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Articles 751 - 780 of 255747

Full-Text Articles in Life Sciences

Tardigrade Bio-Exploration Reproduction Research Payload, Natalie Brattain, Chloe Nissen, Kylie Nager, Peter Ulrich, Enoch Tonkine Aug 2026

Tardigrade Bio-Exploration Reproduction Research Payload, Natalie Brattain, Chloe Nissen, Kylie Nager, Peter Ulrich, Enoch Tonkine

Discovery Day - Daytona Beach

The Tardigrade Bio-ExplorAtion Reproduction Research Payload (tBEARR) is an external International Space Station (ISS) standardized laboratory payload module mission under development by the Embry-Riddle Orbital Research Association (ERORA), an undergraduate research organization at Embry-Riddle Aeronautical University (ERAU) in Daytona Beach, Florida. As a club-driven mission, tBEARR provides undergraduate students with hands-on experience across all phases of space research, including payload design, biological experimentation, systems integration, and mission operations. The mission is supported by a biology research team focused on stress-response biology, experimental design, and biological validation throughout ground testing, high-altitude balloon flights, and orbital operations.   The primary objective of tBEARR …

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Mri-Based Estimation Of The Hip Joint Center In Infants Using Two Sphere-Fitting Methods, Victoria Melendez Aug 2026

Mri-Based Estimation Of The Hip Joint Center In Infants Using Two Sphere-Fitting Methods, Victoria Melendez

Discovery Day - Daytona Beach

Accurate estimation of the hip joint center (HJC) is critical for biomechanical modeling and clinical assessment. Common methods include predictive methods (e.g., regression equations) and functional methods such as sphere-fitting. In infants, femoral head-based methods are often limited due to incomplete ossification of the anatomy and poor visualization in computed tomography (CT) images. This study evaluates an alternative approach using MRI-based sphere fitting of the ossified acetabular rim, comparing its accuracy to traditional femoral head-based methods. MRI scans of three male infants (ages 10.7- 12.7 months) were used to manually place landmarks on the ossified acetabulum and the cartilaginous boundary …

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Apical-Out Lung Organoids: A Platform For Spaceflight And Cf Research, Valeria Jimenez, Ally Schwennesen Aug 2026

Apical-Out Lung Organoids: A Platform For Spaceflight And Cf Research, Valeria Jimenez, Ally Schwennesen

Discovery Day - Daytona Beach

A genetic condition known as cystic fibrosis (CF) is brought on by mutations in the CFTR gene, which results in chronic lung inflammation and impaired chloride ion transport. CF bronchial epithelial cells enable direct comparison of disease pathology, while normal human bronchial epithelial (NHBE) cells offer an essential model for researching airway physiology. Realistic modeling of respiratory tissue and its reaction to environmental stressors like microgravity is made possible by the creation of 3D lung organoids from these cells. In this project, we developed apical-out organoids, which expose the apical surface of epithelial cells to the external environment. These organoids …

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Investigation Of Biofilm Formation And Osmotic Stress Tolerance Of Nonmotile Escherichia Coli In Simulated Microgravity, Tyler Jenkins Aug 2026

Investigation Of Biofilm Formation And Osmotic Stress Tolerance Of Nonmotile Escherichia Coli In Simulated Microgravity, Tyler Jenkins

Discovery Day - Daytona Beach

Simulated microgravity presents multiple physiological stressors for astronauts, including bone demineralization, muscle loss, and weakening of the immune system. Bacteria serve as viable model organisms to study physiological changes because of their abundance in the human digestive system and skin. Motility in bacteria plays a significant role in cell survival, but few studies have been conducted on microgravity’s effect on motility phenotypes. While motile strains like Escherichia coli K12 have been studied extensively under microgravity conditions, the effects of simulated microgravity on non-motile strains are largely unknown. To better understand this relationship, the nonmotile E. coli MG1655 strain was inoculated …

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Evaluation Of Antimicrobial Resistance In Pathogens Relevant To Long-Duration Space Missions, Natalie Brattain, Yegor Bushnev, Mikayla M. Dutkiewicz Aug 2026

Evaluation Of Antimicrobial Resistance In Pathogens Relevant To Long-Duration Space Missions, Natalie Brattain, Yegor Bushnev, Mikayla M. Dutkiewicz

