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Articles 56941 - 56970 of 255951
Full-Text Articles in Life Sciences
Oregon State Rank Assessment For Cascade Torrent Salamander (Rhyacotriton Cascadae), Eleanor P. Gaines
Oregon State Rank Assessment For Cascade Torrent Salamander (Rhyacotriton Cascadae), Eleanor P. Gaines
Institute for Natural Resources Publications
Oregon state conservation status assessment for Cascade torrent salamander (Rhyacotriton cascadae) using NatureServe methodology, 2022
Oregon State Rank Assessment For Cope's Giant Salamander (Dicamptodon Copei), Eleanor P. Gaines
Oregon State Rank Assessment For Cope's Giant Salamander (Dicamptodon Copei), Eleanor P. Gaines
Institute for Natural Resources Publications
Oregon state conservation status assessment for Cope's giant salamander (Dicamptodon copei) using NatureServe methodology, 2022.
How To Identify Plants, Gabriel Campbell
How To Identify Plants, Gabriel Campbell
Rae Selling Berry Seed Bank and Plant Conservation Program
These slides explain how to identify plants.
Effective Treatments For Onychomycosis, Jonathan Knobel
Effective Treatments For Onychomycosis, Jonathan Knobel
The Science Journal of the Lander College of Arts and Sciences
Background: Onychomycosis is a highly prevalent nail infective disorder. Many treatments, with varied success rates and side effects, are used. Objectives: To assess the most recommended treatment for Onychomycosis with the optimal cure rate and least severe side effects. Search Methods: PubMed, ProQuest, EBSCO Multisearch, and Google Scholar were used to gather information. Search terms such as “Onychomycosis,” and “Effective treatments for Onychomycosis” etc. were used. Results: Effective treatments include oral, topical, nail avulsion, and laser treatments. Topical treatments have low cure rates and minimal side effects. Oral treatments have various side effects but the highest mycological and clinical cure …
Is Deep Brain Stimulation A Desirable Therapy For Parkinson’S Disease?, Chana Steinberg
Is Deep Brain Stimulation A Desirable Therapy For Parkinson’S Disease?, Chana Steinberg
The Science Journal of the Lander College of Arts and Sciences
Parkinson’s disease is a neurodegenerative disorder that currently impacts 6.1 million people globally. Although it has different presentations, its core features are tremors, postural instability, bradykinesia (slowing of movement), and psychological disabilities such as mood disorders and cognitive decline. A primary treatment is Levodopa, but it has limited success. A promising treatment called Deep Brain Stimulation (DBS) has been shown to induce significant improvements in motor skills where Levodopa has failed to help. Deep Brain Stimulation works via implanted electrodes. It has been used successfully in many studies to decrease motor issues associated with Parkinson’s, but potential side effects pose …
Optimal Treatment Of Osteoporosis, Yehoshua Wiederkehr
Optimal Treatment Of Osteoporosis, Yehoshua Wiederkehr
The Science Journal of the Lander College of Arts and Sciences
Osteoporosis affects tens of millions of people in America and is the most common disease of the bones. New treatments are constantly sought, as existing ones have documented side effects. This review seeks to pinpoint the most effective and safe treatment for osteoporosis by looking at head-to-head trials and research regarding combination therapies. This review also looks at the effectiveness of non-pharmacologic treatments and whether any options are beneficial. The importance of an open patient/provider relationship proves itself, as many medications and treatment plans depend on personal factors that need to be measured and weighed by a medical professional together …
The Development And Future Of Prosthetics Controlled By Myoelectrical Impulses, Chaya Podemski
The Development And Future Of Prosthetics Controlled By Myoelectrical Impulses, Chaya Podemski
The Science Journal of the Lander College of Arts and Sciences
Objective: To document the developmental history of prostheses to better understand the circumstances that led to enabling amputees to experience touch through sensory reinnervation surgery in conjunction with an innovative bionic arm; and to prove that sensory reinnervation is the key to further progress. Methods: The topic was researched extensively using scholarly databases and read relevant accounts of experimental studies and outcomes. Results: By examining the progress made in the field of prostheses, it has been determined that a sensory reinnervation technique is at the forefront of bionic limb technology and predict that it will continue to be utilized and …
