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Full-Text Articles in Life Sciences

Associations Between Gad-7 And Phq-9 Scores And Willingness To Seek Treatment, Josephine Shaw Nov 2025

Associations Between Gad-7 And Phq-9 Scores And Willingness To Seek Treatment, Josephine Shaw

Undergraduate Research Symposium Posters

In recent years, mental health concerns among college students have increased significantly. This study aims to analyze data on student willingness and frequency to seek counseling services, such as UNLV CAPS (Student Counseling and Psychological Services), and the appeal of utilizing alternative interventions such as exercise and meditation. This study collected data from UNLV students, faculty, and staff through distribution of a scannable QR code. It included whether they were in therapy, the PHQ-9 and GAD-7, their respective functional impairment questions, and willingness to consider therapy alternatives. Based on respondents’ answers to the PHQ-9, the highest proportion peaked at 36% …


Hawaiian Drosophila Host Plant Preferences, Kyrus Huang, Rodomir Stark Nov 2025

Hawaiian Drosophila Host Plant Preferences, Kyrus Huang, Rodomir Stark

Undergraduate Research Symposium Posters

Understanding how host plant availability influences behavior in Drosophila species provides valuable insight into ecological specialization and speciation. This study examines the effects of different host plants on the reproductive and oviposition behavior of Drosophila silvestris and Drosophila grimshawi. The primary objective of this project is to determine whether females exhibit host-plant preferences during egg-laying. A secondary aim is to assess whether sex and mating status influence host plant preference, specifically comparing male, unmated female, and mated female behavior with two host plants. To test these hypotheses, newly emerged flies were divided into three treatment groups: male-only, female-only, and mixed …


Effect Of Neuroinflammation On Exploratory Behavior In Mice, Gage Pompa, Ariana Mitic, Yader Gomez, Lilian Hagos, Orlando Montiel Nov 2025

Effect Of Neuroinflammation On Exploratory Behavior In Mice, Gage Pompa, Ariana Mitic, Yader Gomez, Lilian Hagos, Orlando Montiel

Undergraduate Research Symposium Posters

Introduction: Mice have been observed in both laboratory and field settings to exhibit a tendency to remain near corners and walls. This trait is known as positive thigmotaxis. Thigmotaxis has been recognized as a fundamental aspect of rodent behavior and used extensively as an anxiety index in mice. Although this characteristic has been recognized as a fundamental aspect of rodent behavior, thigmotaxis has been extensively studied in rectangular and circular environments. However, there is a notable lack of understanding of how alternative geometric configurations can influence this behavior.

Methods and Approach: Using a grid overlaid on the environment the mice …


Assessing How Early Vs. Late Exercise Influences Whole Body Glucose Tolerance And Insulin Signaling Pathways In Quadriceps During Social Jetlag, Ariana Khzarjyan, Austin Cooper, Paula Martinez, Joshua Corpuz, Srushti Wagh, Elias Malek, Todd Schrubb Nov 2025

Assessing How Early Vs. Late Exercise Influences Whole Body Glucose Tolerance And Insulin Signaling Pathways In Quadriceps During Social Jetlag, Ariana Khzarjyan, Austin Cooper, Paula Martinez, Joshua Corpuz, Srushti Wagh, Elias Malek, Todd Schrubb

Undergraduate Research Symposium Posters

BACKGROUND: Circadian rhythms regulate our physiological and metabolic processes throughout a 24-hour cycle. Disruptions to this rhythm with modern lifestyles creates irregular patterns. One of the most common forms of circadian rhythm disruptions amongst humans happens during the weekends, when people tend to stay up later and sleep in later compared to weekdays. This phenomenon is referred to as social jetlag (SJL).

