Life Sciences Commons^™

The Official List Of The Birds Of Nebraska: 2024, Mark A. Brogie

Nebraska Bird Review

The duties of the Nebraska Ornithologists’ Union Records Committee (NOURC 2010) include:

A. The committee shall publish an official list of the birds of Nebraska.
B. The official list will include all those species whose occurrence has been reported in Nebraska (and approved by the NOURC).
C. The committee shall keep the official list current.
D. The committee shall publish a list of species for which details are requested with every sighting reported.

The 2024 NOURC has completed the above-described duties, and the following is a result of its endeavors.

The “Official List of the Birds of Nebraska” was last …

First Confirmed Nebraska Breeding Record Of The Common Raven (Corvus Corax) Since The 19th Century, Eugene A. Huryn, Jacob C. Cooper

Nebraska Bird Review

In Nebraska, the Common Raven was likely widespread prior to 1900, being codistributed with the American Bison (Bison bison). Records in this time are spotty, but consistent. Thomas Say reported a nearly fledged brood—the only confirmed breeding record in this period—at Fort Calhoun in Washington County on May 12, 1820. A Common Raven was collected at Fort Randall, on the Missouri River just north of the modern Nebraska–South Dakota border, in the fall of 1857 during the Lieutenant Warren Expeditions. Another specimen, now lost, was collected by J. B. Hasty in 1899 in Arapahoe, Furnas County. Bruner et …

Summer Field Report, June–July 2025, W. Ross Silcock

Nebraska Bird Review

I have mentioned previously the breeding categories that are available to observers in eBird checklists. This database is becoming more comprehensive and useful, and I encourage observers to use this eBird feature.

Usefulness of Merlin-derived checklists continues to be an issue. As an example, Merlin seems to love White-winged Doves; there were 52 undocumented Merlin reports of this species this summer, no doubt some correctly identified and acceptable if observers had taken a minute to add even minimal observation details to support Merlin’s identifications.

A vexing issue for me is determining the status of midsummer (i.e. between spring and fall …

Repurposing Atractylenolide Iii, A Natural Anti-Inflammatory Compound, For Alzheimer’S Disease, Angela M. Steele

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is a debilitating neurological condition ranked as the fifth leading cause of death in adults over the age of 65. Despite the severity, 98% of drugs have failed as treatments for AD. Current novel drug development approaches have been unable to produce a disease-modifying treatment as they often have a one-target approach, not accounting for the complex nature of the disease. One of the hallmarks of the disease, inflammation, may provide a better target for treatment because it interacts with multiple facets of the disease. Drug repurposing to identify compounds that mitigate inflammation in AD could provide …

Detecting Sonic Hedgehog Expression In The Adult Mouse Brain Using A Gene Expression Tracer, Kendra Stephens-Jones

Dissertations, Theses, and Capstone Projects

Sonic Hedgehog (Shh) is best known for its role in development, yet evidence supports Shh signaling plays a functional role in the adult brain. Previous work demonstrated that Shh is expressed by dopamine (DA) neurons in the ventral midbrain and that loss of Shh from these neurons leads to late-onset motor and structural abnormalities resembling Parkinson’s disease. However, the extent of Shh expression and its connectivity to the striatum in the adult mouse brain remain unclear due to the lack of reliable antibodies for Shh detection. To address this gap, the present study employed Shh ^L/L and DAT-Cre^+/- mice …

Dual Investigations Into Broiler Health: Mitochondrial Gene Expression In Ascites Susceptibility And G-1,25(Oh)₂D₃-Driven Modulation Of Bone And Gut Integrity In Lameness, Layla Hussein Al-Mitib

