Life Sciences Commons^™

Magnesium-Based Metal Matrix Nanocomposite Implants And Nanobubble-Based Delivery Systems: Integrated Strategies For Bone Loss Treatment With Cytocompatibility Evaluation, Lucas José Martinho Bizuti

Honors Undergraduate Theses

This thesis intends to investigate the development of different multimodal therapeutic strategies for combating bone loss. Most specifically, this paper will emphasize the utilization of Magnesium-Based Metal Matrix Nanocomposite Implants (MMNC) and Nanobubble-Based Delivery Systems as options for future treatment focus. The effects of biodegradable magnesium implants were evaluated for cytotoxicity and cytocompatibility via Hematoxylin and Eosin, and Masson’s Trichrome staining, as well as radiological images. The Nanobubble-Based Delivery System is being developed and optimized as a delivery system to target osteoclast activity. This paper focused on optimizing experimental parameters, which include Rotational speeds for nanobubble stimulation under microgravity conditions …

Exploring Anticholinergic Neurotoxicity: Diphenhydramine's Impact On Neuro-2a Cell Morphology, Expression, And Viability, Jordan B. Mcintyre

Honors Undergraduate Theses

Anticholinergic medications, such as diphenhydramine (commonly known as Benadryl), are increasingly recognized for their association with cognitive impairment and neurodegenerative disease. These medications, which inhibit the action of acetylcholine, a neurotransmitter essential for the formation and utilization of the central and peripheral nervous system, have been implicated in conditions such as dementia and may impact fundamental cellular processes like neurogenesis and cell proliferation. This study investigates the effects of diphenhydramine on neurogenesis when introduced to Neuro-2a cells during differentiation. For all studies cells were plated on coverslips or in 6-well plates with differentiation media containing 0 ng/mL, 50 ng/mL, …

Development Of A Split Deoxyribozyme-Based Assay For Detecting Hepatitis B Virus, Dalila Zovko

Honors Undergraduate Theses

Rapid, accessible nucleic acid-based detection methods are needed for hepatitis B virus (HBV). A split deoxyribozyme assay was developed for sequence-specific fluorescence detection. The assay was evaluated using synthetic target and plasmid-derived material. The assay showed target-dependent fluorescence and low-concentration linear range with a LOD of 1.9 nM. The assay supports detection and semi-quantification of HBV genetic material as shown using plasmid-derived transcript samples from HBV genotypes B, C, and D. The selected target corresponded to nt 363–406 of the HBV genome and was chosen based on sequence alignment showing conservation across most genotypes. Genotype-specific detection remains a future application …

Dna Half-Adder Based Calculator Driven By 4j Molecular Switches, Andrea Gissele Canizalez Covaleda

Honors Undergraduate Theses

DNA nanostructures have computing functions due to the predictable base pairing of nucleic acids (Watson–Crick). This property allows the programming of DNA circuits that integrate DNA logic gates capable of recognizing oligonucleotides. This molecular device offers the advantages of biocompatibility and potential applications in personalized medicine for diagnosis and therapies.

Our lab has developed DNA logic gates formed by the connection of YES strands via DNA four-way junctions (4J), which can function as molecular switches to develop a DNA-based calculator. Our DNA half-adder calculator nanostructure is designed to recognize up to three combinations of DNA inputs using three DNA strands …

Analysis Of Alternative Gene Splicing Of Natural Killer Cell Exhaustion Markers During Siv Infection, Soledad B. Zayas

Honors Undergraduate Theses

Natural killer cells play a critical role in the innate immune response against Human Immunodeficiency Virus and Simian Immunodeficiency Virus infections. During HIV/SIV infection, NK cells undergo functional impairment characterized by an imbalance between activating and inhibitory surface receptors. The upregulation of inhibitory receptors, TIGIT and TIM-3, has proven to contribute to NK cell exhaustion during different retroviral infections. Although alternative splicing regulates immunity related genes, its role in TIGIT and TIM-3 expression during SIV infection remains poorly understood. This study aimed to characterize alternative splicing patterns of TIGIT and TIM-3 and evaluate transcript variant expression during SIV infection in …

The Role Of Body Composition In Predicting Fitness Performance Of Law Enforcement Officers, Taylor J. Parmentier