PURPOSE: To determine whether timed exercise (early vs. late) can reduce the negative effects of social jetlag in mice. More specifically, determining whether exercise conducted in the early or late active phase of mice will impact the effects …


Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang Nov 2025

Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …


Integrative Profiling Strategies To Guide Personalized Therapy In Mantle Cell Lymphoma: A Pilot Study, Yang Liu, Holly A Hill, Yijing Li, Joseph Mcintosh, Vivian Jiang, Fangfang Yan, Yixin Yao, Yue Fei, Jared Zhang, Lawrence Qu, Jun Yao, Preetesh Jain, Ken Chen, Michael Wang Nov 2025

Integrative Profiling Strategies To Guide Personalized Therapy In Mantle Cell Lymphoma: A Pilot Study, Yang Liu, Holly A Hill, Yijing Li, Joseph Mcintosh, Vivian Jiang, Fangfang Yan, Yixin Yao, Yue Fei, Jared Zhang, Lawrence Qu, Jun Yao, Preetesh Jain, Ken Chen, Michael Wang

Faculty, Staff and Student Publications

Mantle cell lymphoma (MCL) responds to frontline therapy but is susceptible to relapse. While Bruton's tyrosine kinase inhibitors (BTKi) achieve high response rates, most patients eventually experience disease progression. Predicting responses to subsequent treatments remains challenging due to the lack of an established platform. Heterogeneity in gene alterations and cellular pathways contribute to resistance, complicating treatment approaches. Here, we present a multi-modal profiling platform, targeting key pathways rather than focusing on singular DNA-associated lesions. We identified dysregulated signaling pathways by performing gene expression profiling on 20 MCL samples using a custom MCL MATCH gene set and analyzed the data with …


Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe Nov 2025

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …


First Report Of A Bat Guano Fire From A Cave In Southeast Asia, Sopark Jantarit, Martin Ellis, Pruet Kalasuwan, Neeranuch Phusunti, Pimonsri Mittraparp-Arthorn, Jiranan Pattano, Arnon Chukamnerd, Turdtun Tong-In, Natthawut Khrueaaunruean Nov 2025

First Report Of A Bat Guano Fire From A Cave In Southeast Asia, Sopark Jantarit, Martin Ellis, Pruet Kalasuwan, Neeranuch Phusunti, Pimonsri Mittraparp-Arthorn, Jiranan Pattano, Arnon Chukamnerd, Turdtun Tong-In, Natthawut Khrueaaunruean

International Journal of Speleology

Fires occurring in cave guano are a rare and unusual phenomenon and the occurrence of such events in Southeast Asia is particularly novel. In this study, we document the first recorded instance of a bat guano fire in a tropical cave at Tham Chao Ram in Sukhothai province, northern Thailand. A bacteriological analysis was made of the guano at the fire site and from a control site within the cave. We give a comprehensive review of global reports on bat guano fires in caves, conduct an initial investigation of the physical factors at the fire site and discuss the potential …


Novel Eco-Friendly Synthesis Of Coo Nps: Evaluation Of Their Diode Laser-Enhanced Inhibitory Activity Through Combined In Silico And In Vitro Approaches., Arshad Mahdi Hamad, Sahar Naji Rashid Nov 2025

Novel Eco-Friendly Synthesis Of Coo Nps: Evaluation Of Their Diode Laser-Enhanced Inhibitory Activity Through Combined In Silico And In Vitro Approaches., Arshad Mahdi Hamad, Sahar Naji Rashid

Karbala International Journal of Modern Science

In our study, for the first time worldwide, to the best of our knowledge, cobalt oxide nanoparticles (CoO NPs) were synthesized using naringin (Nar) extracted from citrus peels. The properties of the prepared Nar-CoO NPs were studied using field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), ultraviolet-visible (UV-Vis), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. All the test results demonstrated the efficiency and success of the nanofabrication process. The solution was then exposed to three types of diode lasers: red (650 nm), green (532 nm), and blue (405 nm). The purpose of this study was …


Gdf15 Is A Putative Biomarker For Distinguishing Pulmonary Veno-Occlusive Disease And Pulmonary Arterial Hypertension, Amit Prabhakar, Eckart De Bie, Jacqueline T. Desjardin, Prajakta Ghatpande, Stefan Gräf, Luke S. Howard, S. John Wort, Colin Church, David G. Kiely, Uk Pulmonary Arterial Hypertension Cohort Study Consortium, Emily Sumpena, Thin Aung, Shenrae Carter, Jasleen Kukreja, Steven Hays, John R. Greenland, Jonathan P. Singer, Michael Wax, Paul J. Wolters, Marc A. Simon, Mark Toshner, Giorgio Lagna, Akiko Hata Nov 2025

