynaMed.

OUTCOMES MEASURED: Total night’s sleep duration, number of awakenings, and sleep latency time were all measured …

Pilot Data On Brain-To-Blood Efflux Of B-Amyloid Peptides In Man, Steve Meaney, Maura Heverin, Ingemar Bjorkhem,, Dorotea Religa, John Wahren, Ulf Diczfalusy

Articles

• Alzheimer’s disease (AD) is the most common cause of dementia and affects nearly 40,000 individuals in Ireland. • The b-amyloid peptide (Ab) plays a key role in the pathogenesis of the AD and the presence of Ab plaques in the brain is diagnostic. •The hypothesis posits that Ab deposition is a critical factor in the disease process and that production and clearance of Ab are key drivers of the disease1. •Flux of Ab from the brain is believed to contribute to the overall level of Ab within in brain2 and antibody mediated brain-to-blood efflux has been observed in animal …

It’S Playoff Time – And A Reminder That Brain Health Comes First, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Creating A Christmas Memory For A Huntington’S Family, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

‘Alive And Well’ Captures Struggle Against Untreatable Brain Disorder, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The Cell And Molecular Biology Of Neurodegenerative Diseases: An Overview, Heather L. Montie, Thomas M. Durcan

PCOM Scholarly Works

There is no abstract for this article.

A Huntington’S Thanksgiving Message: Gratitude For Health And The Ability To Work, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Braving Bioethical Challenges: The Importance Of Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

One Year Out Of The Terrible, Lonely Huntington’S Disease Closet, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Diagnosis, Treatment And Follow-Up In Four Children With Biotinidase Deficiency From Pakistan, Bushra Afroze, Mohammad Wasay

Department of Medicine

Biotinidase deficiency is an inherited disorder in which the vitamin biotin is not recycled. If untreated, affected individuals develop neurological and cutaneous symptoms. Untreated individuals with biotinidase deficiency either succumb to disease or are left with significant morbidity. We describe clinical course and follow-up of 4 children from Pakistan. All 4 presented with classical symptoms of biotinidase deficiency and responded dramatically to oral biotin within days to weeks. Biotinidase deficiency is reported in Pakistani children from different part of world, however; there is no such report from Pakistan. This highlights lack of awareness of biotinidase deficiency among physicians in Pakistan

‘Tired Of Waiting,’ Huntington’S Disease Families Engrossed In Efforts To Conduct Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

The End Of Fear And Exclusion: Informing My Health Insurance Plan About The Risk Of Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Hope, Cutting-Edge Science, And Poignant Moments At The World Congress On Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Reaching Out To The ‘Hd Family’ At The World Congress On Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Heading To Rio For The 2013 World Congress On Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Advocacy Meets Science And Medicine: Personal Enrichment And A Coping Mechanism For Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

‘Predicting’ Huntington’S Disease In The Heartland, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.