Life Sciences Commons^™

Assessing Spatial Variability In Observed Infectious Disease Spread In A Prospective Time-Space Series, Chih-Chieh Wu, Chien-Hsiun Chen, Shann-Rong Wang, Sanjay Shete

Faculty, Staff and Student Publications

Most of the growing prospective analytic methods in space-time disease surveillance and intended functions of disease surveillance systems focus on earlier detection of disease outbreaks, disease clusters, or increased incidence. The spread of the virus such as SARS-CoV-2 has not been spatially and temporally uniform in an outbreak. With the identification of an infectious disease outbreak, recognizing and evaluating anomalies (excess and decline) of disease incidence spread at the time of occurrence during the course of an outbreak is a logical next step. We propose and formulate a hypergeometric probability model that investigates anomalies of infectious disease incidence spread at …

Impact Of Irrigation And Micronutrient Treatments On Insect Herbivore Population Dynamics In Soybean, Rahul Debnath, Justin George, Ammar B. Bhandari, Rupesh Kariyat, Gadi V.P. Reddy, James P. Glover, Tulsi P. Kharel, Krishna N. Reddy

Entomology and Plant Pathology Faculty Publications and Presentations

Soybean production is substantially affected by insect pests, necessitating the implementation of appropriate management strategies. Effective irrigation and fertilizer regimes have been found to affect pest populations in agroecosystems. However, their interactive effects on herbivore incidence are less understood. This study reports the abundance and diversity of insect pests, especially hemipteran, lepidopteran, and stink bug species complexes, encountered on soybeans throughout their vegetative and reproductive growth stages under varying irrigation and micronutrient treatments. First, we compared total and major insect pest population densities in irrigated and rainfed conditions. Afterwards, we evaluated how the frequency of insect pests on soybean was …

Post-Rt Head And Neck Dce-Mri: Association Between Mandibular Dose And Ve, Brandon Reber, Renjie He, Moamen R Abdelaal, Abdallah S R Mohamed, Samuel L Mulder, Laia Humbert Vidan, Clifton D Fuller, Stephen Y Lai, Kristy K Brock

Faculty, Staff and Student Publications

Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a functional imaging modality that can quantify tissue permeability and blood flow. Due to vasculature changes resulting from radiation therapy (RT), DCE-MRI quantitative parameters should be significantly different in regions receiving a high radiation dose compared to regions receiving a low radiation dose. This study sought to determine whether a significant difference exists in post-head-and-neck-cancer (HNC)-RT DCE-MRI quantitative parameters (Ktrans and ve) between regions of the mandible receiving a high radiation dose and regions of the mandible receiving a low radiation dose.

Methods: DCE-MRI was acquired from HNC subjects post-RT. The DCE-MRI …

A Needed Nomenclature For Nucleosomes, Michael-Christopher Keogh, Genevieve Almouzni, Andrew J Andrews, Karim-Jean Armache, Cheryl H Arrowsmith, Sung Hee Baek, Mark T Bedford, Emily Bernstein, Jacques Côté, Yael David, John M Denu, Beat Fierz, Benjamin A Garcia, Karen C Glass, Or Gozani, Kristian Helin, Steven Henikoff, Ole N Jensen, Steven Z Josefowicz, Neil L Kelleher, Tatiana G Kutateladze, Herbert H Lindner, Chao Lu, Karolin Luger, Parag Mallick, Catherine A Musselman, Tom W Muir, Ljiljana Paša-Tolić, Robert Schneider, Xiaobing Shi, Yang Shi, Simone Sidoli, Lloyd M Smith, Jessica K Tyler, Cynthia Wolberger, Jerry L Workman, Brian D Strahl, Nicolas L Young

