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Articles 8041 - 8070 of 255934
Full-Text Articles in Life Sciences
A Compartmental Model For Diurnal Atlantic Stingray Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans
A Compartmental Model For Diurnal Atlantic Stingray Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Mathematically Modeling Stoichiometric Drivers Of Heterotrophic N2 Fixation, Corday R. Selden, Rebecca Everett, Halvor H. Halvorson, Megan E. Berberich, Luca Schenone, Angela Peace, Renn Schipper, Edwin Cruz-Rivera, James Powell, Keisuke Inomura, Robinson W. Fulweiler, Amy M. Marcarelli, J Thad Scott
Mathematically Modeling Stoichiometric Drivers Of Heterotrophic N2 Fixation, Corday R. Selden, Rebecca Everett, Halvor H. Halvorson, Megan E. Berberich, Luca Schenone, Angela Peace, Renn Schipper, Edwin Cruz-Rivera, James Powell, Keisuke Inomura, Robinson W. Fulweiler, Amy M. Marcarelli, J Thad Scott
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
A Compartmental Model For Annual Bat Migration, Elena D. Wheatley, Rhianna Yates, Leah Glasser, Christopher Hay-Jahans
A Compartmental Model For Annual Bat Migration, Elena D. Wheatley, Rhianna Yates, Leah Glasser, Christopher Hay-Jahans
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Modeling The Impact Of Treatment During An Ongoing Tuberculosis Outbreak, Bach Le, Jude Shive, Erin N. Bodine
Modeling The Impact Of Treatment During An Ongoing Tuberculosis Outbreak, Bach Le, Jude Shive, Erin N. Bodine
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Analyzing Urban Space-Use Of White-Tailed Deer (Odocoileus Virginianus), Szandra A. Péter, Zehidul Hussain, Solena Kronstedt, Amira Roess, Jennifer Mullinax, Travis Gallo, Taylor Anderson
Analyzing Urban Space-Use Of White-Tailed Deer (Odocoileus Virginianus), Szandra A. Péter, Zehidul Hussain, Solena Kronstedt, Amira Roess, Jennifer Mullinax, Travis Gallo, Taylor Anderson
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Balancing Stability And Complexity In Boolean Models Of Biological Networks, Venkata Sai Narayana Bavisetty
Balancing Stability And Complexity In Boolean Models Of Biological Networks, Venkata Sai Narayana Bavisetty
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
A Compartmental Model For Periodic Animal Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans
A Compartmental Model For Periodic Animal Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
A Compartmental Model For Annual Blue Whale Migration, Leah Glasser, Christopher Hay-Jahans, Elena Wheatley, Rhianna Yates
A Compartmental Model For Annual Blue Whale Migration, Leah Glasser, Christopher Hay-Jahans, Elena Wheatley, Rhianna Yates
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Optimizing The Distribution Of Fruiting Agave On Bat-Friendly Tequila Plantations, Grace Gorreck, Clarissa Azurin, Lois Carpenter
Optimizing The Distribution Of Fruiting Agave On Bat-Friendly Tequila Plantations, Grace Gorreck, Clarissa Azurin, Lois Carpenter
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Spatial Strategies In Ants: Modeling Polydomy, Saya Zeleznik, Fred Adler
Spatial Strategies In Ants: Modeling Polydomy, Saya Zeleznik, Fred Adler
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Modeling Self-Organizing Networks In Life Sciences And Beyond, Nina H. Fefferman
Modeling Self-Organizing Networks In Life Sciences And Beyond, Nina H. Fefferman
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Michigan Academician Volume 50, Issue 1