Discovery Day - Daytona Beach

Antimicrobial resistance is a growing global concern that necessitates the development of effective strategies for selecting appropriate antibiotics, especially in the context of future long-duration space missions, where infection control and treatment options are limited. This study employs the Kirby–Bauer disk diffusion assay to evaluate the antimicrobial susceptibility of Pseudomonas aeruginosa and other clinically and spaceflight-relevant bacterial pathogens such as Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pneumoniae. These pathogens will be tested with commonly used antibiotics and potential natural compounds.   The pathogens will be cultured and isolated onto Mueller–Hinton agar plates. Antibiotic disks, along with various flavonoids disks, such as …

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Metabolic Regulation And Immunity In The Spaceflight Environment, Graeme Grainger, Riley Dienna, Astrid Senko, Angela Cebula, Arden Rodriguez Arden Rodriguez Aug 2026

Metabolic Regulation And Immunity In The Spaceflight Environment, Graeme Grainger, Riley Dienna, Astrid Senko, Angela Cebula, Arden Rodriguez Arden Rodriguez

Discovery Day - Daytona Beach

Long-duration spaceflight exposes astronauts to chronic ionizing radiation and microgravity that disrupts homeostasis in the immune system and cellular metabolism. While simulated spaceflight models demonstrate altered T-cell polarization and sex-dependent shifts toward regulatory phenotypes, the metabolic mechanisms driving these immune changes remain unclear. Immune cell function is tightly linked to metabolic programming, with effector T cells relying on glycolysis and regulatory T cells favoring oxidative metabolism, making them highly sensitive to shifts in nutrient availability and redox balance. Emerging research further suggests that neutrophils act as metabolic regulators capable of reshaping the immune microenvironment through oxidative stress, cytokine production, and …

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Effects Of Human-Animal Interaction On Positive Youth Development: A Replication Study, Allison Pachunka, Jay Jeffries, Lisa Karr, Lena Luck, Bryan A. Reiling, Douglas H. Schultz, Jeffrey R. Stevens Aug 2026

Effects Of Human-Animal Interaction On Positive Youth Development: A Replication Study, Allison Pachunka, Jay Jeffries, Lisa Karr, Lena Luck, Bryan A. Reiling, Douglas H. Schultz, Jeffrey R. Stevens

People and Animals: The International Journal of Research and Practice

Interacting with animals can improve health and well-being across the lifespan. Some programs such as 4-H and FFA center around youth interacting with animals, potentially enhancing youth development. Mueller (2014) investigated whether these interactions and attitudes about animals influenced measures of positive youth development. The aim of our studies was to replicate Mueller’s methods and extend her work by evaluating whether membership in animal-focused youth programs moderate associations between interactions, attitudes, and positive youth development. We did not find strong relationships among human–animal inter-action and positive youth development, which failed to replicate Mueller’s findings. However, we did find relationships between …

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Evaluating The Potential Of Cajanus Cajan (L.) Millsp. Root To Improve Atopic Dermatitis With Different Anti-Inflammatory Models And Active Compounds, Shu-Er Yang, Xiang-Ming Cai, Yu-Wen Chu, Jen-Chieh Tsai, Mey-Fann Lee, Tuzz-Ying Song Aug 2026

Evaluating The Potential Of Cajanus Cajan (L.) Millsp. Root To Improve Atopic Dermatitis With Different Anti-Inflammatory Models And Active Compounds, Shu-Er Yang, Xiang-Ming Cai, Yu-Wen Chu, Jen-Chieh Tsai, Mey-Fann Lee, Tuzz-Ying Song

Journal of Food and Drug Analysis

Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent bacterial infections that cause pruritus, erythema, xerosis and thickening. Cajanus cajan root extract prepared with 95% ethanol (EECR95) has been shown to possess antioxidant, anti-inflammatory, and antibacterial properties in previous studies. This study aimed to evaluate EECR95’s ability to improve AD by inhibiting methicillin-resistant Staphylococcus aureus (MRSA) growth and reducing inflammation. This study found EECR95 effectively inhibits MRSA growth (IC50 = 103.74 μg/mL) and reduces pro-inflammatory cytokine production in an MRSA-keratinocyte-macrophage model. LC/MS/MS analysis revealed the presence of active compounds- flavonoids, isoflavones, and flavonoid glycosides, highlighting EECR95's potential …

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Clara S. Ludlow: Mississippi A & M Graduate And American Military Entomology Pioneer, Bradley Brazzeal Aug 2026

Clara S. Ludlow: Mississippi A & M Graduate And American Military Entomology Pioneer, Bradley Brazzeal

Midsouth Entomologist

The systematic study of the mosquitoes of the world did not begin until the early years of the 20th century. Among the early entomologists to specialize in the field was Clara S. Ludlow, who graduated from Mississippi Agricultural and Mechanical College. Her research began in the Philippines in 1901, while American troops were still fighting in the Philippine-American War, and for over 20 years she researched mosquitoes in connection with the U.S. Army. This article explores Ludlow’s scientific career and the legacy of her research.

