Life Sciences Commons^™

The Head-Direction Signal Is Generated From Two Types Of Head Direction Cells In Brainstem Nuclei, Ryan M. Yoder

Psychology

Head direction (HD) cells discharge based on an animal's directional heading. Computational models propose that a ring-attractor network across the connections between the lateral mammillary (LMN) and dorsal tegmental nuclei (DTN) underlies the signal's generation. These models contain neurons that encode either HD or angular head velocity (AHV), but also require cells that are sensitive to both parameters conjunctively (HD + AHV). Here we identify both types of HD cells in the LMN and DTN of female rats, with one population sensitive to AHV (both symmetric and asymmetric), and the other population insensitive to AHV. Notably, many HD + AHV …

How Plants Defy Gravity, Olivia Y. Kim, Agatha Shaikhutdinova, Joshua Lee, Reece Sit, Daniel Yang, Aliyah Shams, Kathryn Choi, Esther Yoo

STEM for Success Showcase

This educational short book, written by students, uses creative descriptions to make biology and chemistry concepts engaging and easy to understand.

Strengthening The Utah Diabetes Cook Along Program For Statewide Extension Delivery: Curriculum Refinement And Randomized Controlled Trial, Carrie Durward

Funded Research Records

No abstract provided.

Surface And Intradermal Temperature Responses Of Adults To Ambient Heat Stress With And Without Cooling, Zachary J. Mckenna, Elizabeth A. Gideon, Erin Harper, Taysom E. Wallace, Isa A. Farooqi, Craig G. Crandall

Health, Human Performance and Recreation Faculty Publications and Presentations

Accurate measurement of skin temperature is crucial to understanding responses to heat. We tested the hypothesis that intradermal temperature would differ from skin surface temperature during ambient heating with and without fan and water spray (24 degrees C). Nine healthy adults rested in an environmental chamber maintained at 40 degrees C and 15% relative humidity with and without fan, fan + water spray, and water spray. We assessed temperature in the dermal space (intradermal) and on the skin surface (surface) using thermocouple microprobes. In addition, we measured skin temperature using a standard uninsulated thermocouple taped to the skin (standard). During …

Data Accompanying "Landscape Composition Surrounding Restoration Projects Modulates Use By Wildlife: A Case Study Of Mule Deer In Utah", Jaylin Solberg

Browse all Datasets

With mule deer (Odocoileus hemionus), hereafter, deer, populations in decline, wildlife managers have increased their efforts to improve factors that limit population growth. In the State of Utah (hereafter, Utah), these efforts have included habitat restoration which is expected to improve environmental conditions for deer. Some of these efforts include pinon-juniper removal, prescribed burning, and spraying of invasive plant species. Although previous work has demonstrated the local impacts of restoration on deer populations, it is unknown how the environmental conditions in the landscape surrounding restoration treatments may modify local restoration impacts. Identifying how both local and landscape-scale conditions influence deer …

A Multi-Faceted Study Of Antibiotic-Resistant, Opportunistic Pathogens In Wastewater And Environmental Water, Jeanette Calarco

USF Tampa Graduate Theses and Dissertations

More than 2.8 million infections due to antibiotic-resistant bacteria occur annually in the United States, and more than 35,000 people die as a result. Domestic wastewater (sewage), which contains antibiotic-resistant bacteria and antibiotic resistance genes, is collected at treatment plants for removal of contaminants, e.g. pathogenic microorganisms and nutrients. While wastewater treatment is designed to remove antibiotic-resistant bacteria and other microorganisms through treatment and disinfection, some bacteria may escape treatment. Treated wastewater effluent is generally discharged into surface waters; however, some fraction of the effluent may be used as recycled water. Compromised wastewater collection infrastructure and sewage spills can disseminate …

Leveraging Dna Methylation Profiling And Microrna Sequencing To Characterize The Epigenomic Landscape Of Major Depressive Disorder Disease Trajectory, Jan Dahrendorff

USF Tampa Graduate Theses and Dissertations

Major depressive disorder (MDD) is a common and debilitating mental disorder associated with a significant disease burden and economic cost. Despite ample evidence documenting the efficacy of a diverse array of established MDD therapies, a large proportion of patients are inadequately responsive to initial treatment attempts, with first-line treatments leading to remission in only ~30% of the patients. Importantly, about a third of patients even fail to achieve symptom improvement after two or more antidepressant trials, resulting in what is commonly defined as treatment-resistant depression (TRD). The ability to identify which treatments are most likely to elicit a positive response …