Graduate Theses and Dissertations

Modern broiler production faces persistent challenges from metabolic and skeletal disorders, particularly ascites and bacterial chondronecrosis with osteomyelitis (BCO), which compromise animal welfare and production efficiency. This dissertation examines two key factors that contribute to these conditions: mitochondrial gene expression associated with pulmonary hypertension syndrome (PHS) and the role of intestinal barrier integrity in mitigating lameness. In the first study, the expression of mitochondrial genes COXII and ATP6 was evaluated in the breast, thigh, and lung tissues of three broiler genetic lines—ascites-susceptible (SUS), ascites-resistant (RES), and unselected relaxed (REL). While no significant expression differences were observed in muscle tissues, SUS …

Fisheries Science Update - Pilbara Demersal Scalefish Resource - September 2025, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Science Updates

The Department of Primary Industries and Regional Development (DPIRD) monitors the status of Western Australia’s demersal scalefish resources by undertaking periodic stock assessments on key indicator species.

This summary provides key outcomes of the 2024 assessment of the Pilbara Demersal Scalefish Resource (Fisheries Research Report No. 338).

A Consensus Guide To Preclinical Indirect Calorimetry Experiments, Alexander S Banks, David B Allison, Thierry Alquier, Ansarullah, Steven N Austad, Johan Auwerx, Julio E Ayala, Joseph A Baur, Stefania Carobbio, Gary A Churchill, Morten Dall, Rafael De Cabo, Jose Donato, Nathalia R V Dragano, Carol F Elias, Anthony W Ferrante, Brian N Finck, Jose E Galgani, Zachary Gerhart-Hines, Laurie J Goodyear, Justin L Grobe, Rana K Gupta, Kirk M Habegger, Sean M Hartig, Andrea L Hevener, Steven B Heymsfield, Corey D Holman, Martin Hrabě De Angelis, David E James, Lawrence Kazak, Jae Bum Kim, Martin Klingenspor, Xingxing Kong, Sander Kooijman, Louise Lantier, K C Kent Lloyd, James C Lo, Irfan J Lodhi, Paul S Maclean, Owen P Mcguinness, Gema Medina-Gómez, Raghavendra G Mirmira, Christopher D Morrison, Gregory J Morton, Timo D Müller, Yoshihiro Ogawa, David Pajuelo-Reguera, Matthew J Potthoff, Nathan Qi, Marc L Reitman, Patrick C N Rensen, Jan Rozman, Jennifer M Rutkowsky, Kei Sakamoto, Philipp E Scherer, Gary J Schwartz, Radislav Sedlacek, Mohammed Selloum, Saame Raza Shaikh, Shuai Chen, Gerald I Shulman, Vojtěch Škop, Alexander A Soukas, John R Speakman, Bruce M Spiegelman, Gregory R Steinberg, Katrin J Svensson, John P Thyfault, Tony Tiganis, Paul M Titchenell, Nigel Turner, Licio A Velloso, Antonio Vidal-Puig, Christopher S Ward, Ashley S Williams, Christian Wolfrum, Allison W Xu, Ying Xu, Juleen R Zierath, International Indirect Calorimetry Consensus Committee (Iiccc)

Children’s Nutrition Research Center Staff Publications

Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure. Using measurements of respiratory gas exchange, indirect calorimetry can provide non-invasive estimates of whole-body energy expenditure. However, inconsistent measurement units and flawed data normalization methods have slowed progress in this field. This guide aims to establish consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results. By establishing community-driven standards, we hope to facilitate data comparison across research datasets. This advance will allow the creation of an in-depth, machine-readable data …

Resource Assessment Report No. 02: West Coast Demersal Scalefish Resource 2025 Assessment, Emily A. Fisher, David V. Fairclough, Elaine Lek, Jeremy Briggs, Sybrand Alex Hesp, Ainslie Denham

Resource Assessment Reports

The West Coast Demersal Scalefish Resource (WCDSR) comprises over 100 species inhabiting inshore (20-250 m deep) and offshore ( > 250 m deep) waters of the West Coast Bioregion (WCB; north of Kalbarri to east of Augusta). The WCDSR is primarily targeted by commercial, charter and recreational boat-based line fishers, including the commercial West Coast Demersal Scalefish (Interim) Managed Fishery (WCDSIMF). Indicator species selected for monitoring and assessing the status of the inshore suite of the WCDSR include Snapper, WA Dhufish and Baldchin Groper, while indicators for the offshore suite include Hapuku, Bass Groper and Blue-eye Trevalla.

