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Articles 59791 - 59820 of 256064
Full-Text Articles in Life Sciences
Insights Into Using Plants In Management Of Viral Diseases., Vyacheslav Dushenkov, Anna Dushenkov
Insights Into Using Plants In Management Of Viral Diseases., Vyacheslav Dushenkov, Anna Dushenkov
Publications and Research
Botanical therapeutics possess a unique potential in the treatment of viral diseases. The pharmacological base and clinical use of botanical therapeutics have been extensively reviewed. The mode of action(s) may be built either on the direct interference with the virus's ability to enter human cells, virus replication, or exerting immune-modulatory and anti-inflammatory effects. The adjuvant treatment with botanical therapeutics has the potential to result in advances in symptom resolution, decrease in disease burden and shortening its duration.
Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery In Response To Myocardial Infarction, Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Erhe Gao, Brooke M. Ahern, Bryana M. Levitan, Himi Tripathi, David Powell, Ahmed Noor, Garrett A. Elmore, Jonathan Satin, Ashley W. Seifert, Ahmed K. Abdel-Latif
Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery In Response To Myocardial Infarction, Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Erhe Gao, Brooke M. Ahern, Bryana M. Levitan, Himi Tripathi, David Powell, Ahmed Noor, Garrett A. Elmore, Jonathan Satin, Ashley W. Seifert, Ahmed K. Abdel-Latif
Physiology Faculty Publications
Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and response to cardiac injury. In this study, we first examined baseline Acomys cardiac anatomy and function in comparison with commonly used inbred and outbred laboratory Mus strains (C57BL6 and CFW). While our results demonstrated comparable cardiac anatomy and function between Acomys and Mus, Acomys exhibited a higher percentage of cardiomyocytes displaying …
The Evolutionary Origins Of Autism Associated Genes And Their Role In Great Ape Socio-Communicative Behavior, Azeeza Abdulrauf
The Evolutionary Origins Of Autism Associated Genes And Their Role In Great Ape Socio-Communicative Behavior, Azeeza Abdulrauf
Master of Science in Integrative Biology Theses
Autism Spectrum Disorder (ASD) is a set of neurological disorders characterized by reduced social interactions and deficits in verbal and nonverbal communication. Although there are no clear genetic markers for ASD, studies have found associations between gene single nucleotide polymorphisms (SNPs) and patients diagnosed with ASD. For this study, the focus is on OXTR, AVPR1A, and FOXP2. OXTR is reported to regulate empathy and stress reactivity while AVPR1A is reported to regulate stress management and territorial aggression, as well as social bonding and recognition. FOXP2 is one of the first genes to be associated with both speech and language recognition …
Making Agriculture Carbon Neutral Amid A Changing Climate: The Case Of South-Western Australia, Ross Kingwell
Making Agriculture Carbon Neutral Amid A Changing Climate: The Case Of South-Western Australia, Ross Kingwell
Climate Science Research Articles
Making Australian agriculture carbon neutral by 2050 is a goal espoused by several agricultural organisations in Australia. How costly might it be to attain that goal, especially when adverse climate change projections apply to agriculture in southern Australia? This study uses scenario analysis to examine agricultural emissions and their abatement via reforestation in south-western Australia under projected climate change. Most scenarios include the likelihood of agricultural emissions being reduced in the coming decades. However, the impact of projected adverse climate change on tree growth and tree survival means that the cost of achieving agricultural carbon neutrality via reforestation is forecast …
Tax Planning For High Income, Tina N. Barrett
Tax Planning For High Income, Tina N. Barrett
Cornhusker Economics
Agriculture has always been an industry with cyclical income trends. Prior to 2003, the average farm income reported in our annual data would typically go up and down each year -- having a good year and then a bad year and then a good year again. Since then, the trend has been more about longer periods of good, followed by multiple years of down income, etc. These longer stretches also see more extremes and this makes tax planning even more important and more difficult. More important because we are likely not making a decision that only affects one year and …
Ticks (Acari: Ixodidae) Parasitizing Migrating And Local Breeding Birds In Finland, Jani J. Sormunen, Tero Klemola, Eero J. Vesterinen
Ticks (Acari: Ixodidae) Parasitizing Migrating And Local Breeding Birds In Finland, Jani J. Sormunen, Tero Klemola, Eero J. Vesterinen
Harold W. Manter Laboratory of Parasitology: Library Materials
Ticks are globally renowned vectors for numerous zoonoses, and birds have been identified as important hosts for several species of hard ticks (Acari: Ixodidae) and tick-borne pathogens. Many European bird species overwinter in Africa and Western Asia, consequently migrating back to breeding grounds in Europe in the spring. During these spring migrations, birds may transport exotic tick species (and associated pathogens) to areas outside their typical distribution ranges. In Finland, very few studies have been conducted regarding ticks parasitizing migrating or local birds, and existing data are outdated, likely not reflecting the current situation. Consequently, in 2018, we asked volunteer …
Androctonus Turkiyensis Sp. N. From The Şanlıurfa Province, Turkey (Scorpiones: Buthidae), Ersen A. Yağmur
Androctonus Turkiyensis Sp. N. From The Şanlıurfa Province, Turkey (Scorpiones: Buthidae), Ersen A. Yağmur
Euscorpius
A new species Androctonus turkiyensis sp. n. is described and illustrated from the Şanlıurfa Province of Turkey. The new species is compared with A. crassicauda (Olivier, 1807), which was previously misidentified from Turkey. A. crassicauda specimens used for comparison were collected from Kashan County (Iran), the type locality of this species; a neotype from Kashan is designated.
