Life Sciences Commons^™

In Vitro Investigation Of Tumor Selective Piperidones As Therapeutic Agents Against Leukemia Cancer Cells, Lisett Contreras

Open Access Theses & Dissertations

Cancer is a continuous global health issue. It is the second leading cause of death behind heart disease. Disparities across the emergence of cancer and resulting fatalities raise the importance of researching the disease. Treatments are available for certain types of cancers. However, these are typically accompanied by residual problems including side effects and the possibility for relapse. Some treatments attack all cells, leading to unwarranted side effects that make the possibility of living a comfortable life nearly impossible. Other treatments are specific to certain genetic alterations, making them only useful for a small percentage of patients. Not one treatment …

Comprehensive Study Of Human Pathogenic Trypanosomatids: From Chemotherapies To Disease Ecology, Felipe Rodriguez

Open Access Theses & Dissertations

The vector-borne diseases Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp. and Trypanosoma cruzi respectively, are among the most important parasitic diseases in the group of neglected tropical diseases. Even though the two diseases are endemic to the Americas, they affect millions of people worldwide. Leishmaniasis and Chagas disease cause a great array of symptoms and some of them can be fatal if left undiagnosed and untreated. Current treatment regimens are becoming less effective, vaccines are still not available, and diagnosis needs to be improved. Vector control has been responsible for a decrease of diseases in endemic …

Utilizing Computational Approaches To Study Tubulin- Tubulin Electrostatic Interactions, Tolulope Ayodeji Ale

Open Access Theses & Dissertations

Microtubules play significant roles in transporting cargos within the cell, as well as the cell cycle. They are essentially the highway for the transportation of cell organelles. Understanding the interactions among microtubule components is crucial for the treatment of neurodegenerative diseases and cancer. In this study, we utilize a series of computational approaches to study the electrostatic interactions at the binding interfaces of interacting tubulin monomers. Our study revealed that the electrostatic attractive interactions in the αβ tubulin dimer is the strongest while the interaction between two αβ tubulin dimers in the longitude direction is the weakest. The result identified …

Examination Of The Association Between C - Reactive Protein(Crp) And Covid-19 Infection Severity And Length Of Hospitalization, Abdulahi Aremu Ayanwale

Open Access Theses & Dissertations

Chronic stress can lead to many systemic complications and low-grade systemic inflammation including increased levels of inflammatory cytokines, such as C-reactive protein (CRP). CRP is a marker of systemic inflammation and is associated with depression and perceived stress. Elevations can result in ineffective immune responses, thereby increasing the risk of complications and mortality from infections. Recent evidence suggests that uncontrolled inflammatory responses associated with COVID 19 are a major determinant of disease severity.  The COVID 19 is transmitted from one person to another through droplets from coughing, sneezing, talking, touching droplets on surfaces and contamination by hand-to-mouth routes. The mechanism …

An Investigation Of Upper Extremity Motor Impairments In Children Diagnosed With Autism Spectrum Disorder: Motor Planning Vs Motor Execution, Patrick Anthony Cereceres

Open Access Theses & Dissertations

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder typically diagnosedwhen a child displays social and communication impairments, repetitive behaviors, and rhythmic movements like hand flapping. This disorder is unique because of the high variability of symptoms displayed between each individual who is diagnosed. Because of this, no neurological or physiological test exists to diagnose a child with ASD. Current diagnostic tests are various forms of interviews or observations which an experienced clinician must administer. While these tests have been instrumental in diagnosing children with ASD, many go undiagnosed, which can be detrimental as they transition into adulthood. Current literature indicates …

Pets And Problems: Exploring Community Patterns In Calls For Animal Services, Paige Dejarnett

Sociology and Criminology Undergraduate Honors Theses

Pets have historically been viewed as family members, children, property, or economic resources. However, research surrounding animal maltreatment has expressed this issue as an individually-based problem, rather than a community-based phenomenon. Correlations have been found between animal cruelty, antisocial behaviors, and future interpersonal violence, whether this correlation be a predictive relationship, or a resultant relationship. Past research has also found correlations between animal treatment practices and the rural/urban differences of this behavior. However, there are many community-based indicators that have not been explored to understand the distribution of animal maltreatment. This study aims to explore these ideas by analyzing the …