Gdf15 Is A Putative Biomarker For Distinguishing Pulmonary Veno-Occlusive Disease And Pulmonary Arterial Hypertension, Amit Prabhakar, Eckart De Bie, Jacqueline T. Desjardin, Prajakta Ghatpande, Stefan Gräf, Luke S. Howard, S. John Wort, Colin Church, David G. Kiely, Uk Pulmonary Arterial Hypertension Cohort Study Consortium, Emily Sumpena, Thin Aung, Shenrae Carter, Jasleen Kukreja, Steven Hays, John R. Greenland, Jonathan P. Singer, Michael Wax, Paul J. Wolters, Marc A. Simon, Mark Toshner, Giorgio Lagna, Akiko Hata

Biology

To the Editor: Pulmonary veno-occlusive disease (PVOD) is a rare, severe group 1 pulmonary arterial hypertension (PAH) subtype with poor survival (1). PAH-targeted vasodilators can cause life-threatening pulmonary edema in PVOD, underscoring the need for diagnostic tools to distinguish it from other PAH subtypes (1). In patients and mitomycin C–induced (MMC-induced) model animals, aberrant activation of integrated stress response (ISR) via protein kinase R (PKR) drives cardiovascular phenotypes of PVOD (2–4). Inhibition of the PKR-ISR axis, using either the PKR inhibitor C16 or the ISR inhibitor ISRIB, reverses PVOD phenotypes (2–4). Because GDF15 is a cytokine induced by the ISR …


The Role Of Nutrition-Sensitive Interventions In Improving Nutritional Outcomes: Findings From A Systematic Review And Meta-Analysis, Thomas De Hoop, Adria Molotsky, Rebecca Walcott, Pablo Gaitán-Rossi, Sonia Hernández-Cordero, Amos Laar, Torben Behmer, Hoa Thi Mai Nguyen, Averi Chakrabarti, Garima Siwach, Varsha Ranjit, Vania Lara-Mejía, Bianca Franco-Lares, Mireya Vilar-Compte Nov 2025

The Role Of Nutrition-Sensitive Interventions In Improving Nutritional Outcomes: Findings From A Systematic Review And Meta-Analysis, Thomas De Hoop, Adria Molotsky, Rebecca Walcott, Pablo Gaitán-Rossi, Sonia Hernández-Cordero, Amos Laar, Torben Behmer, Hoa Thi Mai Nguyen, Averi Chakrabarti, Garima Siwach, Varsha Ranjit, Vania Lara-Mejía, Bianca Franco-Lares, Mireya Vilar-Compte

Department of Nutrition and Food Studies Scholarship and Creative Works

Background

Maternal and child undernutrition remains a major global health concern despite modest progress. Accelerating reductions in stunting and wasting will require increased investments in nutrition-sensitive interventions, which target nutrition impacts outside of the healthcare setting. This review examines the effects of four types of nutrition-sensitive interventions —cash/food transfers, nutrition-sensitive agriculture, water/sanitation/hygiene, and school nutrition— on maternal and child nutrition outcomes and dietary diversity.

Methods

We synthesized the evidence using an initial broad search and synthesis for nutrition-sensitive interventions, followed by targeted searches and syntheses for specific interventions and nutrition outcomes. Meta-analyses were performed to evaluate the impacts of cash …


Mahi Mahi (Coryphaena Hippurus) Neurocranium, Ameer Tolani, David W. Kerstetter Nov 2025

Mahi Mahi (Coryphaena Hippurus) Neurocranium, Ameer Tolani, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


Navigating Structure, Function, And Stability: Bridging Immunotherapy And Protein Engineering In The Era Of Machine Learning, Christopher J. Haynie Nov 2025