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Oregon State Rank Assessment For Deer-Cabbage (Nephrophyllidium Crista-Galli), Lindsey K. Wise Aug 2026

Oregon State Rank Assessment For Deer-Cabbage (Nephrophyllidium Crista-Galli), Lindsey K. Wise

Institute for Natural Resources Publications

Oregon state conservation status assessment for Deer-cabbage (Nephrophyllidium crista-galli) using NatureServe methodology, 2026.

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Malnutrition Risk, Nutrition Insecurity, Barriers, And Facilitators To Dietary Management Among Adults With Inflammatory Bowel Disease In The Us Rocky Mountain Region: A Cross-Sectional Mixed-Methods Study, Heather Burr, Carrie Durward, Korry Hintze, Getrude Mphwanthe Aug 2026

Malnutrition Risk, Nutrition Insecurity, Barriers, And Facilitators To Dietary Management Among Adults With Inflammatory Bowel Disease In The Us Rocky Mountain Region: A Cross-Sectional Mixed-Methods Study, Heather Burr, Carrie Durward, Korry Hintze, Getrude Mphwanthe

Nutrition, Dietetics, and Food Science Student Research

We conducted an online cross-sectional study to assess malnutrition risk, food and nutrition insecurity, and perceived barriers and facilitators to dietary management among adults (18–64 years old) with a self-reported clinical diagnosis of inflammatory bowel disease (IBD) in outpatient and community settings. We assessed malnutrition risk using the Saskatchewan IBD-Nutrition Risk screening tool, food security risk using the two-item Hunger Vital Signs questionnaire, and nutrition security risk using a validated four-item tool. Open-ended questions elucidated barriers and facilitators to dietary management of IBD. Among 57 participants who self-reported a clinical diagnosis of IBD, 52.6% (n = 30/57) had ulcerative colitis, …

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Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White Aug 2026

Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The southern flying squirrel (Glaucomys volans) is a threatened species in Nebraska that occurs along the Missouri River in the southeastern corner of the state. Recently, a population was discovered in the city of Lincoln, but it is unknown whether this population represents a natural range expansion from the Missouri River population or whether it is isolated and results from a human-assisted movement. A survey of southern flying squirrels in Nebraska is needed, but surveys of this elusive species are challenging. This study investigated and compared two noninvasive survey techniques for rapid detection of flying squirrels: acoustic detectors …

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The Defining Role Of Ago4 And Its Catalytic Activity During De Novo Rna-Directed Dna Methylation, Tianyi Li Aug 2026

The Defining Role Of Ago4 And Its Catalytic Activity During De Novo Rna-Directed Dna Methylation, Tianyi Li

Arts & Sciences Graduate Student Theses and Dissertations

Plant transposable elements and transgenes are continuously targeted for transcriptional repression via the pathway of RNA-directed DNA methylation (RdDM). Although perpetual RdDM of the endogenous genomic loci has been well studied in the field, much less is known about the de novo RdDM pathway, the pioneering round of DNA methylation responsible for triggering and initiating silencing of new transgenes. Despite being two distinct pathways, both perpetual and de novo mechanisms of RdDM require the production of small interfering RNAs (siRNAs) and the key proteins of the ARGONAUTE4 (AGO4) clade. However, the order and likely mechanism of recruitment of AGO4 to …

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Scalable And Accurate Computational Frameworks For Complex Genetic Variants: From Repeat Expansion Discovery To Somatic Mosaicism Benchmarking, Zitian Tang Aug 2026

Scalable And Accurate Computational Frameworks For Complex Genetic Variants: From Repeat Expansion Discovery To Somatic Mosaicism Benchmarking, Zitian Tang