Michigan Academician Volume 50, Issue 1
Michigan Academician
2025 Michigan Academy Conference abstracts.
Khsrp-Mediated Decay Of Axonally Localized Prenyl-Cdc42 Mrna Slow Nerve Regeneration, Matthew D. Zdradzinski, Lauren S. Vaughn, Samaneh Matoo, Kayleigh Trumbull, Terika P. Smith, Davis Noblitt, Courtney N. Buchanan, Ashley Loomis, Elizabeth Thames, Seung Joon Lee, Nora Perrone-Bizzozero, Qun Lu, Jessica M. Larsen, Jeffery L. Twiss
Khsrp-Mediated Decay Of Axonally Localized Prenyl-Cdc42 Mrna Slow Nerve Regeneration, Matthew D. Zdradzinski, Lauren S. Vaughn, Samaneh Matoo, Kayleigh Trumbull, Terika P. Smith, Davis Noblitt, Courtney N. Buchanan, Ashley Loomis, Elizabeth Thames, Seung Joon Lee, Nora Perrone-Bizzozero, Qun Lu, Jessica M. Larsen, Jeffery L. Twiss
Faculty Publications
The small GTPase CDC42 promotes axon growth through actin filament polymerization and this growth is driven by axonal localization of the mRNA encoding the prenylated CDC42 isoform (Prenyl-Cdc42). Here, we show that axonal Prenyl-Cdc42 mRNA levels and the mRNA’s translation are decreased by growth-inhibiting stimulation and increased by growth-promoting stimulation. In contrast, axonal RhoA mRNA transport and translation are increased by growth-inhibiting but unaffected by growth-promoting stimuli. Localized increase in KHSRP in response to growth inhibitory stimulation, through elevation of intracellular Ca2+, promotes decrease in axonal levels of Prenyl-Cdc42 mRNA. Distinct 3’UTR motifs regulate transport and …
Dissolved Organic Matter Composition Differs Across Water Types In Mid-Atlantic And Great Lakes Coastal Regions, Jesse Alan Roebuck, Allison N. Myers-Pigg, Peter Regier, Nicholas D. Ward, Matthew J. Cooper, Kenneth M. Kemner, Amy Marcarelli, Elizabeth C. Minor, Michael Philben, Bongkeun Song, Rodrigo Vargas, Jianqiu Zheng
Dissolved Organic Matter Composition Differs Across Water Types In Mid-Atlantic And Great Lakes Coastal Regions, Jesse Alan Roebuck, Allison N. Myers-Pigg, Peter Regier, Nicholas D. Ward, Matthew J. Cooper, Kenneth M. Kemner, Amy Marcarelli, Elizabeth C. Minor, Michael Philben, Bongkeun Song, Rodrigo Vargas, Jianqiu Zheng
Michigan Tech Publications
Dissolved organic matter (DOM) in coastal surface waters influences local water quality and is an important component of biogeochemical cycling in coastal systems. Many studies have highlighted transformations of DOM along longitudinal river to estuary transects; however, processes that alter DOM composition along lower reaches of rivers and nearshore estuarine waters is poorly understood. The high productivity of coastal environments and their limited representation in Earth System Models further highlights a need for better understanding of DOM transformations along coastal reaches. We leverage a spatially distributed community sampling effort that spans coastal ecosystems across two regions to identify broad spatial …
Paintings Analysis Using Copilot Ai: The Case Of Winston Churchill And Art In His Life, Yuri Zagvazdin
Paintings Analysis Using Copilot Ai: The Case Of Winston Churchill And Art In His Life, Yuri Zagvazdin
Learning and Educational Center Virtual Teaching and Learning Conference
The objective of this presentation is to demonstrate a method for analyzing artistic style and its potential evolution using the Copilot AI platform. As a case study, I explore the paintings of Winston Churchill (1874–1965), the British Prime Minister, who was also a passionate and prolific painter. Although Churchill began painting in his forties, he produced over 500 works, with his final piece completed in 1962.
