Life Sciences Commons^™

Methyl-Lysine Readers Phf20 And Phf20l1 Define Two Distinct Gene Expression-Regulating Nsl Complexes, Hieu T Van, Peter R Harkins, Avni Patel, Abhinav K Jain, Yue Lu, Margarida A Santos

Faculty, Staff and Student Publications

The methyl-lysine readers plant homeodomain finger protein 20 (PHF20) and its homolog PHF20-like protein 1 (PHF20L1) are known components of the nonspecific lethal (NSL) complex that regulates gene expression through its histone acetyltransferase activity. In the current model, both PHF homologs coexist in the same NSL complex, although this was not formally tested; nor have the functions of PHF20 and PHF20L1 regarding NSL complex integrity and transcriptional regulation been investigated. Here, we perform an in-depth biochemical and functional characterization of PHF20 and PHF20L1 in the context of the NSL complex. Using mass spectrometry, genome-wide chromatin analysis, and protein-domain mapping, we …

Counterfactual Analysis Of Differential Comorbidity Risk Factors In Alzheimer’S Disease And Related Dementias, Paul E Schulz, Xiaoqian Jiang

Faculty, Staff and Student Publications

Alzheimer’s disease and related dementias (ADRD) is a multifactorial disease that involves several different etiologic mechanisms with various comorbidities. There is also significant heterogeneity in the prevalence of ADRD across diverse demographics groups. Association studies on such heterogeneous comorbidity risk factors are limited in their ability to determine causation. We aim to compare counterfactual treatment effects of various comorbidity in ADRD in different racial groups (African Americans and Caucasians). We used 138,026 ADRD and 1:1 matched older adults without ADRD from nationwide electronic health records, which extensively cover a large population’s long medical history in breadth. We matched African Americans …

Immunoanalytic Investigation Of Grain Proteins Antigenic For Celiac Disease Patients In An Einkorn Collection, Zsófia Birinyi, Dalma Réder, Ádám Diós, Ilma R. Korponay-Szabó, Éva Hunyadi-Gulyás, Christakis George Florides, Angéla Juhász, Gyöngyvér Gell

Research outputs 2022 to 2026

Our study focuses on the complex characterization of a wild and cultivated einkorn collection of the Cereal Gene Bank of Agriculture Research Institute in Hungary, using proteomics, immune analytics and bioinformatics analyses. In a serological ELISA pre-screen of 208 different Triticum monococcum L. ssp. monococcum and Triticum monococcum L. ssp. aegilopoides genotypes with celiac disease samples high diversity was observed in the immune response. Based on the immune analytic results, four genotypes with significantly reduced immune reactivity were selected for detailed proteomics characterization. Our results confirm the benefits of high-throughput/large-scale pre-screening and the use of a complex examination platform to …

Quantitative Analysis Of Methodological And Environmental Influences On Survival Of Planted Mangroves In Restoration And Afforestation, Daniel Gorman, Mathew A. Vanderklift, Anna Lafratta

Research outputs 2022 to 2026

Mangrove planting has been employed for decades to achieve aims associated with restoration and afforestation. Often, survival of planted mangroves is low. Improving survival might be aided by augmenting the understanding of which planting methods and environmental variables most influence plant survival across a range of contexts. The aim of this study was to provide a global synthesis of the influence of planting methods and background environment on mangrove survival. This was achieved through a global meta-analysis, which compiled published survival rates for the period 1979–2021 and analyzed the influence of decisions about minimum spacing and which life stage to …

An Analysis Of The Effects Of Large Wildfires On The Hydrology Of Three Small Catchments In Central Chile Using Tritium-Based Measurements And Hydrological Metrics, Francisco Balocchi, Diego Rivera, José Luis Arumi, Uwe Morgenstern, Donald A. White, Richard P. Silberstein, Pablo Ramírez De Arellano

