Life Sciences Commons^™

Host-Intrinsic Factors Determine Anti-Tumor Efficacy Of Exercise In Pancreatic Ductal Adenocarcinoma, Sumedha Pareek

Dissertations and Theses (Open Access)

Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths with a low 5-year relative survival rate of approximately 13.3% for all stages combined. We have previously shown that exercise can improve quality of life and enhance functional capacity among patients with PDAC. Exercise induces a variety of changes in the tumor microenvironment with beneficial effects in several tumor types. However, our understanding of the clinical effects of exercise and the mechanisms that mediate anti-tumor effects are limited in pancreatic cancer.

In this project, using C57BL/6 mice from Taconic Biosciences (Tac) and Jackson Laboratories (Jax), we established a …

The Distribution And Reproductive Success Of The Western Snowy Plover Along The Central And Southern Oregon Coast - 2025, David J. Lauten, Kathleen A. Castelein, Mary Lee, Jessica Burr, Marty R. Mccamant, Eleanor P. Gaines

Institute for Natural Resources Publications

We monitored the distribution, abundance and productivity of the federally threatened Western Snowy Plover (Anarhynchus nivosus nivosus) along the central and south coast of Oregon from 3 April – 10 September 2025. We surveyed and monitored plover activity in a project area that included, from north to south, Sutton Beach, Siltcoos River estuary, the Dunes Overlook, North Tahkenitch Creek, Tenmile Creek, Coos Bay North Spit (CBNS), Bandon Snowy Plover Management Area (SPMA), New River Habitat Restoration Area (HRA) and adjacent lands, and Floras Lake. Our objectives for the project area in 2025 were to: 1) estimate the size of the …

Nutrient Utilization Efficiency And Antioxidant Profile Of Bc2 Abaca (Musa Textilis Née) Hybrids, Roberto Barba Jr, Antonio Lalusin

The Philippine Agricultural Scientist

Abaca (Musa textilis Née) is an important fiber crop widely recognized for its superior tensile strength, yet its productivity remains constrained by nutrient inefficiency, poor cropping management, and climatic stresses under manual production systems. Efficient nutrient utilization and an understanding of antioxidant compositions are practically relevant to the productivity of the abaca fiber crop. However, despite the crop’s economic importance, limited studies have examined nutrient uptake dynamics and internal utilization efficiency related to fiber synthesis. This study aimed to demonstrate the nutrient utilization efficiency and antioxidant profiles of BC₂ abaca hybrids in relation to fiber yield and quality. Fiber …

The Economics Of Us Row Crop Production With Large-Scale Autonomous Machines, Joshua Strine, Chad Fiechter, James Lowenberg-Deboer

Department of Agricultural Economics Faculty Publications

Labor challenges are underpinning large multinational farm machine manufacturers' development of autonomy solutions for their large-scale machine offerings. This study simulates a linear optimization model to examine the economics of large-scale autonomous machines for a rotational maize and soybean farm in the Midwest US. Results support the hypothesis that autonomous machines can be economically viable for farms facing severe labor shortages. However, under current technology and pricing structures, conventional mechanization remains the most profitable option for farms with reliable labor. Critical factors shaping the competitiveness of autonomy include subscription fees, field efficiency, and human supervision requirements. As these factors evolve, …

Farm Efficiency And Precision Agriculture Technology, Chad Fiechter, Brady Brewer, Jennifer Ifft, Michael Boehlje

Department of Agricultural Economics Faculty Publications

Precision agriculture technology (PAT) is often viewed as a potential driver of future efficiency gains in farming. Using within-farm variation from an unbalanced panel of Kansas farms, this study examines the impact of PAT bundles on efficiency in generating gross revenue. On average, we find little evidence that these technologies improve efficiency. However, among less efficient farms, several bundles are linked to notable efficiency gains, underscoring the importance of accounting for farm heterogeneity.