Churchill frequently painted scenes from Southern France and Morocco—locations he returned to repeatedly throughout his artistic life. Remarkably, he continued painting even after suffering multiple cerebrovascular accidents. Stroke-induced brain damage is typically detrimental to …
Screening Of Potential Plant Growth‐Promoting Rhizobacteria (Pgpr)-Assisted Phytoremediation To Mitigate Lead Toxicity In Uae Soils, Zeinab A. Mohamed
Screening Of Potential Plant Growth‐Promoting Rhizobacteria (Pgpr)-Assisted Phytoremediation To Mitigate Lead Toxicity In Uae Soils, Zeinab A. Mohamed
Thesis/ Dissertation Defenses
Plant growth-promoting actinobacteria can enhance plant resilience to heavy metal contamination. This study evaluated the effects of 1-aminocyclopropane-1-carboxylate deaminase (ACCD)-producing rhizosphere-competent (RC) and non-rhizosphere-competent (NRC) actinobacterial strains on corn growth and lead (Pb) tolerance. A greenhouse experiment was conducted under Pb stress [1000 mg/kg soil as Pb(NO₃)₂] to compare the two isolates. Inoculated plants performed better than uninoculated controls, particularly in non-contaminated soils. Under Pb stress, the isolates #22 (NRC) and #30 (RC) significantly enhanced plant height, dry weight, and chlorophyll content, with RC isolate #30 exhibiting the most pronounced effects. Identified as Streptomyces mirabilis UAE2, isolate #30 reduced electrolyte …
Isolation And Characterization Of Plant Growth Promoting Rhizobacteria From Soils In The Uae And Their Effect On Plant Salt Tolerance, Layla Zayed Almazrouei
Isolation And Characterization Of Plant Growth Promoting Rhizobacteria From Soils In The Uae And Their Effect On Plant Salt Tolerance, Layla Zayed Almazrouei
Thesis/ Dissertation Defenses
Plants are constantly challenged by environmental stresses that restrict their growth and productivity. In the United Arab Emirates (UAE), soil salinity is a critical barrier to agriculture, particularly for tomato (Solanum lycopersicum), which is highly sensitive to moderate salinity levels (>2.5 dS m⁻¹). This study explored the potential of plant growth–promoting rhizobacteria (PGPR), especially actinobacteria, to enhance salt tolerance in tomato. The objective was to evaluate the effeccts of rhizosphere-competent (RC) and non-rhizosphere-competent (NRC) PGPR on plant physiology and yield in saline sandy soils. Actinobacterial strains were isolated from the tomato rhizosphere were screened for the production of 1-aminocyclopropane-1-carboxylic …
Analysis Of An Effective Training Curriculum: Solutions Toincrease Participants' Interest In Training Teachingmaterials, Maulidya Husnul Khatimah, Yoto Yoto
Analysis Of An Effective Training Curriculum: Solutions Toincrease Participants' Interest In Training Teachingmaterials, Maulidya Husnul Khatimah, Yoto Yoto
Jurnal Pendidikan Sains
This research is important because it analyzes the curriculum as a primary tool for generating and maintaining participant interest. Curricula that are irrelevant, monotonous, or misaligned with participant needs are often the main causes of low motivation and participation. Furthermore, this research encourages the exploration and implementation of more innovative teaching methods and materials in training curricula. External pressure in the form of demands or instructions, rather than internal motivation, drives most training activities. This can reduce engagement and learning effectiveness. To overcome this, training institutions need to design programs that are relevant, flexible, and able to encourage participants' intrinsic …
Augmented Reality-Assisted E-Module On Temperature Andheat Content (Emarks), Tetri Sabrina, Ika Mustika Sari, Dedi Sasmita
Augmented Reality-Assisted E-Module On Temperature Andheat Content (Emarks), Tetri Sabrina, Ika Mustika Sari, Dedi Sasmita
Jurnal Pendidikan Sains