Research outputs 2022 to 2026

Wildfires are an important disturbance affecting catchments’ soil and hydrological processes within. Wildfires are predicted to increase in both frequency and severity under climate change. Here, we present measurements of tritium (3H) in surface water of three streams before and after the ‘las Máquinas’ megafire of January 2017 in central Chile and streamflow metrics. Mean transit times (MTTs) of water were calculated in three coastal catchments with the Mediterranean climate type, covered by native forest, a mixture of native forest and Pinus radiata D. Don, and P. radiata. Lumped parameter models (LPMs) were used to obtain MTTs. Tritium activities from …

Pando Aspen 2021 Remeasure, Paul C. Rogers

Browse all Datasets

Upland aspen (Populus spp.) forests contribute significantly to biodiversity in their circumboreal role as keystone species. The 43-hectare Pando aspen (Populus tremuloides Michx.) clone in Utah, USA, is thought to be the largest living organism on earth, but is faltering due to chronic herbivory. Long-term resilience in aspen communities, including Pando, rests on successful recruitment of vegetative suckers. This is the first trend assessment of this threatened iconic forest using a vital indicators approach. I examined 64 plots using 19 indicators to determine current conditions. Findings show that a genetically uniform Pando is 'breaking up' because of herbivory fencing. Initial …

Making (Remote) Sense Of Lianas, Geertje M. F. Van Der Heijden, Ashley D. C. Proctor, Kim Calders, Chris J. Chandler, Richard Field, Giles M. Foody, Sruthi M. Krishna Moorthy, Stefan A. Schnitzer, Catherine E. Waite, Doreed S. Boyd

Biological Sciences Faculty Research and Publications

1. Lianas (woody vines) are abundant and diverse, particularly in tropical ecosystems. Lianas use trees for structural support to reach the forest canopy, often putting leaves above their host tree. Thus they are major parts of many forest canopies. Yet, relatively little is known about distributions of lianas in tropical forest canopies, because studying those canopies is challenging. This knowledge gap is urgent to address because lianas compete strongly with trees, reduce forest carbon uptake and are thought to be increasing, at least in the Neotropics.
2. Lianas can be difficult to study using traditional field methods. Their pliable stems often twist …

Atypical Tuning And Amplification Mechanisms In Gecko Auditory Hair Cells, Maryline Beurg, Tony Gamble, Aaron H. Griffing, Robert Fettiplace

Biological Sciences Faculty Research and Publications

The auditory papilla of geckos contains two zones of sensory hair cells, one covered by a continuous tectorial membrane affixed to the hair bundles and the other by discrete tectorial sallets each surmounting a transverse row of bundles. Gecko papillae are thought to encode sound frequencies up to 5 kHz, but little is known about the hair cell electrical properties or their role in frequency tuning. We recorded from hair cells in the isolated auditory papilla of the crested gecko, Correlophus ciliatus, and found that in both the nonsalletal region and part of the salletal region, the cells displayed …

Estimation Of The Optimal Nitrogen Dose In A Brachiaria Humidicola-Corn Rotation System In The Colombian Eastern Plains, K. Enciso, S. Burkart

IGC Proceedings (1977-2023)

Improving nitrogen (N) use efficiency by optimizing the N fertilizer application dose is one way to reduce greenhouse gas (GHG) emissions in agriculture and livestock production, especially in higher demanding crops such as corn. Taking a Brachiaria humidicola (Bh)-corn rotation system in the Colombian Eastern Plains, we seek to determine both the optimal economic dose (OED) and the optimal technical dose (OTD) of N, which allow to maximize income at producer level and minimize environmental impacts. This particular rotation system was chosen as research subject given the presence of the residual effect of Biological Nitrogen Inhibition (BNI) in …

Screening And Breeding For Bermudagrass Stem Maggot (Bsm) Resistance Using U.S. Bermudagrass Germplasm, W. F. Anderson, D. Hancock, L. Baxter, W. Hudson, Esteban F. Rios

IGC Proceedings (1977-2023)

