Life Sciences Commons^™

Reshaping The Tumor Microenvironment With Oncolytic Viruses, Positive Regulation Of The Immune Synapse, And Blockade Of The Immunosuppressive Oncometabolic Circuitry, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F Lang, Christopher Alvarez-Breckenridge, Filipa Godoy-Vitorino, Lisha Zhu, W Jim Zheng, Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Marta M Alonso, Derek A Wainwright, Candelaria Gomez-Manzano, Juan Fueyo

Faculty, Staff and Student Publications

Background: Oncolytic viruses are considered part of immunotherapy and have shown promise in preclinical experiments and clinical trials. Results from these studies have suggested that tumor microenvironment remodeling is required to achieve an effective response in solid tumors. Here, we assess the extent to which targeting specific mechanisms underlying the immunosuppressive tumor microenvironment optimizes viroimmunotherapy.

Methods: We used RNA-seq analyses to analyze the transcriptome, and validated the results using Q-PCR, flow cytometry, and immunofluorescence. Viral activity was analyzed by replication assays and viral titration. Kyn and Trp metabolite levels were quantified using liquid chromatography-mass spectrometry. Aryl hydrocarbon receptor (AhR) activation …

Recycled Concrete Aggregates Are An Economic Form Of Urban Riparian Erosion Management With Limited Impacts On Freshwater Chemistry And Microbial Diversity, Rachelle E. Beattie, Bixia Su, Rebecca Thill, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Urban streams are at high risk of riparian erosion which impacts adjacent infrastructure stability. Methods to prevent stream erosion have been proposed including using recycled concrete (RC) materials to help stabilize the streambed; however, little is known about the environmental and biological impacts of using RC in urban streams. RC, new concrete (NC), and river rock controls were evaluated for their impact on water chemistry, water quality, and microbial community composition over 6.5 months in controlled laboratory mesocosms. Concentrations of 19 metals, nutrients, and pH of mesocosms containing RC were not significantly different from the river rock mesocosm throughout the …

Urban Sprawl And Microclimate In The Ga East Municipality Of Ghana, Kwasi Frimpong, Darko Eugene Atiemo, E. J. Van Etten

Research outputs 2022 to 2026

Climatic elements such as temperature and rainfall provide great and unquantifiable benefits to human health. However, rapid urban sprawl has the tendency to undermine these health consequences. The relationship between urban sprawl and microclimate in the Ga East Municipality has been assessed to present the extent of sprawl that inhibit temperature and rainfall in recent times. Methodologically, satellite imagery and meteorological data (minimum and maximum temperature and rainfall) from 1990 to 2020 were used. The results indicate that rapid urban sprawl in recent times has significantly undermined the local climate through land use and land cover changes. There was strong …

The Effect Of Salvia Fruticosa Water Extract In Acetic-Acid-Induced Colitis In Mice, Rim Mrad, Suzana Salhab, Miriam Al-Battal, Jamilah Borjac

BAU Journal - Science and Technology

Inflammatory bowel disease (IBD) including Ulcerative colitis (UC) and Crohn’s disease, is a chronic condition of the intestine characterized by an uncontrolled inflammatory response. Current biologic treatments developed to treat IBD are expensive and associated with significant side effects; thus, alternative approaches are required. Recently, herbal concoctions have emerged as promising intervention. This study investigates the protective effects of Salvia fruticosa (SF) against acetic acid-induced colitis in mice, a model of human inflammatory bowel disease (IBD). Mice were divided into four groups (n=3). IBD was induced with acetic acid (6%). SF was administered by gavage at 1.5ug/kg mimicking folk medicine. …

Novel Fast Analytical Methods For The Analysis Of Fluoxetine In Pure And Pharmaceutical Dosage Form, Diala Jumblat, Alice Bejjani, Azza A. K. Gazy, Marwa El Jamal

BAU Journal - Science and Technology

Novel and accurate analytical methods were developed and validated for the characterization of Fluoxetine in its pure and pharmaceutical dosage form Prozac^®. Fluoxetine was determined by IBA techniques (PIGE, PIXE and RBS). It has been also analyzed spectrophotometrically at 610 nm after oxidation with potassium permanganate in alkaline medium. In addition, Fluoxetine was kinetically determined using the initial rate method, the fixed absorbance method and the fixed time method. Moreover, a Gas chromatography - mass spectrometry technique is proposed for the investigation of Fluoxetine without a prederivatization phase. The spectrophotometric method was performed with a concentration array of …