Data And Code Used For The Manuscript, "Robust Native Aquatic Plant Propagule Banks Limit Curly-Leaved Pondweed", Meghan Slocombe

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The relationship between the invasive curly-leaf pondweed (CLP) and native aquatic plants was explored via a sixteen month mesocosm experiment and annual surveys of the passive revegetation of the newly restored Provo River Delta (Utah, USA) (PRD). These studies took place in 2023 and 2024.

Integrating Pathogenic Variants, Polygenic Risk Score, And Family History For Prostate Cancer Risk Estimation In Men Of African Ancestry, Fei Chen, Xin Sheng, Anqi Wang, Yili Xu, Raymond Hughley, Loreall Pooler, Susan M Gundell, Godfrey Kigozi, Gertrude Nakigozi, Fred Nalugoda, Joseph Kagaayi, Grace Nalwoga Kigozi, Stephen Mugamba, Emmanuel Kyasanku, James Nkale, Vitalis Ofumbi Olwa, Alexander Lubwama, Alex Daama, Resty Nakajugo, Ben Adusei, Mohamed Jalloh, Serigne Magueye Gueye, Andrew A Adjei, James Mensah, Pedro W Fernandez, Akindele Olupelumi Adebiyi, J Olufemi Ogunbiyi, Oseremen Inokhoife Aisuodionoe-Shadrach, Lindsay Petersen, Wenlong Carl Chen, Jo Mcbride, Jeannette T Bensen, James L Mohler, Jack A Taylor, Caroline Andrews, Mbaaga Kigongo, Amanya Colline, Vicky Kiddu, Juliet Namugambe, Shallot Owamaani, Kuteesa Job, Benon Joseph Masaba, Frank Asiimwe, Proscovia Muwanga, Joy Namulondo, Florence Nagawa, Charity Kayiraba, Martin Ogwang, Ronald Okidi, David Oweka, Elio Kitara, James Obonyo, Daniel Lajul, Paul Matovu, Precious Arinda Muheki, Johnson Natumanya, Emmanuel Agaba, Emmanuel Aculokin, Amos Twongyeirwe, George Mutema, Denis Bitamazire, Eboneé N Butler, Sue Ann Ingles, Benjamin A Rybicki, Janet L Stanford, Wei Zheng, Sonja I Berndt, Stephen J Chanock, Chad D Huff, Joseph Lachance, Luc Multigner, Burcu F Darst, Timothy R Rebbeck, Laurent Brureau, Stephen Watya, David V Conti, Christopher A Haiman

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVE: The impact of germline pathogenic variants (PVs) in cancer predisposition genes on risk of prostate cancer (PCa) remains understudied in large populations of African ancestry. This study aims to characterize the range of genetic risk of PCa and aggressive disease phenotypes in men of African ancestry.

METHODS: We analyzed 7176 PCa cases and 4873 controls from seven countries across North America and Africa to assess the association between PVs in 37 cancer predisposition genes and the risk of overall, aggressive, and metastatic PCa. Genes significantly associated with PCa risk were used to estimate lifetime absolute risk based …

Incidence And Risk Factors For Pneumonitis Due To Trastuzumab Deruxtecan In Metastatic Breast Cancer: A Retrospective Cohort Study, Maria Azhar, Felipe Soto, Amber Su, Norma Alicia Vazquez Gonzalez, Kevin Bernal Medina, Cesar Chavez Duran, Colin Chan, Girish S Shroff, Roland L Bassett, Sarah Pasyar, David Zhang, Vickie R Shannon, Mehmet Altan, Melissa P Mitchell, Funda Meric-Bernstam, Jason Mouabbi, Rashmi K Murthy, Saadia A Faiz, Lara Bashoura, Bora Lim, Ajay Sheshadri

Faculty, Staff and Student Publications

Background: Fam-trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that targets human epidermal growth factor receptor 2 (HER2) and delivers a topoisomerase inhibitor payload. T-DXd has been effectively used to treat metastatic breast cancer but causes pneumonitis in 10–15% of cases. Risk factors associated with T-DXd pneumonitis are not well described.

