Life Sciences Commons^™

New Natural Compound Inhibitors Of Pdgfra (Platelet-Derived Growth Factor Receptor Α) Based On Computational Study For High-Grade Glioma Therapy, Wenzhuo Yang, Shengnan Wang, Xiangmao Zhang, Hu Sun, Menghan Zhang, Hongyu Chen, Junxiang Cui, Jinyang Li, Fei Peng, Mingqin Zhu, Bingcheng Yu, Yifan Li, Liu Yang, Wanwan Min, Mengru Xue, Lin Pan, Hao Zhu, Bo Wu, Yinghao Gu

Children’s Nutrition Research Center Staff Publications

Background: High-grade glioma (HGG) is a malignant brain tumor that is common and aggressive in children and adults. In the current medical paradigm, surgery and radiotherapy are the standard treatments for HGG patients. Despite this, the overall prognosis is still very bleak. Studies have shown that platelet-derived growth factor receptor α (PDGFRA) is an essential target to treat tumors and inhibiting the activity of PDGFRA can improve the prognosis of HGG. Thus, PDGFRA inhibitors are critical to developing drugs and cancer treatment.

Objective: The purpose of this study was to screen lead compounds and candidate drugs with potential inhibitors against …

Bibliometric And Visual Analysis Of Research On The Links Between The Gut Microbiota And Pain From 2002 To 2021, Menghan Mao, Yanyu Zhou, Yingfu Jiao, Suqing Yin, Chiwai Cheung, Weifeng Yu, Po Gao, Liqun Yang

Children’s Nutrition Research Center Staff Publications

Background and aims: The gut microbiota is involved in the regulation of pain, which is proved by plenty of evidence. Although a substantial quantity of research on the link between the gut microbiota and pain has emerged, no study has focused on the bibliometric analysis of this topic. We aim to present a bibliometric review of publications over the past 20 years and predict research hot spots.

Methods: Relevant publications between 2002 and 2021 were extracted from the Science Citation Index-Expanded (SCI-EXPANDED) of the Web of Science Core Collection (WoSCC) database on April 22, 2022. CiteSpace (version 5.8 R3c), VOSviewer, …

Developing And Predicting Of Early Mortality After Endovascular Thrombectomy In Patients With Acute Ischemic Stroke, Yimin Chen, Sijie Zhou, Shuiquan Yang, Mohammad Mofatteh, Yuqian Hu, Hongquan Wei, Yuzheng Lai, Zhiyi Zeng, Yajie Yang, Junlin Yu, Juanmei Chen, Xi Sun, Wenlong Wei, Thanh N Nguyen, José Fidel Baizabal-Carvallo, Xuxing Liao

Children’s Nutrition Research Center Staff Publications

Background: Stroke is one of the leading causes of mortality across the world. However, there is a paucity of information regarding mortality rates and associated risk factors in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT). In this study, we aimed to clarify these issues and analyzed previous publications related to mortality in patients treated with EVT.

Methods: We analyzed the survival of 245 consecutive patients treated with mechanical thrombectomy for AIS for which mortality information was obtained. Early mortality was defined as death occurring during hospitalization after EVT or within 7 days following hospital discharge from the …

Knowledge, Attitudes And Practices Of Us-Based Registered Dietitians Regarding Vitamin D As A Key Nutrient In Public Health, Karen S. Basedow

UNF Graduate Theses and Dissertations

Abstract

The purpose of this study was to determine the knowledge, attitude and behavior influences of Registered Dietitians (RDNs) regarding Vitamin D (VD). An electronic questionnaire served as the data collection tool developed using previously validated questions and supplemented with behavior construct questions. Content and face validity was assessed by an expert panel; internal consistency was assessed using Cronbach’s Alpha. Scores were assessed for knowledge to determine dietitian awareness and competency about VD, attitudes of RDNs regarding importance and practices around VD, and influences on RDN behavior including by other healthcare providers (HCP). Relationships between scales for knowledge, attitude and …

Conditioned Territory Defense In Madagascar Hissing Cockroaches (Gromphadorhina Portentosa), Macy R. Albaitis

Honors Theses

In male blue gourami fish (Trichogaster trichopterus), signaled presentation of a male rival produces an aggressive conditioned response that results in an increased likelihood of the male winning the contest (Hollis, 1984). I replicated this classic study in a species that also shows territorial aggression: the Madagascar hissing cockroach (MHC; Gromphadorhina portentosa). During training, four adult male MHCs were designated as “CS+” animals and received a light (NS) followed by visual access to a rival male (US). Simultaneously, another group of four adult male MHCs designated as “UNC” animals received the light (NS) and visual access to a …

