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Articles 5161 - 5190 of 254184
Full-Text Articles in Life Sciences
An Integrated Evaluation Of Trace Mineral Status, Regional Variation, And Supplementation Effects On Circulating Mineral And Reproductive Performance In American Plains Bison, Bailey M. Rodriguez
An Integrated Evaluation Of Trace Mineral Status, Regional Variation, And Supplementation Effects On Circulating Mineral And Reproductive Performance In American Plains Bison, Bailey M. Rodriguez
Electronic Theses and Dissertations
The continued expansion of the American Plains Bison (Bison bison) industry has increased the need for science-based nutritional recommendations tailored specifically to the species, due to limited species-specific research. Because trace minerals influence immune function, growth, and reproductive performance, establishing baseline mineral status and evaluating responses to supplementation are critical for advancing bison production and conservation efforts. This thesis integrates two complementary investigations to evaluate trace mineral status in American Plains bison at both regional and herd management levels. First, a herd level comparison evaluated the influence of differing mineral supplementation strategies on circulating mineral concentrations, herd performance, and reproductive …
Winter-Feeding High Forage Vs. High Concentrate Diets To Beef Cows: Effects On Placental Transcriptomics, Lactation Capacity, And Enteric Methane Emissions, Megan Ann Wehrbein
Winter-Feeding High Forage Vs. High Concentrate Diets To Beef Cows: Effects On Placental Transcriptomics, Lactation Capacity, And Enteric Methane Emissions, Megan Ann Wehrbein
Electronic Theses and Dissertations
Nutritional management and lactation performance are critical factors influencing productivity in cattle. This research includes two complementary studies. The first study was a meta-analysis to develop a lactation curve for Bos taurus cattle in North America using data from machine or hand milked cows. Data from 7 studies were used resulting in 1340 cow-day observations. Milk yield was analyzed by parity (primiparous or multiparous) and feeding management (non-nutrient restricted or nutrient restricted), revealing that primiparous cattle peaked earlier and at lower yields than multiparous cattle, and nutrient restriction reduced peak milk yield. Overall, Bos taurus cattle followed lactation trends similar …
Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk, Yasir A. Alshehry, Matthew S. Halquist Phd, Sandro R.P. Da Rocha Phd
Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk, Yasir A. Alshehry, Matthew S. Halquist Phd, Sandro R.P. Da Rocha Phd
Graduate Research Posters
Background
RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance …
Evaluation Of Neutrophils To Albumin Ratio (Nar) And C-Reactive Protein To Albumin Ratio (Car) As Markers Of Disease Activity In Patients With Ulcerative Colitis, Doaa Salah Abd-El-Fattah, Mohamed Abd El-Maksoud, Salwa M. Abo El-Khair, Ahmed El-Eraky, Amany Hasson
Evaluation Of Neutrophils To Albumin Ratio (Nar) And C-Reactive Protein To Albumin Ratio (Car) As Markers Of Disease Activity In Patients With Ulcerative Colitis, Doaa Salah Abd-El-Fattah, Mohamed Abd El-Maksoud, Salwa M. Abo El-Khair, Ahmed El-Eraky, Amany Hasson
Mansoura Medical Journal
Background Ulcerative colitis (UC) is considered an extensive disease due to the risks of proximal extension, malignant transformation, disability and impaired life quality. This study aimed to explore the role of Neutrophils to Albumin Ratio (NAR) and C - reactive protein to Albumin Ratio (CAR) in evaluation of disease activity in patients with UC. Methods This cross-sectional study included 227subjects classified into two groups; group (I) included 126patients suffering from ulcerative colitis and group (II) included 101 healthy individuals with normal basic laboratory tests matched for age and sex. Estimating disease activity and severity clinically was according to Truelove criteria. …
Management Of Seroma After Posterior Lumbar Spine Decompression, Ayman Mohamed Basha, Ahmed Anas Zahra
Management Of Seroma After Posterior Lumbar Spine Decompression, Ayman Mohamed Basha, Ahmed Anas Zahra
Mansoura Medical Journal
Background: Postoperative seroma formation represents a significant complication following posterior lumbar spine decompression (PLSD) that can compress neural structures, cause radiculopathy, and serve as potential infection sources. This study evaluated the clinical characteristics and therapeutic approaches for seroma formation after posterior lumbar decompression procedures.