Research question: What are the major clinical risk factors for T-DXd pneumonitis?

Study design and methods: We conducted a retrospective study of women with metastatic breast cancer at our institution treated with T-DXd as standard of care between 2020 and 2024. We collected clinical data, including demographics, relevant review …

Targeting Gd2 With Naxitamab Overcomes Gd3 Synthase-Driven Immune Suppression In Triple-Negative Breast Cancer, Vivek Anand, Bolutyfe Oderinde, Maryam Siddiqui, Anudishi Tyagi, Jenny Borgman, Michael Andreeff

Faculty, Staff and Student Publications

Gangliosides are acidic glycosphingolipids involved in cell-adhesion, signal-transduction and tumor progression. GD3 synthase (GD3S/ST8SIA1), a key enzyme in ganglioside biosynthesis, is upregulated in many cancers, including GD2+ breast cancer stem-like cells (BCSCs) in triple-negative breast cancer (TNBC). Here, we demonstrated the immunomodulatory role of GD3S and identified a fully humanized anti-GD2 antibody, naxitamab, as a therapeutic tool to target GD3S/GD2+ breast tumors. GD3S expression correlates with immune-checkpoint activation and reduced immune infiltration. Ectopic overexpression of GD3S suppressed macrophage-mediated phagocytosis and NK or T cell-induced cell death in BC cells. Lipidomic analysis identified GD2 as the major effector ganglioside …

Cofilin Inhibition Ameliorates Piezo2 And Ampa Dysfunction In A Mouse Model Of Angelman Syndrome, Luis O Romero, Manisha Bade, Elisa Carrillo, Sonia Paz-López, Syed A M Hasan, Vasanthi Jayaraman, Valeria Vásquez, Julio F Cordero-Morales

Faculty, Staff and Student Publications

Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported in dorsal root ganglia (DRG) neurons, along with impaired mechanosensitive ion channel activity. Currently, there are no pharmacological targets to prevent the decrease of F-actin in AS. Here, we utilize a first-in-class selective cofilin inhibitor (SZ-3) to restore PIEZO2 function in DRG neurons and glutamate-evoked currents in hippocampal neurons from AS mice. Using atomic force microscopy, we demonstrate that inhibiting cofilin, an actin-severing protein, with SZ-3 increases cellular stiffness by stabilizing the actin …

Prospective Phase Ii Clinical Trial Of Molecular Glioblastoma (Historical Grade 2 And 3 Idh Wildtype Gliomas) Preliminary Novel Exploratory Analyses: Treatment Intensification, Margin Reduction And Epigenetic Stratified Outcomes With Radiation Therapy And Chemotherapy, Debra Nana Yeboa, Benjamin T Whitfield, Ruitao Lin, Chinenye Lynette Ejezie, Todd A Swanson, Chenyang Wang, Subha Perni, Martin C Tom, Jing Li, Susan L Mcgovern, Rebecca Harrison, Nazanin K Majd, Vinay K Puduvalli, Ashley E Aaroe, Monica Loghin, Barbara J O'Brien, Anuj D Patel, Chirag B Patel, Jeffrey S Wefel, Ceylan Altintas Taslicay, Maria Gule-Monroe, Arnold C Paulino, Mary Frances Mcaleer, David R Grosshans, Amol J Ghia, Wen Jiang, Caroline Chung, Moshe Maor, Cheng-Han Yang, Maria A Gubbiotti, Carlos Kamiya-Matsuoka, Leomar Y Ballester, Shiao-Pei Weathers, Jason T Huse

Faculty, Staff and Student Publications

Purpose: Molecular glioblastoma (molGBM) is a variant lacking the full histopathological profile of glioblastoma. We report a trial aimed at addressing the optimal management of this newly recognized rarer form of glioma.

Methods: In this phase II study, molGBM patients were treated with radiation to a dose of 60Gy to the gross tumor volume (GTV) only, and a single smaller margin potentially as low as 1cm to the clinical tumor volume (CTV). As the trial is ongoing, we report on important exploratory biomarker findings correlating with median overall survival (mOS). Analysis included Kaplan-Meier and univariable/multivariable cox proportional hazard models. Available …

Comparing Characteristics Of Southern Illinois And Western Kentucky Soils, Jenna Grab, Jodi Terhorst, Madelyn G. Hughes, Kaitlynn R. Burrus

Scholars Week

Comparing Characteristics

of Southern Illinois and Western Kentucky Soils

Jenna Grab, Kaitlynn Burrus, Madelyn Hughes & Jodi Terhorst

Mentor: Dr. Iin Handayani, Ph.D.