Bermudagrass (Cynodon sp.) is an important perennial forage grass grown in many parts of the world. Bermudagrass Stem Maggot (BSM) (Atherigona reversura Villeneuve) is an insect pest that reduces forage yield and nutritive value if it is not controlled. The pest, native to SE Asia, was first documented in North America in 2009 and is now considered invasive. A collection of over 300 forage bermudagrass accessions was evaluated in the field for susceptibility to BSM in 2014 and 2015. Tolerant lines and susceptible checks were then evaluated for yield loss due to BSM in a replicated field study …

Senior Hunger In The Mountain West, 2019, Ally M. Beckwith, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet highlights data on senior hunger in the Mountain West region in 2019 as originally reported in Feeding America’s The State of Senior Hunger annual series. This report focuses on the extent of food insecurity among seniors in the United States. Seniors are defined as those who are 60 years of age or older.

Enhancing The Capabilities Of Fluid Bed Granulation Through Process Automation And Digitalisation, Marcus O'Mahony, Caroline Mccormack, Chris O'Callaghan, Ian Jones, Gavin Walker, Patrick Cronin

Level 3

This paper describes a PAT-enabled, digitalised, and automated fluid bed granulation system. A multichannel Near-Infrared (NIR) spectrophotometer and a direct imaging particle size and shape analyser in constant dialogue with the SmartX no-code/low-code platform provide a ground-breaking process automation toolset now located at the Bernal Institute in the University of Limerick. Two sets of results are presented for this study, from two iterations of the Advance Dynamic Process Control (ADPC) controller application. The results demonstrate the direct measurement and control of the product’s critical quality attributes through digitality enabled feedback control of processing setpoints and parameters. The platform controlled the …

Glia Excitation In The Cns Modulates Intact Behaviors And Sensory-Cns-Motor Circuitry, Shelby Mccubbin, Douglas A. Harrison, Robin L. Cooper

Biology Faculty Publications

Glial cells play a role in many important processes, though the mechanisms through which they affect neighboring cells are not fully known. Insights may be gained by selectively activating glial cell populations in intact organisms utilizing the activatable channel proteins channel rhodopsin (ChR2XXL) and TRPA1. Here, the impacts of the glial-specific expression of these channels were examined in both larval and adult Drosophila. The Glia > ChR2XXL adults and larvae became immobile when exposed to blue light and TRPA1-expressed Drosophila upon heat exposure. The chloride pump expression in glia > eNpHR animals showed no observable differences in adults or larvae. In …

Body Condition Score Change Throughout Lactation Utilizing An Automated Bcs System: A Descriptive Study, Carissa M. Truman, Magnus R. Campler, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Body condition scoring (BCS) is a traditional visual technique often using a five-point scale to non-invasively assess fat reserves in cattle. However, recent studies have highlighted the potential in automating body condition scoring using imaging technology. Therefore, the objective was to implement a commercially available automated body condition scoring (ABCS) camera system to collect data for developing a predictive equation of body condition dynamics throughout the lactation period. Holstein cows (n = 2343, parity = 2.1 ± 1.1, calving BCS = 3.42 ± 0.24), up to 300 days in milk (DIM), were scored daily using two ABCS cameras mounted …

Non-Native Non-Apis Bees Are More Abundant On Non-Native Versus Native Flowering Woody Landscape Plants, Daniel A. Potter, Bernadette M. Mach

Entomology Faculty Publications

Urban ecosystems can support diverse communities of wild native bees. Because bloom times are conserved by geographic origin, incorporating some non-invasive non-native plants in urban landscapes can extend the flowering season and help support bees and other pollinators during periods when floral resources from native plants are limiting. A caveat, though, is the possibility that non-native plants might disproportionately host non-native, potentially invasive bee species. We tested that hypothesis by identifying all non-native bees among 11,275 total bees previously collected from 45 species of flowering woody landscape plants across 213 urban sites. Honey bees, Apis mellifera L., accounted for 22% …

Development Of Add-On Materials To Supplement Food Safety Modernization Act Trainings In The Western U.S., Jovana Kovacevic

Journal of Extension

During the 2017 annual meeting of the Western Regional Center to Enhance Food Safety, 52 representatives from 15 western states/territories, regional centers funded through USDA-NIFA Food Safety Outreach Program, federal and state government agencies, and non-governmental organizations prioritized topics for the Food Safety Modernization Act (FSMA) training materials that address region-specific agricultural production and processing systems. This article describes supplemental materials or “add-ons” developed to support FSMA-related food safety trainings. Although the materials were developed for the western region stakeholders, they can be applied or adapted to other regions in or outside the U.S. to enhance food safety trainings.