Methods: An observational study was conducted on 140 patients aged 18 years and older who underwent elective PLSD. Patients were systematically evaluated at predetermined intervals using clinical examination and diagnostic imaging when seroma was suspected. Management protocols were stratified according to seroma size, symptom severity, and clinical progression, ranging from conservative compression dressings to percutaneous aspiration …
Computed Tomographic Assessment Of Morphological Parameters Of The Normal Vermiform Appendix In Adults: A Prospective Cross-Sectional Study, Asmaa Mohamed Mansour Mahmoud, Magdy El-Sayed Mohamed Steen, Ahmed Mohamed Tawfik
Computed Tomographic Assessment Of Morphological Parameters Of The Normal Vermiform Appendix In Adults: A Prospective Cross-Sectional Study, Asmaa Mohamed Mansour Mahmoud, Magdy El-Sayed Mohamed Steen, Ahmed Mohamed Tawfik
Mansoura Medical Journal
Background: The vermiform appendix is a hollow tubular structure arising from the cecum, typically located in the right lower quadrant of the abdomen. Aim: This study aimed to estimate the visualization rate of CT scan in the detection of normal appendix, along with its characteristics (length, diameter, and site). Methods: For this prospective cross-sectional investigation, 56 individuals were included who were scheduled to have abdominal CT. The helical scanner was used to acquire CT images with 5 millimeters of collimation and reconstruction for each 2.5 millimeters. The CT films were reviewed by an experienced radiologist, who was unaware of the …
Assessment Of Serum Adropin In Erectile Dysfunction Patients And Its Correlation With Disease Severity, Ahmed M. Eltohami, Sh. Fouad, Khadiga M. El-Hamaky, Abdel Khabir A.
Assessment Of Serum Adropin In Erectile Dysfunction Patients And Its Correlation With Disease Severity, Ahmed M. Eltohami, Sh. Fouad, Khadiga M. El-Hamaky, Abdel Khabir A.
Mansoura Medical Journal
Background Erectile dysfunction (ED) may be considered an indicator of cardiovascular disease (CVD). Adropin is identified to be accompanied by insulin sensitivity, and lipid metabolism, so we aimed to investigate serum adropin levels in ED cases compared to healthy controls (HC). Methods This case control study included 50 men with ED and and control group of 25 agematched, sexually active healthy men with normal erectile function. Cases group was divided into two groups (25 each) as ED patients with and without type 2 Diabetes Mellitus (T2DM). Validated Arabic version of International Index of Erectile Function (IIEF)-5 was used to evaluate …
Impact Of Autonomic Dysfunction On Quality Of Life In Patients With Parkinson's Disease: A Single-Center Exploratory Study, Hadeer Elsaeed Aboelfarh, Ahmed S. Alkotami, Mohamed Galal Elkhateeb, Aya Zhran
Impact Of Autonomic Dysfunction On Quality Of Life In Patients With Parkinson's Disease: A Single-Center Exploratory Study, Hadeer Elsaeed Aboelfarh, Ahmed S. Alkotami, Mohamed Galal Elkhateeb, Aya Zhran
Mansoura Medical Journal
Background: Autonomic dysfunction represents one of the major non-motor manifestations of Parkinson’s disease (PD) and can negatively influence patients’ health-related quality of life (QoL). This study investigated the frequency and severity of autonomic symptoms in individuals with PD and examined their relationship with QoL in a single-center cohort.
Methods: Thirty patients with idiopathic PD were assessed for autonomic dysfunction, quality of life, and motor severity using validated PD–specific rating scales.