Navigating Structure, Function, And Stability: Bridging Immunotherapy And Protein Engineering In The Era Of Machine Learning, Christopher J. Haynie

Theses and Dissertations

The immune system is a remarkably adaptive network, yet it often fails to function optimally due to evasion strategies of pathogens or mutated cells. Many of these evasion strategies involve alterations in protein expression and function. Protein design is an area of computational biology with potential applications in improving protein function and therapeutic protein engineering. This thesis explores methods to enhance immune function and protein design across multiple scales, from molecular engineering of antibody fragments and chimeric antigen receptors (CARs) to cellular immune responses, and computational approaches for protein structure optimization. We characterize Thymidine Kinase 1-specific single-chain antibodies, highlighting both …


Evaluating Policy And Industry-Based Interventions For Healthier Online Food-Away-From-Home Choices: A Scoping Review, Vincenzina Caputo, Jiayu Sun, Ellen J. Van Loo Nov 2025

Evaluating Policy And Industry-Based Interventions For Healthier Online Food-Away-From-Home Choices: A Scoping Review, Vincenzina Caputo, Jiayu Sun, Ellen J. Van Loo

Department of Agricultural Economics Faculty Publications

The rapid digital transformation of the food-away-from-home (FAFH) sector has redefined how consumers access and select meals. Digital delivery platforms such as Uber Eats, Deliveroo, and Meituan have become influential market intermediaries, shaping the nutritional landscape of food environments and raising concerns about their healthfulness. This study reviews empirical evidence on policy-based and industry-led interventions aimed at improving dietary outcomes in digital FAFH environments. Following PRISMA guidelines and using machine-learning–assisted screening (ASReview), 37 peer-reviewed studies were identified across four domains: nutritional labeling, fiscal measures, food-assistance programs, and digital nudges or decision-support tools. Findings indicate that although traditional food-policy instruments designed …


Evaluation Of Nine Sh2 Sweet Corn Cultivars In Southwest Michigan In 2025, Ben Phillips Nov 2025

Evaluation Of Nine Sh2 Sweet Corn Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A bicolor sh2 sweet corn cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). Seeds were donated by Crookham (CK), and Rupp (RP) seed companies. Two synergistic varieties were donated by Chris Difonzo from the Bt resistance project and were treated as unsprayed late-season checks against caterpillar infestation. Overall trial conditions were hot and dry, with moisture stress throughout the trial on a sandy hill. Overhead irrigation provided some relief. A new seeder was used that planted at a lower population than desired. As such, yield suffered in this trial.


Evaluation Of Six Roma Tomato Cultivars In Southwest Michigan In 2025, Ben Phillips Nov 2025

Evaluation Of Six Roma Tomato Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A Roma tomato cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). HM Clause (HM), Lark (LK), and Sakata (SK) seed companies donated 6 cultivars for plastic mulch-bedded hand harvest. Overall, the trial quality was good, with periods of high heat slowing ripening.


Vermicomposting, Hayley Waldbillig, Roslynn Brain, Scott Kent, Roslynn Brain Mccann Nov 2025

Vermicomposting, Hayley Waldbillig, Roslynn Brain, Scott Kent, Roslynn Brain Mccann

All Current Publications

Vermicomposting, or worm composting as it is more commonly known, is the process of using worms to break down discarded food and other organic wastes and convert them into compost and liquid fertilizers.


Five-Year Follow-Up Analysis Of Zuma-5: Axicabtagene Ciloleucel In Relapsed/Refractory Indolent Non-Hodgkin Lymphoma, Sattva S Neelapu, Julio C Chavez, Alison R Sehgal, Narendranath Epperla, Matthew L Ulrickson, Emmanuel Bachy, Pashna N Munshi, Carla Casulo, David G Maloney, Sven De Vos, Ran Reshef, Lori A Leslie, Olalekan O Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph D Rosenblatt, Jacob Wulff, Rhine R Shen, Wangshu Zhang, Soumya Poddar, Harry Miao, Olga Nikolajeva, Caron A Jacobson Nov 2025

