Life Sciences Commons^™

Sequence And Phylogenetic Analysis Of Citrus Maxima (Burm.) Merr. From Tomini Bay, Sulawesi Island, Based On The Maturase K Gene, Brenda Febrina Zusriadi, Novri Youla Kandowangko, Febriyanti Febriyanti

Makara Journal of Science

This study was conducted in the coastal area of Tomini Bay, Sulawesi Island, and it focused on Citrus maxima, a plant known for its unique fruit flesh colors, which range from yellow to pink, and its varying leaf stalk wings. The study aimed to analyze the variations in maturase K (matK) sequences, molecular characteristics, and phylogenetic relationships of two C. maxima samples from Tomini Bay compared to other C. maxima and Citrus species using data available in GenBank. The study utilized DNA barcoding with matK molecular markers, followed by phylogenetic tree construction using the maximum likelihood method …

Detection Method For Escherichia Coli Using Real-Time Polymerase Chain Reaction Targeting The Yhav Gene, Muktiningsih Nurjayadi, Anisa Fitriyanti, Royna Rahma Musie, Gusti Angieta Putri, Puan Aqila Azizah, Helzi Angelina, Grace Grace, Ananda Indah Putri Sihombing, Agus Setiawan, Jefferson Lynford Declan, Gladys Indira Putri, Dandy Akbar Juliansyah, Siti Fatimah, Ayu Berkahingrum, Irma Ratna Kartika, Fera Kurniadewi, Vira Saamia, Shyi-Tien Chen, Bassam Aboemolak, Hesham Ali El Enshasy

Makara Journal of Science

Escherichia coli is a foodborne pathogenic bacterium that can cause diarrhea, while yhaV is a virulence-associated gene linked to the toxin–antitoxin system in E. coli. This study was aimed at evaluating the confirmation, specificity, and sensitivity of a yhaV gene primer using real-time polymerase chain reaction. The yhaV-targeting PCR successfully amplified a DNA fragment with an amplicon length of 207 bp (base pairs) under an annealing temperature optimized to a range of 54 °C to 62 °C via gradient PCR. The PCR using the primer pair produced a consistent Ct (cycle threshold) of 14.14 ± 0.05 and showed …

Employing Seca Recombinant Protein To Generate Polyclonal Antibodies For The Rapid Identification Of Phytoplasma, Arik Arubil Fatinah, Muhaimin Rifa'i, Estri Laras Arumingtyas, Sri Widyarti

Makara Journal of Science

Phytoplasma, a plant pathogen that threatens plant health, can induce diseases such as yellow wilt, virescence, phyllody, and witches’ broom. Although early detection methods using polyclonal and monoclonal antibodies have been developed, synthetic peptides offer advantages such as higher titers, predictable antigenic characteristics and superior sensitivity and specificity. Epitope mapping plays a key role in designing peptide antigens and includes gene synthesis, transformation, expression assessment, large-scale production, and purification. A study using New Zealand male White rabbits was conducted to generate antibodies against phytoplasma. The SecA (395–470) sequence, obtained from the preprotein translocase meets the criteria of being non-homologous, nonallergic, …

Gama Melon Parfum, A Potential Melon Genotype Tolerant Of Salinity Stress, Giri Nugroho, Tatik Chikmawati, Dian Sartika, Adib Fakhruddin Yusuf, Karso Suryo Putro, Vida Rahma Latifah, Budi Setiadi Daryono, Anjar Tri Wibowo, Awik Puji Dyah Nurhayati, Karlia Meitha, Miftahudin Miftahudin

Makara Journal of Science

Melona, Tacapa Gold, and Gama Melon Parfum are novel Melon genotypes that have been introduced for cultivation in the saline-prone coastal region of Bocor Beach, Kebumen, Central Jawa. Elevated salt concentrations in the area pose challenges, impacting yield. The potential of these new genotypes for saline land remains unexplored. This study aimed to assess the morphophysiological and molecular responses of these genotypes to salinity stress. Seeds were germinated in cocopeat and ABmix 3000 solution and treated with 220 mM NaCl until harvest. The analysis included morphology, chlorophyll content, proline accumulation, malondialdehyde levels, and gene expression were analyzed. After 1 week …