Temperature and heat content (calor) material in physics often involves concepts and phenomena that are difficult to observe directly or are abstract (such as energy transfer, particle movement, and changes in state). EMARKS (AR-based E-modules) are important because Augmented Reality (AR) allows the visualization of these abstract concepts in the form of interactive 3D models in the user's real environment. This helps students understand the concepts more concretely and easily. The development of E-modules is an innovation in learning media that is relevant to the demands of the digital era and the needs of modern students. The use of advanced …
The Effect Of Guided Inquiry Model With Deep Learningapproach On Student’S Hots In Elements, Compounds,And Mixtures At Junior High School, Friska Pakpahana, Retno Dwi Suyanti
The Effect Of Guided Inquiry Model With Deep Learningapproach On Student’S Hots In Elements, Compounds,And Mixtures At Junior High School, Friska Pakpahana, Retno Dwi Suyanti
Jurnal Pendidikan Sains
The current education curriculum places a strong emphasis on developing HOTS skills (such as analyzing, evaluating, and creating) to prepare students for the challenges of the 21st century. School learning often focuses on lower-level cognitive domains (memorizing and understanding). This research seeks to address this gap by offering a potentially effective learning model. The guided inquiry model positions students as active participants in learning, encouraging them to investigate, discover, and formulate concepts independently with teacher guidance. This strongly supports the development of critical thinking and problem-solving skills. Therefore, this study aims to analyze the effect of the guided inquiry model …
Development Of Problem-Based Learning Worksheet Toenhance Ecoliteracy: Human Impact On Ecosystem, Ulina M.S. Simangunsong, B. Manurung, Martina Asiati Napitupulu
Development Of Problem-Based Learning Worksheet Toenhance Ecoliteracy: Human Impact On Ecosystem, Ulina M.S. Simangunsong, B. Manurung, Martina Asiati Napitupulu
Jurnal Pendidikan Sains
Ecoliteracy (ecological literacy) is an individual's ability to understand basic ecological principles and make environmentally responsible decisions. Improving ecoliteracy is a crucial foundation for realizing Education for Sustainable Development (ESD), which prepares students to become proactive citizens in protecting the environment. The problem-based learning model helps students learn on their own by using real-world environmental cases to get them to think critically and solve problems. Therefore, this research aims to determine the effectiveness of using problem-based learning worksheets to enhance the ecoliteracy of seventh-grade students. The development model used is 4-D. The research instruments include expert validation forms for subject, …
Development Of E-Lkpd Assisted By Phet Colorado Basedon Discovery Learning: Critical Thinking Skills On Lightmaterial At Junior High School, Flora Yani Saragih, Pintor Simamora
Development Of E-Lkpd Assisted By Phet Colorado Basedon Discovery Learning: Critical Thinking Skills On Lightmaterial At Junior High School, Flora Yani Saragih, Pintor Simamora
Jurnal Pendidikan Sains
Critical thinking is necessary for 21st-century pupils, but PISA data suggest that Indonesian students, especially junior high school students, lack it. The junior high science/physics light material is abstract and involves in-depth reasoning (reflection, refraction, and shadow generation). Without critical thinking, kids memorize formulas or notions without analyzing real phenomena. Discovery learning involves pupils discovering concepts via observation and experimentation. Critical thinking requires initiative, exploration, and reasoning, which these foster. Therefore, this study aims to develop E-LKPD based on Discovery Learning assisted by an interactive simulation of PhET Colorado to strengthen the critical thinking skills of grade VIII students on …
Guided Inquiry Learning Assisted By Crossword Puzzlemedia: Student Scientific Literacy And Critical Thinkingability For Middle School, Agis Putri Niswa, Mariati Purnama Simanjuntak, Ramlan Silaban, Fauziyah Harahap, Ridwan Abdullah Sani
Guided Inquiry Learning Assisted By Crossword Puzzlemedia: Student Scientific Literacy And Critical Thinkingability For Middle School, Agis Putri Niswa, Mariati Purnama Simanjuntak, Ramlan Silaban, Fauziyah Harahap, Ridwan Abdullah Sani