Results: Among the autonomic subdomains, urinary symptoms demonstrated the greatest degree of impairment (median score 41.67%) and showed the strongest correlation with overall PDQ-39 scores (r=0.605, p≤0.001). Higher …
Radial And Carotid Arterial Pulse Signals For Assessing Cardiovascular Function At Rest And During Post-Exercise Recovery In A Heart Transplant Patient: A Case Study, Md Mahfuzur Rahman, Mamun Hasan, Jennifer F. May, John M. Herre, Leryn Reynolds, Zhili Hao
Radial And Carotid Arterial Pulse Signals For Assessing Cardiovascular Function At Rest And During Post-Exercise Recovery In A Heart Transplant Patient: A Case Study, Md Mahfuzur Rahman, Mamun Hasan, Jennifer F. May, John M. Herre, Leryn Reynolds, Zhili Hao
Mechanical & Aerospace Engineering Faculty Publications
Aim: This study investigates the feasibility of using radial and carotid arterial pulse signals to assess cardiovascular (CV) function at rest and during post-exercise recovery in a heart transplant (HTx) patient. Method: Two micro-fabricated tactile sensors were used to simultaneously acquire arterial pulse signals at the radial artery (RA) and carotid artery (CA). Measurements were taken at rest and at multiple time points post-exercise on three subjects: an HTx patient, a percutaneous coronary intervention (PCI; coronary stent) patient and a healthy control. An SDOF-TF-based time-frequency analysis algorithm was applied to extract a comprehensive set of CV parameters, including heart rate …
Considerations For The Analysis Of Urinary Environmental Chemical Concentrations During Pregnancy, Danielle R. Stevens, Kaleigh Hinton, Katie M. O'Brien, Jessie P. Buckley, Barrett M. Welch, Jason A. Watts, Antonia M. Calafat, Julianne C. Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson
Considerations For The Analysis Of Urinary Environmental Chemical Concentrations During Pregnancy, Danielle R. Stevens, Kaleigh Hinton, Katie M. O'Brien, Jessie P. Buckley, Barrett M. Welch, Jason A. Watts, Antonia M. Calafat, Julianne C. Botelho, Elena Sinkovskaya, Ann Przybylska, George Saade, Alfred Abuhamad, Kelly K. Ferguson
Department of Obstetrics & Gynecology Faculty Publications
Background:
Pregnancy physiology may impact indicators of hydration, affecting exposure assessment in gestational studies with urinary chemical biomarkers.
Methods:
We aimed to characterize hydration and demonstrate the impact of different methods for standardizing urinary chemical biomarker concentrations on exposure descriptives in the Human Placenta and Phthalates Study (n = 303, 2017-2020), a prospective pregnancy cohort with eight study visits between 12 and 38 weeks of gestation. We assessed trajectories and predictors of hydration using urine flow rate (UFR) and specific gravity (SG). Likewise, we examined trajectories and predictors of mono-n-butyl phthalate (MBP), for which concentrations were unstandardized or standardized via …
The Critical Role Of Near-Surface Dynamics In Identifying Spawning Areas Of Atlantic Bluefin Tuna In The Gulf Of Mexico, Donald R. Johnson, William J. Teague, Harriet Perry, James S. Franks
The Critical Role Of Near-Surface Dynamics In Identifying Spawning Areas Of Atlantic Bluefin Tuna In The Gulf Of Mexico, Donald R. Johnson, William J. Teague, Harriet Perry, James S. Franks
Gulf and Caribbean Research
Atlantic Bluefin Tuna, Thunnus thynnus (ABFT), migrate long distances to broadcast spawn in the Gulf of Mexico (GOM) basin, the Mediterranean Sea and the Slope Sea (NW Atlantic). These areas have commonalities including a highly dynamic upper ocean eddy environment that draws nutrients from shallow thermoclines and adjacent continental shelves and can provide temporal sanctuaries from some larval predators. In the GOM basin, the Loop Current (LC) and its energetic spin—off eddies sweep weak swimming predators such as jellyfish (Pelagia noctiluca) into lines and aggregations, leaving relatively open areas as temporal sanctuaries for ABFT larvae during the vulnerable …
Oyster Drill (Stramonita Haemastoma Complex) Habitat Preferences In A Shallow Coastal Estuary, Coen Mcgarrah, Cynthia Lupton, Eric Sparks, Jennifer L. Debose
Oyster Drill (Stramonita Haemastoma Complex) Habitat Preferences In A Shallow Coastal Estuary, Coen Mcgarrah, Cynthia Lupton, Eric Sparks, Jennifer L. Debose
Gulf and Caribbean Research
