Life Sciences Commons^™

Pre-Pulse Inhibition In Mutated Mice: Studying Compromised Microglial Cells To Discover New Genetic Connections To Autism, Bailey R. Kramarik

Senior Honors Projects, 2020-current

Microglial cells “play a pivotal role in refining neural networks during early critical periods” (Gabriele & Gray, 2020, p. 1). A disturbance in the functioning of these microglial cells contribute to specific characteristics of some neurodevelopmental disorders- including autism spectrum disorder. In this study, we used a mouse model to study disruptions in cell activity, as understanding the biological and genetic background of autism spectrum disorder could help us provide better treatment and therapy options to those diagnosed.

The mutated mice in this experiment have microglial cells with “compromised fractalkine signaling” (Gabriele & Gray, 2020, p. 4-5). We studied multimodal …

Biodiversity And Global Change In Terrestrial Ecosystems, Timothy John Ohlert

Biology ETDs

Terrestrial ecosystems are critical to human and ecological processes but many gaps in our knowledge remain regarding how terrestrial plant communities assemble and respond to global change. I used field experiments distributed around the world, including long-term experiments from the Sevilleta National Wildlife Refuge (SNWR) in New Mexico and deserts of the southwestern U.S., to evaluate the consequences of drought and other abiotic stressors on plant communities. Dominant grasses were particularly important for the productivity and structure of grasslands at SNWR. In general, the structure of desert plant communities had high resistance to extreme drought, though grasses and other perennial …

Effects Of Neuronal Activation And Psychiatric Drug Treatment On Circhomer1 Biogenesis, Grigorios Papageorgiou

Biomedical Sciences ETDs

There are currently only very few efficacious drug treatments for SCZ and BD, none of which target and improve cognitive symptoms. Thus, there is an emerging need to develop novel therapeutics targeting molecular pathways linked to cognitive function and antipsychotic treatment. Circular RNAs (circRNAs) are stable non-coding RNAs, derived from the covalent back-splicing of precursor mRNA molecules. CircHomer1is a neuronal-enriched, activity-dependent circRNA, derived from the precursor of the long HOMER1B mRNA isoform, which is abundantly expressed in the adult frontal cortex and significantly downregulated in the prefrontal cortex of subjects with psychosis. Even though its relevance to psychiatric disorders …

Review Of Orthochiroides Kovařík, 1998 With Description Of A New Species (Scorpiones: Buthidae), František Kovařík, Graeme Lowe

Euscorpius

The genus Orthochiroides Kovařík, 1998 is reanalyzed. Revised diagnoses and new illustrations for the genus and all four of its species are presented. A new species, O. somalilandus sp. n. from Somaliland is described and illustrated. Phylogenetic relationships of the genus with several other similar genera of small buthids are inferred from a parsimony analysis of 43 discrete morphological characters. The recent synonymy of Orthochiroides with Orthochirus is refuted and the genus is revalidated.

Validity Of Neural Distance Measures In Representational Similarity Analysis, Fabian A. Soto, Emily R. Martin, Hyeonjeong Lee, Nafiz Ahmed, Juan Estepa, Kianoosh Hosseini, Olivia A. Stibolt, Valentina Roldan, Alycia Winters, Mohammadreza Bayat

MODVIS Workshop

No abstract provided.

Visual Expertise In An Anatomically-Inspired Model Of The Visual System, Garrison W. Cottrell, Martha Gahl, Shubham Kulkarni

MODVIS Workshop

We report on preliminary results of an anatomically-inspired deep learning model of the visual system and its role in explaining the face inversion effect. Contrary to the generally accepted wisdom, our hypothesis is that the face inversion effect can be accounted for by the representation in V1 combined with the reliance on the configuration of features due to face expertise. We take two features of the primate visual system into account: 1) The foveated retina; and 2) The log-polar mapping from retina to V1. We simulate acquisition of faces, etc., by gradually increasing the number of identities the network learns. …

Characterization Of Local And Global Statistics In Three Kinds Of Medical Images, And An Example Of Their Role In A Clinical Judgment, Jonathan Victor, Amanda Simon, Craig K. Abbey

MODVIS Workshop

No abstract provided.