Effect Of A Commonly Used Veterinary Antibiotic On Oxidative Stress And Root Transporters Of Edible Legumes And Leafy Crops, Safaa Nassar, Jamilah Borjac

BAU Journal - Science and Technology

Antibiotic accumulation in soil and plants is a rising problem in agriculture creating a serious threat to living organisms in the environment, hence needing huge attention. To this end, glasshouse pot experiments were conducted to simulate contamination by veterinary antibiotic at 150 mg kg^-1 and 4800 mg kg^-1 in a virgin soil in which lentil (Lens culinaris Medik.), chickpea (Cicer arietinum L.), arugula (Eruca sativa Mill.) and cress (Lepidium sativum L.) were grown, aiming at evaluating the potential toxicity of antibiotic in plants roots during their growth period. Biomarkers of toxicity such as malondialdehyde and proline …

Method Of Hybrid Control Based Of Dynamic Objects Of Neuro-Fuzzy Inference, Noilakhon Yakubova

Karakalpak Scientific Journal

The Results of interaction of the work is development of a method of control that allows simplifying, automating and unifying the process of design of the hybrid systems which are a basis of modern automation. To achieve a definite purpose, a method of control of a technical object based on the construction of an adaptive system of neuro-fuzzy inference is developed. The objects of the system of neuro-fuzzy inference are the classical and neuro-fuzzy models of control. Information exchange between models is provided by means of the developed hybrid control system. The result of the interaction of the two models …

Application Of A Synergetic Approach To The Problem Of Synthesizing An Intelligent Control System For Chemical Reactors, Komil Usmanov

Karakalpak Scientific Journal

The article deals with the synthesis of effective algorithms for controlling a chemical reactor and developed a intelligent synergistic controller for a class of indefinite nonlinear dynamic systems. A synergetic control scheme is proposed for solving the control problem for nonlinear systems. Non-linear systems with configurations and parameters that change over time require a completely non-linear model and adaptive control scheme for a practical operating environment. The synthesis of control laws is performed by the method of analytical design of aggregated controllers (ADAR).

Development Of The Implementation Of Iot Monitoring System Based On Node-Red Technology, Anvar Kabulov, Inomjon Yarashov, Salamat Mirzataev

Karakalpak Scientific Journal

This article describes how to design and implement a process for storing environmental information in a database using the Internet of Things. The problems that need to be solved with the help of this IoT system are the growing demand for forecasts in the world, the demand of the world market for a new sustainable method of implementing the digitization environment through the Internet of Things. The design was implemented using Arduino, Node-Red and sensors, selected when choosing a component based on the required parameters and sent to the database for monitoring and processing. A study of previous work and …

Theoretical Features Of Foreign Systems Of Preschool Education, Ayjamal Bazarbaeva

Karakalpak Scientific Journal

This article analyzes the features of preschool education systems in foreign countries. The positive experience and features of some systems are highlighted. Comparison of domestic and foreign systems of preschool education is carried out.

Total Factor Productivity In Dairy Buffalo Milk Production In Nueva Ecija, Philippines, Zadieshar G. Sanchez, Antonio Jesus A. Quilloy, Nora Dm. Carambas, Mark Dondi M. Arboleda

Journal of Economics, Management and Agricultural Development

This study analyzed the total factor productivity in dairy buffalo milk production in Nueva Ecija, Philippines. Specifically, it aimed to identify the factors that affect dairy buffalo milk production and analyze technical efficiency, scale efficiency, and technological change as sources of TFP growth. Panel data was established by gathering data from randomly selected dairy buffalo milk producers in Nueva Ecija for the years 2017 and 2020. The stochastic frontier analysis was applied to a Cobb-Douglas production function with an inefficiency effects model. It was found that the statistically significant factors of milk production were cows, forage areas, and dairy feeds. …

Do Philippine Stocks Catch Coronavirus? Some Econometric Check-Up On Pandemic Data, 2021-2022, Mark Reniel M. Amarila, Luisito C. Abueg