Multi-Strata Silvipastoral Systems For Increasing Productivity And Conservation Of Natural Resources In Central America, Muhammad Ibrahim, Andrea Schlonvoigt, Juan Carlos Camargo, M. Souza
Multi-Strata Silvipastoral Systems For Increasing Productivity And Conservation Of Natural Resources In Central America, Muhammad Ibrahim, Andrea Schlonvoigt, Juan Carlos Camargo, M. Souza
IGC Proceedings (1977-2023)
Conversion of primary forest to pasture is widespread in Central and Latin America and the progressive removal of trees has resulted in environmental degradation and a decline in productivity, simultaneously threatening rural livelihoods and regional biodiversity. Recently there has been keen interest to develop silvipastoral systems for sustainable animal production. Traditional silvipastoral systems are characterised with a diversity of woody perennials that plays an important role in supplying feed to animals in the dry season, production of timber, shade for animals, and in the conservation of natural resources. Improved novel woody perennials such as Morus alba (mulberry) and Trichanthera gigantea …
Transgenesis And Genomics In Molecular Breeding Of Forage Plants, G. Spangenberg, R. Kalla, A. Lidgett, T. Sawbridge, E. K. Ong, U. John
Transgenesis And Genomics In Molecular Breeding Of Forage Plants, G. Spangenberg, R. Kalla, A. Lidgett, T. Sawbridge, E. K. Ong, U. John
IGC Proceedings (1977-2023)
Forage plant breeding has been largely based on phenotypic selection following sexual recombination of natural genetic variation found between and within ecotypes. Advances in plant genetic manipulation over the last 15 years have provided convincing evidence that these powerful technologies can complement and enhance plant breeding programs. Significant progress in the establishment of the methodologies required for the molecular breeding of forage plants has been made. Examples of current products and approaches for the application of these methodologies to forage grass and legume improvement are outlined. Large-scale genomic analysis of many organisms is under way with human, arabidopsis and rice …
Opportunities In Molecular Biology: Enhancement Of The Nutritional Value Of Forages, K. R. Hancock, M. J. Ulyatt
Opportunities In Molecular Biology: Enhancement Of The Nutritional Value Of Forages, K. R. Hancock, M. J. Ulyatt
IGC Proceedings (1977-2023)
Pasture plants, while producing a cost-effective source of feed for grazing ruminants, can frequently be less than optimal in meeting the animals’ nutrient requirements. Over the past half century, there has been a major effort to improve the quantity and nutritional quality of pasture plants using conventional plant breeding. Although considerable progress has been made in improving the quality and agronomic characteristics of our major pasture plants by this means, breeding can only be applied to plants capable of sexual crosses. This poses severe limitations both in terms of speed of progress and in the number of genes available for …
The Role Of Endophytic Fungi In Brachiaria, A Tropical Forage Grass, S. Kelemu, J. F. White, Idupulapati M. Rao
The Role Of Endophytic Fungi In Brachiaria, A Tropical Forage Grass, S. Kelemu, J. F. White, Idupulapati M. Rao
IGC Proceedings (1977-2023)
In temperate zones, endophytic fungi are widely used as biological protection agents for forage and turf grasses. They form nonpathogenic and intercellular associations with grasses and sedges, completing their entire life cycle within the plants’ aerial parts. Our surveys and studies confirmed that various endophytic fungi, including Acremonium spp., also inhabit native savanna grasses and introduced tropical forage grasses. We are now determining the potentially symbiotic relationships between these fungi and C4 tropical forages, specifically between the endophyte A. implicatum and Brachiaria grasses. We treated half of a group of genetically identical clones of Brachiaria with fungicide to generate …
Advances In Endophyte Research. Progress And Priorities In Temperate Areas, L. R. Fletcher, H. S. Easton
Advances In Endophyte Research. Progress And Priorities In Temperate Areas, L. R. Fletcher, H. S. Easton
IGC Proceedings (1977-2023)
Fungal endophytes infect a large number of temperate grass species, genera and tribes (Leuchtmann and Clay, 1997). The majority of these systemic endophytes fall into the genus Epichloe or the closely related Neotyphodium genus.
