Life Sciences Commons^™

A Review Of Mockingbird Song, Jacqueline Milander

Student Theses

The northern mockingbird (Mimus polyglottos) is known for its large repertoire and highly versatile song patterns.  It is a frequent mimic that is thought to continue learning sounds from its environment for the duration of its life.  Utilizing available song studies, this is a comprehensive review of northern mockingbird song, including learning, mimicry, repertoires, song dependence on seasonal cyclicity, and song function, particularly interspecific territoriality. While much discussion has surrounded the idea that northern mockingbirds engage in interspecific territoriality and that vocal mimicry functions in intersexual selection, this review provides new insight into the possibility that latitudinal differences among populations …

Induced Degradation Of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras, Victoria Saca

Student Theses and Dissertations

G protein-coupled receptors (GPCRs) are a family of heptahelical transmembrane proteins that can modulate various cellular signaling pathways and therefore are attractive drug targets. Despite high mutational rates of GPCRs in cancer there are few oncology FDA-approved anti-GPCR drugs, leaving a gap in the therapeutic landscape. Drug discovery platforms such as targeted protein degradation (TPD), provide opportunities to target oncogenic proteins by direct modulation of protein expression. TPD methodologies can be used to target oncogenic GPCRs that are overexpressed or constitutively active, as in the case of constitutively active mutants (CAMs), which have roles in cancer progression. TPD methods include …

Evolution Of A Novel Neuronal Sex-Specifically Spliced Gene In Mosquitoes, Yael Norohasimbola Tsitohay

Student Theses and Dissertations

Female mosquitoes from many species require a blood meal from an animal host as a protein source for egg development and successful reproduction. The majority of mosquito species are generalists in their host preference, feeding on a range of animals including mammals, birds, and amphibians. However, a small fraction of mosquito species have evolved a preference for human hosts. These species are mainly found in the genera Aedes, Culex, and Anopheles, and they have created a global health crisis due to their ability to transmit deadly human pathogens including dengue virus, Zika virus, West Nile Virus, and …

Reproductive Success Is Secured By A Rapidly-Evolving Short Peptide In Female Aedes Aegypti Mosquitoes, Priyanka Lakhiani

Student Theses and Dissertations

The mosquito lineage spans hundreds of millions of years of evolution, and this period has honed the yellow fever mosquito, Aedes aegypti, into a precise and expert predator. While nectar and plant-derived carbohydrates are sufficient sources of nutrition to maintain energy and metabolism, female mosquitoes must acquire multiple ingredients to successfully reproduce and produce offspring. Healthy, motile sperm from a conspecific male and a complete blood meal from a human host are required for females to develop viable eggs, and thus ensure species survival. What are the internal mechanisms that coordinate the acquisition of these key elements with the maturation, …

Ancient Immune Systems: Sensing And Signaling In Bacterial-Phage Conflict, Cameron Grace Roberts

Student Theses and Dissertations

Viruses are among the most significant selective pressures shaping the evolution of life on Earth. In the microbial world, bacteriophages (phage) are bacterial viruses and drive a continuous evolutionary arms race that has led to an extraordinary diversity of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous eukaryotic immune strategies [2]. Experimental studies have validated many of these anti-phage defense systems and revealed the mechanisms by which they disrupt phage infection [3]. Nonetheless, major gaps persist in our understanding of how bacterial immune systems recognize bacteriophage infection to trigger immunity. This dissertation …

The Influence Of Dna Methylation On Both H2a.Z Nucleosome Dynamics And The Zinc Finger And Homeoboxes Transcription Factor Family, Rochelle M. Shih

Student Theses and Dissertations

DNA methylation represents a widespread and heritable modification that exerts substantial influence on chromatin organization and function in many eukaryotic genomes. The presence of DNA methylation has been strongly linked to transcriptional regulation, in both activating as well as repressive ways, though exactly how a small chemical mark can enact such drastic and seemingly opposing effects on gene expression remains an open question. In my thesis work, I describe the influence DNA methylation has on two classes of chromatin proteins, the histone variant H2A.Z and the Zinc Finger and Homeoboxes (ZHX) family of transcription factors. DNA methylation and H2A.Z preferentially …

The Reinnervation Of Sensory Hair Cells Following Lesion Of The Lateral Line Cranial Nerve, Rohan S. Roy

