Life Sciences Commons^™

An Observational Study Of The Effect Of Concomitant Levetiracetam On Apixaban Concentrations In A Hospital Cohort, Chazmyn Riley, Kevin Lam, Cristina Micale, Lynda Thomson, Douglas F. Stickle, Walter K. Kraft

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite the lack of evidence of a mechanism-based drug interaction, some professional organizations have advised caution coadministering apixaban and levetiracetam. Eligible patients taking apixaban with or without levetiracetam for any indication for at least 72 h were screened from the electronic medical records. Plasma samples from 77 patients were retrieved from salvaged clinical blood collections. Apixaban minimum and maximum concentrations (Cmin and Cmax) were compared using descriptive statistics in R. While the median Cmin and Cmax appear to be marginally elevated, there were no apparent differences relative to apixaban alone. These findings suggest no apparent interaction of levetiracetam and support …

Gender-Responsive Knowledge Management Strategies For Vegetable Farmers Of Atok, Benguet , Philippines, Marianne R. De Luna, Farawyn E. Sarmiento

The Philippine Agricultural Scientist

Knowledge transfer in Philippine vegetable production often follows centralized pathways that neglect gendered roles, perpetuating productivity gaps. This study evaluated gender-responsive knowledge management pathways and technology adoption among smallholder vegetable farmers in Atok, Benguet, Philippines. Using a mixed-methods approach combining household surveys (n = 85), Social Network Analysis (SNA), vignettes, and key informant interviews, data were disaggregated by sex to map institutional disparities. Results showed that while women farmers demonstrate higher college completion rates (29%), men farmers cultivate larger average plots (0.57 vs. 0.37 ha), have higher off-farm income, and enjoy greater irrigation access (70.69% vs. 59.26%). Additionally, women derive …

Consumer Preferences And Technical Priorities For Salted Chicken Egg Products In West Java, Indonesia: A Quality Function Deployment Approach, Faizal Syahmurman, Roni Kastaman, Devi Maulida Rahmah, Yosini Deliana, Siti Nurhasanah, Efri Mardawati, Boy Macklin Pareira Prawiranegara

The Philippine Agricultural Scientist

Consumer expectations for salted chicken egg products are multidimensional, making it challenging to systematically translate customer requirements into technical product improvement strategies. The purpose of this study was to determine and rank consumer needs for salted chicken egg products in West Java, Indonesia, and to apply a House of Quality-based Quality Function Deployment (QFD) approach to convert these needs into prioritized technical requirements. A total of 120 consumers participated in a structured survey to evaluate 40 customer requirements. The House of Quality planning matrix integrated customer importance, comparative product performance, improvement requirements, and sales-point considerations to determine customer priorities. The …

Effect Of Sprayer Type, Nozzle Selection, And Herbicide Properties On Spray Deposition And Weed Control Efficacy, Mary Joy M. Abit, Analiza Henedina M. Ramirez

The Philippine Agricultural Scientist

Sprayer application efficiency is influenced by sprayer performance, nozzle characteristics, and herbicide properties, which collectively affect spray deposition and weed control. This study evaluated the effects of backpack sprayer type and nozzle configuration on spray output, droplet characteristics, spray coverage, and deposition under Philippine field conditions and compared these characteristics with weed control responses to glyphosate and glufosinate in separate field experiments. Battery-operated (BO) and hand-pumped (HP) backpack sprayers equipped with flat fan and hollow cone nozzles were evaluated. The BO sprayer provided more consistent spray output and maintained discharge rates closer to the target application volume than the HP …

Impacts Of Land Use Change On Streamflow, Sediment Yield, And Nitrate Loading In A Small Philippine Catchment With Lake Subbasins, Francis Victor T. Panoga, Clarissa Ileana L. Ilao, Maurice A. Duka