Journal of Economics, Management and Agricultural Development

Using daily data from March 1, 2021 to March 31, 2022, the USD-PHP exchange rate and pandemic-related variables such as the number of cases, vaccinations, and stringency index in relation to the movements of Philippine Stock Exchange index (PSEi) were investigated. The paper views vaccination as an instrument for reducing economic uncertainty, subsequently providing a positive sentiment for investors and stock market. Ordinary least squares, autoregressive distributed lags, and vector autoregression was used to show some dynamics based on time series data. Particularly, there are indications of reported cases being negatively correlated and statistically significant for PSEi. Further, impulse response …

Member Engagement And Level Of Satisfaction In A Revitalized Co-Operative Enterprise In Iloilo Province, Philippines, Ma. Rhona P. Beriales

Journal of Economics, Management and Agricultural Development

A co-operative is a member-centered association of individuals with the goal of advancing their economic and social interests. This paper examined member engagement dynamics in a revitalized community-based co-operative in terms of members’ perceived value, member patronage and participation. The study also explored the effect of member engagement to the revitalized co- operative operations and member satisfaction. Using a mixed-methods approach, the study involved a survey of 175 respondents chosen purposively from the co-operative members of good standing. Results showed that members joined the co-operative for economic and personal growth, except for the older members’ goal which was for socialization. …

Mechanism Of Sila- And Germafluorenes For Biological Applications, Shelby Jarrett

Dissertations

2,7-disubstituted silafluorenes and germafluorenes, originally designed for OLED applications, are a class of fluorescent dyes that have gained recent interest as probes for bioimaging and as biosensors to monitor cellular dynamics and interactions. Desirable biological probes absorb in the visible region, have high extinction coefficients, high quantum yield and excellent photostability. Here, their spectral properties are investigated under aqueous conditions for relevant biological applications. These molecules display intense blue fluorescence in the solid state and in solution, have high extinction coefficients, and exhibit appreciable solubility in aqueous solution. To better understand potential applications, the mechanism of fluorescence was investigated. It …

Farmer-Led Small-Scale Irrigation Systems Management In Highland Vegetable Farming In The Cordillera Region, Philippines, Cheryll C. Launio, Marivic O. Abyado

Journal of Economics, Management and Agricultural Development

Much has been said about large-scale and pump irrigation systems but not much published research is available on small-scale farmer-led irrigation systems supporting highland farming. This study described the management of irrigation sources and farmer-led irrigation systems, and conveyance and distribution technologies supporting highland farming. Data were based on FGDs in 30 barangays and a survey of 279 farmers in three highland provinces. Findings show that 91% of farmers use irrigation from springs, rivers, and creeks; 70% of the conveyance and distribution facilities are farmer-initiated and managed, and micro-irrigation technologies such as sprinklers and drip irrigation are accessible. National irrigation …

Scalloped Hammerhead (Sphyrna Lewini) Jaw, Daria W. Ghegan, Brittney Dreyer, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Jaw prep from Sphyrna lewini (Scalloped Hammerhead) obtained from the NSU Fisheries and Avian Ecology

The Mayfly Newsletter, Donna Giberson

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.

Peanut Kernel Integrity Detection Based On Deep Learning Convolution Neural Network, Zhang Jun-Feng, Shang Zhan-Lei

Food and Machinery

Objective: To accurately distinguish intact peanut, nut damaged peanut and epidermis damaged peanut. Methods: A peanut seed integrity detection scheme based on deep learning convolution neural network (CNN) was proposed. The peanut seed color selection system was established and a peanut seed image database was also established; The improved density peak clustering (DPC) algorithm was used to adaptively compress the CNN convolution kernel to effectively balance the network depth and operation efficiency; The improved sparrow search algorithm was used to optimize the CNN super parameter configuration and network structure, and the CNN model suitable for peanut grain integrity detection was …

Determination Furfurals In Tea Products By Quechers-Isotope Is-Gc-Ms/Ms, Liu Can-Di, Chen Bo, Yin Fang-Ping, Zeng Hui

