Life Sciences Commons^™

Salinity Response In Tunisian Durum Wheat Genotypes: Genetic Relationships, Phenotypic Variation, And Ssr Marker-Based Computational Modelling, Rim Mzid, Rayda Ben Ayed, Imène Ayachi, Elyès Babay, İnci̇ Tolay, Lamia Hamrouni, Abdullah Eren, Mohsen Hanana

Turkish Journal of Agriculture and Forestry

This study identifies salt-tolerant durum wheat genotypes for breeding programmes by integrating phenotypic, genotypic, and computational analyses of 27 Mediterranean varieties. Cluster analysis and principal coordinate analysis (PCoA) revealed two distinct genetic groups: modern genotypes (high-yielding Tunisian/Italian cultivars) and ancient genotypes (traditional Tunisian landraces). Among tested cultivars, JnehKhottifa and Grécale exhibited exceptional salinity tolerance, maintaining >80% germination at 200 mM NaCl, while Om Rabiaa and Agili showed sensitivity (<50% germination). Bayesian network modelling was used to explore the probabilistic relationships between simple sequence repeat (SSR) markers (e.g., CFD40 and GWM182, PIC = 0.561) and important traits such as root length and germination rate under stress. Genetic diversity analysis (average PIC = 0.407) highlighted the potential of SSR markers for trait-marker associations. These findings establish a valuable platform for enhancing marker-assisted selection salt- tolerant durum wheat varieties, essential for securing yields in saline-prone Mediterranean regions.

Nitrogen Management In Enhancing Raspberry (Rubus Idaeus L.) Productivity And Sustainable Development In Fruit Cultivation, Aleksandar Leposavić, Žaklina Karaklajić-Stajić, Sezai̇ Erci̇şli̇, Darko Jevremović, Ivana S. Glišić, Branko Popović, Olga Mitrović

Turkish Journal of Agriculture and Forestry

This study investigated the effect of reduced nitrogen (N) fertilizer dosage on the vegetative and generative potential, physical and chemical characteristics, and fruit yield of raspberry (Rubus idaeus L.). Two raspberry cultivars (Willamette and Meeker) were treated with low and high doses of calcium ammonium nitrate and urea over 3 consecutive years (2021–2023) in Western Serbia. Basic floricane traits and fruit quality parameters were analyzed using widely accepted methodologies. The results showed significant variations in primocane growth, floricane traits, and berry quality in response to different N fertilizer doses, whereas soluble solid content (SSC) was more stable. Lower N fertilizer …

The Impact Of Endogenous And Exogenous Fungi In Saline-Alkali Soil On The Growth And Root System Of Pine Trees, Chunfeng Shi, Zhixin Ju, Kan Gao, Wenzhong Fan, Bo Yang

Turkish Journal of Agriculture and Forestry

The objective is to explore planting methods that enhance the ability of black pine to cope with salt stress environments, improve its growth under such conditions, and observe its growth and physiological characteristics under various experimental conditions. For this purpose, endophytic mycorrhizal Indian pear-shaped fungus and ectomycorrhizal two-colored wax mushrooms were selected and inoculated onto potted black pine seedlings, and a control group was set up. After inoculation, the mycorrhizal infection rate, salt damage symptoms, growth rate, root parameters, and various physiological indicators under different salt stress durations were evaluated. Results showed that as the salt concentration was raised to …

Study On The Flow Field Characteristics Of The Air-Suction Jujube Harvester Pipeline Based On Magnetohydrodynamic Airflow Control, Jing Nie, Qi Zhang, Jiashun Jiang, Jingbin Li, Longpeng Ding, Shufeng Li, Liming Xu, Mehmet Çeçen, Savaş Tanrisever

Turkish Journal of Agriculture and Forestry

This study aimed to address the issue of suction force attenuation in the air-suction jujube (red date) harvester due to pipeline pressure loss. The active flow control method based on magnetohydrodynamics was used to optimize the pipeline flow field and reduce pressure loss. Through multiphysics field coupling theory modeling and numerical simulation, the regulatory effects of different electromagnetic field parameters on the pipeline flow field were characterized. An experimental platform was established to verify that the optimized electrode tip density, electrode voltage, and magnetic induction intensity could significantly increase the outflow gas velocity, pressure difference, and harvesting efficiency of the …