The WCDSR is more …

Systematic Review And Evidence Gap Mapping Of Alzheimer's Disease Biomarker Studies In Those With Intellectual And Developmental Disability, Lubnaa B. Abdullah, Ney Alex Alliey, Emma Elizondo, Ney Alliey Rodriguez, Gladys Maestre, James Hall

School of Medicine Publications

There are a relatively small number of investigations into brain aging in those with intellectual and developmental disability (I/DD). This project seeks to (1) characterize the internationally available multi-omics Alzheimer's disease (AD) biomarker studies including those with I/DD, and (2) discuss future research directions. PubMed, Web of Science, and Scopus were searched under the following criteria: cross-sectional or longitudinal AD-omics studies on adults (18 +) with I/DD. 532 studies were identified, 186 studies were evaluated for full-text, 79 studies were excluded, and 117 studies were extracted. Most biological specimens were analyzed in blood, plasma, or serum. Metabolomics, hormonomics, and transcriptomics …

Precise Nutrition 2: Regression Equations Using Koh Protein Solubility To Estimate Digestible Lysine And Digestible Arginine In Commercial Lots Of Soybean Meal That Have Undergone Overprocessing Or Auto Combustion, Nelson Ruiz, Carl M. Parsons, Benjamin Parsons

Poultry Science Faculty Publications and Presentations

The objective of this study was to develop regression equations for lysine (Lys) and arginine (Arg) that would allow poultry nutritionists and formulators to estimate amino acid (AA) digestibility in commercial lots of solvent-extracted soybean meal (SBM) using a newly standardized protocol for KOH protein solubility (KOHPS). A total of 82 SBM samples, selected from 100 samples that were analyzed for in vivo AA digestibility, were analyzed for KOHPS. The KOHPS values ranged from 14 to 88 %, while digestible Lys coefficients ranged from 0.47 to 0.96. Digestible Arg coefficients ranged from 0.62 to 0.98. It became evident from total …

Dynamics And Controls Of Greenhouse Gas Emissions In Bioenergy Croplands, Lovish Kasrija

Tennessee State University Alumni Theses and Dissertations

Agriculture contributes considerably to global greenhouse gas (GHG) emissions, requiring sustainable methods for tackling climate change. This thesis includes two mega-analyses and one field experiment to investigate the impact of conservation tillage and soil amendments on crop productivity and greenhouse gas emissions. The first mega-analysis combined data from 30 meta-analyses to assess the impact of no-tillage (NT), reduced-tillage (RT), and combination NT+RT on crop yields and soil GHG emissions. NT decreased yields by 3.3% and increased N₂O emissions by 8.7%, but RT and NT+RT had no effect. The second mega-analysis found that both NT and RT considerably increased soil organic …

Effects Of Soil Profile Rebuilding Techniques On Soil Properties And Tree Growth, Diksha Tamang

Tennessee State University Alumni Theses and Dissertations

Urban land development usually results in compacted soils, creating unfavorable conditions for tree establishment and growth. Soil Profile Rebuilding (SPR) is an urban soil rehabilitation technique to address soil compaction on site. However, the impacts of SPR on urban soils and tree growth in the southeast region remain unexplored. To address this research gap, this study assessed the efficacy of the SPR techniques in improving degraded urban soils including soil physical, chemical, and biological properties, and tree growth. Twelve experimental plots (12.2 m L*0.5 m W; 5.6 m2) were established using a completely randomized experimental design (4 soil treatments; 3 …

Understanding Performance And Egg Quality Parameters In A Pastured Egg-Type Poultry Breed, Biswajit Kumar Biswas