Relational Graph Convolutional Networks For Predicting Blood-Brain Barrier Penetration Of Drug Molecules, Yan Ding, Xiaoqian Jiang, Yejin Kim

Faculty, Staff and Student Publications

MOTIVATION: Evaluating the blood-brain barrier (BBB) permeability of drug molecules is a critical step in brain drug development. Traditional methods for the evaluation require complicated in vitro or in vivo testing. Alternatively, in silico predictions based on machine learning have proved to be a cost-efficient way to complement the in vitro and in vivo methods. However, the performance of the established models has been limited by their incapability of dealing with the interactions between drugs and proteins, which play an important role in the mechanism behind the BBB penetrating behaviors. To address this limitation, we employed the relational graph convolutional …

An Evidence-Based Lexical Pattern Approach For Quality Assurance Of Gene Ontology Relations, Rashmie Abeysinghe, Yuntao Yang, Mason Bartels, W Jim Zheng, Licong Cui

Faculty, Staff and Student Publications

Gene Ontology (GO) is widely used in the biological domain. It is the most comprehensive ontology providing formal representation of gene functions (GO concepts) and relations between them. However, unintentional quality defects (e.g. missing or erroneous relations) in GO may exist due to the large size of GO concepts and complexity of GO structures. Such quality defects would impact the results of GO-based analyses and applications. In this work, we introduce a novel evidence-based lexical pattern approach for quality assurance of GO relations. We leverage two layers of evidence to suggest potentially missing relations in GO as follows. We first …

Clarifying Drug Reaction Terminology: Insights From Deaf College Students Allergic To Penicillin, Andrew Makarewicz

Undergraduate University Honors Capstones

Penicillin is considered to be the most frequently reported drug allergy, with roughly 10% of the U.S. population reporting an allergy (Lee, 2020; Sakoulas et al., 2019). However, current research suggests that more than 90% of people who report a penicillin allergy are actually not truly allergic (Blumenthal et al., 2015; Pongdee & Li, 2018). Confusion about side effects and allergic responses is a common way for penicillin allergies to be falsely reported (Stone et al., 2020). The Deaf community may experience this confusion at a higher rate due to health literacy barriers that likely hinder their learning and understanding …

The Effect Of The Covid-19 Pandemic On Physical Activity In University Communities, Hannah M. Shouse

Senior Honors Projects, 2020-current

Introduction: In early 2020, the COVID-19 pandemic began, transitioning the university community from in-person learning to virtual learning, and shutting down many industries across the country. This study was conducted in order to analyze how the COVID-19 pandemic affected physical activity in university communities through the transition to virtual learning, and back into in-person learning.

Methods: Individuals who wore exercise tracking devices were recruited from university communities. Step count and activity data was collected from February 2020 to April 2021.

Results: 24 subjects completed the survey, with 17 being from Virginia, and other subjects being from other east coast states. …

The Effects Of High-Intensity Functional Training (Hift) On Perceptions Of Exercise In Middle-Aged Females, Halle Brin

Electronic Theses & Dissertations

The high prevalence of obesity and physical inactivity within the U.S. has become a public health crisis. PURPOSE: To examine the effects of High-Intensity Functional Training (HIFT) on the perceptions and beliefs towards exercise in an inactive sample of females. METHODS: Inactive, middle-aged females (n=8) were recruited to participate in an 8-week supervised and verified intervention (2-weeks High-Intensity Interval Training (On-Ramp), followed by 6-weeks of HIFT) three days per week. Pre- and post-assessments included: body composition (percent body fat (%BF)), strength (1RM bench press (BP), 5RM deadlift (DL)), a stage-graded exercise treadmill test ( O_2max), and a …

Evaluation Of The Major Seed Storage Proteins, The Conglutins, Across Genetically Diverse Narrow-Leafed Lupin Varieties, Arineh Tahmasian, Angéla Juhász, James A. Broadbent, Mitchell G. Nye-Wood, Thao T. Le, Michelle L. Colgrave

Research outputs 2022 to 2026

Lupin seeds have an excellent nutritional profile, including a high proportion of protein and dietary fiber. These qualities make lupin seeds an ideal candidate to help meet the growing global demand for complementary sources of protein. Of consequence to this application, there are nutritional and antinutritional properties assigned to the major lupin seed storage proteins—referred to as α-, β-, δ- and γ-conglutins The variation in the abundance of these protein families can impact the nutritional and bioactive properties of different lupin varieties. Hence, exploring the conglutin protein profiles across a diverse range of lupin varieties will yield knowledge that can …

Improving Nutrition And Food Safety Knowledge Of Small-Scale Fish Processors In Delta State, Nigeria, Grace Adeola Adegoye

Theses and Dissertations

Introduction: Fish is an affordable animal source food that provides nutrition and serves as a source of income for many people especially women in Nigeria. Smoking and sun drying are the processing methods in practice that expose the fish products to possible contaminants which may consequentially negate their nutritive value.