10.27.2025 Ored Connect, Liz Williamson

ORED Newsletter

ORED Field Fest

OTC Director Candidates

Genetic Characterization And High-Resolution Total Mrna Sequencing Of The Millipede Cherokia Georgiana Bollman, 1889, Elena Cruz

Biology Theses

There are approximately 12,000 described species within the class Diplopoda. Only six species, falling within four of sixteen orders, have fully sequenced genomes. No whole genomes are available for incredibly diverse families like Xystodesmidae. Many interesting characteristics in this group are poorly defined at the genetic level, such as the production of a defensive hydrogen cyanide secretion and UV fluorescence in the order Polydesmida. Here, we present a genetic characterization of the polydesmid millipede Cherokia georgiana Bollman, 1889. We include tissue-specific sequencing metrics, alignment and assembly of mitochondrial DNA consensus sequence according to tissue type, and phylogenetic tree construction using …

Allometric And Mobile Terrestrial Lidar Modeling Of Above-Ground Woody Biomass Of Populus In Coppice Production, Heidi Renninger, Krishna P. Poudel

Research Data

Poplars (Populus spp.) and their hybrids are increasingly being grown in coppice production to generate bioenergy feedstocks at frequent intervals. Allometric equations are required to predict aboveground biomass (AGB) of coppiced individuals with minimal field measurements. Likewise, remote sensing tools like LiDAR (light detection and ranging) can be used if models are available to predict AGB from point cloud data. Therefore, this study sought to develop equations to predict dry woody AGB from field measurements and LiDAR data from coppiced poplar field trials containing eastern cottonwood (P. deltoides) and hybrid poplar taxa. We found that taxa-specific allometric …

Pediatric Vs Adult Invasive Aspergillosis In Cancer And Hematopoietic Transplant Patients: Insights From A Matched Cohort At A Tertiary Cancer Center, Saliba Wehbe, Ramia Zakhour, Ray Hachem, Ying Jiang, Hiba Dagher, Roseen Salman, Anne-Marie Chaftari, Issam I Raad

Faculty, Staff and Student Publications

Background: Invasive aspergillosis (IA) is a life-threatening infection in immunocompromised patients, including those with hematologic malignancies and hematopoietic stem cell transplants. While adult IA has been well characterized, data on pediatric populations remain limited, and potential age-related differences are often overlooked in current management guidelines.

Methods: We conducted a retrospective matched cohort study at a tertiary cancer center, evaluating IA cases diagnosed over a 31-year period. Pediatric patients (≤18 years) with proven or probable IA were matched 1:3 with adult IA cases based on year of diagnosis, underlying disease, and history of hematopoietic cell transplantation. We compared demographics, clinical presentation, …

The Influence Of Chlorophyll-A And Sea Surface Temperature On Anchovy Catch Trends (2011-2024) In Kilwa, Tanzania, Renatus Shigi, Prosper L. Mfilinge

Tanzania Journal of Science

Anchovies exhibit varying trends in catch worldwide, with some regions experiencing declines in catch due to overfishing and environmental changes, while others remain stable or experience increases. Kilwa is among the most productive small pelagic fisheries along the Tanzanian coast. This study aimed to investigate the influence of Chlorophyll-a (Chl-a) and Sea Surface Temperature (SST) on anchovy catch trends in Kilwa. The study further examined the relationship between catch per unit effort (CPUE) and total anchovy catch, as well as its implications for fisheries management. The study was conducted at two sites: Kilwa Kivinje and Kilwa Masoko during both the …

Pharmacological Profiling In Cll Patients During Pirtobrutinib Therapy And Disease Progression, Shady I Tantawy, Burcu Aslan, Ganiraju Manyam, Lakesla R Iles, Natalia Timofeeva, Neetu Singh, Nitin Jain, Alessandra Ferrajoli, Philip A Thompson, Keyur P Patel, Sai Prasad Desikan, William G Wierda, Varsha Gandhi

Faculty, Staff and Student Publications

No abstract provided.

The Term Consciousness And Impressive Evidence For Cephalopod Awareness, Donald M. Broom

Animal Sentience

Mather presents comprehensive evidence of cephalopod cognitive ability and of a high level of awareness. The importance of taking account of the biological functioning and adaptations to the living environment is emphasised. An argument is presented that it is better to limit the use of the word conscious to ‘not unconscious’ and to use awareness in relation to the various levels of cognitive functioning.