Linking Plot And Landscape Level Phenology, Alejandra Flores

Open Access Theses & Dissertations

Plant phenology has become popularize since the 1990s to help understand the effects of climate change on vegetation, it is a way to study the patterns of leaf-out, flowering, and senescing of the life-cycle of the plant. The timing from start of season (SOS) to end-of-season (EOS) of plant leaf-out development has important implication on ecosystem productivity and carbon cycling across ecological scales from individual trees to whole regions. The need for plant phenology studies in dryland are highly anticipated, since they make up 40% of the terrestrial landscape and recently have shown the play an important role in the …

Molecular Mechanism Of Dna Bisintercalator Antibiotic Resistance, Priyanka Rajendra Gade

Open Access Theses & Dissertations

Class II UvrA is an ATP-binding cassette protein and a homolog of class I UvrA, the DNA lesion detection component of the universal prokaryotic nucleotide excision repair system. We show that Ecm16, a class II UvrA protein from Streptomyces lasalocidi, specifically recognizes DNA duplex that contains the DNA bisintercalator antibiotic echinomycin. Heterologous expression of Ecm16 in Escherichia coli renders host cells resistant to echinomycin. Interestingly, Ecm16’s antibiotic resistance activity does not require the DNA repair proteins UvrA/B/C/D, indicating that it operates independently of the cell’s nucleotide excision repair pathway. Unlike UvrA, Ecm16 uses the insertion domain to regulate its ATPase …

Natural Regeneration Dynamics And Survival Influenced By Abiotic And Biotic Factors In A Bottomland Hardwood Forest, Lydia J. Voth Rurup

Electronic Theses and Dissertations

Riparian ecosystems are vital to the landscape, providing critical services including water filtration and purification, flood and erosion control, carbon sequestration, biodiversity support, and aesthetic value. Bottomland hardwood forests, however, are threatened by invasive species, land loss/conversion, inconsistent or absence of harvesting disturbances, and altered hydrological patterns, leading to reduced success of desired, native species. This research assessed regeneration dynamics and one-year survival in a seasonally-flooded bottomland hardwood forest at Boggy Slough Conservation Area in East Texas to identify abiotic and biotic factors important for successful establishment of native regeneration. Areas sampled included two that were previously treated with herbicide …

Effects Of Varying Warmup Stimuli On Running Economy, Connor Bigenho

Electronic Theses and Dissertations

Purpose: The purpose of this study was to determine the effects of two potentiating warm-up stimuli (weighted-vest strides and plyometrics) on running economy (RE) over short (5-10 minutes) and longer durations (30+ minutes) of exercise in trained distance runners. Methods: Five recreationally trained male runners were recruited to participate in this study. Each trial consisted of a 10-min self-paced warm-up on the treadmill followed by baseline RE test and baseline leg-stiffness. This was immediately followed by one of two intervention warmup protocols. The protocols consisted of either a series of plyometric movements, 6 x 10-sec strides with a …

Assessing Freezing Effect On Kiwifruit Cultivars And Mapping Suitable Areas For Growing The Crop In Eastern Texas, Lais De Oliveira Machado

Electronic Theses and Dissertations

Kiwifruit is a perennial vine originating from China where it has been grown for centuries. In the United States, green kiwifruit (Actinidia deliciosa) is primarily produced commercially in California. They are fuzzy, green fleshed and well known in the marketplace. Kiwifruit plants require low to moderate soil pH, adequate winter chilling and adequate precipitation to guarantee plant development and good fructification. Actinidia chinesis or golden kiwifruit are smooth skinned, feature golden flesh and are a more recent introduction into the global market. Kiwifruit crops have attributes that favor production in east Texas, including low pest problems, current long …

Role Of Sex Differences On Cancer Cachexia Progression And Fibrosis During Cancer Cachexia Development, Wesley Haynie

Graduate Theses and Dissertations

Cancer cachexia is a multifactorial wasting syndrome characterized by losses in bodymass >5% and occurs in approximately 80% of all cancer patients. Chronic inflammation and fibrosis play roles in cancer cachexia and a greater understanding of these contributing pathways to this pathology will pave the way for potential therapeutic avenues. While inflammation and fibrosis have been researched in various models of cancer cachexia, little to no studies have been performed in both sexes as most previous studies focus on males. PURPOSE The purpose of these studies is to investigate the role of fibrosis on cancer cachexia development as well as …

Development And Evaluation Of Models For Hatchery-Mediated Infection Of Neonatal Broiler Chicks, Brittany Danielle Graham