The asexual Neotyphodium endophytes are asymptomatic, never emerge from between the host grass cells, and are only transmitted vertically, via seed of the host plant. They are believed to have derived from the Epichloe endophytes, (Bacon and White, 2000; Schardl and Wilkinson, 2000) which do emerge from their intercellular habitat and form stromata around the emerging seedhead of their host. This is manifested as the choke …
Does Bambi Need Privacy? The Impact Of Human Recreational Trail Traffic On Abundance And Daily Activity Of The White-Tailed Deer (Odocoileus Virginianus), Diana Alvarez
Journal of Interdisciplinary Undergraduate Research
Humans have a significant impact on wildlife populations. Although not as obvious, even non-consumptive recreational activities (i.e. hiking and mountain biking) can impact wildlife. Previous research has suggested that human traffic can impact the movement patterns of the white-tailed deer (Odocoileus virginianus). Specifically, as human traffic increases, deer sightings decrease. Also, due to their crepuscular nature, deer peak activity is at dawn and dusk, yet one study reported a decrease in deer sightings in the evening that seemed to correspond to a peak in human traffic. However, the cause-and-effect relationship between human traffic and deer daily movements has …
Perceptual Fatigability And Neuromuscular Responses During A Sustained, Isometric Forearm Flexion Muscle Action Anchored To A Constant Level Of Perceived Exertion, Robert W. Smith, John Paul V. Anders, Tyler J. Neltner, Jocelyn E. Arnett, Joshua L. Keller, Terry J. Housh, Richard J. Schmidt, Glen O. Johnson
Perceptual Fatigability And Neuromuscular Responses During A Sustained, Isometric Forearm Flexion Muscle Action Anchored To A Constant Level Of Perceived Exertion, Robert W. Smith, John Paul V. Anders, Tyler J. Neltner, Jocelyn E. Arnett, Joshua L. Keller, Terry J. Housh, Richard J. Schmidt, Glen O. Johnson
Journal for Sports Neuroscience
Objective: The purpose of the present study was to examine the fatigue-induced changes in torque, and the electromyographic (EMG) and mechanomyographic (MMG) responses during a sustained submaximal, isometric forearm flexion muscle action anchored to a constant rating of perceived exertion (RPE). Methods: Eleven women (mean ± SD: age = 20.5 ± 1.9 yrs.; height = 169.9 ± 6.6 cm; body mass = 73.2 ± 15.9 kg) performed 2, 3s forearm flexion maximal voluntary isometric contractions (MVIC) before a sustained isometric muscle action anchored to RPE = 7 until task failure (defined as torque that would require RPE > 7, or the …
Gαi/O-Coupled Htr2c In The Paraventricular Nucleus Of The Hypothalamus Antagonizes The Anorectic Effect Of Serotonin Agents, Eun-Seon Yoo, Li Li, Lin Jia, Caleb C Lord, Charlotte E Lee, Shari G Birnbaum, Claudia R Vianna, Eric D Berglund, Kathryn A Cunningham, Yong Xu, Jong-Woo Sohn, Chen Liu
Gαi/O-Coupled Htr2c In The Paraventricular Nucleus Of The Hypothalamus Antagonizes The Anorectic Effect Of Serotonin Agents, Eun-Seon Yoo, Li Li, Lin Jia, Caleb C Lord, Charlotte E Lee, Shari G Birnbaum, Claudia R Vianna, Eric D Berglund, Kathryn A Cunningham, Yong Xu, Jong-Woo Sohn, Chen Liu
Children’s Nutrition Research Center Staff Publications