Student Theses and Dissertations

Loss of hearing is a prevalent sensory pathology in the United States and worldwide. A significant proportion of deafness is attributed to sensorineural hearing loss, which often involves damage and retraction of the nerve fibers that relay auditory information between the mechanosensitive hair cells of the inner ear and the brain. The restoration of physiologic hearing would require the regeneration of nerve fibers back into the sensory epithelium of the cochlea, followed by the reinnervation of appropriate hair cell targets. Nerve regeneration studies in humans and other mammalian models are lacking due to the limited accessibility of the inner ear. …

Structural And Functional Studies Of The Sars-Cov-2 Niran Domain, Gabriel I. Small

Student Theses and Dissertations

The COVID-19 pandemic was a dramatically disruptive event, wreaking devastation across the globe and radically impacting nearly every facet of human life. For the first time, a significant amount of global money and attention was directed at coronavirus (CoV) research, propelling the field to the forefront of biomedical research. This allowed for the rapid development of a suite of vaccines and antivirals targeting SARS-CoV-2 that aided in ameliorating the effects of the pandemic. SARS-CoV-2 was the third CoV zoonosis of the 21st century and is now endemic. Global understanding of the threats posed by CoVs circulating among animals in the …

Dining In The Dark Atp Sensing In The Female Aedes Aegypti Mosquito, Katherine Adriana Rosas Villegas

Student Theses and Dissertations

Blood feeding is fundamental for female Aedes aegypti mosquitoes, which require this protein-rich meal for egg development. After being attracted to a human host by sensory cues such as body odor, body heat, and carbon dioxide exhaled in human breath, the mosquito lands and probes under the skin to feed on blood. Probing uses the stylet, a sharp appendage ensheathed in the mosquito labium that punctures the skin and is highly specialized for blood ingestion. Previous work from the lab with GCaMP calcium imaging of stylet neurons showed that approximately 50% of stylet neurons respond to blood, and that these …

Investigations Into Why Human (But Not Mouse) Ku70/80 Is Essential Reveal A Role For Human Ku70/80 In Ribosome Biogenesis, George Zakusilo

Student Theses and Dissertations

The requirement of Ku70/80 for ribosome biogenesis in higher primates explains otherwise perplexing essential nature of this double-strand break (DSB) repair factor. We have ruled out telomere protection or DSB repair as the essential function ofKu70/80. Instead, unbiased genome-wide analyses pointed to a role in ribosome biogenesis. Human Ku70/80, but not mouse Ku70/80 is enriched in the nucleolus at the Dense Fibrillar Component (DFC) periphery, likely via co-evolved protein-protein interactions with nucleolar factors. Consistent with its localization in the nucleolus, human Ku70/80 null cells exhibit ribosomal RNA (rRNA) processing defect and consequent shutdown of protein synthesis offer a direct explanation …

Beef Cattle Producers’ Knowledge About And Preferences For Carbon Contracts, Zuyi Wang, Anastasia W. Thayer, Felipe De Figueiredo Silva, Michael Vassalos, Jordan M. Shockley, Nathan Smith

Agricultural Economics Faculty Publications

Carbon contracts have gained attention as a way to incentivize carbon-emissions reduction for the agricultural sector, particularly among beef-cattle producers.

Our study utilized data from a survey of 222 beef cattle producers in the southeastern United States to examine their knowledge, perceptions, and preferences regarding carbon contracts.

Survey respondents demonstrated a lack of accurate knowledge about carbon markets and contract specifications, with many overestimating the price of carbon.

Among the most common barriers to signing contracts were the cost of altering practices, the duration, and insufficient payments.

Further, our results indicated that producers require an additional $103.74/hectare ($42/acre) to accept …

The Complexities Of The Bilingual Advantage, Melisa Sierra

Behavioral Neuroscience Honors Papers

The bilingual advantage hypothesis, which proposes an enhancement of executive functions in bilinguals, remains heavily debated with inconsistent findings across studies. This study investigated working memory performance in bilingual and monolingual young adults using a modified n-back task with an interruption while recording EEG activity. Participants completed 1-back, 2-back, and 3-back conditions across the pre-interruption phase and a post-break 2-back condition. Behavioral measures (accuracy and response times) were analyzed alongside ERP, focusing on P300 and sustained activity components, were analyzed. Results showed a decrease in accuracy as task difficulty increased from 1-back to 3-back, indicating the expected effects of higher …

Building Public Health Data Dashboards: Tutorial Playbook, Elwin Wu, Raymond Balise, Benjamin Katz, Daniel R. Harris, Matthew Bullard, Naleef Fareed, Marc Larochelle, Jennifer Villani