An Open Letter To Leslie, Anne G. Kinne Phd

Journal of Conscious Evolution

This article celebrates the life and work of dear friend and mentor, Allan Leslie Combs, acknowledging his continued presence in my life. Interweaving stories of our relationship with his insights on integral consciousness, Bateson’s concept of aphanipoiesis, Varela et al.’s notion of autopoiesis, and using narrative, storytelling, and autoethnographic methodologies, I tell a tale of becoming that troubles and haunts my past. The sticky tendrils of Ancestral trauma and its transhistorical epigenetic inheritance, once acutely troublesome, are shifting due in large part to the contents of this letter. Woven together, these conscious, intersecting, and interactive lenses show how Leslie has …

Decomposition Processes And Insect Indicators In Forensic Investigations, Eli Taylor

University Honors Theses

Insects play an essential biological and ecological role in human life, and their predictable relationship with decomposing remains has positioned them as a cornerstone of modern forensic science. Since the early 20th century, forensic entomology has provided critical evidence for estimating the postmortem interval (PMI), relying on patterns of colonization, species succession, and insect developmental timelines. Accurate PMI estimations are vital to medicolegal investigations, influencing the interpretation of biological evidence, guiding resource allocation, and informing determinations of cause and manner of death. However, insect activity is profoundly shaped by environmental and ecological variables, including temperature, humidity, seasonal shifts, and geographic …

Prevalence Of Shiga Toxin Producing Escherichia Coli In Illinois Bison Herds, Adam M. Baldocchi

Honors Capstones

Shiga toxin-producing Escherichia coli (STEC) represents an important group of zoonotic pathogens that pose ongoing risks to public health through foodborne outbreaks and environmental transmission. This project evaluated the prevalence and genetic distribution of stx1 and stx2 toxin genes in fecal samples collected from Illinois bison Bison bison) managed under either commercial or preservation conditions. A total of 320 fecal samples were screened for STEC presence by performing enrichment culturing and confirmed by Polymerase Chain Reaction (PCR) for stx1, stx2, and uidA, which confirmed E. coli identity. Of all tested samples, 28.4% were STEC-positive, with stx2 (21.3%) …

Evaluating Metamitron Efficacy For Glyphosate-Resistant Palmer Amaranth (Amaranthus Palmeri) Management In Sugarbeet Across The Central High Plains, Abraham Akuoko

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Herbicide-resistant (HR) Palmer amaranth (Amaranthus palmeri S. Watson) is regarded as one of the most prominent weeds within sugarbeet fields across the Central High Plains, with limited chemical control options. Although a few herbicides are available, their use is restrictive due to crop injury concerns and can only be applied at or after the 2–4 true leaf (TL) growth stage, which will provide no control for already emerged weeds. However, Palmer amaranth often emerges between sugarbeet planting and the 2 TL sugarbeet growth stage. Consequently, as of 2023, there were no herbicide options to control Palmer amaranth in sugarbeet …

Characterization Of Mitochondrial Dna Repair Components And Repair Choices At Targeted Double-Strand Breaks In Arabidopsis Thaliana, Moira Rodriguez

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Plant mitochondrial genomes are complex when compared to most other eukaryotic mitochondrial genomes. They are large and variable in size, expand and rearrange frequently, abundant in non-tandem repeats, but maintain a very low synonymous substitution rate in the remaining coding regions. Many of these complexities can be explained by the increased use of double-strand break repair for DNA damage. To advance the understanding of mitochondrial genome dynamics as it relates to double-strand break repair, we performed a forward genetics screen to identify proteins involved in DNA repair in plant mitochondrial genomes. Through this screen, we identified an RNA/DNA helicase, Suv3, …

Proso Millet In Us High Plains Dryland Agriculture: Systems Resilience, Phenology, And Consumer Preferences For Alternative Grains, Pratiksha Baishya

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Dryland crop production in Nebraska's semi-arid High Plains faces challenges from fluctuating weather impacts of climate change, including extreme temperatures, short growing seasons, and recurring droughts. Proso millet is an alternative crop used to build a more robust three-year rotation in the region, rather than the traditional two-year wheat-fallow cycle. This dissertation provides a systems-level assessment of proso millet, a climate-resilient crop with great potential to support sustainable cropping systems in the US High Plains. Using a field-to-consumer approach, it highlights its agronomic and environmental advantages in dryland rotations, develops a phenological framework to aid future research on production, crop …

