Life Sciences Commons^™

Climate And Non-Genetic Effects On Goat Milk Quality And Casein Prediction Using Machine Learning, Ibrahima Mahamane Abdourhamane, Dilek Arsoy

The Thai Journal of Veterinary Medicine

Milk quality is becoming more and more crucial for farmers with the increasing use of component-based pricing systems in the sector. This study aimed to investigate the effects of climate-related and non-genetic factors on goat milk quality on the island of Northern Cyprus and to predict casein content using machine learning techniques. An analysis was performed on 21,695 goat milk samples collected between 2012 and 2018. Somatic cell count (SCC), standard plate count (SPC), and key milk components such as protein, casein, lactose, and fat were evaluated for different seasons, regions, farm sizes, and raw milk types. Five machine learning …

Stage- And Smoking-Associated Microrna Expression In Lung Adenocarcinoma, Min Huang, Yimin Ge, Huiqin Chen, Caimiao Wei, David Cogdell, Cristina Ivan, Meng Chen, Wei Zhang, George A Calin, Ming Guo

Faculty, Staff and Student Publications

Background: Altered expression of microRNAs (miRNAs) is implicated in lung carcinogenesis, but little research has investigated the association of miRNA alterations with lung cancer stage or smoking status. To identify such alterations in lung adenocarcinoma, we conducted miRNA profiling.

Methods: Lung adenocarcinoma specimens and paired nonneoplastic lung tissues from 58 patients who had received no preoperative therapy and underwent tumor resection from 1991 to 2006 were collected from tumor tissue banks. Thirty (52%) of the tumors were stage I and 28 (48%) stage II or higher. Twenty-five (43%) patients were nonsmokers and 33 (57%) were smokers. To identify miRNAs of …

The Environmental Integration - An Introduction To The Sustainability Of The Urban Heritage Of Nubia (Applied To Gharb Suhail), Ahmed Mohamed Said Elsaadany

Mansoura Engineering Journal

The Nubia region is an important historical and cultural place, as it is distinguished by a unique architectural heritage. The influence of the surrounding environment on the designs of buildings and structures in this region is evident. Traditional architecture arose spontaneously over long periods of time, but it was essentially based on correct scientific concepts. The architecture of Nubia in southern Egypt, which is located on the banks of the Nile River, was a mud architecture that used natural building materials from the environment influenced by Ancient Egyptian architecture, some influences from Islamic architecture represented in privacy and courtyard in …

Toward Resilience In Broadacre Agriculture: A Methodological Review Of Remote Sensing In Crop Productivity, Phenology, And Environmental Stress Detection, Jenny Shen, Hai Wang, Hasnein Tareque

Agriculture Research Articles

Highlights

What are the main findings?

• Remote sensing methodologies for crop performance monitoring were systematically reviewed across the themes of productivity, phenology, and environmental stress.
• Advances and challenges were identified within individual themes and in their integration toward holistic monitoring.

What are the implications of the main findings?

• Emerging integration approaches offer pathways beyond monitoring toward decision-support systems for broadacre agriculture.
• Future directions of advancing resilience-focused applications of remote sensing are proposed.

Abstract

Large-scale rainfed cropping systems (broadacre agriculture) face intensifying climate and resource stresses that undermine yield stability and farm livelihoods. Remote sensing (RS) offers critical tools for improving …

The Tamads2-Tatbl21 Module Enhances Wheat Resistance To Stripe Rust By Activating Tagkl-Mediated Immunity, Shijia Zhao, Hao Chu, Yanan Lu, Jiaqi Chen, Xu Wang, Guangxiang Tian, Mingjing Zhang, Pengyu Song, Yanhui Zhang, Guihua Bai, Gangming Zhan, Zhensheng Kang, Wenming Zheng, Zhengqing Fu, Na Liu

