Life Sciences Commons^™

Efficacy And Safety Of Enasidenib And Azacitidine Combination In Patients With Idh2 Mutated Acute Myeloid Leukemia And Not Eligible For Intensive Chemotherapy, Sangeetha Venugopal, Koichi Takahashi, Naval Daver, Abhishek Maiti, Gautam Borthakur, Nicholas J Short, Lucia Masarova, Ghayas Issa, Xuemei Wang, Bueso-Ramos Carlos, Musa Yilmaz, Tapan Kadia, Michael Andreeff, Farhad Ravandi, Marina Konopleva, Hagop M Kantarjian, Courtney D Dinardo

Faculty, Staff and Student Publications

Preclinically, enasidenib and azacitidine (ENA + AZA) synergistically enhance cell differentiation, and venetoclax (VEN), a small molecule Bcl2 inhibitor (i) is particularly effective in IDH2 mutated acute myeloid leukemia (IDH2mutAML). This open label phase II trial enrolled patients (pts) with documented IDH2mutAML. All patients received AZA 75 mg/m2/d x 7 d/cycle and ENA 100 mg QD continuously. Concomitant Bcl2i and FLT3i were allowed (NCT03683433).Twenty-six pts received ENA + AZA (median 68 years, range, 24-88); 7 newly diagnosed (ND) and 19 relapsed/refractory (R/R). In R/R AML patients, three had received prior ENA and none had received prior VEN. The …

Systematic Decomposition Of Sequence Determinants Governing Crispr/Cas9 Specificity, Rongjie Fu, Wei He, Jinzhuang Dou, Oscar D Villarreal, Ella Bedford, Connie Hou, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu

Faculty, Staff and Student Publications

The specificity of CRISPR/Cas9 genome editing is largely determined by the sequences of guide RNA (gRNA) and the targeted DNA, yet the sequence-dependent rules underlying off-target effects are not fully understood. To systematically explore the sequence determinants governing CRISPR/Cas9 specificity, here we describe a dual-target system to measure the relative cleavage rate between off- and on-target sequences (off-on ratios) of 1902 gRNAs on 13,314 synthetic target sequences, and reveal a set of sequence rules involving 2 factors in off-targeting: 1) a guide-intrinsic mismatch tolerance (GMT) independent of the mismatch context; 2) an "epistasis-like" combinatorial effect of multiple mismatches, which are …

Forage Quality Of Cereal–Common Vetch At Different Age And Proportions, J. L. Zaragoza-Ramirez, P. A. Martinez-Hernandez, Ma. De L. Reyes-Medel

IGC Proceedings (1977-2023)

Cereal plant age at harvesting and the proportion of vetch in the harvested forage from cereal-common vetch mixtures might influence total forage quality. The objectives were to determine forage of a forage mixture cereal-vetch, from cereal harvested at two development stages and vetch at different proportion. Cereals were oats and triticale, cultivars: Chihuahua, Bicentenario and Siglo XXI, the last two were triticale; cereal development stages at harvest were: 50% flowering and hard grain. Vetch was harvested at two development stages: 100% flowering and pod formation, while vetch proportions in the forage mix were: 0, 0.25, 0.5, 0.75 and 1.0. Forage …

Forage Yield Of Oat On The Four Altitude Regions Of The Qinghai-Tibetan Plateau, H. B. Zhang, C. T. Liu, J. Q. Deng, X. L. Yang

IGC Proceedings (1977-2023)

Forage oat (Avena sativa L.) for livestock in Qinghai-Tibet Plateau may be used biomass under widely different altitude conditions. To assess the effect of altitude on the biomass of oats, we conducted an experiment to explore the adaptability of forage oat Jiayan No. 2 in different altitudes for better agronomic traits and higher forage yield. Four regions included Hezheng county (2207 m a.s.l) and Tianzhu county (2407 m a.s.l), Gansu province, Haiyan county (3042 m a.s.l), Qinghai province and Hongyuan county (3460 m a.s.l), Sichuan province were selected, and agronomic data as well as dry matter yield were determined. …