Five-Year Follow-Up Analysis Of Zuma-5: Axicabtagene Ciloleucel In Relapsed/Refractory Indolent Non-Hodgkin Lymphoma, Sattva S Neelapu, Julio C Chavez, Alison R Sehgal, Narendranath Epperla, Matthew L Ulrickson, Emmanuel Bachy, Pashna N Munshi, Carla Casulo, David G Maloney, Sven De Vos, Ran Reshef, Lori A Leslie, Olalekan O Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph D Rosenblatt, Jacob Wulff, Rhine R Shen, Wangshu Zhang, Soumya Poddar, Harry Miao, Olga Nikolajeva, Caron A Jacobson

Faculty, Staff and Student Publications

Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) follicular lymphoma (FL). Here, we report updated clinical outcomes from ZUMA-5 in 159 enrolled patients with R/R indolent non-Hodgkin lymphoma (iNHL; 127 with FL and 31 with marginal zone lymphoma) after a median follow-up of 64.6 months. Patients underwent leukapheresis and received lymphodepleting chemotherapy and axi-cel (2 × 106 CAR T cells/kg). The overall response rate was 90% (75% complete response rate). The median duration of response was 60.4 months, and the median progression-free survival (PFS) was 62.2 months; median time to next …


Acute Myeloid Leukemia With T(10; 17)(P15; Q21)/ Zmynd11::Mbtd1: A Subtype With Minimal Differentiation, Cd7/Cd56 Expression, And Generally Poor Outcomes In Adults, Qing Wei, Naveen Pemmaraju, Sa A Wang, Shimin Hu, Courtney Dinardo, Ghayas C Issa, Carlos E Bueso-Ramos, Jie Xu, Shaoying Li, Jeffrey L Medeiros, Guilin Tang Nov 2025

Acute Myeloid Leukemia With T(10; 17)(P15; Q21)/ Zmynd11::Mbtd1: A Subtype With Minimal Differentiation, Cd7/Cd56 Expression, And Generally Poor Outcomes In Adults, Qing Wei, Naveen Pemmaraju, Sa A Wang, Shimin Hu, Courtney Dinardo, Ghayas C Issa, Carlos E Bueso-Ramos, Jie Xu, Shaoying Li, Jeffrey L Medeiros, Guilin Tang

Faculty, Staff and Student Publications

No abstract provided.


Early Tumor Volume Reduction By Breast Dce Mri Predicts Pathologic Complete Response To Neoadjuvant Therapy In Triple Negative Breast Cancer, Mary S Guirguis, Beatriz E Adrada, Clinton Yam, Debu Tripathy, Rosalind Candelaria, Wei Yang, Miral Patel, Tanya Moseley, Frances Perez, Gary J Whitman, Jessica W T Leung, Huong Le-Petross, Deanna L Lane, Lei Huo, Jennifer K Litton, Vicente Valero, Kelly K Hunt, Banu Arun, Rania Mohamed, Jia Sun, Anil Korkut, Zhan Xu, Sanaz Pashapoor, Jason White, Jong Bum Son, Alastair Thompson, Peng Wei, Jingfei Ma, Stacy Moulder, Gaiane M Rauch Nov 2025

Early Tumor Volume Reduction By Breast Dce Mri Predicts Pathologic Complete Response To Neoadjuvant Therapy In Triple Negative Breast Cancer, Mary S Guirguis, Beatriz E Adrada, Clinton Yam, Debu Tripathy, Rosalind Candelaria, Wei Yang, Miral Patel, Tanya Moseley, Frances Perez, Gary J Whitman, Jessica W T Leung, Huong Le-Petross, Deanna L Lane, Lei Huo, Jennifer K Litton, Vicente Valero, Kelly K Hunt, Banu Arun, Rania Mohamed, Jia Sun, Anil Korkut, Zhan Xu, Sanaz Pashapoor, Jason White, Jong Bum Son, Alastair Thompson, Peng Wei, Jingfei Ma, Stacy Moulder, Gaiane M Rauch