Mthfr C677t Mutation Affects Adipogenic Differentiation Abilities Of Human Bone Marrow-Derived Mesenchymal Stem Cells, Rengi̇m Vural, Di̇cle Çeli̇k, Ersi̇n Berkay Peker, Eki̇n Köni̇, Ayşe Aydanur Kulaç, Zeynep Tokcaer Keski̇n

Turkish Journal of Biology

The effects of 5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) viability, morphology, physiology and differentiation capacity were investigated in this study. For this purpose, primary hBM-MSCs with wild type (WT, C/C), heterozygote (HTZ, C/T) and homozygote (HMZ, T/T) for the MTHFR gene were obtained with ethical committee permission and donor informed. Mutations were detected using RFLP and Sanger sequencing methods from genomic DNA isolated from cells, colonization properties were investigated by CFU-F test and proliferative differences were investigated by MTT test. Adipogenic, osteogenic, and chondrogenic differentiation were induced to study changes in their differentiation …

The Investigation Of Diverse Physiological And Therapeutic Impact Of Cellular-Based Products Derived From Human Cumulus Cells, Derya Burukçu, Sema Yilmaz, Oya Alagöz, Cumhur Kaan Yaltirik, Neci̇p Erkut Attar, Fi̇kretti̇n Şahi̇n, Esra Aydemi̇r Çoban

Turkish Journal of Biology

Particular somatic cells, namely cumulus cells (CCs) that support the oocyte maturation, fertility, and viability by providing the nutrients and energy to the oocyte envelop the mammalian oocyte. In this study, discarded human cumulus tissues were used to reveal the value of hyaluronic acid-rich CCs on several cellular events, including differentiation. Conditioned media, recovered from the primary culture of CCs, were introduced to the human nucleus pulposus cells (hNPCs) which were functionally distorted because of the loss of chondrogenecity. Enlightening the impact of cumulus conditioned media (CCM) on wound healing and angiogenesis was also investigated. In line with these goals, …

Climate Change And Environmental Sustainability Module: Information Booklet, Fozia Parveen, Sara Hassan, Subhan Khan

Books

No abstract provided.

Sentience In Decapod Crustaceans: A General Framework And Review Of The Evidence, Andrew Crump, Heather Browning, Alex Schnell, Charlotte Burn, Jonathan Birch

Animal Sentience

We outline a framework for evaluating scientific evidence of sentience, focusing on pain experience. It includes eight neural and cognitive-behavioural criteria, with confidence levels for each criterion reflecting the reliability and quality of the evidence. We outline the rationale for each criterion and apply our framework to a controversial sentience candidate: decapod crustaceans. We have either high or very high confidence that true crabs (infraorder Brachyura) satisfy five criteria, amounting to strong evidence of sentience. Moreover, we have high confidence that both anomuran crabs (infraorder Anomura) and astacid lobsters/crayfish (infraorder Astacidea) meet three criteria—substantial evidence of sentience. The case is, …

Newsletters, Photos, & Articles June 2021-May 2022, Mandarin Garden Club

Mandarin Garden Club Scrapbooks

Scrapbook includes images, club news and news clippings. Newsletters housed separate. Cover material: Plastic. Size: 11.75" x 10.75" x 2.0625".

Impacts Of Covid-19 On Global Healthcare Management And Research, Stephanie Autore, Santanu De

Biology Faculty Articles

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic has affected most nations at all levels of functioning, individual to governmental. Therefore, it is imperative to evaluate the effects the virus has had on one of the most important socioeconomic global sectors, healthcare. This literature review explores key, recent research and management strategies that have been undertaken in healthcare systems around the world in order to make meaningful attempts at identifying the etiology, diagnosis, and treatment of the disease, and combating the spread of this deadly virus. Healthcare facilities have implemented a variety of changes, all geared towards reducing non-emergency patient visits …

Zebra Mussel Length-Weight Relationships Across Various Substrate Types In Lake Bemidji, Mitch Kehne

Journal of Earth and Life Science

As of November 2021, zebra mussels were confirmed in 270 Minnesotan lakes with another 232 lakes listed as infested due to their connection or proximity to where zebra mussels have been found. With lack of effective treatments to impede their spread, zebra mussels continue to colonize new areas causing ecological as well as economic harm. The goal of this study was to establish a length-weight relationship for the zebra mussel population in Lake Bemidji using shell length (SL) and wet weight (WW), as well as to assess substrate type and log transformed shell length as predictors of log transformed zebra …

Changes In The Minnesota Northern Pike Population Over The Past Thirty Years, Joey Severin