Aim: To improve the knowledge of fish processors on nutrition and safe fish handling.

Methodology: A 3-day participatory training was organized to train 122 fish processors, 95 women, and 25 men. The training was conducted in the three senatorial districts in Delta State, Nigeria. Knowledge was assessed using the pre …

Evaluating Soil Health Changes Following Cover Crop And No-Till Integration Into A Soybean (Glycine Max) Cropping System In The Mississippi Alluvial Valley, Alexandra Gwin Firth

Theses and Dissertations

The transition of natural landscapes to intensive agricultural uses has resulted in severe loss of soil organic carbon (SOC), increased CO₂ emissions, river depletion, and groundwater overdraft. Despite negative documented effects of agricultural land use (i.e., soil erosion, nutrient runoff) on critical natural resources (i.e., water, soil), food production must increase to meet the demands of a rising human population. Given the environmental and agricultural productivity concerns of intensely managed soils, it is critical to implement conservation practices that mitigate the negative effects of crop production and enhance environmental integrity. In the Mississippi Alluvial Valley (MAV) region of Mississippi, USA, …

Cover Crops And Irrigation Impacts On Corn And Soybean Production In The Mid-Southern Usa, Dillon Aaron Russell

Theses and Dissertations

Reducing groundwater withdrawals from the Mississippi River Valley Alluvial Aquifer is imperative to sustain future irrigated cropping systems in the mid-southern USA. This research was conducted to determine the impacts of cover crops and irrigation sensor thresholds on corn (Zea mays L.) and soybean (Glycine max L.) production, water productivity, irrigation water use efficiency, and soil physical properties in the Mississippi Delta. The cover crop treatments included cereal rye (Secale cereale L.), hairy vetch (Vicia villosa R.), wheat (Triticum aestivum L.)-radish (Raphanus sativus L.)-turnip (Brassica rapa L.) mix, and no cover crop. The irrigation thresholds included -40 kPa, -90 kPa, …

Determination Of Flexural Strength Of Structural Red And White Oak And Hardwood Composite Lumber, Alan Sherrington

Theses and Dissertations

In this research, flexural properties of mill-run, in-grade white oak and red oak lumber from a single mill and commercially available laminated hardwood composite were evaluated. Structurally graded green (wet) freshly sawn red oak and white oak 5 by 10-cm (2 by 4-in.) nominal lumber as well as glue-laminated hardwood composite billets were tested in bending and their modulus of rupture (MOR) and modulus of elasticity (MOE) properties were developed. It is well documented that MOR and MOE are two major indicators to evaluate flexural strength of wood lumbers. From these data, summary statistics, design values, and mean separations were …

Food Insecurity And Depression Among Us Adults: The National Health And Nutrition Examination Survey, Nicole Reeder

Theses and Dissertations

Food insecurity has long been a global challenge associated with negative health outcomes. The spectrum of food insecurity corresponds to a spectrum of negative health outcomes that range from kwashiorkor and marasmus to obesity and chronic disease. The burden of food insecurity is a stressor that additionally negatively effects mental health. In this study, the relationship between food insecurity and mental health was examined using data from the National Health and Nutrition Examination Survey (NHANES). Food insecurity was assessed with the 18-item United States Food Security Survey Module, and participants were classified into one of four categories based on their …

Nutrients Associated With Stunting Among Children In Sub-Saharan Africa: A Systematic Review, Abby Mae Reynolds