Southern oyster drill snails (Stramonita haemastoma complex) are nuisance organisms within the Gulf of Mexico. This is due to their damaging impact on recovering and farmed oyster (Crassostrea virginica) populations, which are one of the drills’ main food sources. Oyster reef recovery and increased aquaculture production are priorities for Mississippi and the wider northern Gulf coast. The Grand Bay National Estuarine Research Reserve (NERR) hosts multiple oyster reef restoration sites within its boundaries, yet no comprehensive survey of oyster drill abundance has been conducted in this area to date. Additionally, knowledge of oyster drill preferences for sediment …
First Photo-Identification Resighting Of A Male Sperm Whale (Physeter Macrocephalus) Between Guadeloupe, Lesser Antilles And Andøya, Northern Norway, Rocío Prieto González, Lisa Steiner, Zoë Morange, Tiu Similä, Marten Brill, Cédric Millon, Laurent Bouveret
First Photo-Identification Resighting Of A Male Sperm Whale (Physeter Macrocephalus) Between Guadeloupe, Lesser Antilles And Andøya, Northern Norway, Rocío Prieto González, Lisa Steiner, Zoë Morange, Tiu Similä, Marten Brill, Cédric Millon, Laurent Bouveret
Gulf and Caribbean Research
No abstract provided.
Pollutant Load Reduction In Sarasota Bay, Florida (Usa): Target Development, Implementation, And Outcomes, David Tomasko, Mike Wessel, Jon Perry, Chris Anastasiou, Ryan Gandy
Pollutant Load Reduction In Sarasota Bay, Florida (Usa): Target Development, Implementation, And Outcomes, David Tomasko, Mike Wessel, Jon Perry, Chris Anastasiou, Ryan Gandy
Gulf and Caribbean Research
Between 2006 and 2012, seagrass coverage across Sarasota Bay expanded by 1,108 ha, a 28% increase. During the subsequent years of 2012−2020, 830 ha of seagrass were lost, a 16% decline. In response to these findings, resource management efforts focused on determining the likely reason(s) why those 2 periods had such contrasting trends, to come up with strategies to reverse these losses. Based on results from the seagrass data, the 7—y period of 2006−2012 was designated a “reference period” and water quality data were compared against the subsequent 7—y designated “degraded period” of 2013−2019. Annual average chlorophyll-a (chl-a …
Standardization Of Neuromuscular Reflex Analysis—Role Of Fine-Tuned Vision-Language Model Consortium And Openai Gpt-Oss Reasoning Llm-Enabled Decision Support System, Eranga Bandara, Ross Gore, Sachin Shetty, Ravi Mukkamala, Christopher K. Rhea, Brittany S. Samulski, Amin Hass, Atmaram Yarlagadda, Shaifali Kaushik, Malith De Silva, Andriy Maznychenko, Inna Sokolowska, Kasun De Zoysa
Standardization Of Neuromuscular Reflex Analysis—Role Of Fine-Tuned Vision-Language Model Consortium And Openai Gpt-Oss Reasoning Llm-Enabled Decision Support System, Eranga Bandara, Ross Gore, Sachin Shetty, Ravi Mukkamala, Christopher K. Rhea, Brittany S. Samulski, Amin Hass, Atmaram Yarlagadda, Shaifali Kaushik, Malith De Silva, Andriy Maznychenko, Inna Sokolowska, Kasun De Zoysa
VMASC Publications
Background/Objectives: Accurate assessment of neuromuscular reflexes, such as the Hoffmann reflex (H-reflex), plays a critical role in sports science, rehabilitation, and clinical neurology. Conventional interpretation of H-reflex electromyography (EMG) waveforms is subject to inter-rater variability and interpretive bias, limiting reliability and standardization. This study aims to develop an automated, interpretable, and robust agentic AI–driven framework for H-reflex waveform analysis. Methods: We propose a fine-tuned Vision–Language Model (VLM) consortium combined with a reasoning Large Language Model (LLM)–enabled decision support system for automated H-reflex interpretation. Multiple VLMs were fine-tuned on curated datasets of H-reflex EMG waveform images annotated with expert clinical observations, …
Feeding Mode Is Associated With Infant Night Sleep Trajectories During The First Postnatal Year, Magdalena Olson, Li Liu, Elizabeth Reifsnider, Dean V. Coonrod, Sarada S. Panchanathan, Megan E. Petrov, Corrie M. Whisner
Feeding Mode Is Associated With Infant Night Sleep Trajectories During The First Postnatal Year, Magdalena Olson, Li Liu, Elizabeth Reifsnider, Dean V. Coonrod, Sarada S. Panchanathan, Megan E. Petrov, Corrie M. Whisner
Ellmer School of Nursing Faculty Publications