Jurnal Pendidikan Sains
Scientific literacy and critical thinking skills are two fundamental competencies that students need in the 21st century. Scientific literacy is essential for students to understand and use scientific knowledge to make informed decisions, while critical thinking trains students to analyze information, evaluate arguments, and solve problems logically. Therefore, the intent of this study was to determine the effect of the guided inquiry learning model assisted by crossword puzzle media on students’ scientific literacy and critical thinking skills. The type of research used was quasi-experimental with a two-group pretest-posttest design. The sample consisted of two classes: class VII-8 as the control …
Red Snapper (Lutjanus Campechanus) Neurocranium, Sarah Hendricks, Morgan Indyk, David W. Kerstetter
Red Snapper (Lutjanus Campechanus) Neurocranium, Sarah Hendricks, Morgan Indyk, David W. Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Parameterizing Ion–Lipid Interactions From Local Clusters To Reproduce Experimental Bulk Properties Of Lipid Bilayers, W. Matthew Saunders
Parameterizing Ion–Lipid Interactions From Local Clusters To Reproduce Experimental Bulk Properties Of Lipid Bilayers, W. Matthew Saunders
USF Tampa Graduate Theses and Dissertations
Phospholipids are the main component of cell membranes, providing a delimiting boundary for cells from their environments or from their organelles from the cytosol. Thiscompartmentalization allows cells to maintain quite different solutions within their cells and organelles, including different mixtures dissolved ions. Consequently, these membranes are constantly flanked by complex mixtures of salts at varied concentrations. To study membrane structure, one cannot neglect the contribution of the salts in the local solution. Ions perturb bilayer structure via specific interaction with the phospholipids, primarily with the headgroups. Experimental studies of these systems are somewhat at odds — scattering experiments with different …
Humoral Immune Responses Following Immunization With Sars-Cov-2 Variant Vaccines, Chieh-Yu Liang
Humoral Immune Responses Following Immunization With Sars-Cov-2 Variant Vaccines, Chieh-Yu Liang
Arts & Sciences Graduate Student Theses and Dissertations
Viruses are infectious agents that depend on host cells for replication and can cause diseases ranging from mild illness to severe outcomes, including cancer and death. In the 21st century, several major viral outbreaks have occurred, including the 2002 severe acute respiratory syndrome coronavirus (SARS), the 2009 H1N1 influenza pandemic, the 2012 Middle East respiratory syndrome (MERS), the 2014 Ebola virus outbreak, and most recently, the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 2019. SARS-CoV-2 is a positive-sense, single-stranded RNA virus of the Betacoronavirus genus in the Coronaviridae family. First identified in Wuhan, China, the virus quickly spread …
Program Transition Success: A Practical Guide For Educators Moving Sbae Programs, Evey Choat
Program Transition Success: A Practical Guide For Educators Moving Sbae Programs, Evey Choat
Department of Agricultural Leadership, Education, and Communication: Dissertations, Theses, and Student Research
What tools, strategies, and support systems can help agriculture educators navigate leadership transitions and sustain program success when moving between schools or communities? Teacher mobility and leadership transitions within School-Based Agricultural Education (SBAE) present unique challenges to program continuity, community relations, and professional sustainability. Unlike other subject areas, SBAE teachers often manage multifaceted responsibilities—as classroom instructors, FFA advisors, and community liaisons—making transitions between programs especially complex. This project addresses the lack of structured support for educators navigating these transitions by developing a Program Transition Guide specifically tailored to the needs of agricultural educators in Nebraska.