Journal of Earth and Life Science

Northern pike Esox lucius are one of the most popular game fish in Minnesota. Many anglers have noticed that northern pike seemed to decrease in size throughout much of this state. Catch per unit of effort (CPUE) drives average weight for northern pike; within lakes, as CPUE goes up average weight decreases. Decreases in size has led the Minnesota Department of Natural Resources (MNDNR) to implement new regulations on northern pike. The MNDNR noticed that not all the state has this same problem with Northern Pike, and has broken down the state into three zones, with different protected slots and …

Evaluating The Effects Of Mechlorethamine On The Dermal-Epidermal Junction, Trishaal Janardhanam Raghavendra Rao

Theses and Dissertations

Sulfur Mustard (SM) is a chemical warfare agent first utilized on the battlefield more than 100 years ago. To the present time, no antidote to combat the dermatotoxicity of SM exists. Mechlorethamine (HN2) is a derivative of SM which is used in anticancer therapy. Dermal exposure of HN2 is associated with dermal-epidermal junction (DEJ) disruption (vesication) which limits its clinical usefulness. The primary purpose of the present study was to investigate the mechanisms of vesication caused by HN2 using an in vivo mouse ear vesicant model (MEVM). The ears of male or female C57BL/ 6J mice were exposed to a …

Anti-Neuroinflammatory Effects Of Auricularia Polytricha Extracts On Bisphenol A (Bpa)-Induced Microglial Cell Activation And Reduction Of Hippocampal Cell Damage, Chanin Sillapachaiyaporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bisphenol A (BPA) is widely used in the production of polycarbonate plastics, it has been reported that BPA can activate neuroinflammation. Neuroinflammation is a brain pathology that involves the high levels of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α). An excessive TNF-α expression could result in neuronal cell death and subsequently lead to neurodegeneration. Auricularia polytricha (AP) is an edible mushroom with several medicinal properties. Herein, the anti-neuroinflammatory effects of AP extracts against BPA-induced BV2 microglial inflammation were investigated. Hexane (APH) and ethanol (APE) extracts of AP inhibited BPA-induced neuroinflammation in BV2 cells by reducing the expression of pro-inflammatory cytokines. …

Take It With A Grain (Or More) Of Salt: Why Industry-Backed Dietary Guidelines Fail Americans And How To Fix Them, Caroline Farrington

University of Michigan Journal of Law Reform

The U.S. Dietary Guidelines lack oversight and accountability. The result: Guidelines that reflect food industry interests instead of modern science. This deleterious guidance goes on to govern federally-subsidized food assistance programs and to influence dietary choices throughout the private sector and private life. Ultimately, the Guidelines significantly contribute to the endemic chronic disease they seek to address.

The Guidelines Advisory Committee is notoriously rife with conflicts of interest, and thus most Guidelines scholarship has focused on reforming the Committee. But the 2015 and 2020 Guidelines show that these reforms are insufficient and agency-level change is necessary. In 2015, the Committee …

Does Anyone Get Jargon? How Specialized Scientific Terminology Impacts Accessibility And Communication, Rebecca Fenselau

The Synapse: Intercollegiate science magazine

No abstract provided.

Spare Parts, Sophie Lyon

The Synapse: Intercollegiate science magazine

No abstract provided.

Climate Change In Cities: Unique Environmental Problems In Urban Areas, Sydney Rosensaft

The Synapse: Intercollegiate science magazine

No abstract provided.

The Impact Of Not Being Included In The Dsm: The Continuing Fight For Misophones, Ellie Rapp

The Synapse: Intercollegiate science magazine

No abstract provided.

Plastics And Sustainability: A Possibility Contingent On Science And Policy, Julia Guenther

The Synapse: Intercollegiate science magazine

No abstract provided.

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

No Longer A Choice: Veganism And The Dangers Of Animal Product Consumption, Isabella Bacon

The Synapse: Intercollegiate science magazine

No abstract provided.

A Billion-Dollar Flight Ticket: The Race For Recreational Space Exploration And Experiences, Emma Rekate

The Synapse: Intercollegiate science magazine

No abstract provided.

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

The Synapse 31

The Synapse: Intercollegiate science magazine

No abstract provided.

Project Icebreaker Winds: Using Lake Erie’S Winds For Sustainable Energy, Sydney Rosensaft

The Synapse: Intercollegiate science magazine

No abstract provided.

Nowhere To Come Up For Air: Air Pollution And Environmental Racism In The U.S., Rebecca Fenselau

The Synapse: Intercollegiate science magazine

No abstract provided.

The Synapse 30

The Synapse: Intercollegiate science magazine

No abstract provided.

Math’S Melody And Music’S Order: The Dihedral Group Of Order 24 And Music, Norah Han

The Synapse: Intercollegiate science magazine

No abstract provided.