Life Sciences Commons^™

Investigating The Mechanics And Chemistry Of Sickle Polish Development, Justin Jared Dubois

Graduate Theses and Dissertations

This series of experiments is designed to understand the development and chemistry of sickle gloss. Sickles are common in the archaeological record and have long been studied for their eponymous “sickle gloss”. There is debate as to how this gloss is formed. Five experimental sickles containing flint and novaculite blades were used to harvest high and low moisture content rye and common fescue and associated field weeds. The differences in the development of sickle gloss were examined. High moisture content plants create thick, smooth fields of polish with undulating, billowing margins at a higher developmental speed. Low moisture content plants …

Generation Of A More Immunogenic Fh Vlp Platform To Support Covid-19 Vaccine Development, Jewel E. Voyer, Xinyuan Chen Phd.

Senior Honors Projects

The SARS-CoV-2 based pandemic has seen almost a million deaths in just the United States according to the CDC. This number is due to the increase of variants of COVID-19, therefore calling a demand in vaccine production. Vaccine adjuvants and carriers have been studied to increase the immunogenicity and safety of a variety of immunizations. Flagellin fused Hepatitis B core (FH) virus like particles (VLP) has been studied to have beneficial effects of TLR5, IL6 levels, and lack of body temperature rise in murine study. The FH platform also provides an improvement from its predecessors FljB alone which is a …

Land And Water Resources For Irrigated Agriculture In The Pilbara, Paul Galloway, John A. Simons, Karen Holmes, Dennis Van Gool

Resource management technical reports

This report documents the procedures used to identify suitable locations for irrigation development in the Pilbara region. It is the first study to investigate the potential for irrigated agriculture across the Pilbara. We used a desktop analysis to ascertain water availability and spatial data modelling to determine the potential of the land and soil resource to support irrigated agriculture. This study was part of the Pilbara Hinterland Agricultural Development Initiative (PHADI).

We used existing rangeland land inventory information augmented with digital spatial environmental data, in a process known as map disaggregation, to create soil and landform maps that had a …

When Problems Become Solutions: Harnessing The Osteogenic Capacity Of Disease-Causing Stem Cells To Repair Bone Fractures, Mehreen Pasha

University Scholar Projects

While we often perceive disease as negative, there is potential to engineer seemingly negative biological phenomena into therapeutics to treat a variety of human illnesses. Fibrodysplasia ossificans progressiva (FOP) is a genetic disorder involving uncontrolled, widespread, extraskeletal bone growth, or heterotopic ossification (HO). In FOP patients, stem cells called fibro/adipogenic progenitors (FAPs) follow an abnormal, osteogenic pathway. In the present study, we investigate whether we can adapt these Acvr1 mutant FAPs, which are exceptional at producing bone, to repair bone fractures in otherwise normal patients. The primary aims of this study are (1) to devise and optimize a novel method …

Sequential Illumination In A Tomographic Microendoscopic Probe For Imaging Tumor Microvasculature, Zachariah Neumeier

Biomedical Engineering Undergraduate Honors Theses

Knowledge of colorectal cancer biology is improving how we approach cancer treatment. Specifically, the tumor microenvironment and abnormal angiogenesis are of particular interest. Optical methods are a prime candidate for research of the tumor microenvironment due to their ability to quantitively assess tissue structure and perfusion in real time. Particularly, the “transport scattering regime” has been identified as a method of obtaining high-resolution images and reflectance spectroscopy data; this light scattering regime has been demonstrated compatible with endoscopic imaging systems. In this study, a proof-of-concept optical imaging system is presented, capable of resolving absorbers within scattering turbid media using a …

Repeated Targets Of Natural Selection During Ecological Transitions Of Fish Across Salinity Boundaries, Jonathan P. Velotta, Stephen D. Mccormick, Andrew Whitehead, Catherine S. Durso, Eric T. Schultz