Tennessee State University Alumni Theses and Dissertations

This study investigated the effects of rearing systems on performance, egg quality, and ileal amino acid (AA) digestibility in laying hens (65 weeks of age). A total of 66 hens were distributed into two rearing systems: Cage (2 birds/replication, total 12 birds in 6 replications) and pasture (9 birds/replication, total 54 birds in 6 replications), and reared on three levels of energy diet (11.50 MJ/kg, 12.50 MJ/kg, and 13 MJ/kg). The birds were reared from d 1 to 14 (diet 1), d 15 to 28 (diet 2), and d 29-42 (diet 3). The average temperature, wind speed, and humidity were …

Identification And Characterization Of Peptide Responsive Histone Modification Genes During Root Nodule Symbiosis In Medicago Truncatula, Shivani Dharam

Tennessee State University Alumni Theses and Dissertations

Nitrogen (N) is an essential but limiting macronutrient for crop growth in agroecosystems. Biological Nitrogen Fixation (BNF) is a critical biological process where atmospheric Nitrogen is converted into ammonia by Nitrogen fixing the bacteria called rhizobia, forming mutualistic relationships with legume plants. These interactions are mediated by several signaling pathways and may involve epigenetic modifications like DNA methylations, histone modifications, where gene expression is altered without any change in DNA sequence. Histones are proteins provide structural support to DNA. However, genes encoding enzymes for these post translational modifications are poorly investigated in the Leguminosae family. This project aims to answer …

Genetic Profiling Of Tennessee Johnsongrass And Pigweed Accessions Per Weedicide Resistance And Agronomic Traits, Gouse Mohiddin Shaik

Tennessee State University Alumni Theses and Dissertations

Herbicide-resistant weeds pose an escalating threat to crop productivity in Tennessee, leading to notable economic losses and complicated conventional weed control strategies. Among the most persistent species, Sorghum halepense (Johnsongrass) and various Amaranthus species (pigweeds) have exhibited remarkable adaptability and increasing resistance to widely used herbicides. Addressing this growing issue necessitates a thorough understanding the genetic and biochemical mechanisms that drive herbicide resistance. This study conducted an extensive genetic analysis of Pigweed and Johnsongrass samples collected from a broad range of counties across Tennessee, ensuring representation from both the northern and southern portions of the state’s Eastern, Central, and Western …

Heat Stress On Germinating Tomato Pollen And The Molecular Mechanisms For Heat Response Using Single Cell Type Proteomics, Dibya Thapa Magar

Tennessee State University Alumni Theses and Dissertations

The primary objective of this study is to develop the technical workflow for collecting homogenous germinating pollen samples. Two tomato varieties, Black Vernissage (BV) and Micro Tom (MT), were grown in temperature-controlled plastic greenhouses. For the non-heated control conditions, greenhouse temperature was set at 25C/21oC (16/8 hours; day/night). For the heat-treated greenhouse, temperature was set at 32/25 oC (16/8 hours; day/night). Supplemental light was provided using plant growth LED light. Ten freshly opened flowers were collected and pollen were released into 2ml pollen germination medium (PGM) in 5-ml centrifuge tubes. After centrifugation, pollen pellets were washed three times in 2 …

Cardiovascular And Aortic Wave Reflection Responses To Evening Binge Alcohol Consumption, Grant Thivierge, Ian Greenlund, Jeremy Bigalke, Carl Smoot, Jason R. Carter, John J. Durocher

Michigan Tech Publications

Evening binge alcohol consumption contributes to sleep disruption and autonomic dysregulation that persists into the following morning. However, its impact on morning-after arterial stiffness and aortic wave reflection remains unknown. Using a randomized, crossover, fluid-controlled design, we hypothesized that heart rate (HR), carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and aortic pulsatile load (APL) would be increased acutely after binge drinking at night (study 1) and the morning-after binge drinking (study 2). Participants (n=33, 18 females, 15 males, age 25±1 years, BMI: 27±1 kg/m) completed binge alcohol (4-5 drink equivalent) and fluid control protocols. Study 1 examined cardiovascular …