The anorexigenic effect of serotonergic compounds has largely been attributed to activation of serotonin 2C receptors (Htr2cs). Using mouse genetic models in which Htr2c can be selectively deleted or restored (in Htr2c-null mice), we investigate the role of Htr2c in forebrain Sim1 neurons. Unexpectedly, we find that Htr2c acts in these neurons to promote food intake and counteract the anorectic effect of serotonergic appetite suppressants. Furthermore, Htr2c marks a subset of Sim1 neurons in the paraventricular nucleus of the hypothalamus (PVH). Chemogenetic activation of these neurons in adult mice suppresses hunger, whereas their silencing promotes feeding. In …
Chemical And Biological Characterization Of The Anticancer Potency Of Salvia Fruticosa In A Model Of Human Malignant Melanoma, Sotiris Kyriakou, Venetia Tragkola, Michael Plioukas, Ioannis Anestopoulos, Paschalina S. Chatzopoulou, Eirini Sarrou, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi
Chemical And Biological Characterization Of The Anticancer Potency Of Salvia Fruticosa In A Model Of Human Malignant Melanoma, Sotiris Kyriakou, Venetia Tragkola, Michael Plioukas, Ioannis Anestopoulos, Paschalina S. Chatzopoulou, Eirini Sarrou, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi
School of Veterinary and Biomedical Sciences: Faculty Publications
Malignant melanoma is one of the most aggressive types of skin cancer with an increasing incidence worldwide. Thus, the development of innovative therapeutic approaches is of great importance. Salvia fruticosa (SF) is known for its anticancer properties and in this context, we aimed to investigate its potential anti-melanoma activity in an in vitro model of human malignant melanoma. Cytotoxicity was assessed through a colorimetric-based sulforhodamine-B (SRB) assay in primary malignant melanoma (A375), non-malignant melanoma epidermoid carcinoma (A431) and non-tumorigenic melanocyte neighbouring keratinocyte (HaCaT) cells. Among eight (8) different fractions of S. fruticosa extracts (SF1-SF8) tested, SF3 was found to possess …
Smokejumper Obituary: Steck, William David “Bill” (Pilot 0000), National Smokejumper Association
Smokejumper Obituary: Steck, William David “Bill” (Pilot 0000), National Smokejumper Association
Smokejumper Obituaries
No abstract provided.
Managing Vegetation Around Fruit Trees, Teryl Roper
Managing Vegetation Around Fruit Trees, Teryl Roper
All Current Publications
Fruit trees thrive along the Wasatch Front and in many other locations in Utah. Backyard fruit trees are very common in Utah, and producers quickly become attuned to insect and disease pests that can swiftly spoil substantial amounts of fruit. They are typically less aware of the detrimental effect of competing vegetation around fruit trees. This fact sheet describes the nature of vegetation competition and proposes management strategies to reduce or eliminate competition.
The First Troglobitic Scorpions From Hispaniola, Greater Antilles: Two New Species Of Cazierius Francke, 1978 (Scorpiones: Diplocentridae), Rolando Teruel, Solanlly Carrero Jiménez, Gabriel De Los Santos
The First Troglobitic Scorpions From Hispaniola, Greater Antilles: Two New Species Of Cazierius Francke, 1978 (Scorpiones: Diplocentridae), Rolando Teruel, Solanlly Carrero Jiménez, Gabriel De Los Santos
Euscorpius
Two new species of the Greater Antillean endemic scorpion genus Cazierius Francke, 1978, are herein described from the island of Hispaniola. They were found inside isolate limestone caves in the Dominican Republic and are fully troglomorphic, thus, apparently being strict troglobites that represent the first ever documented for this genus. The present additions raise the number of Hispaniolan species of both Cazierius and the family Diplocentridae Karsch, 1880, to five and ten, respectively.