Background: Short sleep and formula feeding during infancy are associated with increased risk of childhood obesity. Feeding practices and sleep arrangements vary during infancy and may also be dynamic, yet their impact on infant night sleep duration remains unclear. Understanding these relationships is crucial for formulating recommendations to support breastfeeding and address sleep concerns. Objective: We examined the association between feeding mode and parent-reported infant night sleep duration during the first postnatal year, while additionally evaluating night-weaning and bedsharing as contextual sleep-related practices. Methods: Infants in the Phoenix Metropolitan Area (n = 193) were followed up at 3, 8, 13, …
Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht
Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht
Department of Biomedical and Translational Sciences Faculty Publications
Background
Suppressing estradiol (E₂) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin-mediated glucose uptake, and induces insulin resistance. We examined whether E₂ deprivation also impairs microvascular flow and cardiac function.
Methods
Offspring of untreated baboons, letrozole-treated baboons, or letrozole plus E₂ (maternal s.c. injections during the second half of gestation) underwent contrast-enhanced microbubble ultrasonography to quantify microvessel flow and echocardiography to assess cardiac performance.
Results
Letrozole reduced maternal serum E₂ by 95% (p < 0.01). In letrozole offspring, microbubble flux rate (β) fell 55% (p < 0.02), replenishment was 5 s slower (p < 0.03), and microvessel flow declined 40% (p = 0.05); all were restored by added E₂. Indices of systolic (isovolumic contraction), diastolic (isovolumic relaxation), global performance (Tei index), and cardiac output were unchanged.
Conclusion
Prolonged gestational E₂ deprivation programs a reduction in microvascular flow without altering cardiac function; maternal E₂ prevents this, supporting E₂'s role in …
Element-Based Predictive Modeling Of Hydrothermal Liquefaction Bioproducts Derived From Corn Stover, Isamu Umeda, Meicen Liu, Yi Zheng, Jiefu Wang, Zhiwu Wang, Sandeep Kumar
Element-Based Predictive Modeling Of Hydrothermal Liquefaction Bioproducts Derived From Corn Stover, Isamu Umeda, Meicen Liu, Yi Zheng, Jiefu Wang, Zhiwu Wang, Sandeep Kumar
Civil & Environmental Engineering Faculty Publications
The hydrothermal liquefaction (HTL) process offers an energetic advantage over pyrolysis because it does not require prior drying of the biomass feedstock. However, there are significant challenges in simultaneously estimating both the yields and characteristics of products from the HTL of biomass with theoretical support. This study developed a unique element-based kinetic model to predict the yields, higher heating values, and fuel characteristics of solid residue and heavy bio-oil, based on the temperature, residence time, solid loading, and elemental composition (C, H, N, and O) of corn stover. Furthermore, the model predicted the weights of dissolved carbon and nitrogen in …
Comparative Mass Spectrometry Analysis Of High And Low Centrifugation Extracellular Vesicle (Ev) Pellets From Healthy Urine Following Tamm-Horsfall Protein Removal, Dana Bielopolski, Luca Musante, Henrik Molina, Douglas Barrows, Samantha Upson, Lifang Yang, Thomas Carrol, Jonathan N. Tobin, Rhonda G. Kost, U. Erdbrügger
Comparative Mass Spectrometry Analysis Of High And Low Centrifugation Extracellular Vesicle (Ev) Pellets From Healthy Urine Following Tamm-Horsfall Protein Removal, Dana Bielopolski, Luca Musante, Henrik Molina, Douglas Barrows, Samantha Upson, Lifang Yang, Thomas Carrol, Jonathan N. Tobin, Rhonda G. Kost, U. Erdbrügger
Department of Biomedical and Translational Sciences Faculty Publications
Objectives
Urinary extracellular vesicles (uEVs) are potential biomarkers for renal physiology and disease. Their isolation is challenged by Tamm-Horsfall protein (THP) contamination, particularly in high-speed ultracentrifugation (P100) fractions. Low-speed (P20) fractions contain biologically relevant uEVs, yet their proteomic composition is underexplored. This study evaluates strategies for THP removal to optimize mass spectrometry analysis and characterizes P20 and P100 uEV proteomes and its combination in healthy urine.