Community Solar Dehydrator Plans, Kate Weigel, Roslynn Mccann

All Current Publications

As interest in home gardening and self sufficiency surged during the pandemic, many are looking for ways to preserve foods from their newfound harvests. This fact sheet provides an overview of how to build a community solar food dehydrator for food preservation, based on our experience doing so for the community of Moab, Utah. A list of needed building materials, tools, and specific plans are included.

Consumption Of Sugar-Sweetened Beverages And Its Potential Health Implications In Indonesia, Ratu Ayu D. Sartika, Atmarita Atmarita, M. I Zulkarnain Duki, Saptawati Bardosono, Lindawati Wibowo, Widjaja Lukito

Kesmas

The broad availability of sugar-sweetened beverages (SSBs) in the Indonesian market is increasing consumption. It, combined with escalating incidence and prevalence of diabetes and related non-communicable diseases (NCDs), and the ongoing debate on policies, has called for a comprehensive review as described in this study. Data was compiled from various sources but mainly gathered from the reported or published documents because of no direct access to the necessary data set. The lack of studies that assessed the direct relationship between SSB consumption and health outcomes in the Indonesian context also became a strong reason for the preparation of this review …

Body Image, Quality Of Life, And Their Predicting Factors In Pregnant Women: A Cross-Sectional Study, Zeynab Rezaei Fard, Arman Azadi, Yousef Veisani

Kesmas

Pregnancy can influence women’s psychological health, including body image and quality of life. This study aimed to examine the relationship between body image and quality of life and their predicting factors in pregnant women. This cross-sectional study was conducted on 250 pregnant women referred to health centers in Ilam City, Iran. Participants were selected using a random sampling method. Data collection tools comprised a sociodemographic questionnaire, Body Image Concern Inventory (BICI), and quality of life questionnaire (Short Form-12). Data were analyzed using statistical software. The mean ± SD of body image concern and quality of life was estimated at 31.77 …

The Estimation Of Excess Mortality During The Covid-19 Pandemic In Jakarta, Indonesia, Madona Yunita Wijaya

Kesmas

Indonesia is among the countries affected by the coronavirus disease 2019 (COVID-19) pandemic, and DKI Jakarta Province recorded the highest number of deaths. This study aimed to analyze the excess mortality across five administrative cities in Jakarta stratified by gender to assess the pandemic impact on mortality. The monthly mortality data from January 2018 to December 2020 was obtained through government sources. This data helped to measure excess mortality by estimating the baseline mortality had the COVID-19 pandemic not occurred. The analysis used a linear mixed model because of its ease and flexibility in forecasting subject-specific mortality. The results showed …

Increased Thyroid Hormone Levels In Pesticide Sprayer At Agricultural Area, Aditya Pawitra, Khuliyah Candraning Diyanah, Mohd Talib Latif, Beni Hari Susanto, Muhammad F D Lusno

Kesmas

Pesticides used massively in the agricultural sector would cause many poisoning and serious health problems. Organophosphate pesticides have been identified as endocrine-disrupting chemicals. This study aimed to compare thyroid hormone levels between the sprayers chronically exposed to pesticides and the control respondents who had never been exposed to pesticides. This study was an analytical observational with a cross-sectional design. The total number of respondents was 150, 50 as sprayers and 100 as control respondents. The venous blood samples were examined using the Enzyme-Linked Immunosorbent Assay (ELISA). The findings significantly showed that the sprayer had a higher level of thyroid-stimulating hormone …