Advances In Rhizobial Research – Progress Priorities In Temperate Areas, Angela Sessitsch
Advances In Rhizobial Research – Progress Priorities In Temperate Areas, Angela Sessitsch
IGC Proceedings (1977-2023)
Rhizobia are well known for their capacity to establish a symbiosis with legumes. During this symbiosis the bacteria inhabit root nodules where they reduce atmospheric nitrogen and make it available to the plant. Biological nitrogen fixation (BNF) is an important source of nitrogen and the various legume crops and pasture species often fix as much as 200-300 kg nitrogen per hectare (Peoples et al., 1995). Globally, symbiotic nitrogen fixation has been estimated to amount to at least 70 million metric tons of nitrogen per year (Brockwell et al., 1995). Furthermore, in many cases nitrogen fertilizers are not efficiently used by …
The Legume – Rhizobia Symbiosis. Does It Vary For The Tropics Relative To The Mediterranean Basin?, J. G. Howieson, A. Mcinnes
The Legume – Rhizobia Symbiosis. Does It Vary For The Tropics Relative To The Mediterranean Basin?, J. G. Howieson, A. Mcinnes
IGC Proceedings (1977-2023)
Symbiotic N fixation from legumes is one of the most important biological processes on the planet. It currently provides the majority of the N requirement in agriculture, yet will have to double if cereal crop production is to meet world demand by 2020 (Kennedy and Cocking 1997). To effectively harness the value of biological N fixation from legumes we need to more fully understand G2 x E; where G refers to the genotypes of both the legume (Gl) and its microsymbiont (rhizobia; Gr), and E refers to the edaphic environment in which the symbiosis is …
Advances In Forage Legumes: Shrub Legumes, M. H. Shelton
Advances In Forage Legumes: Shrub Legumes, M. H. Shelton
IGC Proceedings (1977-2023)
Forage tree legumes benefit agriculture through their multi-purpose contributions to livestock feeding, to productivity of farming systems, and to protection of the environment.
Of the several hundred forage tree legume species regarded as having potential for forage only c. twenty are in common use. These are listed together with their agroecological range and tolerance of adverse environments including acid soils, cool temperatures, low rainfall, poor drainage and high salinity. The value of many species to ruminants is limited due to low nutritive value arising from low protein availability and low acceptability caused principally by high condensed tannin content. Only 10 …
Alfalfa, J. H. Bouton
Alfalfa, J. H. Bouton
IGC Proceedings (1977-2023)
Cultivated alfalfa or lucerne (Medicago sativa spp. sativa) is the most important forage legume in the world with approximately 32 million hectares cultivated mainly in the temperate regions of both the northern and southern hemispheres. Intensive research has been conducted on the management and physiology of the crop and a major seed industry has developed world wide. Since insect and disease pests are numerous in alfalfa, development of cultivars with the proper fall dormancy and a broad genetic base for pest resistance has been pursued in order to provide increased adaptation, persistence, and yield. There has been a …
Carbon And Nitrogen Isotopic Discrimination In Alfalfa For High Yield And Quality Forage, W. S. Oliveira, P. P. A. Oliveira, M. Corsi, S. M. Tsai
Carbon And Nitrogen Isotopic Discrimination In Alfalfa For High Yield And Quality Forage, W. S. Oliveira, P. P. A. Oliveira, M. Corsi, S. M. Tsai
IGC Proceedings (1977-2023)
Biological nitrogen fixation and assimilation of CO2 can be indirectly monitored in alfalfa (Medicago sativa L.) through the variation of the stable N and C isotopes in the plant (Δ values). Such measurements result in a simple, non-destructive and reliable method for identification of alfalfa cultivars of high yield and nutritional quality. A program for selection of 12 alfalfa cultivars under field and controlled conditions (lysimeters) included determination of biomass and N accumulation. Under controlled conditions yields ranged from 1.77 to 2.47 ton/ha/month (Pioneer 5312 and WL-605) and N2-fixed varied from 77.43 to 84.01% for total N (Brazilian …
Evaluating Consumers’ Perception Of Gluten-Free/Clean-Label Muffins, Vanesa Chicaiza
Evaluating Consumers’ Perception Of Gluten-Free/Clean-Label Muffins, Vanesa Chicaiza
LSU Master's Theses
The gluten-free-natural-ingredient (GF/NCL) product demand is globally increasing and driven by the growing prevalence of celiac-diseases. Nevertheless, the quality of GF product is often inferior compared to wheat-flour counterparts due to the removing of gluten, which, compromises the appearance, structure, and nutritional value. The addition of fiber into GF/NCL products has been considered to improve nutritional values while maintaining quality attributes. According to the US-FDA, a product containing ≥2.5 grams of fiber/serving can be claimed as a “good-source-of-fiber.” However, adding dietary fiber to baked products affects their qualities, and hence possibly lowering product acceptability.