Forage Production And Grazing Behaviour Of Beef Cattle In Agrosilvopastoral Systems In Brazil During The Dry Season, M. Pereira, P. Zawada, J. Werner, M. M. Macedo, R. G. Almeida, U. Dickhoefer

IGC Proceedings (1977-2023)

We aimed at evaluating the microclimate, canopy structure, and grazing behaviour of cattle on Brachiaria sp. pastures within continuous pasture (CON), integrated crop-livestock (ICL), and crop-livestock-forestry (ICLF) systems in Brazilian dry season. Forage accumulation was monthly assessed in four paddocks per system from May to August 2019. To characterize the microclimate, air temperature and relative humidity were measured every hour and temperature-humidity index calculated. Grazing behaviour of 12 Nellore heifers per system (mean bodyweight 355 standard deviation±32.6 kg) was recorded by chewing sensors on nine continuous days (1 d adaptation + 8 d measurement) of three 15-d periods. Four animals …

Forage Accumulation And Quality Of Three Contrasting Ecotypes Of Tall Fescue (Schedonorus Arundinaceus) Managed Under Frequent Defoliation, J. Mattera, O. Scheneiter, I. Cattoni, E. Pacente, P. Barletta, O. Bertín

IGC Proceedings (1977-2023)

In the past, tall fescue ecotypes were compared under intermediate management defoliation frequency, but now has station, Argentina (-33 ° 56 'S, -60 ° 33' W) in autumn 2016, on a typical Argiudoll soil. The treatments were cultivars representing three ecotypes of tall fescue: (i) - Mediterranean (cv. Flecha), (ii) - Intermediate (cv. Royal Q 100) and (iii) - Continental (cv. Lujan INTA). Each plot consisted of 7 rows 6.0 m long, 0.2 m apart (8.4m² plot size) arranged in a randomized complete block design with 4 replicates. The first cut was done at the end of September when …

Benefits Of Cover Cropping Systems In Walnut Orchards As Sustainable Agricultural Practice, Ana Medic, Consuelo B. Baez Vega

CSU Journal of Sustainability and Climate Change

In recent years walnut orchards implemented cover crops in between rows to improve soil’s quality, lessen soil’s erosion, increase organic matter, manage nutrient movement and availability, enhance water retention, and expand microbe, insect, and flora diversity. Commonly selected cover crops in California are from families Poaceae, Brassicaceae, and Fabaceae. Considerations should be made when choosing a particular cover crop mixture to enhance multiple benefits and improve sustainable practices in orchard settings. An experiment was conducted in a walnut orchard to compare functionality and benefits of three systems multi-crop, monocrop, and no vegetation cover crop system. The following components were evaluated: …

Sustainable Agriculture Through Data Analytics, Arthur Carlos, Xayaphone Salinthone, Michelle Nguyen, Aimee Jacobs

CSU Journal of Sustainability and Climate Change

There is an increasing need for sustainable agriculture in light of climate change and growing populations. Certified B Corporations meet the highest standards of verified social and environmental performance, public transparency, and legal accountability to balance profit and purpose. This paper describes a student-learning project that develops an Environmental Management System (EMS) using data analytics to improve a family-owned farming business's decision-making process for efficient natural resource allocation, as well as the reporting requirements associated with their B Corp Certification. This project's primary resource is water reporting, but it may be expanded to include other resources.