Arts & Sciences Graduate Student Theses and Dissertations

Whole-genome sequencing (WGS) offers a comprehensive view of genetic variation in human disease, but translating sequencing data into reliable biological and clinical insight depends on both the deployment of appropriate computational tools and the availability of rigorous benchmarking resources to evaluate them. This dissertation addresses both requirements through two complementary lines of work. In a cohort of 788 patients with idiopathic peripheral neuropathy (IPN) from the Peripheral Neuropathy Research Registry, a WGS-based pipeline integrating ExpansionHunter Denovo and ExpansionHunter with unsupervised genotype clustering identified biallelic RFC1 AAGGG repeat expansions in 2.3% of all IPN cases and 6.9% of patients with pure …

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Interplay Between Patterning And Morphogenesis During Zebrafish Embryonic Development, Chia-Teng Chang Aug 2026

Interplay Between Patterning And Morphogenesis During Zebrafish Embryonic Development, Chia-Teng Chang

Arts & Sciences Graduate Student Theses and Dissertations

Patterning and morphogenesis occur concurrently during embryonic development. In many contexts, both processes are regulated by morphogen signaling: morphogens specify spatially organized cell identities while also influencing the cell behaviors that shape tissues. This creates a reciprocal problem. Morphogen signaling can affect how cells move, while cell movement can change how cells experience and interpret morphogen signals. This dissertation investigates this reciprocal problem during zebrafish gastrulation and neurulation. First, it examines how the ventral-to-dorsal bone morphogenetic protein (BMP) activity gradient regulates germ-layer morphogenesis during gastrulation. BMP signaling is known to pattern dorsal–ventral cell fate and regulate mesodermal convergence and extension …

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Assessing Non-Thermal Plasma In Cutaneous Regeneration, Arden Rodriguez, Meliah Martin, Graeme Grainger, Arineh Shahbazi Aug 2026

Assessing Non-Thermal Plasma In Cutaneous Regeneration, Arden Rodriguez, Meliah Martin, Graeme Grainger, Arineh Shahbazi

Discovery Day - Daytona Beach

Chronic and acute wounds remain a significant clinical challenge, particularly in austere and resource-limited environments where access to advanced care is restricted. Non-Thermal Plasma (NTP) has emerged as a promising, non-invasive modality with reported antimicrobial and regenerative properties; however, its mechanisms of action and effects on human skin tissue require further characterization. The scope of this project is to engineer and utilize a 3D human skin epithelial model to evaluate the effects of NTP on wound healing. We will first build a 3D epithelial tissue model that will simulate human skin, followed by modeling and evaluation of wound pathology and …

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From Dust To Growth: Microbial Pathways To Extraterrestrial Farming, Stefani Capasso Villanueva, Nupur Kulkarni Aug 2026

From Dust To Growth: Microbial Pathways To Extraterrestrial Farming, Stefani Capasso Villanueva, Nupur Kulkarni

Discovery Day - Daytona Beach

From Dust to Growth: Microbial Pathways to Extraterrestrial Farming addresses the fundamental challenge of sustaining long-term human habitation on other planets. In the era of the Artemis missions, establishing a cost-effective, bioregenerative food source is critical to reducing logistical dependency on Earth, and mitigating the physiological stressors faced by spacecrew through improved nutrition. This study initially investigated the viability of cultivating Mizuna, a proven ISS model organism, in a substrate of Martian regolith simulant amended with organic compost. Following iterative trials, it was found that the plant survival rate was extremely low, even after varying percentages of compost and simulant. …

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The Osteocyte-Osteoblast Network Requires Dynamic Mechanical Loading For Key Functions, Kevin Kowalski Aug 2026

The Osteocyte-Osteoblast Network Requires Dynamic Mechanical Loading For Key Functions, Kevin Kowalski

Discovery Day - Daytona Beach

Spaceflight investigations have demonstrated that reduction in gravity-induced loading regimes is detrimental to maintenance Earth-normal bone and marrow. Mechanistically, however, there are still gaps in knowledge about how the reduction in gravity influences the different niches within the tissue. For example, cortical bone is a stable semi-solid structure that allows for only minor deformations before failure, while marrow is a viscous hydrogel-like material that can resist significant fluidic and compressive forces. We hypothesize that maintenance of different niches within the bone microenvironment are dependent on different loading regimes, and that the collective impact if gravity-induced loading needs to be considered …

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Impact Of Inspiratory Muscle Training On Diaphragm Hypertrophy, Exercise Performance, And Immune Response, Riley Dienna, Sabrina Ehrenfort, Joshua Frankenfield, Olivia Hartmann, Ben Kerns, Gianpiero Lara, Meliah Martin, Emma Norris, Louis Pandolfo, Rachel Phillips, Stella Roane, Dominic Sandell, Sabrina I. Santini-Bousson, Madison Stroud, Cecilia Zoutewelle, Erica Bryant Aug 2026