Female Cardioprotection In A Mouse Model Of Alcohol-Associated Cardiomyopathy, Joshua M. Edavettal, Meagan Donovan, Nicholas R. Harris, Xavier R. Chapa-Dubocq, Keishla M. Rodríguez-Graciani, Janos Paloczi, Liz Simon, Bysani Chandrasekar, Jason D. Gardner

School of Graduate Studies Faculty Publications

Chronic alcohol misuse is the leading cause of non-ischemic dilated cardiomyopathy, and the molecular mechanisms underlying the development of alcohol-associated cardiomyopathy (ACM), particularly regarding sex-specific susceptibility and mitochondrial contributions, are not fully known. In this study, we utilized a preclinical model of chronic + binge ethanol consumption to investigate sex differences in disease severity and mitochondrial function. Male and female C57BL/6J mice were fed ethanol or control liquid diets for 30 days, with 2 binge episodes on days 10 and 30. Cardiac morphology was assessed via echocardiography and cardiac function via left ventricular pressure-volume catheterization. Mitochondrial function was evaluated ex …

Comparative Analysis Of Citrate Synthase Activity In Skeletal Muscle, Liver, And Adipose Tissue In Beef Cattle, Abigail Webb

Honors Program: Senior Projects (Public)

Mitochondrial efficiency plays a central role in determining how cattle partition nutrients toward muscle growth or adipose deposition, yet little is known about tissue-specific differences in mitochondrial density among tissues or among beef cattle. This study aimed to quantify mitochondrial density in muscle, liver, and adipose tissue samples from beef cattle and evaluate its potential relationship with metabolic efficiency. Tissue samples of semitendinosus muscle (ST), liver, and subcutaneous adipose (SC) were collected, homogenized, and analyzed for citrate synthase (CS) activity using a fluorometric assay as a proxy for mitochondrial density. Preliminary analyses revealed that the semitendinosus muscle displayed the highest …

The Consciousness Inherent In Chasing Your Tail, Sergio M. Pellis Dr.

Animal Sentience

Who is conscious and how do we know? Complexity in behavior and cognition is certainly a clue that cannot be ignored in identifying this trait, and as Mather’s target article shows, it is hard not to imagine consciousness arising in cephalopods. But how complex is complex? An alternative may be gleaned from the fact that all living things rely on negative feedback to navigate their worlds, and this requires all sentient beings knowing what is to be stabilized in reflection to themselves. If so, consciousness is a universal trait.

Apitherapy: Therapeutic Potential Of Bee Products In Human Health, Vezir Januzi, Albina Jaha, Hyzer Rizani, Nexhat Balaj

UBT International Conference

Apitherapy is a form of alternative medicine based on the therapeutic use of bee products, such as honey, propolis, royal jelly, pollen, beeswax, and bee venom. These substances have been used for centuries in traditional medicine for their documented antimicrobial, anti-inflammatory, and anti-allergic properties. With the development of biomedical sciences and interest in natural treatments, apitherapy is gaining increasing attention in contemporary medicine. This study aims to review the local and international scientific literature on the impact of apitherapy on human health. The analysis focuses on the findings of experimental and clinical research evaluating the preventive and therapeutic effects of …

The Impact Of Chemical Parameters Of Surface Water Quality In Prizren And Sources Of Pollution, Sami Gashi, Vehebi Sofiu, Nexhat Balaj, Besar Veseli

UBT International Conference

Our study investigates several chemical indicators of pollution whose parameters have negative impacts on surface water quality in Prizren, focusing on several seasonal months and identifying pollution sources. During a one-year period, water samples were taken at key locations, in the Lumbardh River of Prizren, to analyze several parameters such as pH, dissolved oxygen (DO), biochemical oxygen demand (BOD5), chemical oxygen demand (COD), total dissolved solids (TDS). Surface water quality is subject to more frequent pollution of these parameters especially in different months of the year and were closely monitored to understand their impact on water quality during droughts. The …

Impacts Of Pesticides And Herbicides On Air, Soil, And Water Ecosystems, Ibush Luzha, Smajl Rizani, Jehona Luzha Beqiraj