Effect Of Red And Blue Light On Lipid, Protein, Carbohydrate, And Pigment Contents Of Navicula Sp., Sofyan Maulana, Aulia Setyo Nurul Hida, Ismia Wulandari, Siti Mudrikah, Dedy Kurnianto, Khusnul Qonita Maghfiroh, Ria Amelia, Tia Erfianti, Renata Adaranyssa Egistha Putri, Irika Devi Anggraini, Septhian Marno, Eko Agus Agus Suyono

Makara Journal of Science

Light quality critically modulates the physiology of diatoms, influencing photosynthetic efficiency and metabolite synthesis. This study examines how monochromatic red (620–750 nm) or blue (450–495 nm) light affects the biochemical profiles and pigment production in Navicula sp. versus white light (control). Cultures were grown in sterile f/2 medium, and biomass was tracked via OD₆₈₀. Biochemical analyses included lipids (Bligh and Dyer method), carbohydrates (phenol-sulfuric acid assay), proteins (Bradford assay), and pigments (spectrophotometric quantification). The growth dynamics were modeled using logistic and Gompertz equations. No significant differences in OD-based growth rates, carbohydrates, proteins, or lipids content were observed with …

Tv Versus Video Games: Their Distinctive Effects On Adolescent Behavior And Academic Achievement, Faiaz Rahman, Kathy L. Schuh

Mid-Western Educational Researcher

The current paper uses data collected from a publicly available, nationally representative data set to examine the effects of TV viewing and video gaming on adolescent behavioral problems and cognitive achievement. Results revealed that extended hours of TV viewing were associated with greater anxiety/depression and antisocial problems. On the other hand, extended hours of video gaming were associated with higher reading comprehension scores. Differing effects of TV viewing and gameplay by an individual’s sex was also found during the analysis. It is also important to note that the opposite effects that the two media has on outcomes, indicate that, although …

Enhancing Science Learning Outcomes With Sitaya Miniature Media: A Quantitative Study Of Elementary Education, Gilang Kripsiyadi Praramdana, Hamdan Hamdan, Agus Gunawan, Fauziah Dwi Hijriani

Jurnal Pendidikan Sains

This study investigates the impact of SITAYA Miniature media on the learning outcomes of grade VI students in science subjects at SDN 2 Darma. Conventional teaching methods, often less engaging for students, were identified as a significant factor contributing to low academic performance. The study employed a quantitative research approach, with a randomized sample of 43 students divided into an experimental group (24 students) and a control group (19 students). Pretest and posttest data were collected using a structured test instrument, and statistical analyses, including normality, homogeneity, t-tests, and N-Gain tests, were conducted to assess the effectiveness of SITAYA Miniature …

Chacahoula 2025, Volume 92, Alayna Pellegrin

Chacahoula

The 2025 issue of Chacahoula includes December 2024 and May 2025 graduating classes, as well as stunning photography student life on the banks of Bayou Desiard. With features covering students, faculty, and staff, this year's time capsule preserves an academic year in the life of the University of Louisiana at Monroe.

Organic Glycinate Trace Minerals Improve Hatchability, Bone And Eggshell Breaking Strength, And Mineral Uptake During Late Laying Cycle In Layer Breeders, Mujtaba Akram Jahangir, Muhammad Muneeb, Muhammad Farooq Iqbal, Syeda Maryam Hussain, Syed Sohail Habib, Sohail Ahmad, Kasim Sakran Abass, Nasir Mukhtar, Rashed A. Alhotan, Ali R. Al Sulaiman, Ala E. Abudabos