Faculty Publications

Wheat stripe rust (Puccinia striiformis f. sp. tritici, Pst) poses a catastrophic threat to global food security. While MADS-box transcription factors regulate development and abiotic stress, their roles in plant-pathogen immunity remain enigmatic. In this study, we identified TaMADS2, a Pst-induced MADS-box gene, as a positive regulator of wheat resistance. Functional analyses demonstrated that TaMADS2 overexpression significantly enhanced Pst resistance, whereas its knockdown rendered wheat more susceptible. Further investigation revealed that TaMADS2 interacts with trichome birefringence-like protein 21 (TaTBL21) to activate glycerol kinase-like (TaGKL) expression. Silencing TaGKL in wild-type or TaMADS2-overexpressing lines …

Benchmarking Dna Foundation Models For Genomic And Genetic Tasks, Haonan Feng, Lang Wu, Bingxin Zhao, Chad Huff, Jianjun Zhang, Jia Wu, Lifeng Lin, Peng Wei, Chong Wu

School of Medicine Faculty Publications

The rapid evolution of DNA foundation models promises to revolutionize genomics, yet comprehensive evaluations are lacking. Here, we present a comprehensive, unbiased benchmark of five models (DNABERT-2, Nucleotide Transformer V2, HyenaDNA, Caduceus-Ph, and GROVER) across diverse genomic and genetic tasks including sequence classification, gene expression prediction, variant effect quantification, and topologically associating domain (TAD) region recognition, using zero-shot embeddings. Our analysis reveals that mean token embedding consistently and significantly improves sequence classification performance, outperforming other pooling strategies. Model performance varies among tasks and datasets; while general purpose DNA foundation models showed competitive performance in pathogenic variant identification, they were less …

Workplace Policy And Associated Factors Of Minimum Acceptable Diet Practices: An Online Survey Among Working Mothers In Indonesia, Fadhila Iswi Deandra, Judhiastuty Februhartanty, Muchtaruddin Mansyur

Kesmas

Working mothers in Indonesia may influence complementary feeding practices, particularly their ability to ensure that their infants properly meet the minimum acceptable diet (MAD). In this cross-sectional study, an online survey was distributed through various online platforms where participants were recruited using convenience sampling. The questionnaire covered sociodemographic factors, workplace policies, and infant and young child feeding (IYCF) practices. Descriptive and logistic regression analyses were conducted. A total of 394 working mothers participated, of which over 90% of the respondents reported meeting minimum dietary diversity, minimum milk frequency, minimum milk feeding frequency, and MAD indicators as assessed with a standardized …

Emission Characterization And Health Risk Assessment Of Volatile Organic Compounds From Automotive Painting In Thailand, Vanitchaya Kultan, Sarawut Thepanondh, Jutarat Keawboonchu, Nattaporn Pinthong, Wissawa Malakan

Kesmas

The automotive industry is a significant source of volatile organic compound (VOC) emissions, particularly from solvent-based painting processes. This study evaluated VOC characteristics and distribution to assess associated health risks for workers and communities at varying distances from automotive painting facilities in Thailand, focusing on stacks and wastewater treatment plants that handle solvent-containing wastewater. The findings revealed aromatic compounds were predominant (66% of the total emissions), followed by oxygenated VOCs (26%). The stacks mainly emitted aromatics such as toluene and ethylbenzene, whereas the wastewater released oxygenated VOCs, particularly methyl isobutyl ketone and methyl ethyl ketone. The exposure concentrations in each …

Benchmarking Dna Foundation Models For Genomic And Genetic Tasks, Haonan Feng, Lang Wu, Bingxin Zhao, Chad Huff, Jianjun Zhang, Jia Wu, Lifeng Lin, Peng Wei, Chong Wu

Faculty, Staff and Student Publications

The rapid evolution of DNA foundation models promises to revolutionize genomics, yet comprehensive evaluations are lacking. Here, we present a comprehensive, unbiased benchmark of five models (DNABERT-2, Nucleotide Transformer V2, HyenaDNA, Caduceus-Ph, and GROVER) across diverse genomic and genetic tasks including sequence classification, gene expression prediction, variant effect quantification, and topologically associating domain (TAD) region recognition, using zero-shot embeddings. Our analysis reveals that mean token embedding consistently and significantly improves sequence classification performance, outperforming other pooling strategies. Model performance varies among tasks and datasets; while general purpose DNA foundation models showed competitive performance in pathogenic variant identification, they were less …