Theses and Dissertations

Law enforcement officers (LEOs) perform physically demanding tasks such as foot pursuits, lifting, carrying, dragging, and physical restraint. Effectively performing these duties requires significant muscular strength, endurance, and cardiorespiratory fitness. Lower fitness levels pose risks for reduced health, performance, slower recovery, increased fatigue, and potentially affecting decision-making under strenuous conditions. The purpose of this study was to identify the strongest predictor of physical fitness performance among active-duty LEOs. Body composition analysis and a comprehensive fitness evaluation of twenty-nine male LEOs (age: 36.2 ± 9.3 years, body mass (BM): 95 ± 13.7 kg, height: 1.8 ± 0.1 m) was completed. The …

Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib

ASEAN Journal on Science and Technology for Development

The review article demonstrates the importance of power electronics in propelling the increase of renewables and increasing the efficiency of contemporary electrical grids. In particular, it highlights the need for bidirectional converters for effective energy management in vehicle-to-grid (V2G) systems with two-way power transfer. The paper examines the series of complications offered by the significantly large integration of power electronic converter-interfaced renewables, such as those related to system steadiness, power quality, and resignation bottlenecks. Also, it recognizes a mix of new technologies, such as wide bandgap (WBG) semiconductors like silicon carbide (SiC) and gallium nitride (GaN), that deliver superior performance …

Extraction And Characterization Of Fresh And Dehydrated Cactus (Opuntia Ficus Indica) Polysaccharide For Hydrogel Preparation, Aye Thwe Thwesoe, May Myat Khine

ASEAN Journal on Science and Technology for Development

In this research, extraction of polysaccharide compounds from Cactus (Opuntia Ficus Indica) leaves in both fresh and dehydrated condition by solvent precipitation method using three types of water, acid (HCL) and NaOH. Before extraction, the physicochemical properties were examined to determine optimum yield (%) of extracted polysaccharide by optimization of Box-Behnken Design (BBD) of response surface methodology (RSM). The polysaccharide-based acrylamide hydrogel was prepared by free radical polymerization. The functional and structural characterization was done by FTIR, XRD and SEM for examination of extracted polysaccharide as raw polymer backbone in hydrogel preparation and prepared hydrogel as adsorbent for metal removal. …

Unlocking Green Potential In Indonesian Small Medium Enterprises: Challenges And Opportunities For Sustainable Vermicelli Production, Togar W. S. Panjaitan, Karina Agustin, Prayonne Adi, Jani Rahardjo, I Nyoman Sutapa

ASEAN Journal on Science and Technology for Development

Due to limited initiatives and support, the transition to green manufacturing among small and medium enterprises (SMEs) in developing countries remains challenging. Through a critical literature review and case study of the Indonesian vermicelli industry, this study highlights the importance of collaboration and strong policies to address this. Other findings also reveal that the energy intensity and emissions in the sector exceed best practice benchmarks, with the cooking and drying stages contributing significantly to emissions due to high energy consumption. Lack of government regulations, company awareness, and understanding of applicable practices and technologies creates challenges in green manufacturing. The study …

Hybrid Model For Phishing Website Detection Using Transfer Learning, Atul Dubal, Mansi Subhedar, Santosh Dhamala, Manasi Patil

ASEAN Journal on Science and Technology for Development

The rapid digitization of human activities has intensified reliance on internet-based platforms, creating fertile ground for cybercriminal exploits such as phishing. Despite advancements in detection mechanisms, phishing attacks continue to evolve, leveraging sophisticated visual mimicry to deceive users. This paper proposes a robust vision-based phishing detection system using ensemble deep learning to analyse webpage screenshots. The framework integrates transfer learning with pre-trained VGG16 and DenseNet121 models, extracting complementary low-level texture features (edges, gradients) and high-level hierarchical patterns (logos, layouts). These features are fused through a custom classifier with dropout regularization to mitigate overfitting. A balanced dataset of 3,000 webpage screenshots …

Ai-Assisted Hybrid Ga–Pso Channel Allocation Under 3gpp Tr 38.901 Uma For Efficient 5g Radio Resource Management, Sharada Narsingrao Ohatkar