EEB Articles

Ecological transitions across salinity boundaries have led to some of the most important diversification events in the animal kingdom, especially among fishes. Adaptations accompanying such transitions include changes in morphology, diet, whole-organism performance, and osmoregulatory function, which may be particularly prominent since divergent salinity regimes make opposing demands on systems that maintain ion and water balance. Research in the last decade has focused on the genetic targets underlying such adaptations, most notably by comparing populations of species that are distributed across salinity boundaries. Here, we synthesize research on the targets of natural selection using whole-genome approaches, with a particular emphasis …

Halodash: The Deep And Shallow History Of Aquatic Life's Passages Between Marine And Freshwater Habitats, Eric T. Schultz, Lisa Park Boush

EEB Articles

This series of papers highlights research into how biological exchanges between salty and freshwater habitats have transformed the biosphere. Life in the ocean and in freshwaters have long been intertwined; multiple major branches of the tree of life originated in the oceans and then adapted to and diversified in freshwaters. Similar exchanges continue to this day, including some species that continually migrate between marine and fresh waters. The series addresses key themes of transitions, transformations, and current threats with a series of questions: When did major colonizations of fresh waters happen? What physiographic changes facilitated transitions? What organismal characteristics facilitate …

How Flow Regime Affects Predator-Prey Relationships Of Stream Darter And Shiner Species, Anna E. Richardson

Biological Sciences Undergraduate Honors Theses

Analysis of the interactions between abiotic and biotic factors of environments and ecosystems is a highly valued area of research. This study focuses on the interactions between the biotic component of predation and foraging of certain stream fish species and the abiotic component of the flow regime that those species reside in. Gut content analysis followed by statistical calculations in the form of t-tests and chi -quared tests were performed on two fish species who both inhabited a stream with a groundwater flashy flow regime as well as a stream with a runoff flashy flow regime. The research showed that …

Evaluation Of Selected Nuproxa Feed Additives For Protection Against Lameness And Improving The Wellbeing Of Broilers In A Lameness Challenge Model, Jaren Hernandez

Biological Sciences Undergraduate Honors Theses

A common concern in commercial industries profiting from broiler chickens is their inability to yield a completely healthy flock. Bacterial Chondronecrosis with Osteomyelitis poses a threat to these companies by impairing the birds' proximal and distal tibial and femoral heads. In 2000, roughly 17.3% of broiler chickens were affected by Bacterial Chondronecrosis with Osteomyelitis which caused a substantial economic loss in the industry (McNammee et al., 2000). BCO cannot be tied to a particular bacterial species; this experiment focuses on evaluating the efficacy of certain commercial feed additives while determining the bacterial species causing BCO in this set of the …

Broiler Efficiency As Affected By Dietary Protein Supply And Grain Source, Victoria Reid

Animal Science Undergraduate Honors Theses

This experiment was conducted to compare the effects of different diet compositions on performance and carcass yield of male broilers from 15 to 36 days of age. In total, 593 male birds were divided across a randomized design that consisted of 6 dietary treatments, each with 8 replications. The treatments included pelleted diets that varied in grain type and crude protein (CP) value: 3 sorghum-based diets at 20%, 18.75%, and 17.5% CP and 3 corn-sorghum blended diets at the same CP levels. CP amounts impacted only body weight gain and feed conversion rate while feed intake only differed with grain …

Effects Of Retail Case Environment And Led Lighting Temperature On Color And Oxidation Of Previously Frozen Ground Beef Patties, Devin Elaine Whiteside

Animal Science Undergraduate Honors Theses

The purpose of this study was to investigate different environments of retail cases and LED lighting temperatures to observe how these conditions affect oxidation of previously frozen ground beef patties. Coarse ground beef (85% lean) was purchased from a commercial beef processor, fine ground through a 10 mm grinder plate, and then formed into 1/3-pound patties with an automatic patty forming machine. Patties were then randomly assigned to four different treatments: open-front display cases with 3000 K lighting (OPEN3000), open-front cases 3500 K lighting (OPEN3500), reach-in door display with 3000 K lighting (CLOSED3000), and reach-in door display at 3500 K …

The Effects Of Water With Anti-Inflammatory Capabilities (Wac) On Circulating Inflammatory Biomarkers At Rest And Following Resistance Exercise, Brittany Martin