Methods
Urine from a healthy volunteer was processed via sequential centrifugation at 21,200 g (P20) and 164,244 g (P100). THP removal was performed using low ionic strength buffer (P20) and size-exclusion chromatography (P100). Western …
Ovarian Cancer Immunology And Immunotherapy: Editorial Note, Chris D. Platsoucas
Ovarian Cancer Immunology And Immunotherapy: Editorial Note, Chris D. Platsoucas
Biological Sciences Faculty Publications
[Introduction] As the guest editor of the Special Issue on Ovarian Cancer Immunology Immunotherapy, I would like to include certain brief comments on the current state of the field and to introduce the Special Issue. Ovarian carcinoma and malignant melanoma are the first human tumors where immune responses, primarily restricted to autologous tumor cells, were first demonstrated. T-cell lines and clones developed in recombinant interleukin-2 (rIL-2) from tumor-infiltrating lymphocytes (TIL) from these tumors exhibited cytotoxicity and/or cytokine production, primarily restricted to autologous tumor cells. The T-cell receptor (TCR) and the CD3 differentiation antigen on effector T cells and HLA on …
Bayesian Multivariate Modelling Of Lone Star (Amblyomma Americanum) Tick Life Stage Abundance And Temporal Trends To Inform Public Health Risk In Virginia, Thabo Lephoto, Henry Mwambi, Oliver Bodhlyera, Holly Gaff
Bayesian Multivariate Modelling Of Lone Star (Amblyomma Americanum) Tick Life Stage Abundance And Temporal Trends To Inform Public Health Risk In Virginia, Thabo Lephoto, Henry Mwambi, Oliver Bodhlyera, Holly Gaff
Biological Sciences Faculty Publications
The increasing abundance of ticks poses a growing public health concern due to heightened human exposure to tick bites. The lone star tick (Amblyomma americanum: Ixodida: Ixodidae), a common human-biting species in the United States, has expanded its range in recent years. However, how its different life stages vary across time, habitats, and locations remains insufficiently understood. We analyzed tick abundance data collected in southeastern Virginia between 2009 and 2018, focusing on larval, nymphal, and adult life stages. A Bayesian multivariate modelling framework was used to examine seasonal patterns, habitat effects, spatial variation, and biological links between life stages. Two …
Left In The (Road) Dust: Analyzing Advanced Clean Cars Ii In California’S Disadvantaged Communities, Jj Hoffman
Left In The (Road) Dust: Analyzing Advanced Clean Cars Ii In California’S Disadvantaged Communities, Jj Hoffman
Pomona Senior Theses
Across the United States, air pollution disproportionately impacts minority groups. California’s Advanced Clean Cars II (ACC II) waiver was positioned to lead to significant environmental justice impacts, such as reductions in emissions and adverse health outcomes, by establishing stricter regulations for vehicle emissions and ensuring that 100 percent of new passenger vehicle sales are zero-emission by 2035. As the federal government recently nullified ACC II, pollution, and by extension health, could worsen, especially in disadvantaged communities. The thesis established several important relationships, including how disadvantaged communities experienced higher traffic, pollution, and worse health outcomes than non-disadvantaged communities. Though the results …
Feral Horses And Native Ungulates: Evaluating The Potential For Competition In Predator–Prey Communities Of Alberta’S Upper Foothills, Birch Gano
Graduate Student Theses, Dissertations, & Professional Papers