Wood-Water Relationship And Micro-Chemical Properties Of Huminated Archaeological European Elm (Ulmus Laevis P.), Amir Ghavidel, Shennan Wang, Miklós Bak, Lauri Rautkari, Reza Hosseinpourpia

Michigan Tech Publications

Archaeological wood requires effective conservation to prevent further degradation, and traditional modifications such as polyethylene glycol (PEG) have limitations, including hygroscopicity and chemical degradation over time. To explore alternative modification, this study was conducted to investigate the suitability of humins, crosslinked with different concentrations of succinic acid (SA), to protect archaeological elm wood from the Agapia Monastery against water and to determine the modification mechanism. Key parameters such as dimensional stability, moisture sorption isotherms, and determination of accessible hydroxy groups as a function of humination modification were analyzed using dynamic vapor sorption (DVS). The modification mechanism was studied by microstructural …

Exploring Boundaries With Food, Substances, And People In Substance Use Recovery: A Qualitative Analysis, Tiffany Champagne-Langabeer, Audrey Sarah Cohen, Kriti Shrestha, Jie Zhu, Audrey Lopez, Alisha Campbell, Christine Bakos-Block

Faculty, Staff and Student Publications

Background: In the United States, over 47 million youth and adults live with a substance use disorder (SUD). These individuals are frequently malnourished and have metabolic dysregulation as a result. Nutrition interventions incorporating a mindfulness-based approach help recovery efforts that are physical and mental.

Objective: The objective of this study was to explore and analyze the perspectives and experiences of individuals with SUD regarding emotional regulation and nutrition. The study used a mixed methods approach to generate insights for improving recovery support and developing future interventions.

Design: In 2024, an exploratory mixed methods study was conducted based on a large …

Durability Of Tannin-Citric Acid Modified Scots Pine Against Weathering And Fungal Exposures, Sheikh Ali Ahmed, Gianluca Tondi, Reza Hosseinpourpia

Michigan Tech Publications

Wood modification is essential to enhance the performance and longevity of wood as a material while maintaining its natural and sustainable characteristics. By modifying wood, its properties can be significantly improved without the need for toxic preservatives. Thus bio-based wood modification is vital for enhancing wood properties sustainably, reducing environmental impact, and meeting the demand for eco-friendly, non-toxic, and renewable material solutions. In this study, bio-based formulae were used on pine sapwood for enhanced decay and weathering resistance. Quebracho tannin solutions (20 %) with different concentrations of citric acid (CA) as a cross-linker were prepared and then vacuum-pressure impregnated in Scots …

Comprehensive Review Of In Vitro Approaches For Environmental Heavy Metal Exposure, Manas Warke, Madeline English, Camila Padilla, Lexie Gasco, Wendy Leisner, Rupali Datta, Smitha Rao

Michigan Tech Publications

Heavy metals are ubiquitous environmental pollutants, contaminating air, soil, and water via the erosion of natural deposits, as well as originating from anthropogenic sources, such as agriculture, industries, transportation, and landfills. The increasing utilization of heavy metals over the years, combined with the persistent nature of metals in the environment poses a direct threat to human and environment health. Although regulatory limits have been established for toxic metals, assessing the associated health risks using real-life exposure scenarios remains challenging. In this review, we summarize the development and use of in vitro models based two- and three-dimensional cell culture systems, focusing …

Whole Genome Sequence Analysis Of Low-Density Lipoprotein Cholesterol Across 246 K Individuals, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Eric Van Buren, Sara Haidermota, Darina Postupaka, Whitney Hornsby, Joshua C. Bis, Joanne Curran, John Blangero

Human Genetics Publications

Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larger sample sizes from diverse cohorts, thereby increasing the likelihood of discovering novel insights into complex traits. Furthermore, emerging methods in genome-wide rare variant association testing further improve power and interpretability.