Impact Of Inspiratory Muscle Training On Diaphragm Hypertrophy, Exercise Performance, And Immune Response, Riley Dienna, Sabrina Ehrenfort, Joshua Frankenfield, Olivia Hartmann, Ben Kerns, Gianpiero Lara, Meliah Martin, Emma Norris, Louis Pandolfo, Rachel Phillips, Stella Roane, Dominic Sandell, Sabrina I. Santini-Bousson, Madison Stroud, Cecilia Zoutewelle, Erica Bryant

Discovery Day - Daytona Beach

The muscles involved in breathing, notably the diaphragm and intercostal muscles, play a role in determining the exercise capability of an individual. These muscles perform the work required for breathing, and as exercise intensity increases these muscles increase their activity to allow the respiratory system to meet the increased metabolic demands of exercise. Fatigue of these muscles reduces exercise tolerance and performance. In addition, the inflammation caused by acute maximal exercise is impacted by the level of training of the individual, and thus, inspiratory muscle training (IMT) may impact the inflammation due to exercise. We will test the hypothesis that …

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From Sunscreen To Seafood: Tracing The Ecological And Human Health Risks Of Oxybenzone Contamination In Local Fish, Alyssa Brasko Aug 2026

From Sunscreen To Seafood: Tracing The Ecological And Human Health Risks Of Oxybenzone Contamination In Local Fish, Alyssa Brasko

Discovery Day - Daytona Beach

Oxybenzone (benzophenone-3) is a widely used ultraviolet (UV) filter in sunscreens, offering protection against harmful radiation but raising significant environmental concerns due to its persistence and toxicity in aquatic ecosystems. This ongoing study aims to investigate the bioaccumulation and ecological impact of oxybenzone in fish species along Florida’s Space Coast, contributing to a broader understanding of its environmental fate and potential human exposure through seafood consumption. The research will employ advanced analytical techniques, including Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC), to quantify oxybenzone levels in locally sourced fish. Fish samples will be obtained from the non-profit organization …

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Gene Therapy Strategies To Enhance Antifungal Immunity In Microgravity, Riley Dienna Aug 2026

Gene Therapy Strategies To Enhance Antifungal Immunity In Microgravity, Riley Dienna

Discovery Day - Daytona Beach

During spaceflight, the immune system of astronauts becomes impaired due to microgravity, resulting in increased susceptibility to infections caused by pathogens such as Candida albicans. One of the most common clinical treatments for aggressive candidiasis is amphotericin B, a polyene antimycotic that targeted ergosterol in the fungal cell membrane and compromised the stability of the membrane. However, due to the chemical similarities between ergosterol and cholesterol, this treatment also affects the somatic cells of patients it is administered to. A novel treatment is therefore required to combat the aggressive fungal infection while minimizing damage to the host’s cells. This project …

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Modeling Population Growth With Logistic And Modified Logistic Equations, Mihil Dimpal Patel Aug 2026

Modeling Population Growth With Logistic And Modified Logistic Equations, Mihil Dimpal Patel

Discovery Day - Daytona Beach

Population growth models are essential tools for understanding how biological populations change over time under environmental constraints. This study examines population dynamics by comparing the classical exponential growth model with the logistic growth model. While exponential growth assumes unlimited resources and results in unbounded population increase, the logistic model incorporates a carrying capacity that limits growth as resources become scarce. To better represent real-world conditions, the logistic model is extended by introducing modifications such as harvesting terms and time-varying carrying capacities, which account for external removal of individuals and changing environmental limits. The equilibria of these models are determined, and …

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Exercise Intensity And The Effects On Mood And Wellbeing, Emily Amortegui, Ashley Albert, Riley Ensor, Keyanna Keyanna Jackson Aug 2026

Exercise Intensity And The Effects On Mood And Wellbeing, Emily Amortegui, Ashley Albert, Riley Ensor, Keyanna Keyanna Jackson

Discovery Day - Daytona Beach

With many students dealing with anxiety, sadness, and high levels of stress, mental health issues among college students have grown in intensity. A lot of research has been done on the possible benefits of physical activity for mental health, but most of it focuses on correlations rather than the biological mechanisms. The purpose of this study is to examine the effects of varying exercise intensities on physiological stress markers and mood in college students ages 18 to 25. To assure precise intensity levels, participants from Embry-Riddle Aeronautical University will work out at low, moderate, and high intensities while wearing heart …