Graduate Theses and Dissertations

Formaldehyde fumigation has been used to control the microbial load in commercial hatch cabinets. The hatch cabinet environment promotes replication and dissemination of both apathogenic and pathogenic microorganisms. As the microbial load increases during the hatching phase, formaldehyde eliminates airborne microorganisms circulating in the hatch cabinet environment. Due to the hazardous properties of formaldehyde, non-toxic alternatives to formaldehyde fumigation to control the microbial bloom in hatch cabinets are needed. The objectives of the present dissertation were to develop challenge models using singular or multiple microorganisms associated with the microbial bloom to simulate contamination that occurs in commercial hatch cabinets. Initially, …

Law Library Blog (December 2021): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

Greenhouse Gas Emissions From Two Contrasting Beef Systems From Birth To Slaughter In Eastern Nebraska, Levi J. Mcphillips

Department of Animal Science: Dissertations, Theses, and Student Research

Over the last 15 years, the increase in land use for corn and soybean has come at the expense of acres of grasslands and perennial forages employed in conventional beef-production systems. Implementing alternative cow-calf production systems into existing cropping systems may be a solution for reduced land availability and reducing total greenhouse gas emissions (GHG). Therefore, GHG from a conventional (CONV) pasture-based cattle production system with cows wintered on corn residue and summer grazing of brome pasture were compared to partial-confinement system (ALT) with cows and calves in a drylot during the summer and grazing cover crops and corn residue …

Small Grain Cereal Cover Crops For Late Fall Or Early Spring Grazing, Kallie J. Calus

Department of Animal Science: Dissertations, Theses, and Student Research

Beef cattle operations are confronted with early spring and late fall forage deficiencies. Producers in integrated crop and livestock systems can fill forage gaps using cover crops as a forage source in between cash crops.

A five-year study evaluating forage production, growing calf performance and economics of grazing an oats cover crop planted after corn silage (CS) and high moisture corn (HMC) corn harvests was conducted. The economic analysis accounted for costs of establishing and grazing the oats and the value of calf gain to determine fall grazing system profitability. Steers had greater average daily gain grazing oats after CS …

Management Of Late Summer Planted Annual Forages For Grazing And The Impacts Of Novel Sweet Bran Plus Products On Performance And Carcass Characteristics Of Beef Finishing Steers, Devin Anthony Jakub

Department of Animal Science: Dissertations, Theses, and Student Research

Two separate grazing studies were conducted to evaluate: 1) the effects of rapeseed inclusion into late summer planted oats on the performance of growing steers during late fall and winter (Exp. 1) and 2) the effects of forage allocation on forage utilization and performance of steers grazing a late summer planted oat-rapeseed mix (Exp. 2). Variation in the corn wet milling process can result in negative effects on animal performance, nonetheless, there remains interest in further exploration and refinement of corn wet milling byproducts to achieve optimal byproduct compositions and cattle performance. Thus, another experiment was conducted to evaluate the …

Impact Of Wood-Sourced Biochar On Carbon And Nitrogen Capture In Beef Feedlot Systems, Jessica L. Sperber

Department of Animal Science: Dissertations, Theses, and Student Research

A feedlot growing and finishing experiment evaluated the effect of including pine-sourced biochar at 0.8 (growing) and 1.0% (finishing) of dietary DM on steer performance, carcass characteristics, and greenhouse gas (GHG) production (Exp 1). Two nutrient mass balance experiments were conducted during winter and summer seasons to evaluate the effect of spreading unprocessed red cedar biochar on the feedlot pen surface on manure nutrient capture and cattle performance (Exp 2). In Exp. 1, the inclusion of biochar in the growing diet did not impact steer performance. The inclusion of biochar in the finishing diet significantly reduced intake and gain, resulting …

Utilizing Online Resources To Enhance Distribution Of Competitive Animal Evaluation Knowledge And Benefits, Brooke L. Parrish

Department of Animal Science: Dissertations, Theses, and Student Research

In recent years, the shift toward online education has revealed new challenges for learners to retain information, and for educators to find new and engaging ways to present content. This mixed methods, action research study explores the need and creation of online resources for competitive horse judging through surveys and pilot groups. The study was broken into four cycles. The first was an adult learner analysis survey, distributed through email Listservs and extension social media pages, to aid in answering the research questions: what expert horse judging instructors indicate their students should be learning, and what resources they need. Based …

