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Articles 51031 - 51060 of 255931
Full-Text Articles in Life Sciences
The Impact Of Steam-Flaked Rye Replacing Steam-Flaked Corn On Performance And Carcass Characteristics Of Yearling Steers And The Effect Of Exogenous Megasphaera Elsdenii Administration Techniques On Ruminal Fermentation And Blood Parameters In An Acidosis Challenge Model, Samantha K. Wagner
Department of Animal Science: Dissertations, Theses, and Student Research
A feedlot study was conducted to evaluate the effects of replacing steam-flaked corn (SFC) with steam-flaked rye (SFR) in the diets of yearling steers (Exp. 1). A separate study was conducted to evaluate the effects of three different administration techniques of Megasphaera elsdenii NCIMB 41125 on rumen fermentation and blood parameters in an acidosis challenge model (Exp. 2). In Exp. 1, SFC was replaced with SFR to create four different treatments, each differing in the ratio of SFC:SFR. The four treatments were 0:100, 25:75, 50:50, and 100:0 SFR:SFC (as a percentage of the grain inclusion). Increasing inclusions of SFR resulted …
Feto-Maternal Outcomes Of Pre-Eclampsia: A Retrospective Study, Linda Varghese, Neenumol Babu, Niya V.C
Feto-Maternal Outcomes Of Pre-Eclampsia: A Retrospective Study, Linda Varghese, Neenumol Babu, Niya V.C
Manipal Journal of Nursing and Health Sciences
Introduction: Pre-eclampsia is a multisystem multifactorial disease unique to pregnancy with unknown aetiology which is characterized by blood pressure ≥140/90 mmHg after 20 weeks of gestation associated with proteinuria ≥300 mg/24- hour urine specimen. It complicates about 2-10% of pregnancies worldwide. Objectives: To determine the prevalence and evaluate feto-maternal outcomes of pre-eclampsia. Methods: This was a retrospective study conducted at Amrita Institute of Medical Sciences, (AIMS) Kochi from 1 August 2017 to 31 July 2018. This study was done by retrospective analysis of the delivery register (Labour room) and hospital medical records. Results: The prevalence of pre-eclampsia is 2.5% and …
A Protein-Based Therapeutic Combination For The Treatment Of Hard-To-Heal Wounds, Graham L. Strauss
A Protein-Based Therapeutic Combination For The Treatment Of Hard-To-Heal Wounds, Graham L. Strauss
USF Tampa Graduate Theses and Dissertations
Chronic wounds present many clinical challenges in relation to the successful treatment and closure of the damaged tissue. Most current treatment methods focused on one or two aspects to drive wound closure, while most chronic wounds are multifactorial environments with many of those dependencies relying on the termination of one another to effectively gain tissue construction, closure, and full skin thickness and composition. Natural wound healing processes allude to potential biologics that can impede the chronic breakdown of tissue, while restoring deposition of new tissue, and effectively leading to a healed wound. Proteases secreted by the body’s immune system lay …
Differentiation And Temperature Adaptation Of Pampus Echinogaster Based On Genome-Wide Snps, Yuan Li, Fangrui Lou, Shigang Liu, Hai Li, Jiali Xiang, Binbin Shan, Longshan Lin, Xuan Zhuang
Differentiation And Temperature Adaptation Of Pampus Echinogaster Based On Genome-Wide Snps, Yuan Li, Fangrui Lou, Shigang Liu, Hai Li, Jiali Xiang, Binbin Shan, Longshan Lin, Xuan Zhuang
Biological Sciences Faculty Publications and Presentations
Climate change and overfishing have led to the degradation of the quality and stock of Pampus echinogaster. Exploring the genetic structure and local adaptive evolutionary mechanisms of P. echinogaster is crucial for the management of this species. This population genomic study of nine geographical populations of P. echinogaster in China was conducted by specific-locus amplified fragment sequencing (SLAF-seq). A total of 935,215 SLAF tags were obtained, and the average sequencing depth of the SLAF tags was 20.80×. After filtering, a total of 46,187 high-consistency genome-wide single nucleotide polymorphisms (SNPs) were detected. Based on all SNPs, the population size of the …
Influence Of Guideline Operationalization On Youth Activity Prevalence In The International Children’S Accelerometry Database, Catherine Gammon, Andrew J. Atkin, Kirsten Corder, Ulf Ekelund, Bjorge Herman Hansen, Lauren B. Sherar, Lars Bo Anderson, Sigmund Anderssen, Rachel Davey, Pedro C. Hallal, Russell Jago, Susi Kriemler, Peter Lund Kristensen, Soyang Kwon, Kate Nothstone, Russell R. Pate Ph.D., J. O. Salmon, Luis B. Sardinha, Esther M.F. Sluijs
Influence Of Guideline Operationalization On Youth Activity Prevalence In The International Children’S Accelerometry Database, Catherine Gammon, Andrew J. Atkin, Kirsten Corder, Ulf Ekelund, Bjorge Herman Hansen, Lauren B. Sherar, Lars Bo Anderson, Sigmund Anderssen, Rachel Davey, Pedro C. Hallal, Russell Jago, Susi Kriemler, Peter Lund Kristensen, Soyang Kwon, Kate Nothstone, Russell R. Pate Ph.D., J. O. Salmon, Luis B. Sardinha, Esther M.F. Sluijs
Faculty Publications
Introduction
The United Kingdom and World Health Organization recently changed their youth physical activity (PA) guidelines from 60 min of moderate- to vigorous-intensity PA (MVPA) every day, to an average of 60 min of MVPA per day, over a week. The changes are based on expert opinion due to insufficient evidence comparing health outcomes associated with different guideline definitions. This study used the International Children’s Accelerometry Database to compare approaches to calculating youth PA compliance and associations with health indicators.