Faculty, Staff and Student Publications

Histone post-translational modifications (PTMs) are crucial to eukaryotic genome regulation, with a range of reported functions and mechanisms of action. Though often studied individually, it has long been recognized that the modifications function by combinatorial synergy or antagonism. Interplay may involve PTMs on the same histone, within the same nucleosome (containing a histone octamer), or between nucleosomes in higher-order chromatin. Given this, the field must distinguish ever greater complexity, and the context in which it is studied, with brevity and precision. The proteoform was introduced to define individual forms of a protein by sequence and PTMs, followed by the nucleoform …

Forage Sampling Guide For Agronomic Crops, Jody Gale, Matt Yost, Megan Baker, Michael Pace, Earl Creech, Grant Cardon, Kalen Taylor, Cody Zesiger, Tiffany Evans, Rhonda Miller, Clara Anderson

All Current Publications

Forage sampling is a valuable tool that provides producers with quality information for calculating feed rations and marketing their forages. To ensure that this information is accurate and reliable, it is important to understand how to collect these samples correctly. Sampling tools have been developed that simplify this process and improve accuracy.

Advancing Peptide-Based Vaccines Against Candida: A Comparative Perspective On Liposomal And Synthetic Formulations, Hong Xin

School of Graduate Studies Faculty Publications

The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing on the FM-SNAP vaccine, a bivalent liposomal formulation targeting the surface-expressed peptides fructose bisphosphate aldolase (Fba) and methionine synthase (Met6). Compared to earlier constructs such as MP12, FM-SNAP achieves superior immunogenicity and long-lasting protection at lower antigen doses. It elicits balanced Th1/Th2 cytokine responses and demonstrates durable efficacy in both immunocompetent and complement-deficient mouse models. The platform's compatibility with clinically approved adjuvants (MPLA and QS-21), …

Reversible Arginine Methylation Of Pi3kc2Α Controls Mitotic Spindle Dynamics, Yena Cho, Jee Won Hwang, Mark T Bedford, Dong Hee Na, Dae-Geun Song, Su-Nam Kim, Yong Kee Kim

Faculty, Staff and Student Publications

Microtubules, composed of αβ-tubulin dimers, undergo dynamic polymerization and are fundamental to cell structure and function. In the current study, we discovered that phosphatidylinositol 3-kinase class 2α (PI3KC2α) acts as a novel regulatory factor in microtubule dynamics. Specifically, asymmetric dimethylation of PI3KC2α at the R175 residue (R175me2a) by coactivator-associated arginine methyltransferase 1 (CARM1) enhances its interaction with α-tubulin, stabilizing microtubule assembly. Furthermore, lysine Demethylase 4 A (KDM4A) serves as an arginine demethylase for PI3KC2α R175me2a. During mitosis, protein kinase C (PKC)-mediated phosphorylation of KDM4A results in its dissociation from PI3KC2α, preventing demethylation and increasing R175me2a levels. This facilitates spindle formation …

Factors Influencing Employee Green Behavior And Employee Green Attitude Among Muslims In Indonesia, Kurnia Sari Kasmiarno, Mahjus Ekananda, Gina Destrianti Karmanto

Journal of Environmental Science and Sustainable Development

In a Muslim majority, developing country like Indonesia, religion shapes employees’ work ethic and professional behavior, embedding spiritual and cultural values into the workplace. Despite the increasing attention to pro-environmental behavior, previous studies have largely examined Green Human Resource Management (GHRM), religiosity, and environmental concern separately, often focusing on a single sector. This leaves employees from various occupational backgrounds underexplored. This study aims to examine the effects of Green Concern (GC), Green Motivation (M), GHRM, and Religiosity (REL) on Employee Green Behavior (EGB) and Employee Green Attitude (EGA) of Muslim employees in Indonesia. Data were collected through a quantitative survey …

A Mast Cell Receptor Mediates Post-Stroke Brain Inflammation Via A Dural-Brain Axis, Ruchita Kothari, Mostafa W Abdulrahim, Hyun Jong Oh, Daniel H Capuzzi, Collin B Kilgore, Sumil K Nair, Yaowu Zhang, Nathachit Limjunyawong, Sarbjit S Saini, Jennifer E Kim, Justin M Caplan, Fernanado L Gonzalez, Christopher M Jackson, Chetan Bettegowda, Judy Huang, Bhanu P Ganesh, Chunfeng Tan, Raymond C Koehler, Rafael J Tamargo, Louise D Mccullough, Risheng Xu, Xinzhong Dong