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Effects Of Microgravity And Gamma Radiation On Biofilm Growth, Anya Pavlidis, Kaitlyn Mills Mills, Eva Mcclory, Grant Erlinder, Allen Qiu Aug 2026

Effects Of Microgravity And Gamma Radiation On Biofilm Growth, Anya Pavlidis, Kaitlyn Mills Mills, Eva Mcclory, Grant Erlinder, Allen Qiu

Discovery Day - Daytona Beach

Biofilms are collections of bacteria that commonly grow on a variety of surfaces. They are resistant to environmental impacts as bacteria fortify themselves to a surface. Biofilms are commonly found on Earth, but more problematically are also found on spacecraft. On the ISS biofilms have developed in spaces like the workout area, food spaces, and most concerning in the Water Recovery System (WRS). Biofilms tend to react differently to attempted cleaning methods in space than they do on Earth and can be located in extremely difficult to reach places.   This study aims to explore the effects of gamma radiation on …

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Interactive Effects Of Tissue Temperature And Hydration State On Tendon Mechanical Properties Using A Chicken Drumstick Model, Makayla Maso, Kiara Maso, Mikayla Hulvey Aug 2026

Interactive Effects Of Tissue Temperature And Hydration State On Tendon Mechanical Properties Using A Chicken Drumstick Model, Makayla Maso, Kiara Maso, Mikayla Hulvey

Discovery Day - Daytona Beach

This study focused on the effects of temperature and hydration on tendon extensibility. Four experimental groups were tested using chicken leg tendons tested ex vivo: cold and dehydrated, cold and hydrated, warm and dehydrated, and warm and hydrated. Each treatment group was pulled with an increasing load and measured. It was hypothesized that the warm and hydrated test group would extend the furthest. This was based on studies citing increased bodily flexibility with increasing body temperature as well as stiffness at lower temperatures. Combining temperature and hydration state allowed for not only individual effects of variables to be tested but …

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Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee Aug 2026

Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Japanese encephalitis virus (JEV), the prototype member of the JEV serogroup within the genus Orthoflavivirus (family Flaviviridae), is closely related to West Nile virus (WNV), Murray Valley encephalitis virus (MVEV), and St. Louis encephalitis virus (SLEV). To characterize antigenic cross-reactivity within this group, we evaluated 15 region-specific rabbit antisera, previously generated against nearly the entire JEV protein-coding region, by immunoblotting whole-cell lysates from BHK-21 cells infected with WNV, MVEV, or SLEV, with JEV included as a reference. Six antisera (α-EN-term, α-NS2B, α-NS3N-term, α-NS3C-term, α-NS5N-term, and α-NS5C-term) robustly recognized homologous …

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Malt1 Protease Inhibition Restrains Glioblastoma Progression By Reversing Tumor-Associated Macrophage-Dependent Immunosuppression In Mice, Juliana Hofstätter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah Crentsil, Gabriela Debom, Linda Klei, Mei Smyers, Chaim Sneiderman, Kristina Schwab, Rajesh Acharya, Aivi Nguyen, Josie Emery, John Little, Jeffrey Meridew, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda Mcallister-Lucas Aug 2026

Malt1 Protease Inhibition Restrains Glioblastoma Progression By Reversing Tumor-Associated Macrophage-Dependent Immunosuppression In Mice, Juliana Hofstätter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah Crentsil, Gabriela Debom, Linda Klei, Mei Smyers, Chaim Sneiderman, Kristina Schwab, Rajesh Acharya, Aivi Nguyen, Josie Emery, John Little, Jeffrey Meridew, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda Mcallister-Lucas

College of Life Sciences Faculty Papers

MALT1 protease is an intracellular signaling molecule that promotes tumor progression via cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied in lymphocytes, and little is known about its role in tumor-associated macrophages. We show that MALT1 is expressed in glioblastoma (GBM)-associated macrophages. Mechanistically, GBM tumor cells induce a MALT1-NF-κB signaling axis in macrophages, leading to enhanced macrophage migration and polarization toward an immunosuppressive ('M2-like') phenotype. Inactivation of MALT1 protease promotes transcriptional reprogramming that reduces migration and restores a macrophage anti-tumor 'M1-like' phenotype. Preclinical in vivo analysis shows that MALT1 inhibitor treatment results in immuno-reactivity of GBM-associated macrophages …