Evaluation Of Cattle Management For Systems With Limited Perennial Pasture, Morgan Grabau

Department of Animal Science: Dissertations, Theses, and Student Research

Due to the conversion of perennial pasture and hay land to cropland in the western corn belt region, alternative methods of cow/calf management are being used to decrease reliance on perennial forages. These include grazing corn residue and feeding cow/calf pairs in confinement. Previous research has shown that limit-feeding a diet of low-quality forage and energy-dense co-products to cows in confinement is cost-effective. However, this strategy may limit the intake of the young calf and thus their performance. A study was conducted to evaluate the impacts of two alternative calf management strategies when pairs are in confinement, early weaning or …

Feeding A New Corn Milling Coproduct To Lactating Dairy Cattle: Examination Of Whole Animal Energy And Nitrogen Balance, Addison Lee Carroll

Department of Animal Science: Dissertations, Theses, and Student Research

New coproducts are continually developed in the ethanol production industry. With that, the new product originates from the dry milling process which is unlike the traditional process as nitrogenous based particles are concentrated from the residual fiber by sieving post fermentation. Although high protein coproducts have been available since the mid 2000’s. These new products must be evaluated for chemical composition so that they can be accurately described in feed libraries that are used in commercial ration formulation software. While chemical composition provides us an initial and useful description of a feed product, in vivo nitrogen and energy balance studies …

Host Genetics And Phenotype Associations Within The Bovine Rumen Microbiome, Waseem Abbas

Department of Animal Science: Dissertations, Theses, and Student Research

Rumen microbes have a symbiotic relationship with the host where the host provides a suitable environment and microbial fermentation fulfill nearly 70% of the energy needs of the host. Rumen microbes play a central role in host performance and health. To date, most rumen microbiome studies have focused on the influence of diet on microbial species composition. In addition to dietary factors, studies have suggested that host genetic markers could influence the colonization of gastrointestinal microbiota. However, our understanding of the host-microbiome interaction and how host phenotype is influenced by the rumen microbiome is limited. This dissertation demonstrates: (1) host …

Investigation Of Toxic Chemicals In Plant-Based Milk Alternatives, Chukwunonso A. Anakwue

Dissertations (2016-Present)

Milk is a dietary component consumed all over the world and is known to be essential for development in children. Despite all the nutritional advantages associated with milk consumption, several issues like lactose intolerance, and high lipid content, etc., negatively affects the perception of cow milk consumption, and has grown into general health concerns. Issues with cow milk consumption drove for a healthier alternative and this led to plant-based milk alternatives (PBMA). Several studies have linked consumption of these PBMAs with other negative effects such as: allergy, poor nutrient profile and the presence of other foreign chemicals. This study’s main …

Arkansas Corn And Grain Sorghum Performance Tests 2021, J. F. Carlin, R. B. Morgan, R. D. Bond

Arkansas Agricultural Experiment Station Research Series

Corn and grain sorghum performance tests are conducted each year in Arkansas by the University of Arkansas System Division of Agriculture. The tests provide information to companies marketing seed within the state and aid the Arkansas Cooperative Extension Service in formulating recommendations for producers. The 2021 corn performance tests contained 70 hybrids and were conducted at the Northeast Research and Extension Center (NEREC) at Keiser, the Lon Mann Cotton Research Station (LMCRS) near Marianna, the Bell Farming Company (BFC) near Des Arc, the Rohwer Research Station (RRS) near Rohwer, and the Rice Research and Extension Center (RREC) near Stuttgart. The …

The Pest Kill Rate Of Thirteen Natural Enemies As Aggregate Evaluation Criterion Of Their Biological Control Potential Of Tuta Absoluta, Joop C. Van Lenteren, Alberto Lanzoni, Lia Hemerik, Vanda H.P. Bueno, Johanna G. Bajonero Cuervo, Antonio Biondi, Giovanni Burgio, Francisco J. Calvo, Peter W. De Jong, Silvia N. López, M. Gabriela Luna, Flavio C. Montes, Eliana L. Nieves, Pascal Osa Aigbedion-Atalor, Maria B. Riquelme Virgala, Norma E. Sánchez, Alberto Urbaneja