Institute for Biomedical Informatics Faculty Publications

Public health data dashboards have substantial potential to improve transparency, understanding, and decision-making at multiple levels, from individuals to public health practitioners and policymakers. However, creating effective dashboards presents many challenges. In this case-based tutorial on public health dashboard development, we share lessons learned from our experience developing data dashboards for the HEALing Communities Study (HCS), a National Institutes of Health (NIH)–funded, community-engaged intervention to deploy evidence-based practices to reduce opioid overdose deaths in 67 communities across 4 states. We present key decision points dashboard teams must address, along with the major considerations and trade-offs that shaped our approach. First, …

Rewilding The Coral Reefs, Magali Rodriguez, Luciana Alvillar

Posters - 2026

Coral reefs are among the most valuable ecosystems globally, contributing an estimated $10 trillion annually and supporting hundreds of millions of people through food, livelihoods, and coastal protection. (NOAA 2026) They also provide critical habitat for diverse marine species. However, reefs are rapidly declining due to rising ocean temperatures, acidification, pollution, invasive species, and physical disturbances. Globally, 30–50% of coral reefs have already been lost(NOAA 2026), and without intervention, many may face extinction by the end of the century. Rewilding and restoration efforts have become essential strategies to address this crisis. Initiatives such as NOAA’s Coral Reef Conservation Program highlight …

Greenhouse Gas Report For Western Australian Wild-Catch Fisheries And Aquaculture 2004-2025, Christophe D'Abbadie, Johnny Machon, Dipesh Maharjan, Mark Goninon, Pia Dobson, Jason How, Rodney Duffy Dr., Ainslie Denham, Shaye Carman, Trina Anderson

Climate Science Published Reports

This report provides a comprehensive analysis of greenhouse gas (GHG) emissions from Western Australian wild-catch fisheries and aquaculture for the fiscal years (FY) 2004/05 to 2024/25. These industries represent important components of the Western Australian primary production sector, with distinct emissions profiles and trends.

Key Findings:

Emissions from wild-catch fisheries have declined significantly over time, from approximately 0.341 million tonnes of carbon dioxide equivalent (Mt CO₂e) in FY 2004/05 to 0.136 Mt CO₂e in FY 2024/25, a reduction of approximately 60%.

Emissions from aquaculture in FY 2024/25 were approximately 0.350 Mt CO₂e, reflecting substantial industry growth from near-negligible levels in …

Impacts Of Native And Nonnative Plant Species On Avian Community Diversity, Matty John Mackay, Steven Van Dang, Brandon Lee Corn

SPARK Symposium Presentations

Avian communities play an essential role in maintaining a healthy ecosystem dynamic by regulating insect populations, assisting in plant pollination, and seed dispersal. These contribute to the overall health of natural ecosystems and mitigate ecological disruptions that would arise in their absence. However, the introduction of non-native invasive plant species can interrupt the balance avian communities bring to ecosystems by reducing availability of food sources, altering habitat structures, increasing competition among individuals, and disrupting ecological relationships through rapid invasion of ecological spaces. Point count observations of birds at Shelby Bottoms Park, Nashville, Tennessee in areas dominated by non-native privet and …

Leveraging Research-Based Knowledge Translation Via Rural Libraries To Improve Maize Postharvest Practices In Uganda, Jackline Estomihi Kiwelu, Patrick Ngulube

Libraries

Background: Rural community libraries are increasingly recognised for providing localised knowledge, yet their potential to support agricultural extension services and improve access to postharvest knowledge in Uganda remains underexplored.
Objectives: This study examined the postharvest information needs of smallholder maize farmers and explored how community libraries can be leveraged to translate and repackage research-based knowledge to meet these needs.
Method: A mixed-methods parallel design was employed. Data were collected from a survey of 312 maize farmers, personal interviews and two focus group discussions (FGDs) with 22 extension workers and four librarians. Desk research was conducted to analyse relevant documents. Quantitative …

Chronic Alcohol Consumption Enhances The Differentiation Capacity Of Hematopoietic Stem And Progenitor Cells Into Osteoclast Precursors, Hami Hemati, Madison B. Blanton, Jude Koura, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Chronic alcohol consumption (CAC) is associated with an enhanced risk of bone fracture, reduced bone density, and osteoporosis. In a rhesus macaque model of voluntary ethanol consumption, CAC induces functional, transcriptomic, and epigenomic changes in hematopoietic stem and progenitor cells (HSPCs) and their resultant monocytes/macrophages, skewing them toward a hyper-inflammatory response. In the present study, those studies were extended to investigate alterations in osteoclast development, which, in postnatal life, differentiate from HSPCs and play a critical role in maintaining bone homeostasis. Spectral flow cytometry revealed a skewing of HSPCs toward granulocyte-monocyte progenitors in the CAC group, consistent with an increased …