Can Androgenetic Alopecia Be Reversed And What Are The Effective Treatments?, Michelle Aminova
Can Androgenetic Alopecia Be Reversed And What Are The Effective Treatments?, Michelle Aminova
The Science Journal of the Lander College of Arts and Sciences
Androgenic alopecia (AGA), also known as male and female pattern baldness, is the loss of hair on the scalp for both men and women. The onset of hair loss for men suffering from this condition can occur as early as their teens or early 20s. Symptoms include a receding hairline and gradual disappearance of hair at the vertex and frontal scalp. When women have female pattern baldness (FPB), their hair doesn’t appear thinning until they reach their 40s or older. Generally, women experience a thinning of the hair over the whole scalp, with the most extensive hair loss at the …
Are Clear Aligners Better Than The Conventional Orthodontic Fixed Appliances?, Adelle Perkelvald
Are Clear Aligners Better Than The Conventional Orthodontic Fixed Appliances?, Adelle Perkelvald
The Science Journal of the Lander College of Arts and Sciences
Clear aligner therapy (CAT) has become an attractive alternative for orthodontic treatment as more adolescents and young adults pursue othodontic care. CAT is comprised of removable transparent appliances that offer a more aesthetic appearance to prospective patients. Recent studies have shown that CAT efficiency and efficacy for orthodontic procedures for cases of mild to moderate malocclusions are of equal or greater caliber to those of conventional fixed appliances. Clear aligners are also found to be less painful, better for periodontal health, and more accessible in comparison with fixed appliances. For those meeting the criteria for CAT, clear aligners may be …
Using Image To Assist Students In Construct Searching Concepts And Framing Research Questions, Junli Diao
Using Image To Assist Students In Construct Searching Concepts And Framing Research Questions, Junli Diao
Open Educational Resources
No abstract provided.
In Silico Analysis Of Xth Gene Family From Barley (Hordeum Vulgare L.) And Their Comparative Expression Analysis During Germination, Hülya Akdemi̇r Koç, Merve Seven, Ümi̇t Cem Derman, Andrew John Harvey
In Silico Analysis Of Xth Gene Family From Barley (Hordeum Vulgare L.) And Their Comparative Expression Analysis During Germination, Hülya Akdemi̇r Koç, Merve Seven, Ümi̇t Cem Derman, Andrew John Harvey
Turkish Journal of Botany
Changes in plant cell walls are critical for expansion and growth. Xyloglucan endotransglycosylase/hydrolase (XTH) enzymes are the major modifiers of xyloglucan within the cell wall and are present as large gene families. Despite the paucity of xyloglucan in barley, our analyses of the barley genome revealed at least 42 XTH genes, the most XTH members recorded for a monocot genome to date. In this paper, we show a detailed look at the barley XTH gene family, including detailed bioinformatics analyses of conserved protein motifs and structure, phylogenetic relationships, and a comparison of the expression patterns during germination and seedling growth …
New Species And New Record In Agaricus Subg. Minores From India, Entaj Tarafder, Arun Kumar Dutta, Krishnendu Acharya
New Species And New Record In Agaricus Subg. Minores From India, Entaj Tarafder, Arun Kumar Dutta, Krishnendu Acharya
Turkish Journal of Botany
Two new species of Agaricus, namely A. midnapurensis and A. purpureosquamulosus, belonging to A. subg. Minores, are proposed here as new to science based on specimens collected in West Bengal, India. Agaricus midnapurensis is distinguished by its medium-sized basidiomata with a pileus covered by greyish brown to brown or dark brown squamules, ellipsoid to broadly ellipsoid basidiospores with a mean value of 7.3 × 5.4 µm, and broadly clavate to pyriform cheilocystidia, 22-28 × 10-14 µm. Agaricus purpureosquamulosus has purplish coloured pileus squamules, ellipsoid to elongate basidiospores with a mean value of 7.3 × 4.5 µm, and clavate cheilocystidia measuring …
Shackletonia Backorii - A New Species Of Lichenised Fungus From James Ross Island (Antarctic Peninsula), Mehmet Gökhan Halici, Mi̇that Güllü, Ekrem Bölükbaşi, Merve Kahraman Yi̇ği̇t