Hutson School of Agriculture, Murray State University, Kentucky, USA

ABSTRACT

Assessing soil quality indicators is essential to determining soil health for plant growth. The objective of this study was to determine and compare various physical and chemical characteristics of soils in Western Kentucky (KY) and Southern Illinois (IL). Twenty-seven undisturbed and twenty-seven disturbed soil samples were collected from September 5th-27th from fields in Mascoutah and Metropolis, Illinois, along with fields in Schochoh and Benton, Kentucky. All soil …

Evaluating Soil Responses To Three Different Tillage Practices, Robert L. Burchett, Cordale L. Straub Senior, Logan D. Renfrow Sophomore

Scholars Week

Evaluating Soil Responses to Three Different Tillage Practices

Luke Burchett, Logan Renfrow, and Cordale Straub

Mentor: Dr. Iin Handayani Ph.D

Hutson School of Agriculture, Murray State University, Kentucky, USA

ABSTRACT

Tillage systems can greatly affect soil health by changing its structure, chemistry, and biological activity. This study examined how soil organic carbon (SOC), soil pH, soil moisture, soil organic matter (SOM) responds under three tillage systems: no-till, biannual tillage, and conventional tillage. Soil samples were taken from a 1–7.6 cm depth during September 2025 across three locations. The no-till site was located in Caldwell County, Kentucky, on an irrigated double-crop …

Impact Of Crop Rotation And Species Variation On Soil Quality Indicators, Somasekhar Auduti, Uday Kiran Pittala, Pratibha Adhikari

Scholars Week

Impact of Crop Rotation and Species Variation on Soil Quality Indicators

Pratibha Adhikari, Somasekhar Auduti, Uday Kiran Pittala

Mentor: Dr. Iin P. Handayani, Ph.D.

Hutson School of Agriculture, Murray State University, Murray, KY, USA

Designing crop rotations that counter the negative effects of monocropping requires crop choices that build carbon and create stable pore structure. The objective of this research was to evaluate the effects of crop rotation on selected soil health indicators and to interpret soil health conditions across agricultural fields. Soil samples were collected from West Farm, Murray, KY, from six crop fields—corn, soybean, tobacco, millet, cotton, and …

Assessing Soil Properties Under Pastures Managed For Different Livestock Systems In Western Kentucky, Chandralekha Joga Miss

Scholars Week

Soil health plays a vital role in sustainable agriculture, particularly in pasture-based livestock systems that influence physical and chemical soil properties. This study evaluated the effects of different livestock systems on surface soil characteristics in western Kentucky. Soil samples were collected from September 16 to September 22, 2025. Six fields were selected, representing beef, equine, swine, sheep/goat, poultry, and control (no livestock) systems. Both disturbed and undisturbed samples were collected from one soil depth (0–7.5 cm) to assess physical and chemical properties including bulk density (BD), total porosity, macroporosity, soil water holding capacity (SWHC), soil water at field capacity (SWFC), …

Shaping The Soil: A Comparison Of Equine, Bovine, And Ungrazed Hay Fields, Brody Ellis Higgs, Taylor Madison Wynn, Scottie Craig Berry

Scholars Week

Shaping the Soil: A Comparison of Equine, Bovine, and Ungrazed Hay Fields

Brody Higgs, Taylor Wynn, and Scottie Berry

Mentor: Dr. Iin. P. Handayani, PhD.