Health, Human Performance and Recreation Undergraduate Honors Theses

Purpose: To determine the effects of waters with anti-inflammatory capabilities (WAC) influence circulating inflammatory biomarkers at rest and following resistance exercise. Methods: Participants completed a heavy lifting protocol and drank water with anti-inflammatory capabilities for a total of six weeks. Blood samples were taken at different at 9 different time intervals to assess concentrations of anti-inflammatory markers and to quantify inflammatory biomarkers. Those time intervals included pre-AHREP 1 and post-AHREP 1, 24-hr post-AHREP 1, 48-hr post-AHREP 1, 3-week check-up, pre-AHREP 2, post-AHREP 2, 24-hr post-AHREP 2, and 48-hr post-AHREP 2. Background: The biomarkers that were focused on were: IL-6 …

Effects Of Recess On Educational Outcomes In Elementary School Children, Katelyn Whitham

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: Because physical activity is beneficial for physical and mental health, the declining opportunities to implement adequate recesses in schools are devastating for children. If educational outcomes are positively affected by increased recess time or quality, schools are more likely to receive funding for programs and resources that support this renovation to recesses, providing research in lacking topics. Purpose: The purpose of this systematic review is to find related, academic articles for cross examination of data collected on the effects that recess has on educational outcomes so that schools may use this as a resource to receive funding to increase …

Determining The Protocol And Testing Feasibility And Intensity Of The Burn2learn Interventions And Measures In College Students, Sarah Schwarz

Health, Human Performance and Recreation Undergraduate Honors Theses

High-intensity interval training(HIIT) is a time-efficient form of exercise that combines aerobic and resistance training methods. HIIT workouts have been found to improve executive functioning, therefore making it beneficial for school aged children. This study is an extension of the Burn2Learn protocols developed in Australia. The purpose of this study is to develop the protocol and testing feasibility and intensity of the Burn2Learn activities in college students, specifically comparing an exercise only (Gym) HIIT session and an exercise + cognitive activity (Brain) HIIT session. The participants of this study consisted of 15 undergrad students aged 20-22. Participants took mEMA cognitive …

Mechanistic Basis For The Role Of Resistance And Tolerance Determinants In Antibiotic Treatment Failure, Misha Iqbal Kazi

Biology Dissertations - Archive

Failure of antibiotics in treatment of nosocomial Gram-negative bacterial infections has created a substantial burden for global public health. The β-lactam class of antibiotics includes last resort carbapenems, which are used to combat multidrug resistant Gram-negative bacterial infections. Production of β-lactamase enzymes that degrade these antibiotics is the primary mechanism β-lactam resistance in Gram-negative bacteria. While FDA-approved serine-β-lactamase inhibitors are co-formulated with β-lactam antibiotics to prevent their inactivation during treatment, no metallo-β-lactamase inhibitors have been approved for clinical use. The first study employs an innovative antimicrobial discovery platform to identify peptide inhibitors against the New Delhi metallo-β-lactamase-1 (NDM-1), which is …

Pif Transposable Elements Domestication And Genetic Novelty In Insects, Fatema Ruma

Biology Dissertations - Archive

Transposable elements or TEs, are selfish genetic elements that represent a major component of a eukaryotic genome. They are genetic units that can move and amplify within a host genome. Mobilization of these TEs can be harmful to the host genome as they can transpose to new locations and can be a source of disruptions to the genetic information, DNA breakage and ectopic recombination. It has been shown, however, that TE proteins can be domesticated/co-opted and supply functions for major adaptations. There are two broad classes of TEs: Class I or retro-transposable elements and Class II or DNA elements. It …

Pestfacts Wa Issue 05 - May 2022, Jean Galloway, Cindy L. Webster, Steve Collins

PestFacts WA

PestFacts WA Issue 05 - May 2022 contents:

• Blackleg and the risk of sowing canola on canola
• Meet PestFacts WA team member – Steve Collins

Pestfacts Wa Issue 04 - May 2022, Svetlana Micic, Benjamin S. Congdon, Cindy L. Webster, Andrea Hills, Ravjit Khangura

PestFacts WA

PestFacts WA Issue 04 - May 2022 contents:

• Grasshoppers are hatching
• Aphid activity and turnip yellows virus detections
• Downy mildew and damping off in canola
• Nodorum blotch in wheat
• Plant disease webinar recording can now be viewed online

Estimating Cattle Density Using Wildlife Cameras, Emily Bonebrake

Undergraduate Honors Capstone Projects

Quantifying the abundance and distribution of animal populations is critical for effective wildlife research and management. Due to their cost-effectiveness, wildlife cameras have become an increasingly popular tool for estimating population densities. Previously, this technique relied on ‘capture-recapture’ models that utilized re-sightings of individually marked animals, but in recent years methods have been developed to estimate the population densities of unmarked animals. One such method is the random encounter and staying time (REST) technique, which does this by assuming that the cumulative time animals stay within the view of the camera scales linearly with the number of individuals. This allows …

Antimicrobial Assay Of Sagebrush Roots, Lauren Rachel (Moody) Mcfadden

Undergraduate Honors Capstone Projects

Plants produce secondary metabolites for various functions, one of which is antibacterial activities. Sagebrush has historically been used by Native Americans for different medicinal purposes, suggesting that it may have secondary metabolites that would have medicinal values, including antimicrobial activities, and can be a natural source for antibiotics. This study aims to carry out the antimicrobial activity of Sagebrush root extract against a handful of bacteria. We tested the antimicrobial activity of root extract of Sagebrush against six bacteria such as Bacillus subtilis, Bacillus cereus, E. coli DHSα (Lab cloning strain), Agrobacterium tumefaciens GV3101 (Lab cloning strain), Pseudomonas …

Evolution Of Floral Microbes And The Resulting Effects On Pollinator Preference, Hailey Hatch

Undergraduate Honors Capstone Projects

Floral microbes are an overlooked aspect of the extended floral phenotype. Through altering floral nectar chemistry, they can mediate interactions between flowers, pollinators, and other floral microbes, with significant implications for plant and pollinator health. Interactions between floral microbes and pollinators are critically important to understand, as pollinators provide important ecosystem services in both natural and agriculture systems. Here, I explored how floral nectar traits affected both evolution and competition within the floral yeast Metschnikowia reukaufii, the floral bacterium Bacillus subtilis, and other microbes isolated from Brassica rapa nectar, an important plant model system and oilseed crop. To …

A Study On The Impact Of Diet On Unified Fire Authority Firefighter Performance, Marin Easton

Undergraduate Honors Capstone Projects

Objective: This project aimed to examine the impact of nutrition knowledge, dietary intake, and physical activity on firefighters’ performance on their routine physical assessment (RPA).

Methodology: Members of the Unified Fire Authority, the largest fire agency in Utah with more than 400 sworn firefighters serving 15 communities representing 440,000 residents, were invited via email to participate in this cross-sectional study. Participants (N=92) completed a 40- question survey that assessed specialized diet adherence, dietary intake, nutrition knowledge (using questions from the General Nutrition Knowledge Questionnaire;1 point for each correct answer [26 points possible]), regular physical activity (International Physical Activity Questionnaire), and …

A Music Composition Through The Use Of Animal Sounds, Andy Nguy

Undergraduate Honors Capstone Projects

The knowledge on animals has been studied over many years by researching and understanding animal behavior and creativity with music. Bioacoustics shows a great deal when it comes to collecting sounds through many principles for sound data collection. With saved recording of animals, music, speeches, and so much more, it has impacted the way music is created through technology. Music production has been advancing in many creative ways. The foundation of sound manipulation is musique concrète. The project uses these concepts of audio recording and digital sounds to produce a composition that includes animal sounds.