Food and Machinery

Objective: This study aimed to establish a new method for detecting furfurals in tea. Methods: A gas chromatography tandem mass spectrometry (GC-MS/MS) method was established for the simultaneous determination of furfural, 5-methylfurfural, 5-hydroxymethylfurfural and 2-Acetylfuran in tea. The sample pretreatment method and GC-MS/MS method were optimized. Furfural-D4was used as the internal standard. The sample was extracted by acetonitrile, treated and purified by QuEChERS method, and determined by GC-MS/MS multi reaction monitoring (MRM). Results: The four furfurals showed good linear relationship in the mass concentration range of 1.25~200.00 μg/L, with the correlation coefficient ≥0.999 0, and the detection limit (S/N …

Research On Food Safety Supervision System In Chinese Cross-Border E-Commerce Market, Shi Gao-Yan

Food and Machinery

The development status of the cross-border E-commerce market was introduced, and the shortcomings of the current cross-border e-commerce food safety supervision system in my country was analyzed. Moreover, the direction of food safety supervision system construction in cross-border E-commerce was also discussed, from the following aspects of the food information traceability system, food safety risk early warning system, enterprise credit management system and consumer rights protection system.

Uncertainty Evaluation Of Cadmium Content In Kelp (Laminaria Japonica) By Graphite Furnace Atomic Absorption Spectrometry, Liu Lan-Ying, Lu Xin, Li Ying, Luo Tu-Yan

Food and Machinery

Objective: To improve the accuracy of the results of cadmium (Cd) content in kelp (Laminaria japonica) by graphite furnace atomic absorption spectrometry (GF-AAS). Methods: The concentration of Cd element in kelp sample was measured by using GF-AAS after microwave digestion according to the standard of GB 5009.15—2014. Combining with the experimental process and mathematical model, the possible sources of measurement uncertainty were firstly identified, then the components of each standard uncertainties were calculated, and finally each parameter of uncertainties was synthesized, and the whole uncertainty was evaluated. Results: when the value of Cd concentration in kelp was 0.202 …

The Legal Regulation Problem Of False Food Advertisement And Its Solution, Meng Jing

Food and Machinery

In this paper, the current legal system regarding deceptive food advertisements in China has been discussed deeply and issues of current legal system have been analyzed. To solve the issues, a way for optimizing food legal system was explored and several measures which assist to improve the legal system for eliminating deceptive food advertisements have been proposed. Overall, relevant legal regulations published domestically and intenationally should be sorted out and the law enforcement of government sectors should be enhanced to constrain people who want to advertise deceptive food information.

Study On Flow Channel Distribution Of Different Twin Screw Extruder Under Different Screw Contact State, Shang Jia-Wei, Zhang Li-Mei, Huang Zhi-Gang, Zhang Yi-Wei, Li He

Food and Machinery

Objective: In order to explore the distribution law of the flow channel of polylactic acid in different screw contact states of the counter-rotating twin-screw extruder. Methods: Partially meshing screw and non-meshing screw were established by Solidworks software. Numerical sim-ulation was carried out using POLYFLOW fluid simulation software. The pressure field, shear rate field and viscosity field of polylactic acid fluid under different contact states of three screws were compared. Results: The counter-rotating twin-screw extruder in the partially meshed state has better pressure-building ability and dispersing and mixing ability for polylactic acid. Conclusion: The extrusion effect of polylactic acid in the …

Research On The Application Of Minimalist Style In Food Packaging Design, Chao Xin-Jiao, Zhang Si-Jia

Food and Machinery

This paper introduces the origin of minimalism, discusses the advantages of minimalism style in food packaging design, and expounds the application of minimalism style in food packaging design from four aspects: Food packaging color, graphics, modeling and materials.

Effects Of Natural Compound Preservative And Its Vacuum Synergy On The Shelf Life Of Pre-Conditioned Pork Filling Stuffing, Liu Ping-Yun, Wang Jun-Ru, Ding Yi-Dan, Zhang Gen-Sheng

Food and Machinery

Objective: To study the effect of food preservatives on the freshness of pre-conditioned pork filling stuffing and to solve the problem of easy spoilage and very short shelf life of pre-conditioned pork filling stuffing. Methods: The changes of physicochemical and microbiological indexes of the pre-conditioned pork filling treated with vacuum-packed co-combination preservatives during storage were determined using the total number of colonies or TBA values as evaluation criteria. Results: The optimal ratio of preservatives were as followed: 0.049% nisin, 0.207% D-isoascorbate sodium, 0.029% rosemary extract. Vacuum-packed synergistic compounding preservative treatment can effectively delay the changes of total bacterial colony, …