Shackletonia Backorii - A New Species Of Lichenised Fungus From James Ross Island (Antarctic Peninsula), Mehmet Gökhan Halici, Mi̇that Güllü, Ekrem Bölükbaşi, Merve Kahraman Yi̇ği̇t
Turkish Journal of Botany
The new lichen species Shackletonia backorii Halıcı, Güllü & Kahraman is described from James Ross Island, which is located in the North-East Antarctic Peninsula region. The new species is morphologically most similar to S. insignis (Søchting & Øvstedal) Søchting, Frödén & Arup, which was described from Livingstone Island (North-West Antarctic Peninsula region). These two species have a similar bluish grey to blackish thallus with a microfruticose and coralloid structure and red brown or almost black zeorine apothecia, but S. backorii has rhomboid ascospores and grows on soil whereas S. insignis has ellipsoid ascospores and occurs in sheltered crevices of rocks. …
Genome-Wide Identification And Evolutionary Analysis Of Cngc Gene Families In Sixteen Brassicaceae Plant Genomes, Akram Ali Baloch, Kaleem U. Kakar, Asma Abro, Muhammad Mushtaq, Zarqa Nawaz, Abrar Hussain
Genome-Wide Identification And Evolutionary Analysis Of Cngc Gene Families In Sixteen Brassicaceae Plant Genomes, Akram Ali Baloch, Kaleem U. Kakar, Asma Abro, Muhammad Mushtaq, Zarqa Nawaz, Abrar Hussain
Turkish Journal of Botany
Cyclic nucleotide-gated channels (CNGCs) are ligand-gated calcium signaling channels, play vital biological functions. Nonetheless, the CNGC gene families have not been well studied in Brassicaceae which includes commercially important and evolutionary model crops. Here, using in silico approaches, we recognized 414 CNGC genes in sixteen sequenced genomes of Brassicaceae species, which represent 10 genera of 8 tribes, ranging between 10-51 genes. These CNGCs can be classified into four main groups (I-IV) and two subgroups (IV-A and IV-B), of which, Group-II CNGC is the oldest that has gradually disappeared from the Arabis alpina L. genome. These results present a comprehensive overview …
Anthropogenic Influences On The Decline, Restoration, And Eco-Evolutionary Dynamics Of Lake Superior’S Coaster Brook Trout, Austin Johnson
Anthropogenic Influences On The Decline, Restoration, And Eco-Evolutionary Dynamics Of Lake Superior’S Coaster Brook Trout, Austin Johnson
Dissertations, Master's Theses and Master's Reports
The coaster brook trout is a life history variant of the brook trout (Salvelinus fontinalis) that is characterized by either lake residency or migration between stream and lake habitats. Coaster brook trout were once widespread throughout Lake Superior and its tributaries, but populations declined sharply in the late 19th and early 20th centuries. Historically, brook trout were a popular target of recreational and subsistence fishing in the Lake Superior basin, and it has been hypothesized that angling pressure combined with multiple forms of industrial development are what drove the coaster brook trout’s decline. In the mid …
Conservation Value Of Working Landscapes In Mesoamerica For Nearctic-Neotropical Migratory Birds, Samuel L. Oliveira
Conservation Value Of Working Landscapes In Mesoamerica For Nearctic-Neotropical Migratory Birds, Samuel L. Oliveira
Dissertations, Master's Theses and Master's Reports
Populations of many of Nearctic-neotropical migratory birds have declined in the past several decades, recent estimates suggested a dramatic loss of 2.5 billion birds over the past 50 years in North America. Habitat loss and degradation represent a major threat in the tropics. Managed agroecosystems have the potential to mitigate some impacts of land conversion, however, little is known regarding the habitat quality provided by working landscapes in the overwintering range. In this research, we surveyed the migratory bird community in the rapidly expanding oil palm plantations in southern Mexico; and also the declining population of the Wood Thrush ( …
Effects Of Mindfulness And Stress Management On Neurocardiovascular And Psychological Outcomes, Aditi P. Vyas
Effects Of Mindfulness And Stress Management On Neurocardiovascular And Psychological Outcomes, Aditi P. Vyas
Dissertations, Master's Theses and Master's Reports