Radiologist-Validated Automatic Lumbar T1-Weighted Spinal Mri Segmentation Tool Via An Attention U-Net Algorithm, Aryan Kalluvila, Ethan Wang, Michael C Hurley, Colbey Freeman, Jason M Johnson

Faculty, Staff and Student Publications

Background/Objectives: Spinal MRI segmentation has become increasingly important with the prevalence of disc herniation and vertebral injuries. Artificial intelligence can help orthopedic surgeons and radiologists automate the process of segmentation. Currently, there are few tools for T1-weighted spinal MRI segmentation, with most focusing on T2-weighted imaging. This paper focuses on creating an automatic lumbar spinal MRI segmentation tool for T1-weighted images using deep learning.

Methods: An Attention U-Net was employed as the main algorithm because the architecture has shown success in other segmentation applications. Segmentation loss functions were compared, focusing on the difference between BCE and MSE loss. Two board-certified …

Developmental Stage-Dependent Transcriptomic Responses To Neonatal Intraventricular Hemorrhage, Elizabeth Wallace-Anthony, Miriam Zamorano, Hemendra J Vekaria, Braden B Oldham, Kiara P Umpornpun, Scott D Olson, Stefano Berto, Brandon A Miller

Faculty, Staff and Student Publications

Neonatal intraventricular hemorrhage (IVH) is a major complication of preterm birth, yet how developmental stage influences the brain's response to injury remains unclear. We performed single-nucleus RNA sequencing on rat brains 24 h after IVH at postnatal day 2 (PND2) or day 5 (PND5) to define transcriptional responses across cell types. We identified 42 distinct cell populations and found that PND5 brains exhibited a markedly stronger immune and inflammatory response to IVH, with a threefold increase in differentially expressed genes compared to PND2. Microglia were the most perturbed cell type at both stages, showing increased oxidative stress and polarization toward …

Met Overexpression Is Associated With Superior Immunotherapy Benefit In Advanced Non-Small Cell Lung Cancer, Hui Li, Lingzhi Hong, Pedro Rocha, Rafael Bach, Luisa M Solis Soto, Waree Rinsurongkawong, Bingnan Zhang, Haniel A Araujo, Yasir Y Elamin, Mehmet Altan, Claudio A Arrechedera, Jianling Zhou, Khaja B Khan, Wei Lu, Elliana Young, Carl M Gay, Tina Cascone, Lauren A Byers, Ferdinandos Skoulidis, George Blumenschein, Frank V Fossella, Anne Tsao, Marcelo V Negrao, Natalie Vokes, Jia Wu, Hai T Tran, Ignacio I Wistuba, J Jack Lee, Don L Gibbons, Ara A Vaporciyan, John V Heymach, Xiuning Le, Jianjun Zhang

Faculty, Staff and Student Publications

Background/objectives: MET overexpression is common in non-small cell lung cancer (NSCLC). The correlation between MET overexpression and immune checkpoint inhibitor (ICI) efficacy in NSCLC is underexplored.

Methods: In this retrospective observational cohort study, we curated a dataset of 279 stage IV NSCLC patients who received ICI treatment and had MET expression assessed by CLIA-certified immunohistochemistry (IHC) assay. MET expression was graded on a scale from 0 to 3+, with overexpression defined as 2+ or 3+. Clinicopathological features associated with MET expression were assessed using logistic regression. Overall survival (OS) and progression-free survival (PFS) were evaluated via Kaplan-Meier analysis and the …

Red Midge Larvae Are An Invertebrate Alternative Diet To Beef Liver For Planarian Husbandry, Jonah Pacis , '25, Danielle Ireland, Evangeline Coffinas, Jerome Sheehan, Kate Sun , '27, Eva-Maria S. Collins