Theses and Dissertations

The purpose of this study was to identify specific nutrients or nutritional biomarkers of dietary intake that are associated with stunting among children ages 2 and older in sub-Saharan Africa. This is a systematic review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Twelve studies from sub-Saharan Africa met the eligibility criteria, including 11 observational studies and one randomized control trial. Nine of the 12 studies assessed dietary intake of macronutrients. Four studies found a significant association between proteins and stunting. Four found that children with stunting had lower dietary fat intakes or lower …

The Guatemala Rabbit Project: A Household Agricultural Intervention Program Evaluation Using The Re-Aim Framework, Jessica Martin Graves

Theses and Dissertations

Amongst the breathtaking and mountainous landscapes of the Western Highlands is a highly indigenous Mayan population stricken with challenges of food insecurity and extreme poverty. Despite efforts by governmental and non-governmental organizations alike to combat these challenges, the results of chronic malnutrition have led to some of the highest child stunting rates in all of Guatemala, particularly in the department of Totonicapán, where this study took place. To date, information is limited regarding agricultural programs that utilize the rabbit as a model to reduce food insecurity in Guatemala. Thus, a novel agricultural education program, Guatemala Rabbit Project (GRP), was developed …

Diversity-Productivity Relationships In Forests Of The Southeastern United States: Leveraging National Inventory Data And Tree Functional Traits, Elizabeth Baach

Theses and Dissertations

Numerous studies have evaluated the relationship between biodiversity and productivity, with general trends suggesting a positive relationship. While most studies only use species richness, this study also analyzed how productivity changes with functional diversity and Shannon’s diversity index. Functional diversity gives important context to the examination of biodiversity-productivity relationships due to the direct link between organisms’ functional traits and their role in a given ecosystem. This study used data from the USDA Forest Service Forest Inventory and Analysis (FIA) database collected in Alabama, Louisiana, and Mississippi to estimate plot-level productivity and diversity. Structural equation modeling was used to determine the …

Chronic Lymphocytic Leukemia Progression Diagnosis With Intrinsic Cellular Patterns Via Unsupervised Clustering, Pingjun Chen, Siba El Hussein, Fuyong Xing, Muhammad Aminu, Aparajith Kannapiran, John D Hazle, L Jeffrey Medeiros, Ignacio I Wistuba, David Jaffray, Joseph D Khoury, Jia Wu

Faculty, Staff and Student Publications

Identifying the progression of chronic lymphocytic leukemia (CLL) to accelerated CLL (aCLL) or transformation to diffuse large B-cell lymphoma (Richter transformation; RT) has significant clinical implications as it prompts a major change in patient management. However, the differentiation between these disease phases may be challenging in routine practice. Unsupervised learning has gained increased attention because of its substantial potential in data intrinsic pattern discovery. Here, we demonstrate that cellular feature engineering, identifying cellular phenotypes via unsupervised clustering, provides the most robust analytic performance in analyzing digitized pathology slides (accuracy = 0.925, AUC = 0.978) when compared to alternative approaches, such …

Procedures For Genetic Modification Of Miscanthus X Giganteus, A Biomass Crop, Anjali Arpan

Theses and Dissertations

Development of genetic improvement procedures for the bioenergy crop, Miscanthus × giganteus (M×g; triploid), are desired for trait improvement. Agrobacterium tumefaciens has been used in other Miscanthus spp. for genetic improvement, but not in M×g, nor have more than a few genes been introduced at a given time. Transformation procedures for M×g were developed; studies included use of A.tumefaciens (strain LBA4404) and A. rhizogenes (strain A4) for introduction of seven genes isolated (by other researchers) from Sorghum bicolor involved in sorgoleone biosynthesis (an allelopathic compound), and selectable marker gene neomycin phosphotransferase II. Procedural development included generation of …

Growing Tea In Mississippi, Qianwen Zhang

Theses and Dissertations

Tea is the most popular beverage worldwide, second only to water. The United States is the third largest importer of tea in the world, importing a total of about 260 million pounds tea annually. With increased demand for locally sourced food products, questions are raised regarding whether domestic production of tea is feasible. Compared to major tea producing countries with centuries of growing history, tea production in the U.S. is limited and requires research support in many aspects of tea production. The objectives of this study were to investigate plant growth, leaf morphology, and seasonal chemical compositions in tea leaves …

Effects Of Pruning Timing, Leaf Removal, And Shoot Thinning On 'Midsouth' Winegrape Quality In South Mississippi, Haley Nicole Williams