Food and Animal Sciences Faculty Research

This study evaluated the effects of replacing inorganic trace minerals with organic glycinate forms at two inclusion levels in layer breeders during the late laying cycle over 6 weeks (66 to 72 weeks of age). For this, a total of 180 layer breeders (162 hens and 18 males; Lohmann LSL Ultralite) were randomly divided into three treatment groups having six replicates of nine hens each and one male for each replicate following a completely randomized design (CRD). The dietary treatments included: (1) Basal diet + inorganic trace minerals at breed recommended levels (ITM100), (2) Basal diet + organic trace minerals …

Where The Buffalo Roam: Ungulate Influences On Quaking Aspen And Willow Communities In The Greater Yellowstone Ecosystem, J. Boone Kauffman, Dian L. Cummings, Robert L. Beschta, William J. Ripple

Aspen Bibliography

Quaking aspen (Populus tremuloides) and willows (Salix spp.) are keystone species of montane and shrub-steppe landscapes of the Western United States. Intact communities dominated by these species provide a wide range of ecosystem services, harboring an exceptional proportion of landscape biodiversity. Land use, especially overgrazing by large ungulates, is among the greatest threats to these ecosystems. To examine the effects of wild ungulates and levels of grazing at Yellowstone National Park (YNP) and the adjacent Gallatin National Forest, we sampled plant community composition and vegetation structure of aspen and willow communities both inside and outside of exclosures. …

Inflammation And Detection: Rethinking The Biomarker Landscape In Gastric Cancer, Keykavous Parang, Koosha Paydary

Pharmacy Faculty Articles and Research

Gastric carcinoma is a leading cause of cancer-related mortality worldwide, yet reliable noninvasive biomarkers for its early detection remain limited. As research continues to elucidate the inflammatory underpinnings of tumor initiation and progression, it has become increasingly clear that pro-inflammatory cytokines may hold promise as diagnostic adjuncts. Serum cytokines such as interleukin (IL)-1β, IL-6, IL-8, and interferon-gamma have been frequently reported as elevated in gastric cancer patients compared to healthy individuals. These molecules, known for their roles in modulating tumor-promoting inflammation, angiogenesis, and immune evasion, may serve as accessible indicators of disease presence or progression. Several studies have shown that …

Evaluation Of Robotic Swabbing And Fluorescent Sensing To Monitor The Hygiene Of Food Contact Surfaces, Siavash Mahmoudi, Clark Griscom, Pouya Sohrabipour, Yang Tian, Chaitanya Palleria, Philip G. Crandall, Dongyi Wang

Biological and Agricultural Engineering Faculty Publications and Presentations

Effective environmental monitoring is critical for preventing microbial and allergenic cross-contamination. However, manual swabbing methods, commonly used to verify hygienic conditions, are prone to inconsistent results because of variability in pressure, coverage, and techniques. Two novel solutions will be explored to address these challenges: a robotic swabbing system with tactile sensing control, and a fluorescence/absorbance spectrometer for non-contact, protein-based residue detection. The robotic system was evaluated against trained and untrained humans, measuring water pickup, surface coverage, and pressure consistency. Concurrently, the fluorescence system analyzed model poultry protein soil to correlate spectral patterns with contamination levels. The robotic system demonstrated statistically …

Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M. P. Shade, Daniel Dicorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, John Blangero, Joanne E. Curran

School of Medicine Publications

To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associations of these genetic scores with neurological outcomes in >17k participants (36% men, mean age 55 yrs) from the Trans-Omics for Precision Medicine (TOPMed) program (50% Non-Hispanic White, 23% Black/African American, 21% Hispanic/Latino American, and 4% Asian American). We report significant negative associations (P <  0.002) of the cross-population (P = 1.3 × 10-5) and European (PEA = 3.0 × 10-8) fasting insulin PSs with total cranial volume, and of a metabolic syndrome European PS with general cognitive function (BEA = -0.13, PEA = 0.0002) and lateral ventricular volume (BEA = 0.09, PEA = 0.002). We identify suggestive negative associations (P <  0.007) of metabolic syndrome and obesity pPSs with general cognitive function, and of lipodystrophy pPSs with total cranial volume. A higher genetic predisposition to IR is associated with lower brain size, and a genetic predisposition to specific IR-related type 2 diabetes subtypes, such as metabolic syndrome and mechanisms of IR mediated through obesity and lipodystrophy, is potentially involved in cognitive decline.