Biology Faculty Works

Freshwater planarians are an emerging model for toxicology and neuroscience because of their amenability to rapid behavioral screening and remarkable ability to regenerate a cephalized nervous system. As invertebrates, planarians can help reduce the use of vertebrates in research; however, laboratories typically maintain planarians on diets of homogenized organic beef or chicken liver, raising ethical concerns with feeding a vertebrate diet. Organic liver is difficult to obtain, and preparation methods vary, introducing intra- and interlaboratory variability. Here, we show that Dugesia japonica planarians can be maintained for over a year on commercially available red midge larvae (RML), a natural prey …

Transdisciplinary Perspectives On Ai: The Fourth Annual Conference Of The European Culture And Technology Laboratory, Connell Vaughan, Ioana Madalina Moldovan, Silivan Moldovan, Noel Fitzpatrick

Books/Book Chapters

The fourth annual conference of the ECT Lab+ was hosted by Technical University of Cluj-Napoca over two days in October 2024 at the Cluj Innovation Park. The conference brought together experts from the Arts, Humanities, Social Sciences, Technology, and other fields to discuss and reflect on the advent of Artificial Intelligence and how the associated technologies are transforming how we live, work and study. Under the title Transdisciplinary perspectives on AI: Alternative Histories, Current Practices and Possible Futures the conference moved beyond simplistic technophila and technophobia to consider whether we can co-evolve with these new technologies which combine machine learning …

Soluble Immune Factor Profiles In Blood And Csf Associated With Lrrk2 Mutations And Parkinson's Disease, Roshni Jaffery, Yuhang Zhao, Sarfraz Ahmed, Jackson G Schumacher, Jae Ahn, Leilei Shi, Yujia Wang, Yukun Tan, Jiayin Zhang, Ken Chen, Hussein Tawbi, Jian Wang, Michael A Schwarzschild, Weiyi Peng, Xiqun Chen

Faculty, Staff and Student Publications

Mutations in LRRK2, a leading genetic cause of Parkinson's disease (PD), are linked to immune dysregulation, but the immune profiles in the periphery and central nervous system (CNS) remain incompletely defined. This study utilized a large cohort of serum samples (n = 651) and matched CSF samples (n = 129) from LRRK2 mutation carriers and non-carriers, with and without PD, to assess immune regulators using Luminex immunoassay. After correction for multiple comparisons, LRRK2 mutations were associated with significantly elevated serum levels of SDF-1 alpha and TNF-RII, while CSF markers such as BAFF, CD40L, and IL-27 were nominally reduced. Regardless of …

A Phase 1/2 Study Of Ds-1594 Menin Inhibitor In Relapsed/Refractory Acute Leukemias, Jayastu Senapati, Marina Konopleva, Ghayas C Issa, Elias Jabbour, Tapan Kadia, Courtney Dinardo, Gautam Borthakur, Naveen Pemmaraju, Nicholas J Short, Musa Yilmaz, Indraneel Deshmukh, Joie Alvarez, Sanam Loghavi, Guilin Tang, Hussein A Abbas, Michael Andreeff, Kapil Bhalla, Narasimha M Midde, Nabil Said, Amy Noyalis, Derek E Mires, Jing Ning, Lianchun Xiao, Farhad Ravandi, Guillermo Garcia-Manero, Hagop M Kantarjian, Naval G Daver

Faculty, Staff and Student Publications

Several menin inhibitors are in development targeting menin dependent leukemias, however available preclinical results show variable level of activity. We report the phase 1 portion (to establish a recommended phase 2 dose [RP2D]) and pharmacokinetic analysis of a phase 1/2 first-in-human clinical trial of DS-1594b menin inhibitor. Eligible patients included adults (≥ 18 years of age) with relapsed/refractory (R/R) acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) including but not restricted to those with KMT2A-rearrangement (r) or NPM1 mutation. Seventeen patients at a median of age 56 years (range, 19-82 years) were treated, 15 (88%) had R/R AML, and …