Results: Here, we conduct the largest meta-analysis of whole genome sequencing for low-density lipoprotein cholesterol (LDL-C), a therapeutic target for coronary artery disease, analyzing data from 246 K participants and integrating 1.23B variants from the UK Biobank and the Trans-Omics …

Feed Prices, Substitution Patterns, And Technical Efficiency In Feedlot Cattle, Andrew E. Anderson, James L. Mitchell, Jamie R. Luke

Agricultural Economics and Agribusiness Faculty Publications and Presentations

The cattle feeding industry is sandwiched between relatively volatile commodity markets, and efficiency is critical. Changing prices for feedstuffs may cause substitution and output effects, in turn impacting technical efficiency. Using Kansas feedlot data, we estimate the effects of feed prices on cattle performance, focusing on the feed conversion ratio, average daily gain, and days on feed. Results show that several feed prices do indeed impact technical efficiency. These results have implications for management adapting to changing feed prices. Further, there are policy implications for programs that may impact commodity prices.

Procedures For Rangeland Condition Assessment In The Kimberley 2025, Department Of Primary Industries And Regional Development, Western Australia

Natural resources published reports

This report defines the procedures used in 2025 by DPIRD to complete rangeland condition assessment (RCA) in the Kimberley region which has grass-based pastures. For the rest of the pastoral estate, DPIRD uses the Procedures for RCA in the Pilbara and southern rangelands which have predominantly shrub pastures.

RCA is the process DPIRD uses to make systematic, station-level assessment of rangeland. Rangeland condition considers both the condition of pastures (as defined in the 'Pasture condition guide for the Kimberley') and soils as determined by erosion, using the erosion assessment method on pastoral lands in Western Australia. The methods have evolved …

Mucinous Cystic Neoplasms Of The Pancreas And Liver Share A Similar Dna Methylation Profile With Mucinous Ovarian Tumors, Zoe Leoni, Teodor G Calina, Tobias Janik, Elena Grafenhorst, Eliane T Taube, Christopher Cm Neumann, Baoqing Chen, Elena I Braicu, Jalid Sehouli, Thomas Malinka, Wenzel Schöning, Johann Pratschke, George A Calin, David S Klimstra, Jamal K Benhamida, Irene Esposito, Markus Möbs, David Horst, Simon Schallenberg, David Capper, Mihnea P Dragomir

Faculty, Staff and Student Publications

The origin of mucinous cystic neoplasms (MCNs) remains a major challenge in hepato-pancreato-biliary pathology. These cystic tumors are defined by their mucinous epithelium and ovarian-like stroma, with an estimated 10% risk of progression to invasive carcinoma. The origin of the ovarian-like stroma remains a subject of debate. In this study, we conducted immunohistochemical profiling, targeted DNA sequencing, and genome-wide DNA methylation analysis on a cohort of 15 pancreatic MCNs (MCN-P) and six hepatic MCNs (MCN-L). Using immunohistochemistry and targeted DNA sequencing, we unequivocally established the diagnosis of MCN. Unsupervised DNA methylation profile analysis of reference classes of pancreatic neoplasms (11 …

Rna-Binding Proteins Mediate The Maturation Of Chromatin Topology During Differentiation, Bondita Dehingia, Małgorzata Milewska-Puchała, Marcin Janowski, Mahmoud-Reza Rafiee, Misbah Abbas, Aleksandra Piotrowska, Jan Senge, Piotr Blaut, Dietrich Walsh, Jacqueline Severino, Debadeep Chaudhury, Sajjad Iqbal, Rogelio Montiel-Manriquez, Sylwia Jankowska, Peyman Zare, Wolfgang Huber, Jianliang Xu, Rafael Casellas, Timo Zimmermann, Paweł Dłotko, Jeroen Krijgsveld, Aleksandra Pękowska