There has been a higher prevalence of developing anxiety due to frequent episodes of stress among adults in recent years. Chronic anxiety can contribute to the prevalence of elevated blood pressure and hypertension. High anxiety and stress also contribute to overactivation of the sympathetic nervous system which can be quantified by increased muscle sympathetic nerve activity (MSNA). Sympathetic overactivation can lead to vasoconstriction and loss of arterial elasticity. Anxiety, MSNA, blood pressure, and arterial stiffness are all interconnected, thus studying these relationships is crucial to understand the underlying mechanisms for prevention and treatment of cardiovascular disease (CVD). Non-pharmacological and mind-body …
Effects Of Azadirachta Indica Extract On Inhibition Of Glutamate-Induced Neuronal Cell Apoptosis Via Preventing Excessive Mitophagy Activation And Inhibiting Endoplasmic Reticulum Stress In Ht-22 Cells, Kuljira Mongkolpobsin
Effects Of Azadirachta Indica Extract On Inhibition Of Glutamate-Induced Neuronal Cell Apoptosis Via Preventing Excessive Mitophagy Activation And Inhibiting Endoplasmic Reticulum Stress In Ht-22 Cells, Kuljira Mongkolpobsin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Neurodegenerative diseases (NDs) are the age-related diseases which represent a major cause of mortality in aging population nowadays. Previous studies have shown that glutamate, the most abundant excitatory neurotransmitter, significantly increases in extracellular fluid of the patient’s brain and is the cause of neurodegeneration in NDs. The increase of extracellular glutamate elevates reactive oxygen species (ROS) accumulation and calcium (Ca2+) which exacerbate mitochondrial function, followed by inducing MAPK pathway and endoplasmic reticulum (ER) stress, respectively. In addition, Ca2+ overload also triggers calpain, a Ca2+ dependent protease, activity which further stimulates Cdk5/p35/p25 signaling leading to neuronal apoptosis. Azadirachta indica A. Juss. …
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
The Thai Journal of Pharmaceutical Sciences
Black cumin seed oil (BSCO) is widely used to maintain health and strengthen the people of Indonesia’s immune system and proved to be safe for kidneys. However, the effect of BSCO usage in a healthy kidney is remaining unknown. This study was aimed to determine the impact of the 20-day administration of BCSO on kidney function in healthy volunteers. We conducted a pre- and post-control design trial in 36 healthy volunteers. The volunteers had to hold a valid health certificate from the hospital, be willing to be involved in the research as evidenced by their willingness to complete and sign …
Improved Virus Inhibition By Microencapsulated Monoclonal Antibody Against Porcine Epidemic Diarrhea Virus, Rachatapan Junchay, Patcharapong Thangsunan, Kittipat Supchukun, Jakarwan Yostawonkul, Sasithon Temisak, Kaewta Rattnapisit, Teerapong Yata, Waranyoo Phoolcharoen
Improved Virus Inhibition By Microencapsulated Monoclonal Antibody Against Porcine Epidemic Diarrhea Virus, Rachatapan Junchay, Patcharapong Thangsunan, Kittipat Supchukun, Jakarwan Yostawonkul, Sasithon Temisak, Kaewta Rattnapisit, Teerapong Yata, Waranyoo Phoolcharoen
The Thai Journal of Pharmaceutical Sciences
Porcine epidemic diarrhea virus (PEDV) has been affecting the swine industry, especially in suckling pigs with a high mortality rate. Among all the strategies to overcome PEDV, boosting mucosal immunity in the pig intestines through oral administration appears to be more efficient than other routes. However, there are biological obstacles such as an acidic environment that could damage biologics, a product from organisms often used for PEDV treatment. The plant-derived 2C10 monoclonal antibody (mAb) from Nicotiana benthamiana produced by transient expression was revealed as one of the potential candidates against PEDV through oral delivery. Herein, we demonstrated the calcium-alginate microencapsulation …
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Thai Journal of Pharmaceutical Sciences
Brevundimonas diminuta (B. diminuta) is found in the healthcare environment and in the community. At present, there are few reports of infections caused by this microorganism, especially in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A 44-year-old woman undergoing CAPD was diagnosed with a B. diminuta infection. Ceftriaxone was given both intravenously and intraperitoneally. After treatment with ceftriaxone, the peritoneal dialysis fluid white cell count, neutrophil count, and symptoms improved. To the best of our knowledge, this is the first case report of a B. diminuta infection in a patient had undergoing CAPD in Thailand.