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a heterogeneous disease with variable response to neoadjuvant systemic therapy (NAST). Patients with pathologic complete response (pCR) following NAST have improved survival. Our goal was to establish readily accessible imaging biomarker to identify which TNBC patients will have pCR. Building on prior favorable results in the literature, we hypothesized that manually measured tumor volume changes at DCE-MRI may predict pCR early during NAST. This prospective study included 287 stage I-III TNBC patients who underwent DCE-MRI at baseline, after two and four cycles of NAST, with pCR accessed at surgery (NCT02276443). Tumor volume and percentage tumor …


Genome-Wide Association Study Of 398,238 Women Unveils Seven Loci Associated With High-Grade Serous Ovarian Cancer, Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington De Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel De La Hoya, Anna Defazio, Allison Depersia, Yuan Chun Ding, Jennifer A Doherty, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A Mcneish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Yen Y Tan, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah Nov 2025

Genome-Wide Association Study Of 398,238 Women Unveils Seven Loci Associated With High-Grade Serous Ovarian Cancer, Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington De Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel De La Hoya, Anna Defazio, Allison Depersia, Yuan Chun Ding, Jennifer A Doherty, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A Mcneish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Yen Y Tan, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah

Faculty, Staff and Student Publications

Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants for 398,238 women from the Ovarian Cancer Association Consortium (OCAC), UK Biobank (UKBB) and Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) to identify novel HGSOC susceptibility loci. Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was TP53 3’-UTR SNP rs78378222-T’s association with HGSOC (per-T-allele relative risk (RR) = 1.44, 95% CI:1.28–1.62, P = 1.76 × 10−9). Polygenic scores (PGS) were developed using OCAC and CIMBA data and trained on FinnGen data. The optimal PGS included 64,518 …


Tca Cycle Mode Switch Determines The Fate Of Pirtobrutinib-Tolerant Persister Cells In Mantle Cell Lymphoma, Wei Wang, Qingsong Cai, Yang Liu, Lei Nie, Heng-Huan Lee, Fangfang Yan, Yue Fei, Yixin Yao, Yijing Li, Lin Tan, Philip L Lorenzi, Ying-Nai Wang, Jun Yao, Zhihong Chen, Joseph Mitchell Mcintosh, Cheng-Tai Yu, Preetesh Jain, Vivian C Jiang, Jovanny Vargas, Xiaolin Li, Tianci Zhang, Shaoying Li, David Santos, Selvi Thirumurthi, Erin Heather Seeley, Lukas Mikolaj Simon, Christopher Flowers, Chi Young Ok, Michael Wang Nov 2025

Tca Cycle Mode Switch Determines The Fate Of Pirtobrutinib-Tolerant Persister Cells In Mantle Cell Lymphoma, Wei Wang, Qingsong Cai, Yang Liu, Lei Nie, Heng-Huan Lee, Fangfang Yan, Yue Fei, Yixin Yao, Yijing Li, Lin Tan, Philip L Lorenzi, Ying-Nai Wang, Jun Yao, Zhihong Chen, Joseph Mitchell Mcintosh, Cheng-Tai Yu, Preetesh Jain, Vivian C Jiang, Jovanny Vargas, Xiaolin Li, Tianci Zhang, Shaoying Li, David Santos, Selvi Thirumurthi, Erin Heather Seeley, Lukas Mikolaj Simon, Christopher Flowers, Chi Young Ok, Michael Wang

Faculty, Staff and Student Publications

Bruton tyrosine kinase inhibitors (BTKis) and cell therapy have successfully been used to treat mantle cell lymphoma (MCL). However, therapy resistance inevitably emerges. Cancer cells can progressively develop stable resistance by traversing through a transient drug-tolerant persister (DTP) state. The mechanisms enabling DTP cells to reversibly adapt to therapies and evolve to acquire heterogeneity remain poorly understood, and characterizing DTP cells in MCL continues to pose a challenge for clinic translation. Here, using pirtobrutinib, a recently US Food and Drug Administration-approved noncovalent BTKi, we identified pirtobrutinib-tolerant persister cells exhibiting morphological variability by presenting a unique population of enlarged cells (giant …