The Philippine Agricultural Scientist

This study assessed the impacts of land use changes on streamflow, sediment yield, and nitrate loading in the Macopa River Basin and 2 connected lake subbasins, Sampaloc and Bunot, in San Pablo City, Laguna, Philippines. A Soil and Water Assessment Tool (SWAT+) model was developed using topographic, soil, climate, and land use data from 1997 to 2022, incorporating land use layers for 2003, 2010, 2015, and 2020. Calibration for streamflow (2006 to 2007) showed good agreement with data (NSE = 0.73, R² = 0.80), while validation (2017 to 2018) yielded lower accuracy, reflecting limitations in available observed data. Hindcasting results …

Spatial Dependence Of Technical Efficiency Of Rice Farms In Camagong San Vicente Farmers Irrigators Association Inc., Cabusao, Camarines Sur, Philippines, Anthony James C. Albis, Julieta A. Delos Reyes, Antonio Jesus A. Quilloy, Jaine C. Reyes, Valerien O. Pede

The Philippine Agricultural Scientist

This study assessed the technical efficiency of rice farms and examined how neighboring farms influence productivity among members of the Camagong San Vicente Farmers Irrigators’ Association Inc. in Cabusao, Camarines Sur, Philippines. Employing Stochastic frontier analysis and spatial econometric models, the research identified key determinants of productivity and technical efficiency. Moran’s Index and visual geospatial analysis revealed significant clustering of technical efficiency, confirming spatial dependence among farm locations. The spatial lag model was selected after robust diagnostic tests, including Lagrange multiplier tests, to capture the influence of neighboring farms on individual efficiency levels. Results indicate substantial variability in technical efficiency …

Assessment Of Rabbit Production And Marketing Systems In Selected Regions In Luzon, Philippines, Cristy M. Bueno, Maria Cynthia R. Oliveros, Dinah Pura T. Depositario, Kaito O. Furusho

The Philippine Agricultural Scientist

Rabbit meat is emerging as an alternative protein source in the Philippines. To strengthen this growing industry, this study assessed existing rabbit production and marketing systems in selected regions in Luzon, Philippines, identifying key challenges and areas for improvement. Survey interviews were conducted with 67 raisers from 6 regions (Cordillera Administrative Region, Regions I, II, III, and IV-A, and the National Capital Region) using convenience sampling. A descriptive cross-sectional design with a mixed-method approach was employed, with data analyzed using descriptive statistics. Respondents were mostly smallhold raisers with ≤50 dam level of New Zealand White and California White as the …

Physical Soil Health Indicators In Paired Certified Organic And Conventional Farms: A Multi-Case Study In The Philippines, Victorino A. Bato, Gina Villegas Pangga

The Philippine Agricultural Scientist

There is a common perception that organic products and practices are good for the health of consumers, plants, the environment, and particularly the soil. In the Philippines, organic agriculture was enacted into law (i.e., Republic Act No. 10068) in order to encourage farmers to shift to organic farming and reap its benefits, including better soil health through improved soil physical properties. This study compared certain soil physical properties of certified organic farms in the Philippines with those of a conventional cropping system. Results showed significantly higher soil aggregate stability (high values of percent water-stable aggregates and mean weight diameter, both …

Building Wellbeing Through Nature And Adventure For Justice-Involved Youth, Lewis Kogan, Meagan Ricks, Janna Coulter, Miranda Margetts, Lori Butterfield, Ben Ukoh-Eke

Outcomes and Impact Quarterly

Justice-involved youth often experience elevated levels of stress, mental health challenges, and reduced access to positive developmental opportunities. A nature- and adventure-based youth development program designed to strengthen resilience, self-efficacy, nature-connectedness, and well-being among justice-involved youth was piloted in 2025 to address these challenges. Pilot findings indicated improvements in resilience, self-efficacy, hopefulness, and connectedness to nature.

Youth Gopher Trapping: Benefits For Agriculture And Youth, Melanie Heaton, Kalen Taylor

Outcomes and Impact Quarterly

Utah State University Extension partnered with local government and conservation districts to reduce agricultural losses while creating meaningful opportunities for youth. Over three years, 92 participants removed 3,941 rodents, earned $26,620, and gained practical skills through hands-on conservation work. The program shows how Extension-led partnerships can strengthen agricultural profitability, youth development, and community collaboration at the same time.