Lack Of Imagination Can Bias Our View Of Animal Sentience, Brian Key, Deborah Brown
Lack Of Imagination Can Bias Our View Of Animal Sentience, Brian Key, Deborah Brown
Animal Sentience
How an animal reacts to a sensory stimulus is often used to assess whether that animal can experience feelings such as pain and pleasure. This behavioural path is typically complemented with reference to how a human would normally respond to and experience an analogous stimulus. Together, these approaches can lead to a “hard to imagine otherwise” argument for feelings. It is time to go beyond these qualitative assessments and to now determine whether a nervous system can execute the neural functions necessary for sentience.
Addressing Rice Waste In University Cafeterias Using Material Flow Analysis And System Dynamics Modeling, Abigail Marie T. Favis, Charlotte Kendra Z. Gotangco-Gonzales, Ana Erika Lareza
Addressing Rice Waste In University Cafeterias Using Material Flow Analysis And System Dynamics Modeling, Abigail Marie T. Favis, Charlotte Kendra Z. Gotangco-Gonzales, Ana Erika Lareza
Environmental Science Faculty Publications
Food waste has emerged as one of the focus areas in sustainability research. At the Ateneo de Manila University, previous studies have found that food waste is composed mainly of rice. This study, therefore, analyzed cafeteria rice systems in the university through a material flow analysis (MFA) to identify key factors for formulating effective rice waste reduction techniques and then applied the results toward developing system dynamics (SD) models as tools for decision-making. The MFA found that the total mass of produced known rice waste was 49.48 kg/d. The largest sources of rice wastes were the upstream processes of the …
Influence Of Beef Carcass Weight On Carcass Chilling, Steak Case Life And Quality Traits, Trevor C. Dehaan
Influence Of Beef Carcass Weight On Carcass Chilling, Steak Case Life And Quality Traits, Trevor C. Dehaan
Electronic Theses and Dissertations
The objective of this thesis was to determine the influence of beef carcass weight on chilling and pH decline of beef carcasses, as well as color, case life and tenderness of steaks from the round, loin, rib and chuck. Twelve carcasses were allotted by hot carcass weight (HCW) into Heavyweight (HW) and Lightweight (LW) groups. Temperature decline, pH decline and thermal image temperature were measured in the round, loin, rib, and chuck for approximately 48 hours. Carcass data including 12th rib fat thickness, ribeye area, and marbling score were collected. The Semitendinosus (ST), Longissimus lumborum (LL), Longissimus thoracis (LT) and …
Phosphorus Use And Management Based On Fertilizer Placement, Rate Of Application, And Soil Biota In No-Till Situations, Brennan Alexander Bingham Lewis
Phosphorus Use And Management Based On Fertilizer Placement, Rate Of Application, And Soil Biota In No-Till Situations, Brennan Alexander Bingham Lewis
Electronic Theses and Dissertations
Phosphorus (P) pollution has become a concern among multiple scientific organizations as it leads to eutrophication, an algal bloom that depletes lacustrine and marine ecosystems of native species. Multiple strategies can be implemented to reduce phosphorus loss from agriculture fields, which is often implicated as a cause of eutrophication. Soil phosphorus chemistry results in phosphate fertilizers absorbing to clay minerals over time. Soil phosphorus is lost from agricultural fields primarily through wind and water erosion. No-till practices prevent soil erosion, which reduces the phosphorus from loading into waterways. Fertilizer placement affects phosphorus loss. Surface application of phosphorus fertilizers increases the …
Targeted Browsing With Goats For Eastern Redcedar (Juniperus Virginiana L.) Control, Alanna M. Hartsfield
Targeted Browsing With Goats For Eastern Redcedar (Juniperus Virginiana L.) Control, Alanna M. Hartsfield