Use Of Pregnancy Associated Glycoproteins To Determine Fetal Age Throughout Gestation And Clearance Rate In Postpartum Beef Cattle, Adalaide C. Kline, Julie Walker, Taylor N. Andrews, Saulo Menegatti Zoca, Kaitlin M. Epperson, Lacey K. Quail, Jerica J.J. Rich, Jim R. Rhoades, George Perry

SDSU Beef Day 2022 Summary Publication

Study Description:

Previously identified pregnant females from four different herds and postpartum females from one herd were utilized. Blood samples were collected (n = 1,753; study 1) between d 28 and 285 of gestation and (heifers n = 418 and cows n = 657; study 2) once a week for up to 12 weeks after calving. Serum was tested in duplicate using a commercially available blood pregnancy test, IDEXX Alertys Pregnancy Test. In study 1, procedures were modified to allow PAG concentrations to fall within the detectible range of the assay. Data were analyzed using the MIXED procedure of SAS …

Annotated Checklist Of The Avian Species Observed At The Gordon Natural Area (West Chester University, Pa) 2003-2022. Version X, Nur Ritter, Josh R. Auld

Gordon Natural Area Bird Survey Documents

Data from eBird (through 1/24/2022) and from the 2004 West Chester Bird Club Survey of the GNA

Summary Data Number of Surveys: 112 'Site Visits' by 44 Birders. Note: this does not count the birders who participated in the 2004 West Chester Bird Club Survey as participants were not identified by name on the data sheets.

Number of Taxa: 128 Species, in 88 Genera and 38 Families. Years Noted: Although the title suggests that observations began in 2003, data for three species that were seen in the Gordon during 1970 are included here. This inclusion is because one of these …

Gay Anderson – Covid 19 Oral History Project, Gay Anderson, Institute Of Child Nutrition. Child Nutrition Archives.

Oral History Project (all interviews)

During 2022 the Child Nutrition Archives conducted multiple interviews investigating how child nutrition professionals dealt with the Covid 19 pandemic and its effects on the operations of school feeding programs. This interview examines the experiences of Gay Anderson, School Nutrition Director in the Sioux Falls School District in South Dakota. Gay has almost 40 years of experience in food service.

Potential Effectiveness Of Registered Dietitian Nutritionists In Healthy Behavior Interventions For Managing Type 2 Diabetes In Older Adults: A Systematic Review, Laurel Dobrow, Isabella Estrada, Nasira Burkholder-Cooley, John Miklavcic

Food Science Faculty Articles and Research

Purpose: A systematic review was conducted to assess how the involvement of a registered dietitian nutritionist (RDN) in healthy behavior interventions (HBIs) potentially affects outcomes in older adults with type 2 diabetes (T2D).

Methods: Literature was searched for primary research published between 2016 and 2020 on HBI involving a RDN affecting outcomes in older adults with T2D. Evaluations of hemoglobin A1c (HbA1c), blood glucose, blood pressure, cholesterol, anthropometry, body composition, medication usage, healthcare cost, and self-efficacy and/or adherence to healthy behaviors outcomes were selected for inclusion. All the literature included were summarized, evaluated for certainty of evidence criteria, and assessed …

Characterizing The Decision Process In Setting Corn And Soybean Seeding Rates, David A. Hennessy, Alexander J. Lindsey, Yuyuan Che, Laura E. Lindsey, Maninder Pal Singh, Hongli Feng, Elizabeth M. Hawkins, Sakthi Subburayalu, Roy Black, Eric A. Richer, Daniel S. Ochs

Journal of Extension

Selecting optimal corn and soybean seeding rates are difficult decisions to make. A survey of Ohio and Michigan farm operators finds that, although generally keen to learn from others, they tend to emphasize their own experience over outside information sources. Soybean growers declare university and extension recommendations as more important than do corn growers. In response to direct queries and in free comments, growers place more emphasis on understanding the agronomic and technological problems at hand than on adjusting to the market environment. Given the decision environment, we argue that these responses are reasonable.

Cultural Sensitivity: A Requirement When Developing Food Safety Interventions, Lillian Nabwiire, Angela M. Shaw, Gail R. Nonnecke, David D. Minner, Ellen Johnsen, Louis E. Petersen Jr

Journal of Extension

Extension materials that are sensitive to changing demographics and culture increase relevance and compliance with food safety practices. Produce safety extension materials were developed for U.S. Virgin Islands (USVI) produce growers to help with compliance with a new food safety rule. We developed employee training materials based on a needs assessment and behavioral change was evaluated six months after dissemination. The original materials were not seen as culturally appropriate but after modifications, improvements in food safety practices and behavior changes were observed. These results suggest that extension educators should seek feedback from target populations about potential interventions before implementation.