ASEAN Journal on Science and Technology for Development

The increased traffic and heterogeneity in the 5G/B5G network require efficient radio resource management (RRM). However, the existing methods, such as GA and PSO, have poor convergence speed and require proper initial conditions. Additionally, learning-based methods have high computational complexity. Hence, in this paper, a novel AI-assisted Hybrid Channel Allocation (AI–HCA) framework is proposed by using a support vector regression (SVR)-based predictive initialization method and GA-PSO optimization. Simulation results using the 3GPP UMa channel model show that the proposed method has a 28% reduction in call blocking probability (CBP), a 15-25% enhancement in spectral efficiency (SE), and a 18-25% enhancement …

Sustainable Conductive Rpla-Carbon Black Filament For Additive Manufacturing Via Single-Screw Extrusion, Zaidan Faraby Zulkarnain, Shakina Hawapi, Aini Zuhra Abdul Kadir, Muhd Ikmal Isyraf Mohd Maulana, Nor Akmal Fadil, Najlaa Nazihah Mas’Ood, Mohd Rizal Alkahari, Saidin Wahab

ASEAN Journal on Science and Technology for Development

The growing demand for low-cost, sustainable conductive filaments for additive manufacturing motivates the exploration of recycled polymer feedstocks as alternatives to virgin materials. However, the effects of prior thermal reprocessing on both the electrical performance and morphological integrity of recycled PLA (rPLA)–carbon black (CB) composite filaments remain insufficiently characterised, particularly under single-screw extrusion conditions. This study fabricates and characterises conductive filaments from virgin PLA and rPLA, each loaded with CB at 0.2, 0.6, and 1.0 wt%, using a low-cost desktop single-screw extruder. Melt blending was found to be essential for achieving continuous filament extrusion, as ball milling produced insufficient filler …

Assessing Decision Making Of United States Arboreta: A Survey Of The Main Drivers Behind New Planting Selections, Sophia Reavley

Theses and Dissertations

When an arboretum needs to replace fallen specimens, what are they looking for in the new plant that will be added to the collection? Arboreta are locations where trees and shrubs can be studied in an area where the public can also enjoy them. This study looks to see what aspects of scientific value (conservation status, diversification, ornamental value, etc.) and what external factors (budgets, public opinion, research articles, etc.) of new species selections become the main driver in decision making. An anonymous online survey was used to collect data from arboreta and botanical gardens of the United States that …

Predictors Of Successful Conservative Lung Surgery In Endobronchial Tumors, Ahmed Mohamed Abdelfattah Ahmed Omar, Amr Abdellateef Hassan, Sameh Ibrahim Elsayed

Mansoura Medical Journal

Background: Endobronchial tumors, though rare, often present centrally and may cause airway obstruction. Historically managed by pneumonectomy, conservative lung surgery has emerged as a viable alternative with reduced morbidity. Methods: This retrospective study included 69 adult patients with endobronchial tumors treated surgically at Mansoura University between 2005 and 2024. Patients were divided into two groups: Group 1 underwent pneumonectomy; Group 2 non-pneumonectomy. Clinical, radiological and bronchoscopic data were analyzed to identify predictors of successful conservative surgery. Results: Tumor location, proximity to the carina, preserved distal lung tissue, and higher preoperative FEV1% were significantly associated with conservative surgical success. Therapeutic bronchoscopy …

Impact Of Social Media On Acne Treatment Practices In Egypt, Hadeer Fathy, Moheiddin Fakhry Alghobary, Nada Mohmed Elhadidy, Sara Hamdy Fouad

Mansoura Medical Journal

Background: Acne is one of the most prevalent global diseases, affecting up to 85% of adolescents and young adults and contributing to significant psychological burden. Despite available treatments, many patients rely on social media for guidance, where misinformation and unauthorized drug promotion can negatively influence Acne Vulgaris management.

Aim: The aim of this research is to determine the influence of social media information on the selected treatment method of Egyptian patients with Acne Vulgaris

Patients and methods: This is cross‑sectional study targets Acne Vulgaris patients aged ≥15 with current or past AV who use social media. Data was collected through …

Triglyceride Glucose Index As A Predictor Of Insulin Resistance In Patients With Hypothyroidism, Nadeen El-Nakeeb, Mohammed A. Helaly, Ahmad S. Hasan, Rania Bahriz

Mansoura Medical Journal

Background: Thyroid hormones play a key role in glucose metabolism, and hypothyroidism is frequently associated with impaired insulin secretion, altered glucose disposal, and insulin resistance (IR).

Aim: This study aimed to assess insulin resistance in patients with hypothyroidism using the triglyceride–glucose (TyG) index in comparison with the homeostasis model assessment of insulin resistance (HOMA-IR).