Improving Public Perceptions Of Dairy Production Through On-Farm Educational Tours, Drew Swartz, Justin Wyatt Clawson, Jaydee Gunnell, Elise Jenson, Dylan Waldron, Jenna Dyckman

Outcomes and Impact Quarterly

Utah dairy producers identified public perceptions as a top concern. Utah State University Extension partnered with Cache County organizations to offer dairy farm tours. Participants reported increased knowledge, more favorable perceptions, and stronger intentions to engage with agriculture, supporting experiential education as a means to strengthen understanding of dairy production.

A Qualitative Exploration Of Drinking Culture For Women In The Workforce, Anna Savage

Proceedings of the New York State Communication Association

This study investigates how the drinking culture of companies differ for women in male-dominated industries compared to female-dominated industries. Through interviews with six women in a convenience sample, I compared the experiences of women in different industries to examine a variety of factors including whether they felt pressured to drink alcohol in social settings, how their experiences at office events impacted how they view and are viewed by their coworkers and managers, and what the effects of the drinking culture are on the culture inside their company. I found that women in male-dominated industries were much more likely to be …

Bathurst Burr And Its Control, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Bathurst burr (Xanthium spinosum) is a declared pest in Western Australia (WA). This factsheet describes the nature of the plant, requirements land owners/occupiers must adhere to, control methods, and how to search, detect, and report it.

Bathurst burr is a summer growing annual shrubby plant originating in South America. In south west Australia, some mature plants survive well into winter, with the result that burrs may be found for most of the year. The weed spreads entirely by burrs, which are usually carried by people or animals, attached to clothes, fur, or other fibre by their hooked spines. They may …

Noogoora Burr And Its Control, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Noogoora burr, also known as cocklebur (Xanthium strumarium), is a declared pest in Western Australia (WA). This factsheet describes the nature of the plant with links to requirements that land owners/occupiers must adhere to and control methods.

Native to western United States of America. Locally abundant in parts of the Kimberley, especially near water courses. Occasionally found in the South West region of WA.

Characterization Of Mettl3/14-Mediated M6a Modification In Human Transcriptome Using Nanopore Direct Rna Sequencing, Emily Kurtyan, Andrew J. Stein, Kelly J. Abdalla, Zhangerjiao Yuan, Miten Jain, Fadia Ibrahim

Department of Biochemistry and Molecular Biology Faculty Papers

Post-transcriptional RNA modifications modulate diverse aspects of RNA metabolism. N6-methyladenosine (m6A), one of the most abundant internal RNA modifications, is deposited by the core methyltransferase complex, METTL3 and METTL14. Oxford Nanopore Technologies (ONT) platform permits direct, single RNA molecule sequencing while preserving native modifications. However, without rigorous benchmarking, the accuracy and reproducibility of modification detection remain uncertain. Here, we leveraged ONT to comprehensively profile bona fide m6A modifications in cellular RNAs at single-nucleotide resolution by integrating two direct RNA sequencing chemistries (RNA002 and RNA004) with the m6Anet and Dorado modification-detection models. We independently depleted METTL3 and METTL14 in human cells …

Insect Monitoring Without Pitfalls: Seven Steps For Robust Insect Sensing Systems, Jamie Alison, Luca Pegoraro, Jarrett Blair, Yuval Cohen, Birgen Haest, Jacob Idec, Jacob Kamminga, Jenna Lawson, Meng Li, Leandro Aparecido Do Nascimento, Charlotte L. Outhwaite, Benjamin Rutschmann, Maximilian Sittinger, Mariana Abarca, Et Al

Biological Sciences: Faculty Publications

1. Data shortages fuel controversy about an ongoing insect biodiversity crisis. Insects are immensely diverse and functionally critical for ecosystems, yet data on their trends remain patchy and biased. Sensors, ranging from camera traps and acoustic recorders to weather radar stations, are set to transform data collection in entomol- ogy. Meanwhile, AI models that extract biological information from sensors are improving at a startling rate.