Faculty, Staff and Student Publications

Topologically associating domains (TADs) and chromatin architectural loops impact promoter-enhancer interactions, with CCCTC-binding factor (CTCF) defining TAD borders and loop anchors. TAD boundaries and loops progressively strengthen upon embryonic stem (ES) cell differentiation, underscoring the importance of chromatin topology in ontogeny. However, the mechanisms driving this process remain unclear. Here we show a widespread increase in CTCF-RNA-binding protein (RBP) interactions upon ES to neural stem (NS) cell differentiation. While dispensable in ES cells, RBPs reinforce CTCF-anchored chromatin topology in NS cells. We identify Pantr1, a non-coding RNA, as a key facilitator of CTCF-RBP interactions, promoting chromatin maturation. Using acute CTCF …

Author Correction: Oncolytic Dnx-2401 Virotherapy Plus Pembrolizumab In Recurrent Glioblastoma: A Phase 1/2 Trial, Farshad Nassiri, Vikas Patil, Leeor S Yefet, Olivia Singh, Jeff Liu, Rachel M A Dang, Takafumi N Yamaguchi, Mariza Daras, Timothy F Cloughesy, Howard Colman, Priya U Kumthekar, Clark C Chen, Robert Aiken, Morris D Groves, Shirley S Ong, Rohan Ramakrishna, Michael A Vogelbaum, Simon Khagi, Thomas Kaley, Jason M Melear, David M Peereboom, Analiz Rodriguez, Maxim Yankelevich, Suresh G Nair, Vinay K Puduvalli, Kenneth Aldape, Andrew Gao, Álvaro López-Janeiro, Carlos E De Andrea, Marta M Alonso, Paul Boutros, Joan Robbins, Warren P Mason, Adam M Sonabend, Roger Stupp, Juan Fueyo, Candelaria Gomez-Manzano, Frederick F Lang, Gelareh Zadeh

Faculty, Staff and Student Publications

No abstract provided.

Designing An Electronic Patient-Reported Outcomes Information Infrastructure Supported By The Re-Aim Implementation Framework, Amy C Moreno, Angela Peek, Toshiko S Stein, Kevin R Shook, Sara M Ali, Laia Humbert-Vidan, Aileen Chen, Miriam Lango, Anna Lee, Michael Spiotto, William H Morrison, Adam S Garden, Jack Phan, Steven J Frank, Katherine Hutcheson, David I Rosenthal, Clifton D Fuller, G Brandon Gunn

Faculty, Staff and Student Publications

Objective: Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life and survival. However, the implementation of electronic PROs (ePROs) remains a challenge from technical and evaluation perspectives. Our objective was to construct a robust electronic health record (EHR)-integrated ePRO information infrastructure founded on RE-AIM (reach-effectiveness-adoption-implementation-maintenance) principles.

Materials and methods: We used Epic Systems as our EHR platform to build the MD Anderson Symptom Index Head and Neck Module (MDASI-HN) for release to all patients undergoing evaluation and/or treatment in our HN Radiation Oncology clinics. RE-AIM metrics were established …

The Antifungal Mechanism Of Entv-Derived Peptides Is Associated With A Reduction In Extracellular Vesicle Release, Giuseppe Buda De Cesare, Melissa R Cruz, Shane A Cristy, Luis A Vega, Robert Zarnowski, Antonino Zito, Shantanu Guha, David R Andes, Danielle A Garsin, Michael C Lorenz

Faculty, Staff and Student Publications

Candida albicans, an opportunistic fungal pathogen, causes systemic and superficial infections, especially in immunocompromised patients. Treatment of fungal infections is complicated by limited antifungal options and the development of drug resistance. Previous work from our group demonstrated the efficacy of the anti-virulence peptide EntV and shorter variants against C. albicans infection in various animal models, including mouse models of oropharyngeal candidiasis and disseminated infection and a rat venous catheter model. However, the mechanism of action, which abrogates fungal virulence without fungicidal or fungistatic activity, has remained unknown. We used a combination of cell biological, biochemical, genomic, and genetic approaches to …