UBT International Conference

Pesticides and herbicides, widely used agents in modern agriculture and environmental management for controlling pests and weeds, contribute to increased food production. However, their massive and often uncontrolled use has raised serious concerns about negative impacts on natural ecosystems. This paper comprehensively analyzes their effects on three key environmental components: air, soil, and water. In terrestrial ecosystems, these chemicals alter microbial biodiversity, harm beneficial organisms such as earthworms and pollinating insects, reduce soil fertility, and persist and bioaccumulate. In aquatic ecosystems, they contaminate surface and groundwaters through runoff, leaching, and atmospheric deposition, cause acute and chronic toxicity to aquatic organisms …

The Impact Of Sugar And Artificial Sweeteners On Consumer Health Through Beverage Consumption, Besa Salihu, Vlora Rama Demiri

UBT International Conference

The consumption of sugar-sweetened beverages and artificial sweeteners is an important health issue, being linked to metabolic and other chronic diseases. This research examines the impact of these substances on consumers' health and their perceptions of the safety of these products. This study aims to assess the impact of sugar and artificial sweetener consumption on health, analyze consumers' perceptions, and examine their awareness of the effects of these substances. Quantitative methodology was used through an online questionnaire distributed on Google Forms, with a total of 57 participants. The data were analyzed using the SPSS program to identify consumption patterns and …

The Role Of The Media In Health Education And Disease Prevention, Laura Binxhija, Diana Sejdiu, Bislim Krasniqi

UBT International Conference

This study examines the role of media in health education and disease prevention through a combined approach of literature review and empirical analysis. The survey was conducted through a structured questionnaire administered to a representative sample of 160 people. The data showed that 91.7% consider media an influential factor in shaping their health behaviors, while 85% reported making significant health-related decisions—such as visiting a doctor or changing dietary habits—based on information obtained from media sources. Social media (45%) and online portals (35%) emerged as the dominant channels for accessing health information. Despite a high perceived level of trustworthiness (48.5% considered …

Bioaqua Cost Action: Biomolecular Pathways To Sustainable Aquaculture – Transforming European Fish Farming Through Innovation And Collaboration, Besa Shahini

UBT International Conference

European aquaculture is at a turning point. The sector is growing fast, but it also faces heavy disease pressure, rising costs, and stricter environmental demands. The BIOAQUA COST Action (CA22160) offers a new way forward. Instead of treating problems after they appear, it focuses on biomolecular tools that prevent them from the start. This paper looks at how continuous pathogen monitoring, water prophylaxis, eco-friendly treatments, and noninvasive welfare checks can cut losses, reduce antibiotic use, and strengthen biosecurity while keeping consumer trust. It also introduces BIOAQUA’s five working groups, which cover water prophylaxis, alternative treatments, fish welfare, sustainability pathways, and …

Effects Of Breed, Diet And Other Factors On The Quality Of Fresh Milk In Physical And Chemical Aspects Case Study Vita Dairy, Ardit Hoti

UBT International Conference

This study evaluates the effect of breed and nutritional factors on the physicochemical properties of fresh milk at the Vita dairy in Istog.Eighty milk samples were analyzed, collected from 20 farms with four cow breeds: Holstein, Simmental, Red Holstein, and Montbéliarde, during the months of May–June 2024. The samples were assessed for parameters such as: fat, protein, lactose, pH, acidity, specific gravity, dry matter, and freezing point.The results show that milk from the Holstein breed has a higher content of fat (4.02%), protein (3.30%), and lactose (4.70%) compared to Simmental. Specific gravity and dry matter were also higher in Holstein …

Technological Processing Of Wheat And Comparative Quality Analysis Of Flour Types Produced In 2024 And 2025, Nora Rrahimi, Aulona Sfishta, Resul Sahiti

UBT International Conference

Wheat (Triticum spp.) is one of the most important agricultural crops worldwide and plays a key role in feeding the population. It is a fundamental raw material for staple foods such as bread, pasta, and other dough-based products. Flour, produced through wheat processing, is classified into types based on ash content, degree of refinement, and nutritional composition. Among the most widely used are types 400, 500, and 850, each with distinct technological properties and applications in the food industry. This paper studied the technological process of wheat milling and conducted a comparative analysis of flour types 400, 500, and 850 …

International Conference On Food Science, Nutrition And Agriculture, University For Business And Technology (Ubt) In Kosovo

UBT International Conference

UBT Annual International Conference is the 14th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …

Thrombi From Stroke Due To Cardioembolic Etiology Have Higher Cd11b-Positive Cells Compared To Large Artery Atherosclerosis, Carson Finger, Gomana Emara, Gabriel S Chiu, Kelly Li, Sunil Sheth, Chunfeng Tan, Maria Parekh, Mehmet Enes Inam, Deepa Dongarwar, Bharti Manwani

Faculty, Staff and Student Publications

Identifying the underlying etiology of ischemic stroke is crucial for implementing effective stroke prevention measures. In the era of thrombectomy, ischemic stroke thrombus composition has gained considerable interest in the recent years. However, only a limited studies have analyzed the inflammatory milieu of the thrombus in association with stroke etiology. Atrial Fibrillation (AF), a common etiology of large strokes, is difficult to detect, but is known to be an inflammatory disease with a dominance of CD11b cell types (characterizes bone marrow derived myeloid cells such as monocytes, neutrophils, macrophages, and natural killer cells) in the atria. We hypothesized that thrombi …

14th International Conference On Business, Technology And Innovation 2025, University For Business And Technology - Ubt

UBT International Conference

Welcome to IC – UBT 2025

UBT Annual International Conference is the 14th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …

Understanding Rice Production Stagnation In The Philippines: Regional Evidence And Development Implications, Henry Bartelet, Alenn Jhulia D. Prodigalidad, Janelle S. Dy, Jan Gabriel N. Manzano

Quantitative Methods and Information Technology Faculty Publications

Despite decades of investment in agricultural research and rice development, the Philippines continues to face stagnation in domestic rice production. This persistent trend, occurring despite a sizable arable land base and large rural workforce, has contributed to the country’s growing reliance on rice imports to meet national food needs. In response, the government has implemented a tariff-based import system designed to fund domestic productivity improvements. While previous studies have explored the technical and environmental constraints affecting rice production, such as irrigation shortfalls, land degradation, and climate variability, few have examined recent national trends using regionally disaggregated data alongside qualitative insights. …

Predicting Species Assemblages At Wildlife Crossing Structures Using Multivariate Regression Of Principal Coordinates, Thomas J. Yamashita, Daniel G. Scognamillo, Kevin W. Ryer, Richard Kline, Michael E. Tewes, John H. Young Jr., Jason V. Lombardi

School of Earth, Environmental, & Marine Sciences Faculty Publications

Wildlife populations are in decline due to human threats, including highways. Strategies for reducing road impacts on wildlife include wildlife fencing which keep animals off roads and wildlife crossing structures (WCSs) which provide safe passage across roads. Wildlife crossing structures are diverse and transportation managers are often interested in identifying which WCS designs are effective for target species so a model that predicts target species usage of WCSs is likely to be beneficial to managers and biologists. Wildlife crossing structures are typically built for select species but are utilized by other species, so it may be beneficial to examine WCS …

Setdb1 Is Critically Required For Uveal Melanoma Growth And Represents A Promising Therapeutic Target, Imène Krossa, Céline Pisibon, Yann Cheli, Karine Bille, Mélanie Dalmasso, Sabah Hamadat, Chrystel Husser, Marie Irondelle, Julien Cherfils-Vicini, Frédéric Soysouvanh, Sacha Nahon-Esteve, Arnaud Martel, Sandra Lassalle, Jean-Pierre Caujolle, Célia Maschi, Stéphanie Baillif, Dan Hasson, Saul Carcamo, Andrerw E. Aplin, Irwin Davidson, Emily Bernstein, Valeria Naim, Robert Ballotti, Corine Bertolotto, Thomas Strub

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Metastatic uveal melanomas are highly resistant to all existing treatments. To identify actionable vulnerabilities, we conducted a CRISPR-Cas9 knockout screen using a library composed of chromatin regulators. We revealed that the lysine methyltransferase, SETDB1, plays a critical role in metastatic uveal melanoma cell proliferation and survival. Functionally, SETDB1 deficiency induces a DNA damage response, senescence-like state and growth arrest. Knockdown of SETDB1 is associated with a decreased expression of genes related to replication and cell cycle. Moreover, deficiency in CDC6, an essential regulator of DNA replication, phenocopies SETDB1 inhibition. Using a pre-clinical model, we further demonstrated that anti-SETDB1 therapy impairs …