Dental Microwear And Diets Of Late Miocene Primates From Rudabánya, Hungary, Peter S. Ungar, Anna K. Wilcox, David R. Begun

School of Dentistry Faculty Publications

Objectives: This study focuses on a dental microwear texture analysis of European pliopithecids and dryopithecins from the Miocene primate site of Rudabánya, Hungary. The goal is to determine whether these taxa, found in part together in the same deposits, differed in their food preferences, or at least consumed, on a daily basis, in a manner that might have facilitated sympatry. Materials and Methods: Here we report on a molar surface texture analysis of all available fossil primates from Rudabánya that preserve antemortem microwear. This includes both Anapithecus hernyaki (n = 14) and Rudapithecus hungaricus (n = 5, including one from …

Recovery Of Salmonella And Listeria Monocytogenes From Nonporous Surfaces Based On Surface Sampler Type, Zeynal Topalcengiz, Sahaana Chandran, Francis Torko, Kristen E. Gibson

Food Science Faculty Publications and Presentations

Surface sampling devices ranging in material composition and size can be used in environmental monitoring programs. This study aimed to compare the bacterial recovery efficiency of surface samplers on stainless steel (SS) and polypropylene (PP) surfaces. Separate cocktails of Listeria monocytogenes and Salmonella enterica strains were spot inoculated (1 mL; 40 spots x 25 mu L) on SS and PP surfaces at high (7 log) and low (4 log) concentrations. A cellulose sponge sampler, polyurethane foam sponge sampler, and polyolefin nonwoven fabric sampler were utilized for bacteria recovery from SS and PP surfaces at two surface areas: 1x [929 cm2 …

Poziotinib For Egfr Exon 20-Insertion Nsclc: Clinical Efficacy Of The Phase 2 Zenith Trial And Differential Impact Of Egfr Exon 20 Insertion Location On Sensitivity, Xiuning Le, Jacqulyne P Robichaux, Monique Nilsson, R S K Vijayan, Ashwin Ravichandran, Jia Wu, Yasir Y Elamin, Lingzhi Hong, Jun Pei, Jun He, Sonia Patel, Hibiki Udagawa, Sriramvignesh Mani, Chang Woon Jang, Jeffrey M Clarke, Nishan Tchekmedyian, Jonathan W Goldman, Mark Socinski, Gajanan Bhat, Sharon Leu, Veronica Bunn, Zhenqiang Su, Sylvie Vincent, John W Lawson, Jason B Cross, John V Heymach

Faculty, Staff and Student Publications

EGFRex20 insertions (EGFRex20ins) can be classified as near- and far-loop based on the insertion location, however, the impact of location on responses to various EGFR tyrosine kinase inhibitors (TKIs) is poorly understood. In vitro studies show that afatinib, poziotinib, and zipalertinib more potently inhibited near-loop than far-loop insertions, whereas mobocertinib has similar IC50 in both groups. Molecular dynamics simulations reveal that near-loop insertions have multiple conformational states and lower transitional energy than far-loop insertions. ZENITH20 trial cohort 1 (NCT03318939) evaluates poziotinib in EGFRex20 NSCLC patients (n = 115) and demonstrates an objective response rate of 14.8% (95% Confidence …

An Updated Checklist Of The Mammals Of Türkiye, Mustafa Sözen, Faruk Çolak

Turkish Journal of Zoology

Between 1982 and 2025, the number of extant wild mammal species worldwide rose from 4170 to 6706. The Turkish mammal fauna also showed a similar trend, with the number of mammal species listed for Türkiye rising from 89 to 173 in just 33 years, from 1989 to 2021. A shift in species numbers like this calls for regular updates to Türkiye’s mammal species lists as well as the preparation of new checklists. Apart from changes in the number of species, numerous taxonomic changes and rearrangements also lead to changes in mammal lists. We arranged an updated mammal checklist by reviewing …