Theses and Dissertations

‘MidSouth’, a relatively low maintenance interspecific hybrid bunch grape currently grown in South Mississippi, has low sugar and high acid levels for red wine use. Two studies, conducted at the Mississippi State University McNeill Research Unit in 2020 and 2021, determined the effects of pruning timing, leaf removal, and shoot thinning on ‘MidSouth’ development and fruit and wine quality. Treatments in the first study included early versus normal pruning timing, both with and without leaf removal, and treatments in the second study included leaf removal, shoot thinning, and control vines. Cluster temperatures, leaf chlorophyll, berries per cluster, berry and cluster …

Novel Strategies In Near Infrared Spectroscopy (Nirs) And Multivariate Analysis (Mva) For Detecting And Profiling Pathogens And Diseases Of Agricultural Importance., Johjan Mariana Santos Rivera

Theses and Dissertations

The time required for the identification of pathogens is an important determinant of infection-related mortality rates and disease spread for species of relevance in agriculture. Conventional identification methods require a processing time of at least one to twenty days. Therefore, inaccurate empirical treatments are often provided while awaiting further identification, such that most cases progress with further aggravation of symptoms, contamination of other animals or plants, generating economic loss from decreased yield, and increased mitigation costs. Thus, there is a need for innovative, non-destructive, and rapid analytical techniques that provide reagent-free, portable, reliable, and holistic approaches to detect diseases in …

Cross-Laminated Timber (Clt) Mechanical Properties Evaluation., Laurice Mara Spinelli Correa

Theses and Dissertations

As the use of engineered wood products as such as cross-laminated timber (CLT) evolves in United States, it’s imperative to understand its behavior under different circumstances as well as to explore new possible streams for product’s application. In that matter, it was proposed that a research study would be developed to evaluate the performance of CLT panels focusing on strength and stiffness properties. To accomplish this goal, three main objectives were traced: 1) To complete preliminary test on traditional lumber in order to observe notched wood failure behavior focusing on strength, ductility, and failure mode; 2) To perform mechanical testing …

Identification Of Pneumococcal Membrane Proteins Involved In Colonization/Biofilm Formation And Cognate Host Cellular Receptors, Yoonsung Hu

Theses and Dissertations

Colonization is prerequisite for infection and transmission of Streptococcus pneumoniae, or pneumococcus. Currently available pneumococcal conjugate and pneumococcal polysaccharide vaccines can provide protection against a limited number of capsular serotypes. Implementation of vaccines has decreased the frequency of invasive pneumococcal disease and their colonization rates, but only in a serotype-dependent manner. This has led to serotype replacement in pneumococcal ecology and increased invasive disease caused by non-vaccine serotypes. Development of conserved protein-based vaccine that can provide protection against all pneumococcal serotypes is needed. Numerous surface proteins are conserved in all serotypes, and some are known to be involved in …

Is Agriculture Being Implemented In Private School Classrooms? The Impact Of Teacher Willingness And Availability Of Resources., Casey Moss

Theses and Dissertations

Agricultural literacy has been a topic of concern as most of the population have little to no understanding of agriculture, and the impact it has on society. Agricultural literacy can be defined as “having knowledge and understanding of agriculturally related scientific and technologically based concepts and processes required for personal decision making” (Meischen & Trexler, 2003, p.44). Numerous studies have been conducted to determine the significance of agricultural literacy beginning with elementary aged children and continuing through high school. The majority of studies conducted focus on public school students and teachers. This has led to a gap in the knowledge …

Plugging Into A New Age: The Impact Of Social Media Use On Undergraduate Students’ Perceptions Of Production Agriculture And Consumer Decisions, Shannon K. Allen

Theses and Dissertations

Today, 84% of young adults between the ages of 18-29 use at least one social media site (Pew Research Center, 2020) and are in the stages of emerging adulthood where they are making independent decisions for the first time (Arnett, 2000). As society becomes more technologically advanced, we become further removed from agriculture (Powell & Agnew, 2011; Dale et al., 2017). Thus, resulting in a separation between consumer and producer (Wilson & Lusk, 2020; Holt & Cartmell, 2013). This leaves the opportunity for society to turn to social media for agriculture information leading to negative perceptions of agriculture (Eyck, 2000; …