Evolution Of Static Allometry And Constraint On Evolutionary Allometry In A Fossil Stickleback, Kjetil L. Voje, Michael A. Bell, Yoel E. Stuart

Biology: Faculty Publications and Other Works

Allometric scaling describes the relationship of trait size to body size within and among taxa. The slope of the population-level regression of trait size against body size (i.e. static allometry) is typically invariant among closely related populations and species. Such invariance is commonly interpreted to reflect a combination of developmental and selective constraints that delimit a phenotypic space into which evolution could proceed most easily. Thus, understanding how allometric relationships do eventually evolve is important to understanding phenotypic diversification. In a lineage of fossil Threespine Stickleback (Gasterosteus doryssus), we investigated the evolvability of static allometric slopes for nine traits (five …

Forest And Plantation Soil Microbiomes Differ In Their Capacity To Suppress Feedback Between Geosmithia Morbida And Rhizosphere Pathogens Of Juglans Nigra Seedlings, Geoffrey M. Williams, Matthew D. Ginzel

Purdue University Libraries Open Access Publishing Fund

Thousand cankers disease (TCD) is hypothesized to have a greater impact on eastern black walnut (Juglans nigra) in urban forests and plantations compared with natural forest stands. Along with other factors such as resource availability, the phytobiome could partly account for observed differences in disease severity across management regimes. We investigated the extent to which J. nigra-associated soil microbiomes from plantations and natural forests modulate (i) the amount of necrosis caused by Geosmithia morbida in 1-year-old seedlings, and (ii) relative abundance of rhizosphere endophytes and opportunistic pathogens Fusarium and Rhizoctonia in response to aboveground inoculation with G. morbida. Our results …

Influence Of Core Temperature On Psychomotor Performance During Cold Weather Military Training, Douglas Jones, Rebecca Weller, Stephen Eggan, Nicholas Roberts, Weimin Zheng, Jay Heaney, Timothy Dunn

Journal of Human Performance in Extreme Environments

Purpose: Cold environments may deteriorate psychomotor performance due to slowing of neuronal signals, distractions caused by pain and discomfort, and a loss of manual dexterity. The extent to which core temperature (T_c) influences psychomotor performance in the cold has not been established. Therefore, psychomotor performance and T_c were assessed during a cold weather military training exercise to evaluate this relationship.

Methods: Thirty-six military personnel (age: 26 ± 4 yr, ht: 175 ± 8 cm, wt: 79.1 ± 11.1 kg) participating in cold weather training volunteered for this study. Participants completed a 10-min immersion in cold (1°C) water, …

Iam Hiq—A Novel Pair Of Accuracy Indices For Imputed Genotypes, Albert Rosenberger, Viola Tozzi, Heike Bickeböller, Susanne M. Arnold, The Integral-Ilcco Consortium

Markey Cancer Center Faculty Publications

Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental. Several accuracy measures have been proposed and some are implemented in imputation software, unfortunately diversely across platforms. In the present paper, we introduce Iam hiQ, an independent pair of accuracy measures that can be applied to dosage files, the output of all imputation software. Iam (imputation accuracy measure) quantifies the average amount of individual-specific versus population-specific genotype information in a linear manner. …

Fibrogenesis And Adipogenesis In Farm Animals And Rodents, Chaoyang Li

LSU Doctoral Dissertations

In this dissertation, we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on different animal models to help the discovery of new treatments in cardiovascular disease, beef breeding strategies, and feed nutrition modifications.