Improving Diagnostic Accuracy In Preoperative Glioma Classification: Performance Of Knowledge-Enhanced Large Language Models Compared With Radiologists, Shuang Li, Xin Fang, Yuqi Jin, Yujiao Deng, Wei Hu, Bing Wu, Xiaobo Zhou, Guotai Wang, Kang Li, Qiang Yue

Faculty, Staff and Student Publications

Accurate preoperative MRI classification of gliomas is essential but challenging due to complex radiological features and inter-observer variability. This study evaluated three large language models (LLMs) for VASARI-based glioma classification compared to radiologist interpretations. We retrospectively analyzed 150 histopathologically confirmed gliomas (43 circumscribed astrocytic, 53 high-grade diffuse, 54 low-grade diffuse gliomas) using standardized MRI protocols. Three radiologists extracted VASARI features, while three LLMs (GPT-4, Claude3.5-Sonnet, Claude3.0-Opus) analyzed these features using standard input-output or knowledge-enhanced prompting incorporating diagnostic guidelines. Knowledge-enhanced prompting consistently outperformed standard prompting, improving diagnostic consistency (intra-model agreement: Sonnet κ = 0.91, Opus κ = 0.92, GPT-4 κ = …

Economically Optimal Soil Sampling Density And Application Technology For Potassium Fertilizer For Soybean In The Mid-Southern Us, Bayarbat Badarch, Aurelie Poncet, Shelby Ridar, Nathan Slaton, Michael Popp

Agricultural Economics and Agribusiness Faculty Publications and Presentations

To maximize beneficial potassium (K) fertilizer use in irrigated soybean (Glycine max. (L.) Merr.) fields with spatially varying soil-test K (STK), the value of added information from more precise STK maps must be greater than the associated information collection costs. In eleven fields, we modeled the impact of soil sampling densities (SD) ranging from 2.2 samples ha-1 in the largest field (41.2 ha) to 13.59 samples ha-1 in the smallest field (7.4 ha) on STK maps with 0.4 ha grid size. The accuracy of profit-maximizing fertilizer rate prescription maps varied by SD and subsequent yield estimates using either uniform …

Comparative Cytogenetics Study Via Fluorescent Chromosome Banding Of Three Solanum L. Species, Mona Abd Elgawad, Rim Hamdy, Ibrahim El Garf, Amany Sallam Abdo

Turkish Journal of Botany

Solanum L. subg. Solanum sect. Solanum has a wide distribution in Egypt with multiple overlapping morphological features, rendering the taxonomy of the Solanum nigrum complex difficult at the species level. This study focused on the S. nigrum complex, which consists of S. nigrum L., S. sinaicum Boiss., and S. villosum Mill. Cytogenetic characterization can provide additional taxonomic data and can be used to evaluate genetic diversity at the species level. We performed karyotype analysis of 3 Egyptian species for the first time by studying fluorescence banding patterns via 4’6-diamidino-2-phenylindole (DAPI) and chromomycin A3 (CMA). The three species vary noticeably in …

Biochar Derived From Different Sources Ameliorates The Phytochemical And Physiological Characteristics Of Foxtail Millet (Setaria Italica) Under Water Stress, Mohammad Keshavarz, Ehsan Bijanzadeh, Hamid Reza Boostani

Turkish Journal of Botany

Organic material, such as biochar, can improve soil fertility and crop yield under water stress. A pot experiment was conducted to consider the effects of biochar on the pigment content, enzyme activity, physiological characteristics, and nutrient uptake of foxtail millet under water stress. Plants were tested under normal, mild, and severe irrigation regimes (100%, 75%, and 50% field capacity, respectively) using different biochar sources (licorice root biochar (LRB), cow manure biochar (CMB), cotton residue biochar (CRB), and municipal waste biochar (MWB)) and a control without fertilizer. Under severe water stress, the chlorophyll a content and total chlorophyll increased by 137.3% …