Hutson School of Agriculture, Murray State University, Murray, Kentucky, USA

ABSTRACT

Kentucky raises grazing species for multiple reasons, including food, recreation, and show. The most common of them are equine and bovine. These animals graze many acres across the state of Kentucky and impact soil properties in their pastures. This study was conducted on three pasturelands across Caldwell and Calloway counties in Kentucky. The pastures consisted of a cow pasture, a horse pasture, and a …

Assessing Soil Quality Indicators In Leguminous And Non-Leguminous Cropping Systems, Kabita Budthapa, Kranthi Vinukonda, Ramya Sree Teeguri

Scholars Week

It is crucial to understand how different cropping systems influence soil health to boost the efficiency of resources and sustainable agricultural outputs. This study examined the effects of leguminous (soybean and pea) and non-leguminous (sunflower and maize) cropping systems on selected soil characteristics. On September 16th, 2025, soil samples (24 disturbed and 24 undisturbed) were collected from the 0-7.5 cm depth of West Farm, Murray, Kentucky. Disturbed samples were analyzed for pH, soil organic matter (SOM), and soil organic carbon (SOC), while undisturbed samples were used to determine bulk density, porosity, soil water holding capacity (SWHC), and soil water field …

Comparative Assessment Of Soil Properties In Cropland And Forested Areas In Western Kentucky, Shiba Hari Dhakal, Abinash Dhungana, Ramson K C

Scholars Week

Soil health is profoundly influenced by its physical and chemical properties. These properties rely on land use systems; consequently, impact on soil functions and agricultural sustainability. The objective of this study was to determine selected physical and chemical properties affected by crop and forest management in Western Kentucky. Two crop and two forested areas with six replications each were selected for this study in September 2025 in Calloway County, Kentucky. A total of 24 disturbed and 24 undisturbed soil samples were collected at 0-7 cm depth. Disturbed samples were analyzed for soil pH, soil organic matter (SOM), and soil organic …

Evaluating Fungicide Efficacy In One And Two-Pass Fungicide Programs, Carson Buchanan

Scholars Week

Evaluating Fungicide Efficacy in One and Two-Pass Fungicide Programs

Carson Buchanan

Mentors: Dr. Megan Taylor, Dr. Iin Handayani

Murray State University, Murray, Kentucky, USA Abstract

Plant diseases continually threaten corn yields year after year. This study compared regionally important corn hybrids in a one-pass and two-pass application system. Eight rows of sixteen hybrids were planted in a field in Bargersville, Indiana. These hybrids consisted mostly of regionally important Dekalb hybrids, along with some competitive Pioneer hybrids. The entire field then got a V8 application of Stratego YLD. The field was then split in half and one half of the field …

Adaptation Of Exome Sequencing Methods For Low-Quality Genomic Dna Extracted From Aged Fta Micro-Cards In Sudden Death Investigations, Gerges Samir Nazir

Thesis/ Dissertation Defenses

DNA degrada􀆟on and insufficient gDNA quan􀆟ty and purity, preserving genomic DNA on FTA Micro-Cards presents substan􀆟al difficul􀆟es for forensic inves􀆟ga􀆟ons of unexpected fatali􀆟es. Through the use of lowquality genomic DNA recovered from four-year-old dried blood using FTA Micro-Cards, this effort seeks to enhance and op􀆟mize exome sequencing. Samples were sequenced using Next-Genera􀆟on Sequencing (NGS) with Illumina DNA Prep with Exome 2.0 Plus Enrichment with mitochondrial panel, star􀆟ng at 0.1 ng/μl of gDNA.To improve the coverage of mitochondrial genes, a mitochondrial DNA spike-in was included, and the samples were sequenced using the NextSeq 1000/2000 pla􀆞orm, employing the onboard DRAGEN Enrichment Pipeline …

A Fine Lady And Excellent Field Botanist: Sister Remberta Westkaemper, O.S.B., Stephen G. Saupe

Biology Faculty Publications

This report provides a brief biography of Sister Remberta and an overview of her botanical activities

Red Snapper (Lutjanus Campechanus) Neurocranium, Riley B. Glogowski, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

A Study Of Nonlinear Duffing Equations Using The Haar Wavelet Method, Kumbinarasaiah S., Yeshwanth R., Nandeesh K C.