All Peer-Reviewed Publications

Ecologists study how populations are regulated, while scientists studying biological pest control apply population regulation processes to reduce numbers of harmful organisms: an organism (a natural enemy) is used to reduce the population density of another organism (a pest). Finding an effective biological control agent among the tens to hundreds of natural enemies of a pest is a daunting task. Evaluation criteria help in a first selection to remove clearly ineffective or risky species from the list of candidates. Next, we propose to use an aggregate evaluation criterion, the pest kill rate, to compare the pest population reduction capacity of …

Semiochemical Signatures Associated With Differential Attraction Of Anopheles Gambiae To Human Feet, Maurice O. Omolo, Isaiah O. Ndiege, Ahmed Hassanali

All Peer-Reviewed Publications

Background: Several human-produced volatiles have been reported to mediate the host-seeking process under laboratory conditions, yet no effective lure or repellent has been developed for field application. Previously, we found a gradation of the attractiveness of foot odors of different malaria free individuals to Anopheles gambiae sensu stricto Giles. In this study, foot odor of the individual with the most attractive 'smelly' feet to the An. gambiae was collected, analyzed and attractive blend components identified. Methods: The foot odor of the individual with the most attractive 'smelly' feet to the An. gambiae was trapped on Porapak Q and analyzed by …

In Situ Nitrogen Mineralization And Nutrient Release By Soil Amended With Black Soldier Fly Frass Fertilizer, Dennis Beesigamukama, Benson Mochoge, Nicholas Korir, Changeh J. Ghemoh, Sevgan Subramanian, Chrysantus M. Tanga

All Peer-Reviewed Publications

Although black soldier fly frass fertilizer (BSFFF) is effective on crop performance, information on nitrogen (N) mineralization and nutrient release capacity of soils amended with BSFFF is lacking. This study utilized field incubation experiments to investigate the ammonification, nitrification, microbial populations, and quantities of nutrients released by soils amended with BSFFF and commercial organic fertilizer (SAFI) for a period equivalent to two maize cropping seasons. For the control treatment, no BSFFF or SAFI was added. Results indicated that most of the N in BSFFF amended soils was available in the ammonium form, while soils treated with SAFI had higher nitrate …

A System Dynamics Model For Pests And Natural Enemies Interactions, Bonoukpoè Mawuko Sokame, Henri E.Z. Tonnang, Sevgan Subramanian, Anani Y. Bruce, Thomas Dubois, Sunday Ekesi, Paul André Calatayud

All Peer-Reviewed Publications

Stemborers (Busseola fusca, Sesamia calamistis and Chilo partellus), the fall armyworm (Spodoptera frugiperda) and associated parasitoids constitute an interacting system in maize fields in Kenya. This work aims at developing and evaluating models that represent the evolution of those interactions by applying system thinking and system dynamics approaches with its archetypes [causal loop diagram (CLD), reinforcing (R) and balancing (B)] to analyse the population of these multi-species systems. The software Vensim PLE 8.0.9 was used to implement the models and carry out the simulations of single- and multi-species systems. The results showed that when a single pest species with its …

How Are Agricultural Research Projects Conceiving Innovation? An Assessment Of The European Union Multi-Actor Projects, Samuel Brea Martinez-Collado

Graduate Theses and Dissertations

Horizon research programs are the European Union’s lighthouse for innovation and research concerning the agri-food chain, the management of natural resources, and the bioeconomy. Their innovation strategy approach is one that pursues the practical application of the research via the collaboration of all actors involved. Such strategy is the reflection of a Multi-Actor Approach as their procedure to enhance innovation. This paper presents the main trends and directions 101 Multi-Actor Projects (MAPs) are following on said approach towards innovation. The analysis is based on the use of well-defined “pathways” and “measures” proposed in the Guidelines for Evaluation of Innovation in …

Identification Of Biomarker Systems Of Autism Spectrum Disorder And Uterine Cancer, Allison Hickman

All Dissertations

Complex diseases and disorders pose a challenge to scientists due to their variable and often inconsistent genetic and environmental underpinnings across affected individuals. Because of this variability, large condition-specific datasets and corresponding analytical tools and approaches are being curated as resources to investigate potential genetic trends in complex diseases and disorders. In this Dissertation, I used DNA- and RNA-based resources to discover polygenic biosignatures associated with Autism Spectrum Disorder (ASD) or uterine cancer. To explore the intersection of small-effect common DNA variants and regulation in ASD, I discovered and analyzed trends in allelic associations at eQTLs within ASD-affected individuals. Association …