Electronic Theses and Dissertations
As eastern redcedar (ERC) (Juniperus virginiana L.) grassland encroachment progresses, all potential control methods should be explored in the interest of Great Plains grassland health and longevity. Targeted browsing with goats has been proven as an effective control method on some juniper species; however, little is known about its ability to control ERC. These studies intend to mend knowledge gaps of how targeted browsing with goats control ERC by causing tree death without chemicals or machinery. The first study is two 3x3 Latin squares comparing protein-supplemented diets. The second study is a randomized complete block design of five 0.224 ha …
Regulatory Roles Of An Atypical Ubiquitin Ligase Ube2o In Orphans Of Multi-Protein Complexes For Degradation, Yi Lv, Feiyue Xing
Regulatory Roles Of An Atypical Ubiquitin Ligase Ube2o In Orphans Of Multi-Protein Complexes For Degradation, Yi Lv, Feiyue Xing
Turkish Journal of Biology
UBE2O as an atypical ubiquitin-conjugating enzyme possesses an E2-E3 hybrid enzyme activity. It can regulate substrate levels or transcriptional activities by cooperating with other E3 ubiquitin ligases or forming homomeric complexes displaying intrinsic E2 and E3 activities. UBE2O controls the quality of cell proteome including protein degradation, modification, transport and location. Recent studies reveal that UBE2O plays a vital role in intracellular protein ubiquitination processes by regulating BMP/SMAD, TRAF/ NF-κB, mTOR/HIF1a and IL-1ß/IRAK4 signaling pathways, c-Maf stability and BAP1 subcellular location, which is proposed as a quality control supervisor of multiprotein complexes for degradation. Its abnormality leads to a variety …
Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan
Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan
Turkish Journal of Biology
Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …
Palmitic Acid Declines Glucose Uptake In Hepg2 Cells Via Modulating Phosphoglucomutase 1 To Repress Phosphatidylinositol 3 Kinase/Protein Kinase B And Jnk Pathways Via Inducing Microrna-124-3p, Linghui Zhang, Shengli Zhang
Palmitic Acid Declines Glucose Uptake In Hepg2 Cells Via Modulating Phosphoglucomutase 1 To Repress Phosphatidylinositol 3 Kinase/Protein Kinase B And Jnk Pathways Via Inducing Microrna-124-3p, Linghui Zhang, Shengli Zhang
Turkish Journal of Biology
Diabetes resulting from insufficient insulin secretion or insulin resistance (IR) is a highly prevalent metabolic disease. Since microRNAs have been linked with elevated IR, the current research hypothesized that miR-124-3p has a role in IR and the establishment of IR and type 2 diabetes (T2DM). The study aimed to explore the molecular mechanisms of miR-124-3p which influence IR leading to T2DM establishment. HepG2 cells were cultured in vitro, and palmitic acid (PA) was used to construct the IR cell model. In the IR model, transfection of miR-124-3p or phosphoglucomutase 1 (PGM1) linked plasmids were transfected into HepG2 cells. RT-qPCR was …
Enlightening The Molecular Mechanisms Of Type 2 Diabetes With A Novel Pathway Clustering And Pathway Subnetwork Approach, Burcu Güngör, Mi̇ray Ünlü Yazici, Gökhan Göy, Mustafa Temi̇z
Enlightening The Molecular Mechanisms Of Type 2 Diabetes With A Novel Pathway Clustering And Pathway Subnetwork Approach, Burcu Güngör, Mi̇ray Ünlü Yazici, Gökhan Göy, Mustafa Temi̇z
Turkish Journal of Biology
Type 2 diabetes mellitus (T2D) constitutes 90% of the diabetes cases, and it is a complex multifactorial disease. In the last decade, genome-wide association studies (GWASs) for T2D successfully pinpointed the genetic variants (typically single nucleotide polymorphisms, SNPs) that associate with disease risk. In order to diminish the burden of multiple testing in GWAS, researchers attempted to evaluate the collective effects of interesting variants. In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need …