Faculty, Staff and Student Publications

The immune environment surrounding the brain plays a fundamental role in monitoring signs of injury. Insults, including ischemic stroke, can disrupt this balance and incite an exaggerated inflammatory response, yet the underlying mechanism remains unclear. Here, we show that the mast-cell-specific receptor Mrgprb2 regulates post-stroke brain inflammation from the meninges. Mrgprb2 causes meningeal mast cell degranulation after stroke, releasing immune mediators. This process recruits skull bone marrow neutrophils into the dura and further promotes neutrophil migration from the dura into the brain by cleaving the chemorepellent semaphorin 3a. We demonstrate that the human ortholog, MRGPRX2, is expressed in human meningeal …

Rare Variants In Prkci Cause Van Der Woude Syndrome And Other Features Of Peridermopathy, Kelsey Robinson, Sunil K Singh, Rachel B Walkup, Dorelle V Fawwal, Kendra M Vilfort, Amanda Koloskee, Azeez Fashina, Wasiu Lanre Adeyemo, Terri H Beaty, Azeez Butali, Carmen J Buxó, Wendy K Chung, David J Cutler, Michael P Epstein, Brooklynn Gasser, Lord J J Gowans, Jacqueline T Hecht, Anuj Mankad, Lina Moreno Uribe, Daryl A Scott, Gary M Shaw, Mary Ann Thomas, Seth M Weinberg, Eric C Liao, Harrison Brand, Mary L Marazita, Robert J Lipinski, Jeffrey C Murray, Robert A Cornell, Elizabeth J Leslie-Clarkson

Faculty, Staff and Student Publications

Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by lower lip pits and orofacial clefts (OFCs). With a prevalence of ∼1 in 35,000 live births, it is the most common form of syndromic clefting. Most VWS is attributed to variants in IRF6 (∼70%) or GRHL3 (∼5%), leaving up to 25% of individuals without a molecular diagnosis. Both IRF6 and GRHL3 function in a transcriptional regulatory network (TRN) governing differentiation of periderm, a single epithelial cell layer preventing pathological adhesions during palatogenesis. Periderm disruption can elicit a spectrum of phenotypes, including lip pits and OFCs, pterygia, and severe …

The Impact Of Off-Site Manufacturing Technology On The Project Management Triangle In The Saudi Housing Sector, Saad S. Almady, Ahmed M. Alhazmi, Essam S. Almahmoud

Mansoura Engineering Journal

This study examines the impact of Off-Site Manufacturing (OSM) and construction sites on housing projects in the Kingdom of Saudi Arabia. The study aims to strike a balance between achieving the highest quality, lowest cost, and expedited construction of housing units. OSM technology involves the production of construction components outside the site, followed by their transportation and installation on the final site. The study seeks to assess the contribution of OSM’s utilization in enhancing project performance, measured against the project management triangle (quality, cost, and time), and compare it with the traditional construction method. To achieve this objective, a residential …

Implications Of Electric Vehicles Use On Value Co-Creation And Improving Community Welfare, Rastinia Kamila Hanum, Rizal Edy Halim

Journal of Environmental Science and Sustainable Development

Transportation is closely related and to support daily community mobility, 90% of road transportation operates on fossil fuel and it has always been accompanied by new innovations. Electric vehicles are predicted to be the future transportation to reduce greenhouse emissions. This study combines theories on behavioral and technology acceptance to create value co-creation and enhance community well-being. This quantitative study surveyed 210 respondents from the target community especially in Java island, who intend to adopt electric vehicles (EVs) using Google Form. PLS-SEM was used to evaluate research framework which integrates TPB, Technology Acceptance Model (TAM), and Unified Theory of Acceptance …