Nontarget Effects Of Abamectin On Cysts And Three Larval Stages Of Marine Microcrustacean Artemia Franciscana, Hashem Khandan Barani, Sahel Pakzad Toochaei, Narjes Sanchooli

Turkish Journal of Zoology

Abamectin (ABM) is a widely used pesticide in agriculture and aquaculture worldwide. However, limited information is available on the toxic impacts of ABM on nontarget marine organisms, necessitating further research to investigate the toxic impacts of ABM on marine life. Hence, this study examined the acute (0.5–2.5 μg/L for 24 and 48 h) and chronic (0.125–0.5 μg/L for 7 days) toxicity of ABM on the marine microcrustacean Artemia franciscana under different incubation conditions and at different stages of development. To simulate a more realistic environmental scenario, some of the exposure tests were conducted in the presence of food or with …

Environmental Controls On Planktonic Community Variability And Ecosystem Responses In The Romanian Black Sea, Cristina Tabarcea, Elena Bișinicu, George-Emanuel Harcotă, Aurelia Țoțoiu, Oana Vlas, Elena Pantea, Luminita Lazar

Turkish Journal of Zoology

This study examines the structure, distribution, and environmental influences on planktonic communities in the Romanian Black Sea, based on data collected from Black Sea national monitoring stations in June 2023. We assessed the qualitative and quantitative composition of phytoplankton, microzooplankton, mesozooplankton, macrozooplankton, and ichthyoplankton, alongside key environmental factors such as temperature, salinity, dissolved oxygen, and nutrient concentrations (nitrite, nitrate, ammonium, phosphate, and silicate). The results highlight the dominance of dinoflagellates within the phytoplankton community, while copepods constitute the most abundant mesozooplankton group. Species from the Codonellidae family mainly represent microzooplankton diversity, while macrozooplankton is largely dominated by the scyphozoan Aurelia …

A Comparison Between Phalangeal Skeletochronology And Cephalic Parietal Rings In Lizards, Marco A.L. Zuffi, Roberto Sacchi, Marcello Mezzasalma, Maria José Amaral, Miguel Angel Carretero, Fabio Maria Guarino

Turkish Journal of Zoology

The well-defined, layered organization of the cephalic scales in many lacertilians could offer a noninvasive alternative for estimating the individual age of these vertebrates. This study aimed to validate the method of age determination based upon the cephalic scale rings in the genus Podarcis, comparing it to phalangeal skeletochronology, a widely used and highly reliable indirect method for estimating the age of ectotherm vertebrates. We analyzed individuals of P. bocagei (n = 48), P. muralis (n = 16) and P. siculus (n = 8). For each individual, we compared the number of cephalic layers with the number of lines of …

Cytotoxic And Genotoxic Effects Of Minor Temperature Changes And Zinc Oxide Nanoparticles Synthesized Using Plantago Major On Oncorhynchus Mykiss Gonadal Cells, Semra Çi̇çek, Sevda Işik

Turkish Journal of Zoology

Temperature changes and nanoparticle exposure have emerged as critical environmental stressors with potential cytotoxic and genotoxic effects on aquatic species. This study investigates the impact of zinc oxide nanoparticles (ZnO NPs), synthesized using Plantago major leaves, on Oncorhynchus mykiss gonadal (RTG-2) cells under different temperature conditions (23 °C, 24 °C, and 25 °C). RTG-2 cells were exposed to hexagonal ZnO NPs (≤100 nm) at concentrations of 6.25, 12.5, 25, 50, 75, and 100 μg/mL for 24 and 48 h. Cytotoxicity was assessed using the sulforhodamine B assay, and genotoxicity was evaluated via the comet assay. Results demonstrated that both temperature …

Swollen Lymph Node Metastasis In Gastric Cancer: A Forgotten Prognostic Signal In Need Of Clinical Action, Keykavous Parang, Amir Nasrolahi Shirazi