Chronic Alcohol Consumption Reprograms Osteoclast Lineage Communications To Promote Osteoclastogenesis, Hami Hemati, Brianna M. Doratt, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Chronic alcohol consumption increases the risk of osteoporosis and fracture by disrupting bone remodeling, in part by enhancing osteoclastogenesis. However, the cellular mechanisms underlying this process remain incompletely defined. We analyzed scRNA-seq data from osteoclasts differentiated in vitro from bone marrow mononuclear cells obtained from macaques following 12 months of chronic ethanol or isocaloric control solution consumption. Module scoring, trajectory inference with generalized additive modeling (tradeSeq), and CellChat-based analyses of intercellular communication were applied to uncover ethanol-induced changes in metabolic reprogramming, lineage progression, and signaling network dynamics. Module scoring indicated metabolic reprogramming toward oxidative phosphorylation, with reduced glycolytic, migratory, and …

Alcohol Consumption Exacerbates High-Fat Diet- Mediated Disruptions In Myelopoiesis And Osteoclastogenesis In Mouse Models Of Metabolic Dysfunction-Associated Liver Diseases, Hami Hemati, Madison B. Blanton, Lauren Rutt, Nicholas Keiran, Rebecca Geron, Florence Lima, Rebecca L. Mccullough, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Objective: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Alcohol-related Liver Disease (MetALD) exhibit systemic immune abnormalities. Given that such immune dysregulation is closely linked to the skeletal complications frequently observed in MASLD and MetALD, we sought to comprehensively characterize the bone marrow hematopoietic compartment and its link to osteoclastogenesis.

Methods: We utilized bone marrow from mouse models of MASLD (high-fat diet, HFD) and MetALD (high-fat diet plus ethanol, HFD+EtOH), followed by flow cytometric analysis to phenotype hematopoietic stem and progenitor cells (HSPCs), as well as in vitro and in vivo assays to evaluate osteoclastogenesis.

Results: We found that …

Assessing Radio Transmitter Weight Effect And Evaluation Of Northern Bobwhite Chick Survival In Coastal North Carolina, Autumn S. Randall, Theron M. Terhune Ii, Matthew T. Springer, Darin J. Mcneil

Forestry and Natural Resources Faculty Publications

Studies on the earliest life stages are essential to our ecological understanding of avian demography; however, monitoring technologies that allow tracking of small birds are still limited in a variety of ways. One critical limitation, until recently, has been the development of methods for attaching transmitters to young birds with precocial development (e.g., Galliformes, Charadriiformes, etc.). The modified suture technique offers a means to attach transmitters to precocial chicks while accommodating rapid growth characterized by birds with precocial young. Although the sutured transmitter method was developed for northern bobwhite (Colinus virginianus) chicks, there remain key unknowns regarding best …

Aggregation Bias In Multi-Industry Economic Contribution Analysis: The Case Of Kentucky Forest Sector, Domena A. Agyeman, Thomas Ochuodho, Omkar Joshi

Forestry and Natural Resources Faculty Publications

Closely related industries are often aggregated in US forest sector economic contribution analysis, yet the choice of aggregation scheme can influence results. The Impact Analysis for Planning (IMPLAN) system is the most widely applied input–output model for forest economic contribution analysis in the US. In IMPLAN, the level of industry aggregation determines which inter-industry transactions are restricted, thereby influencing the magnitude of estimated indirect and induced effects. Although IMPLAN practitioners can model individual industries to avoid aggregation bias, they must still decide whether to analyze forest industries as a single group, as traditional subsectors, or individually. This decision can alter …

Effects Of Headwater Wetland Restoration On The Demography, Fecundity And Ecology Of The U.S. Federally Threatened White Fringeless Orchid (Platanthera Integrilabia) In The Cumberland Plateau Of Kentucky, Tara R. Littlefield, Catherine Hoy, Christopher Barton

Forestry and Natural Resources Faculty Publications

Wetland habitats represent a critical component of biodiversity hotspots that support numerous rare species, including terrestrial orchids. In North America, over half of all terrestrial orchids are found in wetlands, more than a quarter of which are now threatened with extinction (G1–G3). This concerning trend is exacerbated by a lack of information on effective restoration strategies aimed at orchids and other species that inhabit these areas. The white fringeless orchid, Platanthera integrilabia (Correll) Luer, the subject of this study, is restricted to mostly shaded wetland habitats along the Cumberland Plateau of the Appalachian Mountains and has suffered widespread declines due …