2. Realising the potential of automated monitoring means progressing from proof- of-concept studies to scalable insect sensing systems. However, stakeholders face severe operational challenges when adopting a growing suite of sensors, models and protocols for …

Genomic Investigation Of Population Structure In A Secretive, Semi‐Fossorial Snake (Colubridae: Tropidoclonion Lineatum) Across The Great Plains, Taylor Probst, Cameron D. Siler, Drew R. Davis

School of Integrative Biological & Chemical Sciences Faculty Publications

With advances in genomic technologies, it has become increasingly feasible to generate large numbers of loci to address population genetic and phylogeographic questions. Nevertheless, many widespread and relatively abundant species remain unsampled using molecular approaches. The lined snake ( Tropidoclonion lineatum ), a semi‐fossorial snake distributed across the Great Plains, is one such example. Despite the historical recognition of multiple subspecies based on noted variation in morphological characters, no formal molecular investigation of population structure has been conducted to date due to a paucity of vouchered genetic samples. Here, we present the first genomic assessment of range‐wide population structure in …

Best Practices For Managing Human–Beaver Conflicts In North America: Balancing Ecological Benefits And Human Interests, Alec J. Sundelius, Jerry Altermatt, Doug Brimeyer, Derek J. Broman, Jared Duquette, Cory Mosby, Falyn Owens, Shawn Rossler, David B. Ruid, Brian F. Wakeling, H. Bryant White

Human–Wildlife Interactions Monographs

We explore the complexities of managing beaver (Castor canadensis) conflicts in North America, describing the most common approaches used by natural resource management agencies to address conflicts. We identify specific conflicts caused by beavers, the ecological benefits beavers provide, and the tools commonly used to address conflicts. We discuss regional differences in beaver management strategies, including ecosystem restoration and conflict prevention. We specifically discuss a variety of management practices including public education, land use management, trapping, translocation, exclusion, shooting, dam removal, repellants, and harvest incentive programs; we then review the challenges and benefits of these tools. We discuss …

A Decision Analytic Approach To Hierarchical Decisions For Double-Crested Cormorant Conflict Resolution, Kelly F. Robinson, Travis O. Brenden, Alex Maguffee, Charles R. Bronte, Randall M. Claramunt, Thomas R. Cooper, Robin L. Debruyne, Brian S. Dorr, James F. Farquhar, Jana R. Lantry, James R. Jackson, David G. Fielder, Rachel L. Pierce, Doug Schultz

United States Department of Agriculture Wildlife Services: Staff Publications

Double-crested cormorants (Nannopterum auritum) are piscivorous, migratory waterbirds that often conflict with fisheries interests in North America, stemming from depredation effects on fish populations. A new permitting process in the United States allows natural resource agencies to request permits for lethal take of cormorants in special instances like depredation of managed fish stocks. This rule does not include guidance for when cormorant take might be actionable. We developed a hierarchical structured decision making (SDM) framework for evaluating whether, when, and how much cormorant take might be necessary. A broad-scale, or “umbrella,” SDM framework established the overarching problem, objectives …

State Of The Fisheries: Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2024/25, Stephen J. Newman, Ainslie Denham, Lebo Selemela, Jenny Moore

Status Reports of the Fisheries and Aquatic Resources

The Status Reports of the Fisheries and Aquatic Resources of Western Australia (SRFAR) provides an annual update on the state of the fish stocks and other aquatic resources of Western Australia (WA). These reports outline the most recent assessments of the cumulative risk status for each of the aquatic resources (assets) within WA’s six bioregions using an Ecosystem Based Fisheries Management (EBFM) approach. The Department of Primary Industries and Regional Dveelopment’s (DPIRD) risk based EBFM framework is the WA Government’s basis for management of all of WA’s aquatic resources.