Guided by Transformational Leadership Theory …
Compadre: Combined Pedigree-Aware Distant Relatedness Estimation For Improved Pedigree Reconstruction, Grahame F Evans, James T Baker, Lauren E Petty, Alexander S Petty, Hannah G Polikowsky, Ryan J Bohlender, Hung-Hsin Chen, Che-Yu Chou, Kathryn Z Viljoen, Janet M Beilby, Shelly Jo Kraft, Wanying Zhu, Joshua M Landman, Autumn R Morrow, Dayi Bian, Alyssa C Scartozzi, Chad D Huff, Jennifer E Below
Compadre: Combined Pedigree-Aware Distant Relatedness Estimation For Improved Pedigree Reconstruction, Grahame F Evans, James T Baker, Lauren E Petty, Alexander S Petty, Hannah G Polikowsky, Ryan J Bohlender, Hung-Hsin Chen, Che-Yu Chou, Kathryn Z Viljoen, Janet M Beilby, Shelly Jo Kraft, Wanying Zhu, Joshua M Landman, Autumn R Morrow, Dayi Bian, Alyssa C Scartozzi, Chad D Huff, Jennifer E Below
Faculty, Staff and Student Publications
Designing powerful and unbiased genomic studies requires accurate assessment of familial relatedness even when this information is not captured from participants. Characterization of pairwise degrees of relatedness from participants' genetic data enables reconstruction of pedigrees, and several pedigree reconstruction tools have emerged in the last decade. However, limitations of these tools include high computational burden in large datasets, reliance on external information, reduced accuracy in admixed populations, and most notably, an inability to accurately reconstruct pedigrees when only a subset of family members is represented in the genetic data. To improve pedigree reconstruction in large-scale data and in pedigrees with …
Distinct Tumor-Associated Macrophage Signatures Shape The Immune Microenvironment And Patient Prognosis In Renal Cell Carcinoma, Youngsoo Han, Aidan Shen, Cheng-Chi Chao, Lucas Yeung, Aliesha Garrett, Jianming Zeng, Satoru Kawakita, Jesse Wang, Zhaohui Wang, Alireza Hassani, Xiling Shen, Chongming Jiang
Distinct Tumor-Associated Macrophage Signatures Shape The Immune Microenvironment And Patient Prognosis In Renal Cell Carcinoma, Youngsoo Han, Aidan Shen, Cheng-Chi Chao, Lucas Yeung, Aliesha Garrett, Jianming Zeng, Satoru Kawakita, Jesse Wang, Zhaohui Wang, Alireza Hassani, Xiling Shen, Chongming Jiang
Faculty, Staff and Student Publications
Renal cell carcinoma (RCC) accounts for 90% of adult renal cancer cases and is characterized by significant heterogeneity within its tumor microenvironment. This study tests the hypothesis that tumor-associated macrophages (TAMs) influence RCC progression and patient response to treatment by investigating the prognostic implications of TAM signatures. Utilizing independent single-cell RNA sequencing data from RCC patients, we developed eight distinct TAM signatures reflective of TAM presence. A LASSO Cox regression model was constructed to predict survival outcomes, evaluated using the TCGA dataset, and validated across independent RCC cohorts. Model performance was assessed through Kaplan-Meier survival plots, receiver operating characteristic (ROC) …
Menin Inhibitor Ds-1594b Drives Differentiation And Induces Synergistic Lethality In Combination With Venetoclax In Acute Myeloid Leukemia Cells With Rearranged Mixed-Lineage Leukemia And Mutated Nucleophosmin-1, Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A Milne, Marina Konopleva
Menin Inhibitor Ds-1594b Drives Differentiation And Induces Synergistic Lethality In Combination With Venetoclax In Acute Myeloid Leukemia Cells With Rearranged Mixed-Lineage Leukemia And Mutated Nucleophosmin-1, Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A Milne, Marina Konopleva
Faculty, Staff and Student Publications
Mixed-lineage leukemia (MLL) rearrangements and Nucleophosmin-1 (NPM1) mutations are associated with acute leukemias whose pathogenesis is critically influenced by protein-protein interactions between menin and MLL. We hypothesized that targeting the menin-MLL interaction using DS-1594b and blocking the antiapoptotic BCL-2 protein using venetoclax may promote differentiation and enhance eradication of MLL-rearranged and NPM1-mutated leukemias models. We treated acute myeloid leukemia (AML) cell lines with MLL rearrangements, NPM1 mutations, other leukemias and primary samples from AML patients with venetoclax alone, DS- 1594b alone, and their combination. We measured proliferation, viability, apoptosis, and differentiation using a variety of cellular assays, Western blotting, and …