The Determinants Of Covid-19 Vaccine Acceptance In Sumatra, Cindy Sidarta, Andree Kurniawan, Nata P H Lugito, Jeremia Imanuel Siregar, Veli Sungono, Rivaldo Steven Heriyanto, Novia Lauren Sieto, Devina Adella Halim, Claudia Jodhinata, Saraswati Anindita Rizki, Terry Devita Sinaga, Chintya Marcella, Felix Wijovi, Billy Susanto, Elizabeth Marcella, Johan Wibowo, Jonathan Juniard Anurantha, Michelle Imanuelly, Michele Indrawan, Nadia Khoirunnisa Heryadi

Kesmas

In light of the current coronavirus disease 2019 (COVID-19) vaccination programs being implemented worldwide, this study aimed to evaluate the COVID-19 vaccine acceptance survey in Indonesia conducted by the World Health Organization (WHO), the Ministry of Health of the Republic of Indonesia, the National Immunization Technical Advisory Group (NITAG), and the United Nations Children's Fund (UNICEF), published in November 2020. It was found that Sumatra Island having lower COVID-19 vaccine acceptance rates, with Aceh Province displaying the lowest level of vaccine acceptance. Thus, a cross-sectional study was conducted, and a logistic regression analysis was used to identify the factors affecting …

The Development Of A Work Stress Model For Air Traffic Controllers In Indonesia, Lalu Muhammad Saleh, Syamsiar Siang Russeng, Istiana Tadjuddin, Iva Hardi Yanti, Nurul Mawaddah Syafitri, Mahfuddin Yusbud, Yulianah Rahmadani

Kesmas

The workload complexity experienced by and expected air traffic controllers (ATCs) causes psychological fatigue, engenders stressful conditions, and affects their quality of life. This study investigated the development of a model of psychological fatigue in ATCs in Indonesia, which affected their work stress levels and quality of life. This cross-sectional, three-month study focused on 185 ATCs randomly selected from six AirNavs based on strata. The results indicated a relationship between work duration (p-value = 0.033) and stress on ATCs; additionally, a relationship between work time and the opportunity to meet personal life needs (p-value = 0.007) were found. Feelings of …

Effectiveness Of Using Information, Education, And Communication Flowchart Media In Implementation Of Early Breastfeeding Initiation, Rizna Notarianti, Sandra Fikawati, Alifani Faiz Faradhila

Kesmas

Early initiation of breastfeeding (EIB) has many benefits for both the baby and the mother. However, in Bogor City, there are still many babies who do not get EIB when they are born (33.6%). The implementation of EIB is not optimal due to the absence of standard procedures to equalize its theory and perception. This study aimed to investigate the effectiveness of using Information, Education, and Communication (IEC) flowchart media concerning the standard procedure for EIB implementation in the Primary Health Care (PHC) in Bogor City. A quasi-experimental research was conducted on 58 midwives divided into the intervention and control …

A Study On The Impact Of Occupational Fatigue On Human Performance Among Oil And Gas Workers In Indonesia, Achmad Dahlan, Baiduri Widanarko

Kesmas

Occupational fatigue is a serious problem since it may cause several issues, including deteriorating human performance. Some major accidents in the oil and gas industries were associated with the lack of human performance due to occupational fatigue. This study aimed to analyze the impact of occupational fatigue on human performance among oil and gas workers in Indonesia. This study used a cross-sectional design using a self-administered validated questionnaire to gather information on demographic (gender and age), work characteristics (work rotation, work duration, shift work model, day/night shift, job position), sleep debt, sleep quality, occupational (acute and chronic) fatigue, and at-risk …

Aminolevulinic Acid Dehydratase Allelic Frequency And Lead Toxicity In Children Under-Five In A Former Used Lead-Acid Battery Area, Yana Irawati, Haryoto Kusnoputranto, Umar Fahmi Achmadi, Ahmad Safrudin, Alfred Sitorus, Rifqi Risandi, Suradi Wangsamuda, Dendi Hadi Permana, Lepa Syahrani, Farahana Kresno Dewayanti, Puji B S Asih, Din Syafruddin