Pharmacy Faculty Articles and Research

Gastric cancer (GC) remains a leading cause of cancer mortality. While the extent of nodal involvement is a well-known prognostic factor, the specific entity of swollen lymph node metastasis (SLNM), bulky nodal tumor deposits detectable radiologically or pathologically, has received little attention in staging. Recent data from a study by Cui et al demonstrated that SLNM is an independent predictor of very poor survival in GC. Through robust data and rigorous propensity-matched analyses, SLNM emerged not merely as an anatomical finding but as an independent predictor of poor prognosis, even among patients undergoing curative resection. As precision oncology advances, the …

Green Synthesis Of Copper And Silver Nanostructured Particles From Eremurus Plant Extract And Comparison Of Their Optical Properties And Antibacterial Activities, Doaa Ayad Kamil, Ali F. Al-Rawaf, Mohammed Yarub Hani, H.H. Obeed, Tabarek Falah Deindee, Mohammed Ridha Shaeed

Karbala International Journal of Modern Science

In the present investigation, silver (Ag) and copper (Cu) nanostructured particles were synthesized from Eremurus plant by means of an environmentally benign methodology in which plant extracts served as both reducing and stabilizing agents. The resultant nanostructured particles were subjected to characterization techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy (FESEM), and energy-dispersive X-ray spectroscopy (EDXS). XRD analysis confirmed development of Ag nanostructured particles with face-centered cubic (fcc) structure and also Cu nanostructured particles with cubic form. Moreover, the average crystallite dimensions obtained for Ag and Cu were 18.3 nm and 65.7 nm, …

Fabrication And Characterization Of Epoxy Resin Co-Doped With 2,5-Diphenyloxazole And Cerium Fluoride Nanoparticles For Radiation Detection, Akapong Phunpueok, Jaruwan Seangrit, Sarawut Jaiyen, Krittiya Sreebunpeng, Wuttichai Chaiphaksa, Kewalee Nilgumhang, Voranuch Thongpool

Karbala International Journal of Modern Science

This paper presents the fabrication and characterization of a plastic scintillator prepared from epoxy resin doped with 2,5-diphenyloxazole (PPO) and cerium fluoride nanoparticles (CeF₃ NPs) for radiation detection. The CeF₃ NPs were prepared by a chemical process and examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM); it was found that the prepared particles were true CeF₃ NPs with an average particle size of approximately 17 nm. The CeF₃ NPs were co-doped with PPO into epoxy resin and formed into a plastic scintillator of 3 cm in diameter and 2 cm in length. Analysis of …

Fish Oil And Vernonia Amygdalina Leaves-Supplemented Biscuits Increased Insulin Secretion And Suppressed Pro-Inflammatory Cytokines In Type 2 Diabetic Wistar Rats, Omolola Soji-Omoniwa, Uthman Olanrewaju Abdulazeez, Christfavour Oluwaseyi Oloba, Samuel Olajuwon Kolawole, Johnson Opeyemi Olayinka, Emmanuel Olorunleke Oludipe, Anuoluwapo Faith Ajediti, Habib Tajudeen Yusuf

Al-Bahir

This research determined the effect of fish oil and Vernonia amygdalina-enriched biscuits (FVSB) on insulin sensitivity and inflammatory cytokines in type 2 diabetic rats. Forty-nine male rats were grouped into seven, i.e. A-G. Type 2 diabetes (T2DM) was induced in groups B-G by administering 230 mg/kg body weight [BW] NAD (ip) and 65 mg/kg BW streptozotocin (ip). Group A represented the control (Non-diabetic + unsupplemented biscuit), B (untreated diabetic), C (diabetic + 120 mg/kg BW metformin), D-F (diabetic + FVSB at 1g, 2g and 3g leaf inclusion respectively), and G (diabetic + conventional biscuit). The experiment lasted 35 days, …

Multiscale Modelling Of Eg5: Structural Insights Into Microtubule Interactions, Atp Hydrolysis, And Allosteric Inhibition Mechanisms, Soundarya Priya Alexandar Ms

Theses and Dissertations

The mitotic kinesin EG5 is essential for spindle bipolarity and accurate chromosome segregation during cell division, making it a validated anti-cancer target. Unlike conventional microtubule-targeting agents, EG5 inhibitors offer mitosis-specific action, reducing neurotoxicity. Although inhibitors targeting EG5’s allosteric site-I have been extensively studied, mechanistic insights into inhibition at site-II, and their combined effects, remain underexplored. This thesis systematically investigates the structural and dynamic mechanisms underlying EG5 function and its inhibition using an integrative computational approach.