Green Human Resource Management, Employee Behavior, And Organizational Innovation: A Multi-Theoretic Pathway To Sustainable Competitiveness, Iwan Perwira, Hernita Hernita, Suardi Suardi, Andi Tenry Sose, Muhammad Azizurrohman

Journal of Environmental Science and Sustainable Development

As sustainability imperatives reshape global tourism, this study investigates how Green Human Resource Management (GHRM) practices can serve as strategic levers for driving sustainability performance and competitive advantage within Indonesia’s tourism sector. Amid rising environmental expectations and regulatory mandates, the research integrates Social Learning Theory, the Resource-Based View, and Institutional Theory to construct and test a model that links top management support, green organizational culture, and regulatory pressure to GHRM adoption. Using a cross-sectional survey of 510 employees and managers across eco-certified tourism firms in five Indonesian destinations, the study employed Partial Least Squares Structural Equation Modeling (PLS-SEM) to analyze …

A Multidecadal Analysis Of Groundwater Level And Streamflow Decline In Southern Forest Catchments, Western Australia, Richard J. George, Rose-Anne Bell, W. Lachlan Mccaw, Gregory Paul Raper

Natural Resources Research Articles

Previous analysis of hydrological data in the eucalypt dominated forests of Western Australia’s Darling Ranges show that reduced winter rainfall over the last 50 years has lowered groundwater levels and diminished streamflow by up to 70%. Consequently, climate-independent reverse osmosis seawater desalination and groundwater resources now supply Perth and nearby regional areas, as runoff from forested catchments is no longer sufficient or reliable. In the high rainfall (~1200 mm/yr) mixed forest areas dominated by Eucalyptus diversicolor (karri) and Eucalyptus marginata (jarrah) 200 km to the south of Perth (the ‘Southern Forest’), similar analysis of climate impacts on watertables has not …

Preclinical Models Of Melanoma Leptomeningeal Disease To Assess Intrathecal Checkpoint Blockade, Renato A Guerrieri, Grant M Fischer, Jacob R Cortez, Barbara G Knighton, Debora A Ledesma, Courtney W Hudgens, Yimmy F Delcid, Qianghua Hu, Christian Y B Onana, Fernando C L Carapeto, Michael T Tezlaff, Jason T Huse, Patrick Hwu, Elizabeth M Burton, Isabella C Glitza Oliva, Michael A Davies, Sherise D Ferguson

Faculty, Staff and Student Publications

Leptomeningeal disease (LMD) is a subtype of central nervous system metastatic disease that is associated with poor patient outcomes and limited treatment options. There is an unmet need to develop preclinical models of LMD to expedite and improve the development of new therapeutics. Here, we describe the development of multiple orthotopic immunocompetent murine models of melanoma LMD, including their use to assess the efficacy of systemic and/or intrathecal immunotherapy. LMD was established by direct intrathecal injection of murine cell lines (B16-F10, BP, D4M, D4M-UV2, MC38-gp100, RMS, YUMM3.1, and YUMMER1.7) into the cisterna magna of C57BL/6 mice. Tumor take rate, distribution, …

Long-Term Outcomes In Flt3-Mutated Acute Myeloid Leukemia After Frontline Hypomethylating Agent, Venetoclax And A Flt3 Inhibitor, Nicholas J Short, Sanam Loghavi, Musa Yilmaz, Omer Karrar, Kunhwa Kim, Courtney D Dinardo, Tapan M Kadia, Manuel Maroun, Gautam Borthakur, Ghayas C Issa, Joseph Jabbour, Betul Oran, Elizabeth J Shpall, Uday Popat, Keyur P Patel, Mark Routbort, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Faculty, Staff and Student Publications