Feral herbivores are expanding in range and numbers globally, yet their community-level effects in ecosystems are poorly resolved. We evaluated whether feral horses reshape predator–prey–vegetation dynamics in Alberta’s Upper Foothills, Canada, through two pathways; i) potential exploitative competition for forage and ii) apparent competition via shared predators. We combined fecal DNA metabarcoding with remote wildlife cameras to quantify diets, spatiotemporal co-occurrence, and the role of horses in carnivore diet. We analyzed 241 ungulate scats (feral horses, elk, bighorn sheep, cattle, moose, and deer), 96 combined camera-years at 23 sites, and 190 carnivore scats (wolves, cougars, coyotes, bears) from 2023–2025. The …
High Algal Biomass Is Decoupled From Metabolism In The Gallatin River, Cora Mae Steinbach
High Algal Biomass Is Decoupled From Metabolism In The Gallatin River, Cora Mae Steinbach
Graduate Student Theses, Dissertations, & Professional Papers
Assessing eutrophication in rivers is difficult compared to lakes and coastal waters, because most algal biomass occurs on the riverbed and flows interact and co-vary with production (Biggs and Close, 1989; Bernhardt et al., 2018). Riverine eutrophication is typically assessed using algal biomass and water column nutrients (U.S. Environmental Protection Agency, 2000), but biomass is highly variable and labor-intensive to measure, while nutrient concentrations often underestimate enrichment due to rapid biological uptake (Dodds and Smith, 2016). Reach-scale river metabolism can help evaluate long-term functional change in rivers recovering from nutrient enrichment (Arroita et al., 2019; Jankowski et al., 2021; Diamond …
An Ecological-Evolutionary Investigation Of Phenotypic, Genetic, And Environmental Variation And Correlations Among Reproductive Traits Of Tall Goldenrod (Solidago Altissima), Michael J. Wise, Daniel Lavy, David E. Carr, Warren G. Abrahamson Ii
An Ecological-Evolutionary Investigation Of Phenotypic, Genetic, And Environmental Variation And Correlations Among Reproductive Traits Of Tall Goldenrod (Solidago Altissima), Michael J. Wise, Daniel Lavy, David E. Carr, Warren G. Abrahamson Ii
Faculty Journal Articles
Although fitness-related traits are expected to be under strong selection, traits related to reproduction are often quite variable within plant populations. We used data from two large greenhouse experiments to quantify phenotypic, genetic, and environmental variation, as well as genetic tradeoffs that might help explain the maintenance of withinpopulation variation in four traits related to sexual or vegetative reproduction in tall goldenrod (Solidago altissima). The goldenrod population exhibited high levels of both phenotypic and genetic variation for capitulum (flower head) number and size, seed production, and rhizome growth. Significant negative genetic correlations were present between the number of capitula and …
Frame: Fast Reference-Based Ancestry Makeup Estimation Tool, Pramesh Shakya, Ardalan Naseri, Degui Zhi, Shaojie Zhang
Frame: Fast Reference-Based Ancestry Makeup Estimation Tool, Pramesh Shakya, Ardalan Naseri, Degui Zhi, Shaojie Zhang
Faculty, Staff and Student Publications
Motivation: The availability of large-scale genetic data presents a unique opportunity to study the genetic ancestries of individuals, which requires an efficient and scalable method. The existing global ancestry methods are accurate, but they cannot scale to large genetic datasets. Identity-by-descent (IBD) segments are DNA segments shared by individuals such that they are inherited from a common recent ancestor without recombination. These IBD segments, which reflect co-ancestry, provide an efficient alternative for inferring genetic ancestry.