Can Motivation And Self-Efficacy Predict A Law Enforcement Officer’S General And Job-Specific Fitness?, Robert G. Lockie, Maria M. Beitzel, Tyler Campana, Jennifer Kramer, Robin (Rob) Marc Orr, J. Jay Dawes, Joseph Dulla Nov 2025

Can Motivation And Self-Efficacy Predict A Law Enforcement Officer’S General And Job-Specific Fitness?, Robert G. Lockie, Maria M. Beitzel, Tyler Campana, Jennifer Kramer, Robin (Rob) Marc Orr, J. Jay Dawes, Joseph Dulla

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1393-1409, 2025. https://doi.org/10.70252/GEHB5425 Sedentary behaviors contribute to law enforcement officer fitness declines over a career. An officer’s motivation (desire to exercise) and self-efficacy (belief in ability to exercise) could affect whether they exercise and predict resulting fitness. Data from 60 officers (48 men, 12 women) were analyzed. Motivation (amotivation, external, introjected, identified, integrated, and intrinsic regulation) was measured via the Behavioral Regulation in Exercise Questionnaire. A 6-item questionnaire assessed coping (confidence in exercising under challenging conditions) and scheduling (confidence in scheduling exercise) self-efficacy. General fitness variables included sit-and-reach, grip strength, 60-s push-ups, 60-s sit-ups, …


Designing And Writing Effective Data Management Plans For Grant Proposals, Rubab Shahzad, Ibis Anette Moreno-Lozano Nov 2025

Designing And Writing Effective Data Management Plans For Grant Proposals, Rubab Shahzad, Ibis Anette Moreno-Lozano

Day Family Research Lab Workshop Series

Fundamentals of research data management and how to create effective Data Management Plans (DMPs).


Ladyfish (Elops Saurus) Neurocranium, Kaylee M. Blanchard, David W. Kerstetter Nov 2025

Ladyfish (Elops Saurus) Neurocranium, Kaylee M. Blanchard, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


Optimization Of Bioethanol From Plantain Peel Using Saccharomyces Cerevisiae, Akinjide A. Akinola, Olawole O. Olanipekun, Paul A. David Nov 2025

Optimization Of Bioethanol From Plantain Peel Using Saccharomyces Cerevisiae, Akinjide A. Akinola, Olawole O. Olanipekun, Paul A. David

Mansoura Engineering Journal

This research aimed to evaluate the potential of using plantain peels as a raw material for producing bioethanol with the help of Saccharomyces cerevisiae. The study utilized a four-factor Box-Behnken design (BBD) and response surface methodology (RSM) to optimize the fermentation conditions. The factors considered for optimization were substrate concentration (1-4 g), pH (5-7), temperature (30-45°C), and fermentation time (24-96 hours). Through this optimization process, the study found that the optimal conditions for bioethanol production were 4 g substrate concentration, pH 6, 45°C temperature, and 60 hours of fermentation time. Utilizing these optimal conditions resulted in a bioethanol yield of …


Managed Online Panel Discussions As A Participatory Education Approach, Melissa M. Kreye, Kathryn Brooks, Eric Burkhart, Jesse Kreye, Allyson Muth, Calvin Norman, Sanford Smith, Scott Weikert Nov 2025

Managed Online Panel Discussions As A Participatory Education Approach, Melissa M. Kreye, Kathryn Brooks, Eric Burkhart, Jesse Kreye, Allyson Muth, Calvin Norman, Sanford Smith, Scott Weikert

Journal of Extension

We assessed the social learning benefits provided by online panel discussions, where topics and questions on forestry issues were collected from the audience, but the discussions were limited to the people on the panel. We also examined the influence of different panelists including experts, extension professionals and peers. Findings indicate that the panels advanced understanding of issues, but also generated a variety of social benefits (e.g., validation, self-awareness, empathy, passion) that supported views about sustainable forestry and stewardship. Panels that involve peers and extension professionals were slightly better at generating a productive social learning environment, compared to panels containing experts.