Conformational analysis, coarse-grained dynamics, all-atom molecular dynamics simulations, and protein network analysis were performed on EG5 motor domain structures and EG5-microtubule complexes. Results show that …

Complete Genome Sequence Of Rothia Mucilaginosa D1, A Genetically Amenable Strain, Hemendra P. Dhaked, Isabella Andonie, Bo Yang, Vinayka M. Joshi, Zezhang T. Wen

School of Dentistry Faculty Publications

Here, we report the complete genome sequence of Rothia mucilaginosa D1. Unlike many other strains that have been sequenced, R. mucilaginosa D1, a clinical isolate, is genetically amenable. The complete sequencing of the genome provides potential for further studies on the genetics and pathophysiology of this emerging pathobiont.

Next-Gen Tools In Cancer Neuroscience, Vera Thiel, Debpali Sur, Caroline C Picoli, Tamara Mcerlain, Katalina Couto, David J Simon, Yuan Pan, Karen Olivia Dixon, Rajan P Kulkarni, Sebastien Talbot, Alexander Birbrair

Faculty, Staff and Student Publications

The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innovative optical electrophysiological approaches, optogenetics, chemogenetics, engineered viruses, and new methods for visualizing neuronal activity. Collectively, these technologies are revolutionizing how we investigate, manipulate, and characterize distinct components that contribute to the nervous system-cancer interface. In the present review, we discuss the key technologies that are closing the gap between oncology and neuroscience, highlighting the innovations that are propelling the cancer neuroscience field forward.

Rna/Dna-Binding Protein Tdp43 Regulates Dna Mismatch Repair Genes With Implications For Genome Stability, Vincent E Provasek, Albino Bacolla, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Issa O Yusuf, Vikas H Malojirao, Velmarini Vasquez, Gavin W Britz, Guo-Min Li, Zuoshang Xu, Sankar Mitra, Ralph M Garruto, John A Tainer, Muralidhar L Hegde

Faculty, Staff and Student Publications

TDP43 is an RNA/DNA-binding protein increasingly recognized for its role in neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As characterized by its aberrant nuclear export and cytoplasmic aggregation, TDP43 proteinopathy is a hallmark feature in over 95% of ALS/FTD cases, leading to detrimental cytosolic aggregates and a reduction in nuclear functionality in neurons. Building on our prior work linking TDP43 proteinopathy to the accumulation of DNA double-strand breaks (DSBs) in neurons, the present investigation uncovers a novel regulatory relationship between TDP43 and DNA mismatch repair (MMR) gene expression. Here, we show that TDP43 depletion or overexpression …

Effect Of Crop Density On Palmer Amaranth (Amaranthus Palmeri) Emergence And Weed Density Interference Potential In A Furrow-Irrigated Rice System, Tanner Austin King, Jason K. Norsworthy, Thomas R. Butts, Sam Fernandes, Gerson L. Drescher

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

There is a high demand for cultural weed management strategies targeting Palmer amaranth (Amaranthus palmeri S. Watson) in furrow-irrigated rice (Oryza sativa L.) production due to overreliance on herbicides and the lack of a continual flood to prevent weed emergence. Amaranthus palmeri has been shown to reduce corn (Zea mays L.), cotton (Gossypium hirsutum L.), and soybean [Glycine max (L.) Merr.] yields when it interferes with the crop. However, minimal research has been conducted to assess the ability of this weed species to impact rice grain yield. The manipulation of rice seeding rate to enhance rice canopy formation and favor …