Wayu, the Japanese Black cow, are well-known for their high IMF content, while the Brahman cattle have much less marbling. The development of IMF correlated with the increase in the size and number of IMF adipocytes, which have identified to be derived from a group of progenitor cells known as fibro/adipogenic progenitor (FAP) cells because of their bipotent differentiation ability. Interestingly, the …

Neutralizing Interleukin-6 In Tumor-Bearing Mice Does Not Abrogate Behavioral Fatigue Induced By Lewis Lung Carcinoma, Kiersten Scott, Thien Trong Phan, A Phillip West, Cullen M Taniguchi, Robert Dantzer

Faculty, Staff and Student Publications

Tumor growth is associated with metabolic reprogramming of various organs including the liver. This metabolic reprogramming is responsible for the development of behavioral fatigue represented by decreased voluntary wheel running in a murine model of lung cancer. To determine whether interleukin (IL-)6 induced by the tumor is responsible for the metabolic reprogramming, mice injected with Lewis lung carcinoma cells in the flank were treated with an anti-mouse IL-6 monoclonal neutralizing antibody using a 2 × 2 factorial design (+/- tumor and +/- anti-IL-6 antibody). Endpoints were represented by behavioral, metabolic and immune phenotypes. Despite its ability to abrogate the increase …

Neuronal Population Activity Dynamics Reveal A Low-Dimensional Signature Of Operant Learning In Aplysia, Renan M Costa, Douglas A Baxter, John H Byrne

Faculty, Staff and Student Publications

Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal shift in module recruitment as the primary signature of operant learning. Our findings can help guide characterization of learning signatures in systems in which only a smaller fraction of the relevant neuronal population …

Iam Hiq-A Novel Pair Of Accuracy Indices For Imputed Genotypes, Albert Rosenberger, Viola Tozzi, Heike Bickeböller, Integral-Ilcco Consortium

Faculty, Staff and Student Publications

BACKGROUND: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental. Several accuracy measures have been proposed and some are implemented in imputation software, unfortunately diversely across platforms. In the present paper, we introduce Iam hiQ, an independent pair of accuracy measures that can be applied to dosage files, the output of all imputation software. Iam (imputation accuracy measure) quantifies the average amount of individual-specific versus population-specific genotype information in a linear manner. hiQ (heterogeneity in …

Lonnie Burt - Covid 19 Oral History Project, Lonnie Burt, Institute Of Child Nutrition. Child Nutrition Archives.

Oral History Project (all interviews)

During 2022 the Child Nutrition Archives conducted multiple interviews investigating how child nutrition professionals dealt with the Covid 19 pandemic and its effects on the operations of school feeding programs. This interview examines the experiences of Lonnie Burt, who is presently employed as the Senior Food & Child Nutrition Services Director for the Hartford Public Schools where she oversees the school meal program, including Breakfast, Lunch, Afterschool Snacks, At-Risk Supper, Summer Feeding and the Fresh Fruit and Vegetable Program Grant. She has worked in Child Nutrition for the past 33 years and has been in Hartford since 2004. Lonnie also …

Farmers’ Perceptions On Different Forage Types In Southern Highlands Of Tanzania, B. Nzogela, S. W. Mwendia, A. J. Mwilawa, J. Kizima, J. Bwire, A. O. Notenbaert

IGC Proceedings (1977-2023)

Feed and forages take the bulk of inputs required in livestock production. Inadequate forages in quality and quantity in sub-Saharan Africa is responsible for low livestock productivity. Addressing livestock feed requirements presents quick wins in livestock productivity compared to breeding and health. In a Climate Smart Dairy project implemented in Tanzania, we demontrated several forage options to farmers including, two cultivars of Pennisetum purpureum, two Urochloa hybrids, Chrloris gayana and Tripsacum andersonii (control). Where applicable, the grasses were intercropped with either one of the following forage legume, Desmodium intortum, Lablab purpureus or Stylosanthes guiyanensis. Fourteen forage treaments …

Examining The Impact Of Patch Burning On Livestock Grazing Patterns In Edwards Plateau, Texas, W. G. Gao, J. P. A. Angerer, X. B. W. Wu, D. T. Tolleson

IGC Proceedings (1977-2023)