Recovery And Characterization Of Moraxella Species From Bovine Specimens, Laura G. Leger

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

The family Moraxellaceae is made up of a diverse group of 24 named species that fall into three phylogenetic groups. While most Moraxella spp. act as commensal respiratory and/or ocular flora of mammals, some are associated with disease. One of these diseases, infectious bovine keratoconjunctivitis (IBK), has significant welfare and economic impacts to both cattle and cattle producers. Moraxella bovis is the only experimentally determined cause of IBK, however, an association of Moraxella bovoculi with disease has been proposed. Currently, available vaccines do not have high levels of efficacy in the field. Culture based methods are the gold standard for …

Near-Infrared-Spectroscopy-Derived Oxygen Desaturation Rates During Post-Exercise Circulatory Occlusion As Predictors Of Cardiorespiratory Fitness Markers, Carstell Lee

Honors Theses

Cardiorespiratory fitness, measured as maximal oxygen consumption (VO₂max) is a critical predictor of all-cause mortality and overall cardiovascular health. Metabolic carts are the current gold standard for evaluation of VO₂max, but are inaccessible to most facilities and individuals, and are expensive ($20,000+). Near-Infrared spectroscopy (NIRS) has emerged as an accessible and affordable ($5,000-$10,000) alternative for evaluating skeletal muscle oxygenation kinetics and mitochondrial oxidative capacity. However, there is limited research in examining whether NIRS-derived oxygen desaturation rates can be a predictor of cardiorespiratory fitness markers (such as VO₂max and peak power output [PPO]), and whether these measurements show a superior predictive …

Exploring Life History Trade-Offs In The Facultative Eusocial Bee Megalopta Genalis, Ana Gutiérrez Zuluaga

All Graduate Theses and Dissertations, Fall 2023 to Present

Organisms face many trade-offs in how to invest in these traits. One example is the trade-off between reproduction and longevity. Queens of social insects seem to escape this trade-off, producing thousands of eggs daily, despite having a longer lifespan than their workers. Some hypotheses have been proposed to explain this phenomenon, such as an evolutionary change in the molecular pathways that regulate queen investment in maintenance, growth, and reproduction. An alternative hypothesis suggests that the tradeoffs are rarely observed in queens due to the extensive resources provided by the help of workers. While these hypotheses have supporting evidence, they have …

Lagomorphs, Ungulates, And Predation: Exploring Interactions And Quantifying The Effect Of Lagomorph Herbivory In Rangelands, Shantell Marie Garrett

All Graduate Theses and Dissertations, Fall 2023 to Present

Rangelands are expansive ecosystems that make up more than 30% of the total surface land area in the contiguous United States. In the west, they are typically categorized as shrublands, grasslands or deserts with low precipitation. The vegetation communities consist largely of grasses and forbs and are thus widely used for livestock grazing. Despite their barren appearance, rangelands are diverse ecosystems that are home to a wide breadth of species.

The Henry Mountains, located in south central Utah, is one example of this system type. With their inspiring red-rock mesas and towering plateaus, this public land, managed by the Bureau …

Factors Affecting Beef Average Daily Gain And Carcass Traits In Smallholder Farms In Thailand, China Supakorn, Sumalee Supant, Warinthorn Maneerat, Ya-Shiou Chang, Monticha Putsakhum

The Philippine Agricultural Scientist

This study examined the effects of farm management, body weight, fattening duration, breed, and estimated age on average daily gain (ADG) and meat quality traits, such as hot carcass weight (HCW) and dressing percentage (DP). The dataset comprised 3,286 steers from the Livestock Cooperative in Sakon Nakhon province, Thailand, spanning 10 yr (from 2013 to 2023). The mean initial and slaughter weights were 392.92 ± 29.18 kg and 600.75 ± 60.73 kg, respectively. The ADG during the fattening period was 0.95 ± 0.17 kg/d, while HCW and DP averaged 328.86 ± 40.79 kg and 54.75 ± 1.41%, respectively. The beef …

Evaluation Of The Suitability Of Tomato (Solanum Lycopersicum L.) Accessions Grown In A Vertical Container System, Darel Kenth S. Antesco, Lourdes Edano Ma., Renerio Gentallan Jr, Roselyn F. Paelmo, Annalissa L. Aquino