Kesmas

Polymorphisms in the Aminolevulinic Acid Dehydratase (ALAD) gene responsible for the ALAD1 and ALAD2 alleles have been implicated in susceptibility to lead toxicity. This study aimed to determine the allelic frequency of ALAD2 among children living in Bogor District, Indonesia, and its association with blood lead levels (BLLs) and lead toxicity. A cross-sectional study involving 128 children was conducted during September-October 2019 in the former ULAB area in Cinangka Village. The ALAD polymorphism, BLLs, and hematological parameters were evaluated. Blood samples were taken for dried blood spotting on filter paper, blood film, and BLL measurement. The PCR amplification and sequencing …

Public Perception And Obedience With Social Distancing Policies During The Covid-19 Pandemic In Jakarta, Indonesia, Widyamurti Widyamurti, Edwina Bernita Sitorus, Dewi Susanna, Bambang Wispriyono, Aria Kusuma, Renti Mahkota

Kesmas

The Indonesian Government established a social distancing policy to prevent COVID-19 transmission. However, this implementation will be ineffective without the compliance of the people. This study aimed to analyze the relationship between public perception and obedience with social distancing in terms of the variables based on the Health Belief Model. This study used a cross-sectional design with a population of Daerah Khusus Ibukota (DKI) Jakarta’s indigenes within the productive age of 15-64 years. The sample comprised 408 participants, with the independent variables of sociodemographics (age, gender, occupation, and education) and health beliefs (perceived susceptibility, severity, benefits, barriers, and self-efficacy). Meanwhile, …

Current Surgical Indications For Non-Small-Cell Lung Cancer, Nathaniel Deboever, Kyle G Mitchell, Hope A Feldman, Tina Cascone, Boris Sepesi

Faculty, Staff and Student Publications

With recent strides made within the field of thoracic oncology, the management of NSCLC is evolving rapidly. Careful patient selection and timing of multi-modality therapy to permit the optimization of therapeutic benefit must be pursued. While chemotherapy and radiotherapy continue to have a role in the management of lung cancer, surgical therapy remains an essential component of lung cancer treatment in early, locally and regionally advanced, as well as in selected, cases of metastatic disease. Recent and most impactful advances in the treatment of lung cancer relate to the advent of immunotherapy and targeted therapy, molecular profiling, and predictive biomarker …

What And Who Has Determined Adoption? A Study On Improved Forage Technologies In Colombia From An Agricultural Innovation System (Ais) Perspective, K. Enciso, N. Triana, M. Díaz, S. Burkart

IGC Proceedings (1977-2023)

The complex process behind the adoption of improved forages in Colombia remains largely unexplored. Despite governmental and scientific efforts to promote and disseminate the implementation of improved forages for the sake of sustainable livestock production, local livestock producers continue to extensively use native species and adoption rates of more efficient forages remain low. This study explores the dynamics behind the development and diffusion of improved forage technologies in Colombia, from the 1960's to the present through an Agricultural Innovation Systems (AIS) perspective. Here we map the agents involved, classify the roles they exerted over time and reconstruct the historical context …

From Theory To Practice: What Should We Have In Mind When Building Effective And Sustainable Payments For Ecosystem Services (Pes) Schemes For Silvo-Pastoral Systems? Evidence From Colombia, M. Díaz, K. Enciso, N. Triana, S. Burkart

IGC Proceedings (1977-2023)

In most Latin American countries, payment for ecosystem services (PES) can be a useful strategy for restoration and conservation of the environment, increasing productivity and promoting sustainable development in rural areas. Despite these plausible benefits, PES implementation can be challenging due to the contextual framework in which it takes place (e.g. institutional weakness in the implementation and monitoring stages, limited connectivity among stakeholders, low adoption levels of agricultural technology). This study aims at evaluating PES schemes for silvo-pastoral systems in Colombia by considering six dimensions based on an extensive literature review: policy and governance; social context; environmental context; risks and …