Production of sheep, goat, and cattle are major agricultural enterprises on West Texas rangelands, especially in the Edwards Plateau. In this region, the use of fire as a management tool was suppressed until recently. Although previous studies have been conducted to evaluate cattle use of burned versus unburned patches, there has been a lack of studies where combinations of livestock species grazing together on patch burned areas have been evaluated. The objective of this study is to examine grazing patterns of cattle, sheep and goats, both spatially and temporally, on areas where patch burning has been implemented. The study site …

Evaluation Of Morphogenesis And Yield Of Three Pennisetum Purpureum Varieties In South-West, Nigeria, Victoria O. A. Ojo, T. A. Adeyemi, D. K. Oyaniran, G. A. Akinade, Olufemi S. Onifade

IGC Proceedings (1977-2023)

This experiment, conducted at the Federal University of Agriculture, Abeokuta, Nigeria evaluated the morphogenesis of three varieties of Pennisetum purpureum used in this study, which were the local, purple, and FI variety at different stages of growth. The plants were established through vegetative plant parts (stems) sourced from a previously established plot and planted using 1 m × 1 m spacing on plots measuring 4 m × 5 m. The plants were fertilized with split doses of poultry manure at 4 t/ha (equivalent to 120 kg N/ha). The experiment was laid out as a Randomized Complete Block Design. Data on …

Effects Of Stages Of Growth On Dry Matter Yield And Nutrient Composition Of Red Clover In The Year Of Establishment In Jos, Plateau State, Nigeria, T. T. Akpensuen, J. T. Amodu, O. A. T. Namo, R. J. Tanko

IGC Proceedings (1977-2023)

An experiment was conducted in Jos, Nigeria to evaluate the effects of stages of growth on dry matter yield and nutrient composition of Red clover (Trifolium pratense var. AberClaret) in the year of establishment. The treatments were five (5) stages of growth (5, 9, 13, 17 and 21) weeks after sowing (WAS). The five stages of growth were replicated five times in a Latin Square Design. The land was divided into twenty five plots of 3 m X 3 m each. The spacing between each plot was 1m along the rows and columns. Growth components and DM yield were …

Comparison Of Lateral Flow To Other Pregnancy Determination Methods In Order To Determine Accuracy Of Pregnancy Status In Beef Cattle Pre And Postpartum, Adalaide C. Kline, Julie Walker, Taylor N. Andrews, Saulo Menegatti Zoca, Kaitlin M. Epperson, Lacey K. Quail, Jaclyn N. Ketchum, Jerica J.J. Rich, Jim R. Rhoades, George Perry

SDSU Beef Day 2022 Summary Publication

Study Description:

Blood samples were collected from six different Bos taurus herds between day 27 and 285 of gestation (heifers n = 1,205 and cows n = 1,539). Blood samples to determine PAG clearance interval were collected weekly postpartum for up to 12 weeks (heifers n = 418 and cows n = 657). Serum was tested using the lateral flow test and were read by two technicians who were blind to pregnancy status. Level of agreement between the tests were determined by Pearson’s correlation coefficients and Kappa scores. The MIXED procedure of SAS was used to evaluate the effect of …

Smokejumper Obituary: Schmid, Phillip George (Missoula 1955), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Effects Of Maturity And Drying Method On The Nutritive Value Of Tropical Grasses In Nicaragua, Rocky Lemus, R. Van Der Hoek, Y. C. Newman, M. Mena, K. A. Albrecht

IGC Proceedings (1977-2023)

Tropical grasses are key components for both grazing and conserved forages in sustainable livestock systems (beef and dairy) in Central America. The objective of the study was to evaluate grasses used in Nicaragua and their nutritive value contribution as preserved forage during the dry season under different drying methods. Five tropical bunch grasses (Andropogon gayanus, Hyparrheniarufa, Urochloabrizantha, Megathyrsus maximus, and Cenchruspurpureus) were sampled across different farms in Nicaragua in 2014 and 2015 using three replications. Forage samples were collected at 2, 4, 6, and 8-wk maturity as well as season long samples. Samples drying …