Methods: This case-control study was conducted on 100 participants (50 hypothyroid patients and 50 euthyroid controls), aged 18–60 years. All subjects underwent detailed clinical evaluation, anthropometric measurements, and fasting laboratory investigations including glucose, lipid profile, insulin, TSH, and free T4. Insulin resistance was assessed using TyG …

5-Ht1a Receptor Gene Polymorphism (C-1019g) In Patients With Primary Premature Ejaculation, Ali Mohamed Ali Mahmoud, Mohamed Khaled Galal Selim, Sherif Refaat Ismael, Ahmad Shawki Hasan

Mansoura Medical Journal

Background: Twenty to thirty percent of men experience premature ejaculation (PE). The bioactive amine serotonin (5-hydroxytryptamine, 5-HT) produces a diverse array of outcomes in the brain and other tissues. Researchers investigated serotonin in relation to many other activities and events, including sexual functions. This study set out to investigate whether or not there is a correlation between intravaginal ejaculatory latency time (IELT) with the C-1019G promoter polymorphism (rs6295) in 5-HT1A receptor gene in men who have lifelong PE.

Methods: The current study included 50 cases with PE and 50 apparently healthy subjects as a control group. Participants were assessed for …

Rail Sign By Doppler Ultrasound As A Predictor Of Outcome Of Placenta Accreta Spectrum, Ola Khaled Mosaad El Malahy, Mohammed Nezar El Shahat, Lotfy Sherif Sherif, Khaled Samir, Amany A Makroum, Alhussein Ahmed Mohamed

Mansoura Medical Journal

Background: Placenta accreta spectrum (PAS) involves abnormal placental invasion into uterine wall and is associated with life-threatening maternal complications. Doppler ultrasound is the primary diagnostic tool, though its ability to determine invasion depth and predict outcomes remains uncertain. Multidisciplinary management improves safety, and treatment often requires planned cesarean hysterectomy, or conservative management. The aim of this work was to correlate rail signs by Doppler US as a predictor of deep villous invasion and to detect whether rail signs can predict maternal and fetal outcomes.

Methods: This prospective observational study was conducted on 59 patients aged > 20 years old, with PAS …

Impact Of Body Mass Index On Clinical Outcomes In Metastatic Breast Cancer Running Title: Impact Of Bmi On Mbc Outcome, Alaa Abdelrahman Sonbol, Maha Elzaafarany, Ahmed Albehairy, Sherif Refaat

Mansoura Medical Journal

Background: Body mass index (BMI) has been suggested as an important patient-related factor influencing treatment outcomes in breast cancer. This study aimed to evaluate the association between BMI categories and clinical outcomes among patients with metastatic breast cancer (MBC).

Patients and Methods: This retrospective study included 400 patients with MBC. Clinical outcomes assessed included response to first-line treatment, treatment-related toxicity, and status at last follow-up and BMI was calculated using the Quetelet index .

Results: Patients were characterized by a high prevalence of obesity and predominantly good performance status. Disease progression following first-line treatment was the most common …

Role Of Foxl2 Immunohistochemical Marker In Diagnosis Of Ovarian Sex Cord-Stromal Tumors, Correlation With Histopathologic Features And Inhibin Expression, Eman Magdi Hikal, Sylvia Albair Ashamallah, Nadia Abd El-Moniem Nada, Dina Abdallah Ibrahim

Mansoura Medical Journal

Background: Ovarian Sex Cord-Stromal Tumors (SCST) are a broad category of rare neoplasms that exhibit diagnostic challenges. Alpha-inhibin has been traditionally used as immunohistochemical marker (IHC) for SCST, but restrictions as lack of specificity and variability of cytoplasmic staining evolved.  Forkhead box L2 (FOXL2) is one of the earliest markers of ovarian differentiation and is essential for the normal development of granulosa cells and has been identified to be a sensitive and specific marker of Sex Cord-Stromal differentiation.

Aim: Assess FOXL2-IHC expression in different types of SCSTs and correlate its expression with histopathological features and Inhibin-IHC.