Leptin As A Key Driver For Organ Fibrogenesis, Xue-Nan Sun, Shiuhwei Chen, Shangang Zhao, Jan-Bernd Funcke, Megan Virostek, Line Pedersen, Chao Li, Chanmin Joung, Qian Lin, Yan Li, Ayanna Cobb, May-Yun Wang, Kyounghee Min, Lisandro Maya-Ramos, Giovanna Degasperi, Junquan Liu, Ningyan Zhang, Zhiqiang An, Diana R Tomchick, R Max Wynn, Da Young Oh, Philipp E Scherer

Faculty, Staff and Student Publications

Leptin, a hormone primarily secreted by adipocytes, regulates energy balance and systemic metabolism through its interaction with the leptin receptor (LEPR). Beyond these functions, leptin signaling has been implicated in the pathogenesis of tissue fibrosis. Here, we report the x-ray crystal structures of a leptin-neutralizing antibody (hLep3) in the unbound and leptin-bound states. The interaction of this antibody with leptin mimics the interaction of the LEPR with leptin, providing direct insights into the mechanism by which the antibody disrupts leptin signaling. We furthermore evaluate the therapeutic potential of neutralizing leptin with this antibody across distinct mouse models of fibrosis affecting …

Transdiagnostic Alterations In White Matter Microstructure Associated With Suicidal Thoughts And Behaviours In The Enigma Suicidal Thoughts And Behaviours Consortium, Laura S Van Velzen, Lejla Colic, Zuriel Ceja, Maria R Dauvermann, Luca M Villa, Hannah S Savage, Yara J Toenders, Niousha Dehestani, Alyssa H Zhu, Adrian I Campos, Lauren E Salminen, Martin Alda, Ingrid Agartz, Nina Alexander, Rosa Ayesa-Arriola, Elizabeth D Ballard, Nerisa Banaj, Carlotta Barkhau, Zeynep Başgöze, Jochen Bauer, Francesco Benedetti, Klaus Berger, Bianca Besteher, Katharina Brosch, Manuel Canal-Rivero, Simon Cervenka, Romain Colle, Colm G Connolly, Emmanuelle Corruble, Philippe Courtet, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R Cullen, Udo Dannlowski, Jeremy Deverdun, Ana M Diaz-Zuluaga, Lorielle M F Dietze, Jennifer W Evans, Negar Fani, Kira Flinkenflügel, Naomi P Friedman, Ian H Gotlib, Nynke A Groenewold, Dominik Grotegerd, Tomas Hajek, Alexander S Hatoum, Marco Hermesdorf, Ian B Hickie, Yoshiyuki Hirano, Tiffany C Ho, Yuki Ikemizu, Frank Iorfino, Jonathan C Ipser, Yuko Isobe, Andrea P Jackowski, Fabrice Jollant, Tilo Kircher, Melissa Klug, Sheri-Michelle Koopowitz, Anna Kraus, Axel Krug, Emmanuelle Le Bars, Elisabeth J Leehr, Meng Li, Elizabeth T C Lippard, Carlos Lopez-Jaramillo, Ivan I Maximov, Andrew M Mcintosh, Katie A Mclaughlin, Sean R Mcwhinney, Susanne Meinert, Elisa Melloni, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Stener Nerland, Emilie Olie, Victor Ortiz-García De La Foz, Pedro M Pan, Fabricio Pereira, Fabrizio Piras, Federica Piras, Sara Poletti, Andrew E Reineberg, Gloria Roberts, Rafael Romero-García, Matthew D Sacchet, Giovanni A Salum, Anca-Larisa Sandu, Carl M Sellgren, Eiji Shimizu, Harry R Smolker, Jair C Soares, J Douglas Steele, Frederike Stein, Dan J Stein, Benjamin Straube, Lea Teutenberg, Florian Thomas-Odenthal, Paula Usemann, Romain Valabregue, Johanna Valencia-Echeverry, Gerd Wagner, Gordon Waiter, Martin Walter, Heather C Whalley, Mon-Ju Wu, Tony T Yang, Carlos A Zarate, Andre Zugman, Giovana B Zunta-Soares, Kees Van Heeringen, Sanne J H Van Rooij, Nic Van Der Wee, Steven Van Der Werff, Paul M Thompson, Hilary P Blumberg, Anne-Laura Van Harmelen, Miguel E Rentería, Neda Jahanshad, Enigma Suicidal Thoughts And Behaviours Consortium, Lianne Schmaal

Faculty, Staff and Student Publications

Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity and radial diffusivity) for 24 WM tracts and one global measure were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of …