Triplet regimens with a hypomethylating agent, venetoclax and a FLT3 inhibitor yield high rates of response in newly diagnosed FLT3-mutated AML. However, the long-term outcomes and patterns of relapse with these triplet regimens are not well-established. In this retrospective analysis, 73 patients with newly diagnosed FLT3-mutated AML received a frontline FLT3 inhibitor-containing triplet regimen. The composite complete remission (CR) and CR with incomplete hematologic recovery (CRi) rate was 93%. Next-generation sequencing FLT3-ITD MRD negativity (sensitivity: 0.005%) was achieved in 60% of patients after cycle 2 and 90% after cycle 4. The estimated 3-year relapse-free survival (RFS) for FLT3-ITD-mutated and FLT3 …

Attributes Of Artificial Wetlands Colonized By Ambystoma Maculatum On A Virginia Surface Mine, Hunter Hill, Garrett Stiltner, Walter H. Smith

Virginia Journal of Science

Landscapes impacted by surface mineral extraction present a range of artificial wetland habitats potentially useable by pool-breeding amphibians, although little information exists in the literature detailing which attributes influence breeding site selection by wetland amphibian specialists in post-mined landscapes. We compared attributes of artificial wetlands consistently used and unused as oviposition sites by Spotted Salamanders (Ambystoma maculatum) over a six-year period on a 120-ha former surface mine in Wise County, Virginia, USA. Salamanders non-randomly selected wetlands as oviposition sites, with one-third of available wetlands within the study area showing evidence of ovipositioning. Wetlands used as breeding sites were …

How To Identify Leafhoppers, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

These tiny plant-feeding insects are often considered pests due to the damage they can inflict on crops and gardens. Leafhoppers, treehoppers and spittlebugs (or froghoppers) are closely related to cicadas, and planthoppers are their more distant relatives. As their names suggest, most of them can hop.

Attitudes Toward The Continued Protection Of Gray Wolves Under The Endangered Species Act, John A. Vucetich, Jeremy T. Bruskotter

Michigan Tech Publications

In February 2024, the U.S. Fish & Wildlife Service announced their intention to develop – for the first time – a National Recovery Plan under the Endangered Species Act (ESA) for gray wolves in the lower 48 states. In August 2025, a federal judge vacated the U.S. Fish and Wildlife Service's (FWS) decision denying ESA protections for gray wolves in the Western U.S.

Those events represent key context for this report, which describes the results of a web-based survey implemented in July and August of 2025 and designed to assess the attitudes of residents of the contiguous United States, as …

The Effects Of Dietary Protein Source On Spine Regeneration In The Sea Urchin Lytechinus Variegatus, Joseph Cortez, Jami De Jesus, Raven A. Edwards, Jeri L. Brandom, Stephen A. Watts

Expo Student Presentations

2025 Fall Expo Poster Presentation

• Biological & Life Sciences

Endocrine Gene Divergence Reflects Precipitation-Driven Adaptation In Sonoran Desert Rattlesnakes, Makinley Ross Kendrick, Austin Biddy, Greer Dolby

Expo Student Presentations

2025 Fall Expo Poster Presentation

• Biological & Life Sciences

Recruitment Progress And Participant Characteristics In The Glo Study, Andre Odom

Expo Student Presentations

2025 Fall Expo Online Oral Presentation

• Biological & Life Sciences

Aav-Progranulin Gene Therapy Corrects Phenotypes Associated With Progranulin Deficiency Up To One-Year Post Injection In Mouse Model Of Frontotemporal Dementia, Hesham Shiekhtholth, Stephanie Fox, Mary Bullock, Erik Roberson

Expo Student Presentations

2025 Fall Expo Oral Presentation

• Biological & Life Sciences

Fisheries Research Report No. 354: Recreational Fishing For Abalone In Western Australia In 2024/2025 - Estimates Of Participation, Effort And Catch, Claire B. Smallwood, Karina L. Ryan, Lachlan W. Strain

Fisheries Research Reports

The Western Australian Recreational Abalone Fishery (RAF) operates in shallow coastal waters as a hand collection fishery while wading or diving. Three species of abalone are allowed to be caught. Roe’s abalone (Haliotis roei) are generally collected while wading from the shore in accessible nearshore reef complexes along the West and South Coast Bioregions. Greenlip abalone (H. laevigata) and Brownlip abalone (H. conicopora) are collected while wading (including snorkelling and freediving) and diving (using compressed air) predominantly along the South Coast Bioregion.