The Philippine Agricultural Scientist

Growing tomatoes in vertical container systems such as hanging pots presents a promising production system for urban gardening. However, horticultural selections of tomato with traits suited for this system are still limited. The success of different genotypes grown in this system depends on the combination of morphological characters, including plant form, vegetative growth, and root development, as well as yield. This study assessed the morphological characters of 10 tomato accessions to identify those with ideal traits for this system. Results showed that some accessions possess unique traits that enhance their performance in hanging pots. Among the 10 accessions, T2 from …

From Fruit To Nut: Revisiting Pili Nut (Canarium Ovatum Engl.) Production Capacities And Value-Adding Activities In Sorsogon, Philippines, Joey Richard V. Dio, Ryan V. Dio, Dulce Corazon F. Lacson

The Philippine Agricultural Scientist

The value chain of agricultural products significantly influences their profitability and socio-economic contribution. This study developed a descriptive model of the pili (Canarium ovatum Engl.) nut value chain in Sorsogon, the primary producer in the Philippines, and the only province with large-scale commercial operations. Using a descriptive research approach, data were collected through purposive interviews with 15 key informants—farmers, processors, and traders—guided by Porter’s value-chain framework. Results indicate that Sorsogon produces about 3 times the quantity required daily (< 2,233 kg) by Bicol-based processors, leading to underutilization and post-harvest losses attributed to limited storage facilities and market linkages. The processing stage, which converts pili fruits into nuts and kernels, demonstrates the highest operational efficiency, while the trading stage remains constrained by limited market access. Stakeholders often perform overlapping functions, and traditional sun-drying methods remain common. Furthermore, an aging farming population, limited succession planning, and inconsistent implementation of food safety standards continue to pose challenges to industry growth. These inefficiencies result in reduced profitability and restrict expansion. Strengthening the value chain through improved processing systems, broader market integration, and streamlined production activities is necessary to enhance economic returns and support the sustainable growth of Sorsogon’s pili nut industry.

Gastropod Assemblage And Biofilm Abundance On Rocky Shores Of Southern Antique, Panay, Philippines, Mia Jane D. Geneblaza, Karen A. Villarta-Lane

The Philippine Agricultural Scientist

The gastropod assemblage and biofilm abundance, measured as chlorophyll a levels, were examined at 3 rocky shore sites in southern Antique, Panay, Philippines, in February 2024 to address significant gaps in current knowledge and help better understand the ecological dynamics of rocky intertidal zones. A total of 14 families comprising 22 genera and 31 species were identified from the area. The family Littorinidae was the most speciesrich, comprising 9 species. Among these, the scabra periwinkle Littoraria scabra (Philippi 1846) was the most abundant, comprising on average 50.17% of the total abundance across sites. Other identified gastropod families included Muricidae (5 …

Non-Target Organisms And Terrestrial Arthropod Biodiversity In The Corn Agroecosystem: Bt Corn Beyond Acb Pest Management [Review Article], Ireneo L. Lit Jr., Merdelyn T. Caasi-Lit, Kristine O. Abenis

The Philippine Agricultural Scientist

Assessments of risks of modern biotechnology products to non-target organisms (NTOs) are required before a product can be registered and allowed for commercial production. For Bt-engineered plants, data from such studies become part of environmental risk or impact assessments that are reviewed before a hybrid can be registered and allowed for commercial planting. The approaches and methods vary among countries and researchers. Consequently, the choice of species and groups of organisms or guilds that are monitored or studied may range from narrow to broad and encompassing. The inevitability of adverse changes in agroecosystems, including those that involve the corn crop, …

Age-Dependent Reproductive Fitness And Behavioral Dynamics Of The Asian Corn Borer, Ostrinia Furnacalis (Guenée) (Lepidoptera:Crambidae), Marcela M. Navasero, Randolph N. Candano, Maricon Dp Javier, Jethro M. Navasero, Wilson N. De Panis