Fecal Microbiota Transplantation Modulates Gut Microbiota And Lipid Metabolism To Reduce Diarrhea In Low-Birth-Weight Neonatal Calves, Zhanhe Zhang, Duo You, Donglin Wu, Xintong Li, Yang Jia, David L. Harmon, Ming Xu

Animal and Food Sciences Faculty Publications

This study aimed to elucidate the mechanism by which colonic fecal microbiota transplantation (FMT) improves lipid metabolism in low-birth-weight neonatal calves via modulation of the gut microbial ecosystem. In a completely randomized design, seventy newborn Holstein calves (1 day old, 32.63 ± 3.13 kg BW) were assigned to two groups (35 calves/treatment; 30 females and 5 males per group). A healthy calf was used as a fecal donor. A 10% fecal bacterial suspension was prepared and administered colonically (50 mL, twice daily for 5 days). All calves were fed the same milk replacer and weaned using a step-down protocol at …

A Rare Case Of A Silent Pheochromocytoma Concomitant With An Incidentally Found Small Bowel Carcinoid Tumor, Michael Salzle, Anna Szafran-Swietlik, Tobias Carling

West Florida Division GME Research Day 2026

No abstract provided.

Bpa: Effects Of The "Plastic Era", Bianca G. Pietrangeli

Student Work

Infographic review of sources of BPA and its impacts on human health with a focus on osteoporosis.

Wet Aging And Internal Endpoint Cooking Temperature Influence Color Of Lamb Longissimus Lumborum Muscle, Oluwatobi M. Ogunsola

Theses and Dissertations--Animal and Food Sciences

Color is a critical quality attribute that influences consumer purchase decisions for fresh and cooked lamb and is governed by myoglobin's redox chemistry. Wet aging is commonly used to enhance lamb tenderness, while endpoint cooking temperature is the primary determinant of internal cooked color. However, the combined effects of these factors on the color stability of the lamb longissimus lumborum (LL) muscle during refrigerated storage remain unclear. The objective of this thesis was to evaluate the effect of wet aging duration on the color attributes and lipid oxidation of fresh lamb LL chops and endpoint cooking temperature and refrigerated storage …

Trustworthy Multimodal Ai For Medical Imaging: Enhancing Diagnosis, Reasoning, And Human-Agent Interaction In Extended Reality, Jai Prakash Veerla

Computer Science and Engineering Dissertations

The transition from traditional microscopy to digital pathology has digitized diagnostic data, yet clinical workflows remain constrained by two-dimensional screens and passive, opaque analysis tools that fail to capture the spatial complexity of biological systems. While Foundation Models now promise to reason across histology and genomics, a critical disconnect persists between the richness of this data and the limited cognitive bandwidth of clinicians, who currently lack the immersive interfaces and trustworthy agents necessary to utilize it effectively. This dissertation presents a unified framework for "Embodied Agentic AI," establishing a pipeline that augments physician capabilities through immersive visualization, robust security, and …

Toxic Torts Are In Your Blood: An Examination Of Pfas And Tort Liability, Aiden M. Holden

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Abstract

Per- and polyfluoroalkyl substances (PFAS), are a group of chemicals widely manufactured for industrial and commercial applications in the past decade due to their remarkable stability. Despite the “useful” nature of PFAS in various applications, they represent one of the most profound environmental and public health crises of the modern era. The chemical stability of PFAS has made them almost completely resistant to natural degradation, earning them the moniker “forever chemicals.” PFAS forever haunt our plant, contaminating the soil, water, and the blood of approximately 95% of the United States population. As the scale of corporate malfeasance by chemical …

Know Fear: The Culture Of Fear In Community Conversations, Penelope Meredyk, Lotus Porte-Moyel, Fiona Carson, Cosley Bruno, Barrett Clement, Sophia Sproull, Morgan Davis

Undergraduate Theses, Professional Papers, and Capstone Artifacts

“K(no)w Fear” is an award winning piece of verbatim theater based on word-for-word interviews and collected research that's goal was to cultivate a connective and thoughtful community open to exploring what shapes us all: fear. Our GLI Capstone team gathered the resources for this theater piece by conducting interviews with a mixed demographic of people we know as well as strangers on the street, asking questions like: “How do you feel about death?” and “If fear were a place for you, where would it be?” With consent, their answers were used to build an immersive, verbatim theatre piece where actors …