Mansoura Engineering Journal

The main goal of this study is to solve Duffing equations, which are nonlinear differential equations (DEs), using the Haar wavelet technique. The solutions to this equation for an externally pushed and damped oscillator show intriguing dynamic behavior. Mathematicians have recently become more interested in wavelet analysis because of its real-world applications. A few real-world problems have been considered to assess the current methodology. Here, the (OMI) Operational Matrix of Integration and collocation points transform the non-linear ODEs into a system of nonlinear algebraic equations. The resulting system of algebraic equations is then solved using the Newton-Raphson technique to retrieve …

New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Continuing our genomics-driven exploration of butterfly taxonomy, we integrate phylogenetic trees from all protein-coding genes with existing taxonomic and phenotypic knowledge and uncover further insights into butterfly systematics. As a result, one subgenus, 44 species, and 11 subspecies are proposed as new (type species in original combinations or type localities are listed in parentheses): Porphaurea Grishin, subgen. n. (Phoenicops porphyropis Meyrick & Lower, 1902) of Chaetocneme C. Felder, 1860 in Hesperiidae Latreille, 1809; Dione (Agraulis) lamasi Grishin, sp. n. (Peru: Cuzco) in Nymphalidae Rafinesque, 1815; Lasaia (Lasaia) chiapis Grishin, sp. n. (Mexico: Chiapas), Lasaia …

Improving Coral Restoration Outcomes Through Novel Molecular Applications, Matthew H. Gamache

USF Tampa Graduate Theses and Dissertations

Coral reef ecosystems are declining globally from numerous stressors, including localized pollution, disease, and marine heatwaves induced by climate change. To preserve these ecosystems, it is critical to identify corals that can withstand stressors—primarily future marine heatwaves—and prioritize them for coral restoration efforts until these stressors are mitigated. Coral responses to thermal stress can be influenced by several partners, including mutualistic microalgae and a vast prokaryotic community. Here, I use advanced molecular techniques to examine which partners (coral host, algal symbiont, and microbial communities) are associated with coral health, how they contribute to holobiont physiology, and their potential to increase …

Artificial Light At Night Can Worsen Competitive Outcomes Between Native And Invasive Grasses, Shannon M. Murphy, Kylee Grenis, Anna A. Sher

Biological Sciences: Faculty Scholarship

Artificial light at night (ALAN) is an important global disturbance that affects community dynamics, but how it affects species interactions, such as competition, is not well understood and needs investigation. In plant communities, some exotic-invasive plant species seem to be facilitated by ALAN, which may alter competitive outcomes with native plant communities and promote invasion. Despite these intriguing results, whether ALAN affects competitive outcomes between native and invasive species is understudied. Here we tested how ALAN affects competitive outcomes between two native prairie grasses and two grasses that are exotic-invasive in North America. We planted each native species with a …

Effects Of Combining Traditional East Asian And Conventional Western Medicine On Acute Stroke Outcomes, Dong-Seok Gwak, Jong-Sik Lee, Dawid Schellingerhout, Jinyong Chung, Hyerin Oh, Ji Sung Lee, Mikyung Kim, Dong-Jun Choi, Dong-Eog Kim

Faculty, Staff and Student Publications

Background: Traditional East Asian medicine (TM) is widely used in Korea and other East Asian countries. However, the effects of TM treatment on acute ischemic stroke (AIS) outcomes remain unclear, as previous studies lacked a sufficient sample size, a consecutive series design, or a prospective outcome capture approach. We aimed to investigate whether combining TM with conventional Western medicine (CM) treatments (C+TM) leads to better outcomes after AIS, relative to CM treatment alone.

Methods: We retrospectively analyzed 2157 consecutive patients with AIS from a prospectively collected registry (2011-2021) at our center and compared the CM and C+TM groups in terms …

Therapeutic Potential Of Prmt1 As A Critical Survival Dependency Target In Multiple Myeloma, Tabish Hussain, Sharad Awasthi, Farid Shahid, S Stephen Yi, Nidhi Sahni

Faculty, Staff and Student Publications

Multiple myeloma (MM) is a neoplasm of antibody-producing plasma cells and is the second most prevalent hematological malignancy worldwide. Development of drug resistance and disease relapse significantly impede the success of MM treatment, highlighting the critical need to discover novel therapeutic targets. In a custom CRISPR/Cas9 screen targeting 197 DNA damage response-related genes, Protein Arginine N-Methyltransferase 1 (PRMT1) emerged as a top hit, revealing it as a potential therapeutic vulnerability and survival dependency in MM cells. PRMT1, a major Type I PRMT enzyme, catalyzes the asymmetric transfer of methyl groups to arginine residues, influencing gene transcription and protein function through …