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Nuclear Activities And Interactome Of The Ns5 Protein Of Tick-Borne Encephalitis Virus, Maxime Chazal, Aïssatou Aïcha Sow, Elodie Le Seac'h, Dana Hawasheen, Margarida Bonifacio, Mikael Feracci, Ségolène Gracias, Adrià Sogues, Melissa Molho, Heng Pan, Boris Bonaventure, Jean-Pierre Quivy, Geneviève Almouzni, Etienne Decroly, Holly Ramage, Jeffrey R. Johnson, Vincent Caval, Nolwenn Jouvenet Aug 2026

Nuclear Activities And Interactome Of The Ns5 Protein Of Tick-Borne Encephalitis Virus, Maxime Chazal, Aïssatou Aïcha Sow, Elodie Le Seac'h, Dana Hawasheen, Margarida Bonifacio, Mikael Feracci, Ségolène Gracias, Adrià Sogues, Melissa Molho, Heng Pan, Boris Bonaventure, Jean-Pierre Quivy, Geneviève Almouzni, Etienne Decroly, Holly Ramage, Jeffrey R. Johnson, Vincent Caval, Nolwenn Jouvenet

Department of Microbiology and Immunology Faculty Papers

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular processes, including the interferon response. Although viral replication is cytoplasmic, the NS5 protein of several mosquito-borne orthoflaviviruses cycles between the cytoplasm and the nucleus of infected human cells. However, the nuclear localization and function of NS5 of tick-borne orthoflaviviruses, such as tick-borne encephalitis virus (TBEV), remain poorly understood. Microscopy analysis and cell fractionation revealed that the NS5 protein of TBEV localized to both the …

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Phenotypic And Biochemical Responses Of High-Yield Tomato Varieties To Salinity And Drought Stress, Shahida Ferdousee, Myung Hwangbo, Md Sakil Arman, Muhammad Abul Kalam Azad, Ajit Ghosh, Jongsun Kim Aug 2026

Phenotypic And Biochemical Responses Of High-Yield Tomato Varieties To Salinity And Drought Stress, Shahida Ferdousee, Myung Hwangbo, Md Sakil Arman, Muhammad Abul Kalam Azad, Ajit Ghosh, Jongsun Kim

School of Earth, Environmental, & Marine Sciences Faculty Publications

Abiotic stresses can influence plant growth and productivity by causing physiological, biochemical, molecular, and morphological changes. Salinity and drought are increasing in frequency and intensity because of climate change. Therefore, this study assessed four high-yield tomato cultivars under 150 mM NaCl and 260 mM mannitol treatments to characterize physiological (i.e., chlorophyll level, root/shoot length, and relative water content) and biochemical responses (i.e., GLY I/II and DLDH enzyme activities, proline, and hydrogen peroxide). Results indicated that the four BARI tomato varieties showed genotype- and treatment-specific physiological and biochemical responses rather than a single uniform tolerance pattern. BARI tomato 2 maintained relatively …

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First Insular Record And Dna Barcoding Of Euscorpius Vailatii Tropea & Fet, 2015 From Trizonia Island (Fokida, Greece), Konstantinos Kalaentzis, Francesco Frigioni, Alexios Panagiotopoulos, Elias Tzoras, Styliani Minoudi, Alexandros Triantafyllidis Aug 2026

First Insular Record And Dna Barcoding Of Euscorpius Vailatii Tropea & Fet, 2015 From Trizonia Island (Fokida, Greece), Konstantinos Kalaentzis, Francesco Frigioni, Alexios Panagiotopoulos, Elias Tzoras, Styliani Minoudi, Alexandros Triantafyllidis

Euscorpius

Euscorpius vailatii Tropea & Fet, 2015 (Scorpiones: Euscorpiidae), originally described from Aitoloakarnania and Fokida (Greece), is herein reported from Trizonia Island in the Gulf of Corinth, representing the first insular record for the species. The examined specimens are consistent with the diagnostic morphology of E. vailatii. The first molecular data for the species are provided, based on both mainland and insular populations. Comparative analyses further highlight the distinctiveness of E. vailatii from geographically close congeners, while phylogenetic results indicate a sister-taxon relationship with E. erymanthius, supporting a Quaternary biogeographic history shaped by the evolution of the Gulf of …

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