The Philippine Agricultural Scientist

This study evaluated the effects of parental age of the Asian corn borer (ACB), Ostrinia furnacalis (Guenée), on fecundity, egg hatchability, adult longevity, and the duration of pre-oviposition, oviposition, and post-oviposition periods using arranged mating pairs aged 1 to 5 days old. Mating behavior was also observed and documented. The highest fecundity, measured by the number of egg masses and total eggs produced, was recorded in pairings of 1-day-old males and females, indicating a positive effect of young parental age. In contrast, pairings involving 5-day-old males and females resulted in the lowest egg production, demonstrating an inverse relationship between parental …

Oviposition Preference And Behavior Of The Asian Corn Borer, Ostrinia Furnacalis (Guenée) (Lepidoptera: Crambidae), On Corn And Non-Corn Plants Under Semi-Field And Mini-Screen Cage Conditions, Merdelyn T. Caasi-Lit, Jessica B. Baroga-Barbecho, John David C. Cortez, Edwin A. Benigno

The Philippine Agricultural Scientist

Oviposition site selection in Ostrinia furnacalis is a hierarchical, multi-stage process influenced by plant phenology and spatial context. Oviposition preferences under mini-screen cage (Sampaloc) and semi-field (BL2) conditions were evaluated to determine the effects of field size, corn developmental stage, and the presence of non-corn plants on egg deposition patterns. Females deposited significantly more egg masses on 40 DAP (pre-reproductive) corn than on early vegetative-stage plants [Sampaloc: n=437 (40 DAP), n=88 (30 DAP); BL2: n=98 (40 DAP), n=84 (30 DAP)], demonstrating a strong phenological preference, particularly in Sampaloc. The presence of non-corn plants has a negligible …

Characterization Of Adult Emergence Pattern And Eclosion Behavior Of The Asian Corn Borer, [Ostrinia Furnacalis (Guenée)] (Lepidoptera: Crambidae), Under Laboratory And Field Conditions In The Philippines, Marcela M. Navasero, Gelyn D. Sapin, Merdelyn T. Caasi-Lit, Wilson N. De Panis, Randolph N. Candano, Maricon Dp Javier, Jethro M. Navasero, Meijei T. Bangangao

The Philippine Agricultural Scientist

This study focuses on understanding the emergence pattern of Asian Corn Borer (ACB), Ostrinia furnacalis (Guenee), in the Philippines vital in crafting integrated pest management schemes, including insect resistance management against pesticides and Bt protein. Although ACB adults are known to be nocturnal and primarily emerge at night, identifying critical windows of emergence for targeted management actions is essential. In the experiments conducted, the scotophase period is the preferred time for adult emergence under laboratory conditions with 248 adults (80.52%) and 60 adults (19.48%) in the photophase period. A similar trend was also observed under field cage conditions with ACB …

Movement Of The Different Larval Stages Of Asian Corn Borer, Ostrinia Furnacalis (Guenée), On Conventional Corn Hybrid Under Field Caged Conditions, Merdelyn T. Caasi-Lit, Mark Bryan A. Lontoc, Victor V. Alpuerto, Abigail P. De Leon, Jenifer Bigkas-Naungayan, John David C. Cortez, Edwin A. Benigno

The Philippine Agricultural Scientist

Larval dispersal is crucial in pest population establishment in crop fields. The movement of Ostrinia furnacalis (ACB) larvae within corn plots was observed to determine which factors affect larval dispersal in the field. Conventional corn plots (3 rows, 0.70 m apart x 9 plants, 0.20 m apart) were artificially infested with different combinations of larval age and pest density. The distributions of larvae were recorded through destructive sampling at 4, 8, 12, and 16 days after infestation (DAI). The behavior of ACB from the time the hatching larvae break open the egg mass shell to ballooning to start actual movement …

The Effect Of Corn Event Mir162 And The Triple Stacked Hybrid, Bt11 X Mir162 X Ga21, On Key Non-Target Organisms Of Corn, Ireneo L. Lit Jr., Merdelyn T. Caasi-Lit, Kristine O. Abenis, Edwin A. Benigno