Methods: …

Computed Tomographic Assessment Of Morphological Parameters Of The Normal Vermiform Appendix In Adults: A Prospective Cross-Sectional Study, Asmaa Mohamed Mansour Mahmoud, Magdy El-Sayed Mohamed Steen, Ahmed Mohamed Tawfik

Mansoura Medical Journal

Background: The vermiform appendix is a hollow tubular structure arising from the cecum, typically located in the right lower quadrant of the abdomen. Aim: This study aimed to estimate the visualization rate of CT scan in the detection of normal appendix, along with its characteristics (length, diameter, and site). Methods: For this prospective cross-sectional investigation, 56 individuals were included who were scheduled to have abdominal CT. The helical scanner was used to acquire CT images with 5 millimeters of collimation and reconstruction for each 2.5 millimeters. The CT films were reviewed by an experienced radiologist, who was unaware of the …

Impact Of Preoperative Symptom Duration On Postoperative Outcomes Following Lumbar Spine Surgery, Ahmed Anas Zahra, Ayman Mohamed Basha

Mansoura Medical Journal

Background: The optimal timing for lumbar spine surgery (LSS) relative to symptom duration remains debatable. While surgical delays are common, their impact on postoperative outcomes is not fully elucidated. This study evaluated the relationship between preoperative symptom duration and postoperative outcomes following LSS.

Methods: A prospective observational study was conducted on 60 adults undergoing LSS (decompression and/or fusion) at a single university hospital. Participants were stratified into three groups based on symptom duration:Months, 3-12 months, and >12 months. The primary outcome was functional disability assessed by the Oswestry Disability Index (ODI). Secondary outcomes included pain intensity (Visual Analog Scale, VAS), …

Serum Vascular Endothelial Growth Factor Level And Its Correlation With Nail Fold Capillaroscopic Patterns In Patients With Systemic Sclerosis, Samah M. Barakat, Yousra Sadeq, Marwa Besar, Shereen S. Metwally

Mansoura Medical Journal

Objective: to assess the correlation between blood levels of vascular endothelial growth factor (VEGF) and microvascular changes identified by nail fold videocapillaroscopy (NVC) in individuals with systemic sclerosis. Methods: A videocapillaroscope was used to evaluate the microvascular alterations in nail folds in SSc patients. The ELIZA technique was used to measure serum vascular endothelial growth factor (VEGF). Results: Nailfold videocapillaroscopy reveals significant microvascular alterations in patients with systemic sclerosis when compared to controls. Patients' capillary breadth, length, and diameter have increased but their capillary numbers have dramatically decreased. 75% of patients have hemorrhages, although controls do not. Patients with systemic …

Serum High Sensitivity Cardiac Troponin I Level And Its Relation To Severity Of Psoriasis Vulgaris, Aya Hassan Mohammed El-Shamy, Samia Mohammed Abdel Naby, Mohammed Fawzy El Sayed, Amany Ragab Youssef Ahmed

Mansoura Medical Journal

Background: Psoriasis is a chronic inflammatory skin disease affecting 2.5% of the worldwide population. Troponin I levels are accompanied by cardiovascular disease (CVD) risk in psoriatic cases. So, this study was conducted to detect serum levels of high-sensitivity cardiac troponin I (HScTnI) in psoriasis vulgaris (PV) cases compared to healthy controls. Methods: This case-control study included 40 cases with PV and 40 healthy subjects as a control group. Disease severity evaluation was conducted by using the psoriasis area severity index (PASI) score to classify the cases into groups according to severity. Measurement of HScTnI levels was conducted. Results: Mean HsCTn …

Patellar Morphology In Primary Total Knee Arthroplasty Patients With Unexplained Pain, Mohammed Ahmed Abdelkhalek Abdelrazek, Adham Elsharkawey Elgeidi, Yasser Youssef Abdelrahman Abed, Kamel Mohamed Ahmed Ahmed Youssef

Mansoura Medical Journal

Background: An effective surgical procedure for treating end-stage osteoarthritis of the knee (OA) is total knee arthroplasty (TKA). Pain is the main reason why many patients are still unhappy with their results following TKA. Patients who did TKA may experience anterior knee pain (AKP) with or without patellar resurfacing. Research has indicated that the morphology of the patella or trochlear geometry affects the stress on the patellofemoral joint.