Utah Tick Surveillance An Animated Public Service Announcement, Keith Wilson

Undergraduate Honors Capstone Projects

As the United States’ population grows, we develop more land into housing and recreate farther into wilderness areas, consequentially encountering ticks with increasing frequency. As the climate continues to change, tick population distributions are also changing, influencing our population’s exposure to tick-borne diseases. Lyme disease, a tick-borne disease named after Lyme, Connecticut, is one of the fastest growing emerging diseases in North America, and the most prevalent vector-borne infection in the United States. There are two species of tick in North America, Ixodes scapularis and Ixodes pacificus, known to be carriers of the causative agent of Lyme disease, a …

Effect Of Basal Diet And Black Raspberry Supplementation On Gene Biomarkers Of "Leaky Gut" In A Mouse Model Of Colitis-Associated Colorectal Cancer, Eliza Catherine Stewart

Undergraduate Honors Capstone Projects

Colorectal cancer is currently the second leading cause of cancer death in the world. The risk of developing colorectal cancer increases significantly in individuals who suffer from colitis, which is inflammation of the colon lining, seen in Irritable Bowel Disease. The term “leaky gut” is often used to describe increased intestinal permeability and is closely related to colitis. Leaky gut is associated with dysbiosis of the gut microbiota, which can occur through diet. This dysbiosis leads to prolonged inflammation and affects genes that encode for proteins involved in the tight junctions between cells. Compromised intestinal integrity allows for translocation of …

The Evolution And Unraveling Of The American Eugenics Movement, Anneka Walton

Undergraduate Honors Capstone Projects

While the evolution of American eugenics surrounding the time of Nazi Germany has been well-documented, the periods before the explosion of American eugenics and the result of the movement in the wake of the Holocaust are not so well known. Many historically-based works have described the path and growth of eugenics from the time the term was coined to the public acknowledgement of World War II and the point where Americans ended eugenic euthanasia and slowed eugenic sterilizations. There are also many works within the realm of disability history that document these events from the more common social viewpoint. This …

Differential Transcriptome Analysis Reveals That Cache Valley Pm2.5 Triggers The Unfolded Protein Response In Human Lung Cells, Morgan Eggleston

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Worldwide, exposure to air pollution is a serious human health threat. Particulate matter (PM) air pollution is a mixture of suspended solid and/or liquid particles and particle size is determined by its aerodynamic diameter. Fine, or “respirable” particles, typically from vehicle emissions, manufacturing, power generation, agriculture, as well as secondary photochemical reactions, are classified as ≤2.5μm in diameter (PM_2.5). Upon inhalation, PM_2.5 particles can reach the lower, more sensitive regions of the lung, enter the bloodstream, and be distributed to other areas in the body. Large-scale epidemiology studies have shown that PM_2.5 air pollution is associated …

The Impacts Of Increased Precipitation Intensity On Dryland Ecosystems In The Western United States, Martin C. Holdrege

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

As the atmosphere warms, precipitation events become larger, but less frequent. Such increases in precipitation intensity are expected regardless of changes in total annual precipitation. Despite strong evidence for increases in precipitation intensity, disagreement exists regarding how these changes will impact plants, and studies are lacking in many types of ecosystems. This dissertation addresses how increased precipitation intensity affects soil water availability, and how plants respond to any such changes. I address this question in the context of big sagebrush ecosystems and dryland winter wheat agriculture, which are both environments that can be sensitive to changes in water availability. Results …

Refining, Testing, And Applying Thermal Species Distribution Models To Enhance Ecological Assessments, Donald J. Benkendorf

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The temperature of streams and rivers is changing rapidly in response to a variety of human activities. This rapid change is concerning because the abundances and distributions of many aquatic species in streams and rivers are strongly associated with temperature. Linking observations of temperature effects on species distributions with observations of temperature effects on fitness is important for improving confidence that temperature (and not some other variable) is causing the distributions we observe. Furthermore, producing accurate models of temperature effects on species distributions may allow us to develop tools to diagnose whether or not thermal pollution has impaired aquatic life. …

Global Change Effects On Carbon Cycling In Terrestrial Ecosystems, Guopeng Liang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Since terrestrial ecosystems store approximately 3 times more carbon (C) than the atmosphere, they have a significant effect on the atmospheric CO₂ concentration. Although many studies have been conducted to determine global change effects on C cycling in terrestrial ecosystems, the underlying mechanisms remain uncertain. To address this knowledge gap, I utilized meta-analysis, laboratory experiments, and soil microbial community analysis.

In chapter 2, I conducted a meta-analysis to examine whether effects of long-term N addition on plant productivity can shift over time. I found that 44% of studies showed a marked trend (increase or decrease) in the strength of …