The Philippine Agricultural Scientist

Assessments of environmental risks, especially to non-target organisms, are required before genetically modified plants are approved for commercial production. Incorporated genes or traits, whether as single events or stacked or combined with other traits, are treated separately. In compliance with Philippine regulations, confined field trials were conducted to evaluate possible effects of corn event Maximus MIR162 and triple stacked corn hybrid Bt11 x MIR162 x GA21 on non-target arthropods from August 2011 to January 2012 in Laoac, Pangasinan, and Tampakan, South Cotabato. Visual counts and opportunistic sampling, sweep net sampling, pitfall traps, and sticky traps were used at each sampling …

Dendrimer Gel Nanoparticles With Dual-Targeting Of Upar And Ribonucleotide Reductase R2 Influence Necrosis, Apoptosis, And Cell Cycle Arrest In Triple-Negative Breast Cancer, Hsin Yin Chuang, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited treatment options due to the absence of estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) receptors. We previously developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles (GDP-uPA/GTI) with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2) to achieve selective antitumor effects. In this study, we investigated the underlying mechanisms of GDP-uPA/GTI-induced tumor inhibition. In vivo, GDP-uPA/GTI significantly downregulated R2 expression and activated caspase 8 and caspase 3, indicating caspase-dependent apoptosis. Histological evaluation of major organs revealed no observable toxicity. …

An Examination Of The Relationship Between Unilateral Triaxial Jump Test And Power Skating Profile In Female Recreational Ice Hockey Athletes, Abigail Christie Aultz

Boise State University Theses and Dissertations

Introduction: Skating is a fundamental skill in ice hockey that relies on effective directional force and power generation. Due to biomechanical similarities, off-ice jump tests (e.g., vertical and broad jumps) are often used to assess and predict skating abilities and performance. However, most traditional jump tests are unilateral and do not reflect the multidirectional nature of skating propulsion. The relationship between off-ice force production and in-game skating performance remains unclear, particularly in recreational female hockey players, who are biomechanically distinct and underrepresented in research. Although a 45° push-off angle has been shown to optimize force production in elite male athletes, …

Live And Let Fly: Assessing Threats To California Condors, Molly Astell

Boise State University Theses and Dissertations

California condors (Gymnogyps californianus) are a critically endangered species that face threats, both anthropogenic and natural, that slow recovery of their population. The leading causes of death of condors are lead toxicosis, predation, trauma, fire, and collision and electrocution at power lines. As a long-lived and slow-maturing species, each death is consequential and understanding when and where threats occur can greatly benefit management and mitigation. Although the focus of extensive mitigation efforts, lead toxicosis remains the leading cause of death for condors. There has been less effort dedicated to addressing the second-leading anthropogenic threat, interactions with power lines. Such efforts …

Modeling The Deleterious Effects Of An Endogenously Generated Apolipoprotein-E4 Fragment In Transgenic Zebrafish, Emily Egan

Boise State University Theses and Dissertations

Harboring the apolipoprotein E4 allele (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease, yet the mechanisms by which the expressed protein contributes to neurodegeneration remain unknown. Previous studies suggest that proteolytic cleavage of ApoE4 generates amino-terminal fragments that are neurotoxic and may drive cellular dysfunction. To investigate the deleterious effects of one such fragment, nApo_E1-151, in a living vertebrate model, we developed a transgenic zebrafish line using Tol2-mediated transgenesis to endogenously express nApo_E1-151 under the neuron-specific HuC/D promoter. This model utilizes the zebrafish’s genetic accessibility, embryo and larva transparency, and rapid development ex utero to study the …

Shifting Grounds: Knowledge, Power, And Place In Changing Western Rangelands, Molly C. Levy

Boise State University Theses and Dissertations

Public rangelands in the American West are sites of enduring contestation, where ecological change, competing values, and institutional complexity converge. Long-standing debates over livestock grazing, wildlife conservation, and land stewardship highlight fundamental questions of whose knowledge counts, whose authority is legitimate, and how resource use should adapt under shifting social and ecological conditions. This dissertation examines the intersections of knowledge, power, and land use in collaborative governance of contested landscapes. Using the Thunder Basin ecoregion (TBER) in northeastern Wyoming as a case study, I adopt a mixed-methods approach that integrates qualitative interviews, participant observation, archival research, and quantitative analysis of …