Objective: To determine whether clinical scores and pain after TKA without patellar resurfacing were correlated with patellar shape. Methods: This retrospective case control study included 70 cases. We retrospectively assessed patients with …

The Prognostic Value Of Arterial Spin Labeling Mri In Middle Cerebral Artery Ischemic Stroke Patients Receiving Thrombolytic Therapy, Ahmed Effat Saied, Nihal Mohamed El-Batouty, Mohamed Abdel Salam Ali, Merehan Reda Abo Alnaga

Mansoura Medical Journal

Background: Reestablishing blood circulation to the brain represents the primary proven treatment goal for acute ischaemic stroke (AIS). Recombinant tissue plasminogen activator (r-TPA) is a thrombolytic medication that enhances the rate of arterial blood flow restoration, reestablishes tissue perfusion, and leads to better functional recovery. This research aimed to examine changes in regional brain perfusion identified through arterial spin labeling (ASL) and how these changes correlate with functional recovery following ischemic stroke. Methods: This prospective observational research included 50 subjects with AIS in the middle cerebral artery (MCA) territory who were eligible for r-TPA treatment. Each patient underwent comprehensive neurological …

Assessment Of Serum Adropin In Erectile Dysfunction Patients And Its Correlation With Disease Severity, Ahmed M. Eltohami, Sh. Fouad, Khadiga M. El-Hamaky, Abdel Khabir A.

Mansoura Medical Journal

Background Erectile dysfunction (ED) may be considered an indicator of cardiovascular disease (CVD). Adropin is identified to be accompanied by insulin sensitivity, and lipid metabolism, so we aimed to investigate serum adropin levels in ED cases compared to healthy controls (HC). Methods This case control study included 50 men with ED and and control group of 25 agematched, sexually active healthy men with normal erectile function. Cases group was divided into two groups (25 each) as ED patients with and without type 2 Diabetes Mellitus (T2DM). Validated Arabic version of International Index of Erectile Function (IIEF)-5 was used to evaluate …

Outcome Of Conservative Management Of Placenta Accreta Spectrum In Mansoura University Hospital, Nasra Hassan Mohamed, Mohamed Mohamed Eltotongy, Maher Elesewi Kamel Elgaly

Mansoura Medical Journal

Background: Placenta accreta spectrum (PAS) represents a significant global health challenge, with its incidence rising in parallel with the increasing prevalence of cesarean sections (CS). While cesarean hysterectomy is traditionally considered the standard treatment, conservative management offers a fertility-preserving alternative in carefully selected cases. This study aimed to evaluate the safety and effectiveness of conservative treatment for PAS at Mansoura University Hospital over a two-year period.

Methods: This retrospective analytical study included 132 women diagnosed with placenta accreta who underwent conservative management. Patient data, including obstetric history, degree of accreta, bleeding episodes, timing of delivery, and the specific uterine-sparing technique …

The Role Of Vitamin D In Management Of Pediatric Chronic Immune Thrombocytopenia, Eman Magdy Yahia, Suzy Abd El Mabood Abd El Hameed, Dalia Tawfeek Hussein, Amany Mamdouh Shoumah

Mansoura Medical Journal

In children, immune thrombocytopenia (ITP) remains a serious health concern, which is an autoimmune disorder (AID) characterized by an isolated decrease in platelet count, leading to an increased risk of bleeding.

The use of vitamin D supplementation represents a turning point in many autoimmune diseases, with the potential to deliver high cure rates with fewer side effects than previous therapies. In this review, we explore the incidence of ITP , immunopathogenesis, diagnosis and management in pediatric patients. We will discuss the mechanisms of action of vitamin D , focusing on its role in autoimmune diseases especially ITP

Predictive Value Of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio And Ca-125 Dynamics After Neoadjuvant Chemotherapy For Surgical Outcomes And Prognosis In Ovarian Cancer, Asmaa S. Othman, Hend M. Serya, Manar H. Ahmed, Asmaa F. Elfayoumey

Mansoura Medical Journal

Background: The prognosis of patients with advanced-stage epithelial ovarian cancer (EOC) having debulking surgery is greatly influenced by optimal resection. Neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and CA-125 values are examples of inflammatory markers that have been identified as possible predictive markers.

Objective: This study evaluated neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and CA-125 dynamics as predictors of surgical outcomes and survival in advanced ovarian cancer patients receiving neoadjuvant chemotherapy (NACT).

Methods: We conducted a retrospective analysis of 171 patients treated at Mansoura University (2020-2025) with platinum-taxane neoadjuvant chemotherapy followed by interval debulking surgery (IDS). Pre- …