Effect Of Chitosan On The Waterless Preservation Of Urechis Unicinctus, Li Zhong-Kun, Li Zi-Xuan, Liu Chen-Hao, Liu Chun-E

Food and Machinery

Objective: The aim of the study was to decrease the transportation cost while reducing the nutrition loss of Urechis unicinctus. Methods: Chitosan was used for pretreatment of Urechis unicinctus, and the changes of the main nutritional and physiological indexes of the three groups i.e., control group, after waterless preservation group and recovered group, were measured. Results: The optimal concentration of chitosan was 3 g/L. After being pretreated by chitosan, the survival rate of Urechis unicinctus could reach 67% after 64 h of waterless preservation. The survival rate, muscle glycogen, water holding capacity of the experimental group were all …

Nectarine Quality Analysis Algorithm Based On Multi-Spectral Feature Partition, Wang Jie

Food and Machinery

Objective: In order to solve the problem that the spectral image recognition technology is susceptible to interference from similar types, resulting in deviations in the identification of the type and quality of the measured object. Methods: An independent dual-channel spectral acquisition system for visible light and near-infrared light was designed. By controlling the spectral range and spectral resolution of different characteristic regions, the rapid acquisition of absorbance at the characteristic wavelength position was achieved. The function expression form of spectral change and sample quality was established. According to the spectral distribution characteristics of the test sample, the appropriate characteristic wavelength …

Optimization Of Preparation Technology Of Ovalbumin-Peptide By Complex Enzyme And Its Antialcoholic Effect, Qi Xing-Yu, Yan Xiao-Juan, Zhang Hai-Yue

Food and Machinery

Objective: This study aimed to verify the antialcoholic activity of ovalbumin peptide and improve the added value of egg products. Methods: Ovalbumin was hydrolyzed by alkaline protease and trypsin. The activity rate of alcohol dehydrogenase (ADH) was taken as index, and the enzymolysis process was optimized by response surface methodology. The total antioxidant activity, hydrolysis degree, amino acid composition and relative molecular weight of ovalbumin peptide were determined to evaluate the antialcoholic effect of ovalbumin peptide. Results: The optimum enzymatic hydrolysis conditions were as follows. Under the conditions of enzymatic hydrolysis time 5 h, dosage of complex enzyme 3 100 …

Western Australian Regional Development Trust Annual Report 2021-22, West Australian Development Trust

Western Australian Regional Development Trust Annual Reports

The Trust is an independent statutory advisory body to the Minister, established under the Royalties for Regions Act 2009 (Act).

The functions of the Trust are to provide advice and make recommendations to the Minister:

• for the purposes of sections 5(2) and 9(1) of the Act; and
• on any other matter relating to the operation of the Fund that is referred to it by the Minister.

In addition to its monitoring and advisory role, the Trust also works to engage and enhance relationships with key regional stakeholders and influencers to promote greater collaboration and innovation in the delivery of regional …

Lama Rawat Inap Pasien Terkonfirmasi Covid-19 Di Rumah Sakit Universitas Indonesia Dan Faktor Yang Mempengaruhinya., Rizka Fahmia, Helda Helda

Jurnal Epidemiologi Kesehatan Indonesia

Banyaknya kasus COVID-19 membuat daya tampung fasilitas kesehatan hampir tidak mencukupi untuk memberikan pelayanan medis rawat inap yang memadai pada pasien COVID- 19. Studi yang dilakukan di beberapa negara seperti China, Beijing, Vietnam, Amerika Serikat melaporkan durasi dan faktor risiko rawat inap pasien COVID-19 yang bervariasi. Namun, saat ini penelitian tentang durasi dan faktor risiko lama rawat inap pasien COVID-19 di Indonesia masih terbatas. Penelitian bertujuan mengetahui faktor risiko lama rawat inap pasien terkonfirmasi COVID-19 di Rumah Sakit Universitas Indonesia (RSUI). Desain studi potong lintang dilakukan pada 266 pasien terkonfirmasi COVID-19 yang dirawat inap di RSUI selama Maret sampai dengan …