Results: We introduced a reference-based global ancestry inference method called FRAME (Fast Reference-based Ancestry Makeup Estimation). FRAME utilizes partial local ancestry information estimated through IBD …
35 Individuals With Huwe1-Related Neurodevelopmental Disorder And Suggested Clinical Evaluations, Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillman, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano
35 Individuals With Huwe1-Related Neurodevelopmental Disorder And Suggested Clinical Evaluations, Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillman, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano
Department of Pediatrics Faculty Publications
HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X-linked intellectual disability, including in the patients identified by Juberg, Marsidi, and Brooks. This report describes 35 additional cases of individuals with variants in HUWE1 and suggested guidelines for clinical management. Our study includes several female cases, which have not been widely reported previously. Our findings confirm earlier reported clinical features including developmental delay, autism, hypotonia, short stature, and dysmorphic facial features as well …
An Ensemble Classifier For Ordinal Outcomes In High-Dimensional Genomics Data, Heranga K. Rathnasekara, Sinjini Sikdar
An Ensemble Classifier For Ordinal Outcomes In High-Dimensional Genomics Data, Heranga K. Rathnasekara, Sinjini Sikdar
Mathematics & Statistics Faculty Publications
Analysis of genomics data for predicting disease outcomes is a fast-growing field in medical research. There often exist categorical, specifically, ordinal outcomes that need to be predicted based on genomic profiles. This has led to recent development of some high-dimensional ordinal classification methods that can address the large dimensionality of the genomic covariate set. These high-dimensional ordinal models tend to vary widely in their performance depending on the data they are applied to and the evaluation criteria used. In this article, we outline an ensemble ordinal classifier that integrates different ordinal modeling approaches through bootstrap-based model evaluation, multi-metric performance assessment, …
Evaluating Species At Risk In Data-Limited Fisheries: A Productivity-Susceptibility Analysis For Marine Aquarium Fish, Gabrielle A. Baillargeon, Alice A. Wynn, Jemelyn Grace P. Baldisimo, Michael F. Tlusty, Andrew L. Rhyne
Evaluating Species At Risk In Data-Limited Fisheries: A Productivity-Susceptibility Analysis For Marine Aquarium Fish, Gabrielle A. Baillargeon, Alice A. Wynn, Jemelyn Grace P. Baldisimo, Michael F. Tlusty, Andrew L. Rhyne
Biological Sciences Faculty Publications
The marine aquarium trade (MAT) is a significant global industry harvesting millions of wild-caught, live coral reef fishes for public and private aquaria markets in the United States and Europe annually, while supporting fisher livelihoods in the Indo-Pacific. This diverse and species-rich trade is considered data-limited, creating barriers to quantifying the current and future socio-ecological sustainability of the fishery. We present a revised and expanded productivity–susceptibility analysis (PSA) that serves as a holistic risk assessment to estimate the vulnerability of marine aquarium fish to overfishing. Our global analysis includes 306 species that are actively in trade. Improvements to the PSA …
Does Fishery Management For Groupers (Teleostei: Epinephelidae) Protect Them Effectively? Context From The Iucn's Red List Of Threatened Species, Sean T. Fennessy, Christi Linardich, Kevin Rhodes, Joao P. Barreiros, David Pollard, Eloy Sosa-Cordero, Felicia Coleman, Alfonso Aguilar-Perera, Christopher R. Malinowski, Thierry Brulé, Pedro Afonso, Kayan Ma, Min Liu, Muktha Menon, Colin Wen, Stanley K. H. Shea, Sean N. Porter, Matthew Craig, Yvonne Sadovy De Mitcheson
Does Fishery Management For Groupers (Teleostei: Epinephelidae) Protect Them Effectively? Context From The Iucn's Red List Of Threatened Species, Sean T. Fennessy, Christi Linardich, Kevin Rhodes, Joao P. Barreiros, David Pollard, Eloy Sosa-Cordero, Felicia Coleman, Alfonso Aguilar-Perera, Christopher R. Malinowski, Thierry Brulé, Pedro Afonso, Kayan Ma, Min Liu, Muktha Menon, Colin Wen, Stanley K. H. Shea, Sean N. Porter, Matthew Craig, Yvonne Sadovy De Mitcheson
Biological Sciences Faculty Publications
Worldwide, groupers (Epinephelidae) are commercially valued fishes, which also play key ecological roles on tropical and subtropical reefs. In 2007 and 2016, the IUCN's Groupers and Wrasses Specialist Group assessed all 160+ grouper species, with 17 of these being identified as threatened in 2016 and the major threat factor being overexploitation. Our present study aimed to identify whether management measures (MMs) for previously assessed groupers were established, whether these measures aligned with IUCN's Red List categories, and whether they effectively protect grouper populations. Experts in grouper biology and management assigned scores per grouper species based on the extent to which …