The main objective of this research …
Effects Of Freshwater Input On Nutrient Loading, Toxic Cyanobacteria Bloom Development And Cyanotoxin Production In Lake Pontchartrain Estuary, Louisiana, Callie L. Snow
LSU Master's Theses
Estuaries in the northern Gulf of Mexico (GoM) are undergoing profound alterations due to changes in climate and implementation of coastal restoration activities and these may lead to the increasing frequency of harmful algal blooms (HABs). The introduction of large volumes of nutrient-rich, fresh Mississippi River water into nutrient-poor Lake Pontchartrain Estuary is known to substantially change the chemistry and ecology of the estuary, and warm temperatures paired with the persistent nutrient loading into the estuary supports the proliferation of potentially toxic cyanobacteria blooms (CyanoHABs). Throughout 2019, a long-term opening of the Bonnet Carré Spillway (BCS), initially from February to …
Hemp Microgreen Mineral Content, Cannabinoids, Total Phenolics, And Antioxidants, Cheston T. Schayot
Hemp Microgreen Mineral Content, Cannabinoids, Total Phenolics, And Antioxidants, Cheston T. Schayot
LSU Master's Theses
Hemp (Cannabis sativa) L. microgreens were grown to 7 and 12 days with and without supplemental lighting and/or fertilizer. The principal macronutrient found in hemp microgreens was nitrogen (N), followed by potassium (K), phosphorus (P), magnesium (Mg), calcium (Ca), and sulfur (S). The principal micronutrient found in hemp microgreens was iron (Fe), followed by manganese (Mn), zinc (Zn), boron (B), and copper (Cu). Hemp microgreens were similar to other commonly grown microgreen species in minerals except for P and Mg, where they could potentially be an excellent source, and Zn, where they fell below previously reported amounts. The …
Response Of Roseau Cane (Phragmites Australis) To Two Biotic Stresses: Hyalopterus Pruni And Bipolaris Yamadae, Heather E. Cizek
Response Of Roseau Cane (Phragmites Australis) To Two Biotic Stresses: Hyalopterus Pruni And Bipolaris Yamadae, Heather E. Cizek
LSU Master's Theses
Roseau cane (Phragmites australis) is considered an invasive plant because of its ability to replace native plant species. However, in Louisiana it plays an important role protecting coastal infrastructure and being part of the marsh ecosystem in the lower Mississippi River Delta. In recent years, Roseau cane has been affected by a die-off, a problem that has also been reported in some European countries. Possible biotic and abiotic factors that have been associated with the die-off include scale insects, climate change, pollution, salinity levels, and pathogens.
In this research, the individual and combined effect of a foliar disease …
3-Dimensional Structural Determination Of Epidermal Growth Factor-Like Repeat 27 From Mouse Notch1 Using Nuclear Magnetic Resonance Spectroscopy, Justin Grennell
3-Dimensional Structural Determination Of Epidermal Growth Factor-Like Repeat 27 From Mouse Notch1 Using Nuclear Magnetic Resonance Spectroscopy, Justin Grennell
LSU Doctoral Dissertations
NOTCH1 has been associated with a variety of human ailments, such as cancer and heart disease. NOTCH1 is a transmembrane protein that contains 36 epidermal growth factor-like (EGF) repeats, which facilitate cell signaling by binding proteins on neighboring cells. Each repeat contains about 40 amino acids and has to be folded in a specific manner to function properly. The amino acid sequence, carbohydrate pattern, and calcium-binding sites of EGF-like repeats vary, but the pattern along the 36-repeat chain is conserved. The Abruptex region (EGF24-29) of NOTCH1 is a highly glycosylated (having undergone sugar addition) and flexible region, which gained its …
Relating Multivariate Shapes To Genescapes Using Phenotype-Biological Process Associations For Craniofacial Shape., Jose D Aponte, David C Katz, Daniela M Roth, Marta Vidal-García, Wei Liu, Fernando Andrade, Charles C Roseman, Stephen A Murray, James Cheverud, Daniel Graf, Ralph S Marcucio, Benedikt Hallgrímsson
Relating Multivariate Shapes To Genescapes Using Phenotype-Biological Process Associations For Craniofacial Shape., Jose D Aponte, David C Katz, Daniela M Roth, Marta Vidal-García, Wei Liu, Fernando Andrade, Charles C Roseman, Stephen A Murray, James Cheverud, Daniel Graf, Ralph S Marcucio, Benedikt Hallgrímsson
Faculty Research 2021
Realistic mappings of genes to morphology are inherently multivariate on both sides of the equation. The importance of coordinated gene effects on morphological phenotypes is clear from the intertwining of gene actions in signaling pathways, gene regulatory networks, and developmental processes underlying the development of shape and size. Yet, current approaches tend to focus on identifying and localizing the effects of individual genes and rarely leverage the information content of high-dimensional phenotypes. Here, we explicitly model the joint effects of biologically coherent collections of genes on a multivariate trait - craniofacial shape - in a sample of n = 1145 …