Habitat Determines The Effects Of Wild Ungulate Grazing On Soils: Case Studies From The Iberian Peninsula, Jennifer Adams Krumins, Shih-Chieh Chien, Ramon Perea, Emmanuel Antonio Serrano Ferron, Elena Baraza Ruiz, The Incremento Consortium

Department of Biology Faculty Scholarship and Creative Works

Background and Aims

The bidirectional relationship between plants and their soils can be disrupted by the influence of ungulate grazers. Indeed, herbivores affect plant productivity and above-ground community structure, and plants affect soil health and below-ground community structure. However, the effects of herbivory can be subtle and challenging to address experimentally, even in the case of relatively large ungulate grazers. We attempt to resolve this paradox and experimentally test effects of ungulate grazers in two case studies on the Spanish Iberian Peninsula.

Methods

At the two locations, we experimentally enclosed red deer (Cervus elaphus) at high and hyper …

Protective Role Of Salicylic Acid Against Abiotic Stresses In Horticultural Crops: A Review, Faisal Hayat, Xiaoyun Zhang, Mohammed Alyafei, Fareeha Shireen, Ummara Khan, Sumeera Asghar, Sezai̇ Erci̇şli̇, Karthishwaran Kandhan, Mohamed S. Sheteiwy, Yali Zhang, Xiaoyan Lu

Turkish Journal of Botany

Environmental stressors such as drought, floods, salinity, extreme temperatures, and heavy metal toxicity are major threats to horticultural plants because they disrupt plant physiological mechanisms, leading to reduced yield and quality. Salicylic acid (SA) is a plant hormone that regulates various physiological and biochemical functions in plants. Moreover, it regulates hormonal balance, enhances the absorption of essential nutrients, promotes photosynthesis and the production of antistress compounds, and improves stress resistance. This comprehensive review explains several physiological and biochemical activities that are affected by SA under stressful conditions, such as stomatal regulation, antioxidant defense systems, osmotic adjustment and gene expression regulation. …

Tannin Supplementation Alters Foraging Behavior And Spatial Distribution In Beef Cattle, Bashiri Iddy Muzzo, R. Douglas Ramsey, Kelvyn Bladen, Juan J. Villalba

Wildland Resources Student Research

Beef production on chemically uniform grass monocultures can limit nutrient synchrony and contribute to uneven pasture use. We evaluated whether supplementing tannins with bioactive plant secondary compounds improves foraging dynamics and landscape use by beef cattle grazing a meadow bromegrass monoculture in ways aligned with rangeland sustainability. Twenty-four Angus cow–calf pairs were allocated to six 3.6-ha paddocks (four pairs/paddock), randomly assigned to Control (Ctrl; n = 3) or Tannin treatment (TT; n = 3). Animals received 1 kg/cow/day of DDGs, with TT receiving an added 0.4% tannins (2:1 condensed:hydrolyzable). Grazing occurred during four 15-day periods (July– September) across two years. …

Nickel Toxicity To Safflower Seed Germination And Seedling Morphoanatomy, Uğurcan Baran, Sude Tanik, Mert Can Vardar, Güray Ülger, Ahmet Aksoy

Turkish Journal of Botany

The safflowers (Carthamus tinctorius L. cv Olas) grown hydroponically under nickel (Ni) stress were examined in this study. T he effects of 0, 0.75, 1, 3, 5, 10, and 15 mM Ni on seed germination rate, protein, and pigment content of germinating seeds were investigated. Also, the toxicity of 0.75 mM Ni on plant growth, malondialdehyde (MDA) amount, and anatomy of 21-day-old safflower seedlings were studied. Ni adversely affected the germination rate, radicle length, protein, and pigment content of safflower seeds, particularly when higher than 3 mM. It also negatively affected the biomass production, plant length, leaf number, and MDA …

Dna Extrusion Size Determines Pathway Choice During Cag Repeat Expansion, Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R. Monte Carloi Iii, Sarah Barndt, Anna Pluciennik