Understanding Perceptions About And The Practice Of Integrated Pest Management And Biological Control Of The Filth-Breeding Flies By Individuals Involved In The Equine Industry In The United States, Virgillia Adele Beyer-Junfin, Theresa Pesl Murphrey, David Lawver, Barry Boyd, Amy Boren-Alpizar, Rilee Hall, Audra W. Richburg Nov 2025

Understanding Perceptions About And The Practice Of Integrated Pest Management And Biological Control Of The Filth-Breeding Flies By Individuals Involved In The Equine Industry In The United States, Virgillia Adele Beyer-Junfin, Theresa Pesl Murphrey, David Lawver, Barry Boyd, Amy Boren-Alpizar, Rilee Hall, Audra W. Richburg

Journal of Extension

Filth-breeding flies pose significant health risks and costs in the equine industry. Although an arsenal of management strategies exists, integrated pest management (IPM) utilizing biological control (BC) offers cost and labor efficient pest control for equine facilities. Yet, little data exists on IPM adoption across the equine industry in the United States. This quantitative study examines the knowledge, perceptions, and adoption of IPM of those involved in the equine industry. Findings reveal knowledge barriers and time constraints as major preventatives. Preferred communication channels for IPM information are also identified. Recommendations are made for further research and practice in IPM and …


Interpreting Extension Professionals' Viewpoints On Agricultural Climate Change Programming, Aaron B. Wilson, Alli Wenman, Samuel Pratsch, Kenneth Genskow, Patrick Robinson, Dennis Todey, Laurie Nowatzke, Namah Chiamo Taku-Forchu, Moses Wanyakha Nov 2025

Interpreting Extension Professionals' Viewpoints On Agricultural Climate Change Programming, Aaron B. Wilson, Alli Wenman, Samuel Pratsch, Kenneth Genskow, Patrick Robinson, Dennis Todey, Laurie Nowatzke, Namah Chiamo Taku-Forchu, Moses Wanyakha

Journal of Extension

We evaluated Extension professionals' attitudes and beliefs from Midwestern "1862" land-grant universities around three themes: prioritizing climate programming, farmers' perceptions, and the role of Extension leadership in building capacity to integrate climate change into programs. Using key informant interviews and a two-hour virtual workshop, we developed 'coordinate planes' to illustrate the tensions and contradictions among the three themes, with participants expressing highly diverse viewpoints across the region. Results identify the need for Extension leadership to support multi-state programs and shared resources that provide consistent guidance and expectations around climate change programming while recognizing the intrinsic state context and values.


The Land-Grant University’S Role In Lifelong Workforce Development In Food, Agriculture, And Natural Resources: Leveraging The Relationship Between Academic And Extension Programs, T. Grady Roberts, Debra M. Barry, J.C. Bunch, Suzanna Browning, Jason C. Dossett, R. G. (Tre) Easterly Iii, Cassandra Goff, Carla Jagger, Juan Montealegre, Brian E. Myers, Heather Nesbitt, Jason Steward, Jessica Switzer Nov 2025

The Land-Grant University’S Role In Lifelong Workforce Development In Food, Agriculture, And Natural Resources: Leveraging The Relationship Between Academic And Extension Programs, T. Grady Roberts, Debra M. Barry, J.C. Bunch, Suzanna Browning, Jason C. Dossett, R. G. (Tre) Easterly Iii, Cassandra Goff, Carla Jagger, Juan Montealegre, Brian E. Myers, Heather Nesbitt, Jason Steward, Jessica Switzer

Journal of Extension

Today’s food, agriculture, and natural resources (FANR) workforce is constantly evolving. Lifelong learning is no longer a lofty goal but is now a necessity. Colleges of agriculture at land-grant universities have the potential to meet the lifelong learning needs of the FANR workforce. In this article, we present a model where the academic and Extension components of colleges of agriculture at land-grant universities can link together to provide seamless lifelong workforce development. Our model is built on workforce development theory and is based on the traditions of the land-grant universities evolving to meet the needs of the people. Our model …