Recreational fishing for the three abalone species is licensed and highly regulated, especially in the Western Zone (which …

Nebline, October 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Contents

4-H super fair helps youth become beyond ready

What's popping? by Natalie Sehi

Recipes of the month, by Kayla Colgrove: Fish bait snack mix, kicked up popcorn, and cinnamon crunch snack mix

Are your trees for the next storm? by Rachel Anderson

Garden guide: Things to do this month by Mary Jane Frogge

GRO Big Red virtual learning series

Composting demonstration

Promoting language development in young children by Hayley Jackson

Tip sheet for harvest 2025 by John Nelson

Rogers Memorial Day farm field day, September 2025

Heart of 4-H volunteer award: Rachel Wells

Join 4-H to become beyond ready …

West Coast Demersal Scalefish Resource Recovery Support Package: 2024-25 Report, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Published Reports

The West Coast Demersal Scalefish Resource (WCDSR) includes over 100 species in inshore (20–250 m deep) and offshore ( > 250 m) demersal habitats of the West Coast Bioregion. These species are caught by charter, commercial and recreational fishers. The WCDSR is in recovery and managed under a 20-year recovery plan (2010–2030). DPIRD tracks recovery progress through scientific stock assessments of indicator species (snapper, WA dhufish, and baldchin groper) every 3 years. The 2021 WCDSR stock assessment showed limited recovery and additional management action was required. In December 2022, the Minister for Fisheries announced commercial and recreational (including charter) sector management …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Designing Portugal’S Voluntary Carbon Market: Insights From Key Stakeholders, Mahika Shergill

Portugal: Sustainability and Environmental Justice

This project examines the design, integrity, and early implementation challenges of Portugal’s newly established Voluntary Carbon Market (VCM), created through Decree-Law 4/2024 as part of the country’s broader climate-mitigation strategy. The objective of the study is to evaluate whether the market’s regulatory architecture—particularly its treatment of additionality, permanence, methodologies, and co-benefit mechanisms—positions it to function as a credible and viable national carbon-governance instrument. The analysis draws on a mixed-methods approach combining legal and policy review with four semi-structured interviews conducted with policymakers, methodological designers, ecological practitioners, and environmental-law specialists. These interviews reveal that Portugal’s VCM is characterized by strong integrity …

Motives And Community Energy: What Determines Participation In The U.S. And E.U., Belinda Litchtenfeld

Portugal: Sustainability and Environmental Justice

The shift to renewable energies has become a critical means of addressing the climate crisis. Community Energy (CE) has emerged as a ‘bottom-up’ transition to achieve decarbonization within a localized environment. The aim of this paper is to compare the motivations and framings of rural CE projects in the United States and European Union. The paper will compare the case of Loess Wind Farm, located in Rock Port, Missouri, with the Cedillo Solar Community in Caceres, Spain to determine how sociotechnical visions are shaped by the challenges facing communities. The elements of sociotechnical visions- meanings, knowings, doings, and organizings- as …

When The Water Runs Out: Modelling Portuguese Pumped Hydro Storage Adequacy In Multi-Year Extreme Drought Conditions, Meg Gillies

Portugal: Sustainability and Environmental Justice

Portugal’s reliance on Pumped Hydro Storage (PHS) to support grid stability poses increasing risks as the share of renewables in the national energy mix approaches the 2030 goal of 85%, and droughts intensify across the Iberian Peninsula (Silva, 2024). Because simulation tools like EnergyPLAN model only one year at a time, they overlook the cumulative effects of prolonged hydrological stress (Lund, 2024). This research addresses that gap by implementing an iterative multi-year approach in EnergyPLAN, linking yearly simulations to assess how extended drought conditions impact PHS performance. Using a detailed 2024 model of Portugal’s power system and applying dry year …