Department of Biochemistry and Molecular Biology Faculty Papers

DNA triplet repeat expansion causes several primarly neurological disorders like Huntington's disease, myotonic dystrophy type 1, and fragile-X related disorders. There is general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the DNA mismatch repair protein MutSβ leads to repeat expansion by a mutagenic process. By contrast, the FAN1 nuclease attenuates triplet repeat expansion, the molecular basis of which was explained by our recent finding that FAN1 nuclease cleaves and initiates removal of extrahelical extrusions. Here we show that extrusions containing two or more triplet repeats are subject to recognition and processing by either …

Loss Of Idh1 And Idh2 Mutations During The Evolution Of Metastatic Chondrosarcoma, William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M Flanagan, Peter Van Loo

Faculty, Staff and Student Publications

Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.

Predicting The Response Of Triple Negative Breast Cancer To Neoadjuvant Systemic Therapy Via Biology-Based Modeling And Habitat Analysis, Casey E Stowers, Chengyue Wu, Clinton Yam, Jingfei Ma, Gaiane M Rauch, Thomas E Yankeelov

Faculty, Staff and Student Publications

Despite being the standard-of-care treatment, neoadjuvant therapy (NAT) attains a complete response only in approximately half of the patients with triple negative breast cancer. Thus, methods to predict and optimize patient response to NAT are needed. Previously, we employed patient-specific MRI data to calibrate a biology-based mathematical model that describes cell movement, proliferation, and death due to drug at the tumor level and cell proliferation at an image voxel level. We now extend our approach by using MRI data to group voxels into "habitats" whereby tumor cells of a habitat share the same proliferation. With this approach, we now calibrate …

Evolving Towards Efficient Technologies In Power Systems: The Paradigm Of Energy Internet Survey, Dina Emad, Omar Abdel-Rahim, Tanemasa Asano, Sobhy M. Abdelkader

Mansoura Engineering Journal

The Energy Internet represents a significant advancement in the modernization and automation of electricity systems, offering a framework for future smart grids where all electrical devices are interconnected through energy routers. This system integrates advanced power electronics, information technology, and smart control technologies, enabling the accommodation of diverse energy sources and storage devices. With its bidirectional energy flow and sharing capabilities, the Energy Internet holds great promise for the future. However, several challenges must be addressed to fully realize this potential. This review provides an overview of the Energy Internet framework and explores key challenges, particularly those related to energy …

Effects Of Rehabilitative Device On Parkinsonian Gait, Brooke N. Ray, Ksenia I. Ustinova, Joseph E. Langenderfer

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 1422-1440, 2025. https://doi.org/10.70252/TGOI6101 Parkinson’s disease (PD) is second in occurrence among neurodegenerative disorders after Alzheimer’s disease and significantly impacts gait and mobility. This research tested the effect of the NewGait rehabilitative device in PD impaired individuals. Twenty individuals with PD participated in this study. Walking gait for three conditions were analyzed: Normal, wearing NewGait and Post-NewGait. Standard spatial and temporal analysis measures as well as nonlinear measures from recurrence quantification were compared to determine any effects of the device on walking gait. NewGait was perceived to be both comfortable to wear as well as …

Examining The Impact Of Decreased Snowpack On The Rare Frosted Elfin Butterfly’S Host Plant, Christopher Walsh

Biology Student Scholarship

In response to climate change, Earth’s increased global temperature has caused less snowfall and earlier snowmelt in spring. These changes can alter an organism’s phenology, or timing of life history events. Such shifts in phenology may lead to mismatches between interacting species, which are correlated with a decline in the populations of host plant specialists and at-risk species. The rare frosted elfin butterfly (Callophrys irus) is listed as impaired in 5 states, and critically imperiled in 14. These host plant specialists only lay eggs on small yellow wild indigo (Baptisia tinctoria) and wild lupine (Lupinus perennis). If neither plant emerges …