Assets examined in each bioregion include the meso-scale ecosystems and aquatic …

Co-Speech Gestures Destabilize Posture Via Shared Motor-Cognitive Resources, Sasha Lifton Lewis, Weina Lu, Ingo Helmich

Exercise and Sport Studies: Faculty Publications

Speaking and gesturing are fundamental aspects of human communication that commonly occur while main- taining upright posture. Although speech and postural control are known to compete for shared motor-cognitive resources, it remains unclear how co-speech gestures affect balance control and their underlying neural mecha- nisms. Using combined behavioral and neuroimaging approaches, we investigated whether co-speech gestures interfere with concurrent postural control, whether this interference depends on the spatial reference frame (egocentric vs. allocentric), and whether dual-task costs arise from competing motor demands, overlapping cog- nitive processes, or both. Forty-one right-handed adults (25.9 ± 6.8 years) maintained posture—monitored via a wearable …

Guide To The Crawford-Beck Vineyard Collection, Linfield University Archives

Linfield Archives Finding Aids

In 2005, David Beck and Jeanne Crawford purchased Casa-Blanca Vineyard and renamed it as Crawford-Beck Vineyard and owned it for 17 years. This collection focuses on the evolution of Crawford-Beck Vineyards from 2005 to 2023. It contains multiple business documents and records, such as expansion plans, invoices, and LIVE evaluation records. The collection also explores the personal growth and achievements of David and Jeanne Beck, the owners of Craw-Beck Vineyard. This includes their enrollment at Chemeketa Community College, their involvement in the wine industry in Oregon, and their personal assortment of books and articles. The collection also contains material outside …

The Cranial Nerves And Electrical Stimulation, Devin K. P. Adair

Dissertations, Theses, and Capstone Projects

Cranial nerves provide afferent pathways that enable bottom-up modulation of central autonomic and cognitive neural pathways. Because these pathways project to brainstem nuclei such as the nucleus tractus solitarius and engage neuromodulatory systems, including the locus coeruleus, electrical stimulation offers a mechanistically grounded approach to influencing brain function. This thesis tested whether active transcutaneous auricular vagus nerve stimulation (taVNS) produces physiological responses indicative of parasympathetic engagement, defined as decreases in heart rate, increases in heart rate variability, and decreases in respiration relative to a dose-matched earlobe control condition. Using cardiac and respiratory measures as physiological markers, taVNS at the tragus …

The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose

Dissertations, Theses, and Capstone Projects

Tobacco is one of the most widely used substances across the United States; tobacco consumption is linked with several diseases and is one of the leading causes of preventable death in the country. Nicotine is the active substrate found in tobacco products, acting as a stimulant, which reinforces continued use. The introduction of tobacco-free options such as e-cigarettes and oral pouches has driven an increase in nicotine exposure across the population, especially in young adults. Acute nicotine use induces neuroadaptations in the mesolimbic dopaminergic system, which mediates reinforcement learning and addiction, that potentiates reward-related neurotransmission. Furthermore, there are clinical studies …

Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao

Dissertations, Theses, and Capstone Projects

Osteosarcoma (OS), the most common primary bone malignancy of children and young adults, is intrinsically radioresistant, and outcomes for patients with unresectable or metastatic disease have not improved in over four decades. Single-dose radiation therapy (SDRT) is a potent modality against radioresistant, highly vascularized sarcomas, but its application in OS is constrained by dose-dependent normal tissue toxicity. Radiosensitizers achieving tumor control at lower doses therefore offer a direct route to widening the therapeutic window. Critically, OS radioresistance is not tumor-cell-autonomous. It emerges from two coordinated compartments: aberrant DNA repair and antioxidant capacity intrinsic to the tumor cell, and a radioprotective, …

Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric

Dissertations, Theses, and Capstone Projects

Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder with a lifetime prevalence of 5-6% in men, and 10-12% in women (National Center for PTSD). Generalized anxiety disorder (GAD) is a highly prevalent anxiety- and depression-related psychiatric disorder with a lifetime prevalence of 1-2% in men, and 3-4% in women (National Institutes of Health). Both of these disorders disproportionately affect women. A hallmark feature of both disorders is the maladaptive generalization of fear, in which defensive responses extend beyond the original traumatic or threatening stimulus to neutral or unrelated cues. This overgeneralization can become debilitating, disrupting cognitive, emotional, and …

Analysis Of Diterpenoid Alkaloids From American Aconitum Using Lc-Ms Metabolomic Methods, Yi Zhao

Dissertations, Theses, and Capstone Projects

Analysis of Diterpenoid Alkaloids from American Aconitum Using LC-MS Metabolomic Methods

by

Yi Zhao

Advisor: Edward J. Kennelly

Aconitum plants have been used as a traditional medicine in Asian countries for millennia to treat pain, rheumatism, syncope, fever, and other conditions. These therapeutic effects are mainly due to the bioactive diterpenoid alkaloids accumulated in the roots. Comparing with the large records and studies of Asian Aconitum and their medicinal use and the broad bioactive compounds, American Aconitum has been rarely investigated, not to mention how American Aconitum has been used medicinally. Based on previous phylogenetic and chemotaxonomic studies of Aconitum …

Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano

Dissertations, Theses, and Capstone Projects

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein condensates that regulate mRNA storage, translational repression, and decay. While the biochemical principles governing condensate assembly have been extensively studied in vitro, how P-body organization is established and dynamically regulated in vivo to control specific mRNA populations remains poorly understood. This dissertation investigated the molecular and cellular mechanisms that govern P-body architecture and function in the Drosophila melanogaster female germline. First, I identified the conserved LSm protein Trailer Hitch (Tral) as a central organizer of P-body architecture. Using quantitative confocal and super-resolution microscopy combined with chemical perturbations, I showed that Tral coordinates the …

Unraveling Hemispheric Specializations In The Mouse Auditory Cortex: From Diseased Model Comparisons To Development, Demetrios Neophytou

Dissertations, Theses, and Capstone Projects

Hemispheric specialization is a fundamental organizing principle of mature auditory cortical function, allowing the left and right Auditory Cortex (ACx) to perform complementary computations on complex sounds. This division of labor is conserved across species, and mice recapitulate key forms of auditory cortical lateralization, providing access to the synaptic and circuit mechanisms that generate it. Disrupted hemispheric organization is also associated with neurodevelopmental disorders characterized by severe communication impairments, including Rett Syndrome (RTT). Despite this, we know little about how lateralized auditory circuits are assembled during development or why they become differentially vulnerable to neurodevelopmental disruption. Here, using a mouse …

Collecting Holistic Evidence On Agroecology Performance To Accelerate Sustainable Food System Transitions, Sarah K. Jones, Andrea Cecilia Sánchez, Chris Dickens, Matthias S. Geck, Chaturangi Wickramaratne, Veronique Alary, Peter Bolo, Dennis Junior Choruma, Somphasith Douangsavanh, Modou Gueye Fall, Gatien Falconnier, Shweta Gupta, Chris Kettle, Smitha Krishnan, Sylvia Nyawira, Guillermo Orjuela-Ramirez, Boko Michel Orounladji, Piedad Pareja, Telma Sibanda, Christine Lamanna

All Peer-Reviewed Publications

A growing body of research shows the potential of agroecology for enabling a shift to planet-friendly and socially just agrifood systems through context-specific transition pathways. We conduct a scoping review to identify and evaluate the potential of 42 existing agroecology adherence and/or agricultural performance assessment tools to generate credible, legitimate, salient and transferable evidence to inform these transitions. Results show that while multiple relevant tools exist, each of them can be strengthened in at least one area. While most tools are transferable (low time and resource requirements) and have legitimacy (open access with transparent methods), tools have variable saliency (holistic …