Methods
Cross-sectional accelerometer data (n = 21,612, 5–18 yr) were used to examine compliance with four guideline definitions: daily …
Cas9/Nickase-Induced Allelic Conversion By Homologous Chromosome-Templated Repair In Drosophila Somatic Cells, Carissa Klanseck, Victor Lopez Del Amo, Ethan Bier, Annabel Guichard
Cas9/Nickase-Induced Allelic Conversion By Homologous Chromosome-Templated Repair In Drosophila Somatic Cells, Carissa Klanseck, Victor Lopez Del Amo, Ethan Bier, Annabel Guichard
Faculty, Staff and Student Publications
Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template. Here, a
Assessment Of Electronic Health Record For Cancer Research And Patient Care Through A Scoping Review Of Cancer Natural Language Processing, Huan He, Sijia Liu, Sungrim Moon, Michelle Mai, Irbaz B Riaz, Nan Wang, Ping Yang, Hua Xu, Jeremy L Warner, Hongfang Liu
Assessment Of Electronic Health Record For Cancer Research And Patient Care Through A Scoping Review Of Cancer Natural Language Processing, Huan He, Sijia Liu, Sungrim Moon, Michelle Mai, Irbaz B Riaz, Nan Wang, Ping Yang, Hua Xu, Jeremy L Warner, Hongfang Liu
Faculty, Staff and Student Publications
Purpose: The advancement of natural language processing (NLP) has promoted the use of detailed textual data in electronic health records (EHRs) to support cancer research and to facilitate patient care. In this review, we aim to assess EHR for cancer research and patient care by using the Minimal Common Oncology Data Elements (mCODE), which is a community-driven effort to define a minimal set of data elements for cancer research and practice. Specifically, we aim to assess the alignment of NLP-extracted data elements with mCODE and review existing NLP methodologies for extracting said data elements.
Methods: Published literature studies were searched …
Deep Learning-Based Nlp Data Pipeline For Ehr-Scanned Document Information Extraction, Kirk Roberts
Deep Learning-Based Nlp Data Pipeline For Ehr-Scanned Document Information Extraction, Kirk Roberts
Faculty, Staff and Student Publications
OBJECTIVE: Scanned documents in electronic health records (EHR) have been a challenge for decades, and are expected to stay in the foreseeable future. Current approaches for processing include image preprocessing, optical character recognition (OCR), and natural language processing (NLP). However, there is limited work evaluating the interaction of image preprocessing methods, NLP models, and document layout.
MATERIALS AND METHODS: We evaluated 2 key indicators for sleep apnea, Apnea hypopnea index (AHI) and oxygen saturation (SaO
RESULTS: Our proposed method using ClinicalBERT reached an AUROC of 0.9743 and document accuracy of 94.76% for AHI, and an AUROC of 0.9523 and document …
Scientist's Warning On Climate Change And Insects, Jeffrey A. Harvey, Kévin Tougeron, Rieta Gols, Robin Heinen, Mariana Abarca, Et Al
Scientist's Warning On Climate Change And Insects, Jeffrey A. Harvey, Kévin Tougeron, Rieta Gols, Robin Heinen, Mariana Abarca, Et Al
Biological Sciences: Faculty Publications
Climate warming is considered to be among the most serious of anthropogenic stresses to the environment, because it not only has direct effects on biodiversity, but it also exacerbates the harmful effects of other human-mediate threats. The associated consequences are potentially severe, particularly in terms of threats to species preservation, as well as in the preservation of an array of ecosystem services provided by biodiversity. Among the most affected groups of animals are insects—central components of many ecosystems—for which climate change has pervasive effects from individuals to communities. In this contribution to the scientists’ warning series, we summarize the effect …
Synergies Of Integrated Pest And Pollinator Management In Avocado Farming In East Africa: An Ex-Ante Economic Analysis, Charity Wangithi, Beatrice W. Muriithi, Gracious Diiro, Thomas Dubois, Samira Mohamed, Michael G. Lattorff, Benignus V. Ngowi, Elfatih M. Abdel-Rahman, Mariam Adan, Menale Kassie
Synergies Of Integrated Pest And Pollinator Management In Avocado Farming In East Africa: An Ex-Ante Economic Analysis, Charity Wangithi, Beatrice W. Muriithi, Gracious Diiro, Thomas Dubois, Samira Mohamed, Michael G. Lattorff, Benignus V. Ngowi, Elfatih M. Abdel-Rahman, Mariam Adan, Menale Kassie
All Peer-Reviewed Publications
Using synthetic pesticides to manage pests can threaten pollination services, affecting the productivity of pollination-dependent crops such as avocado. The need to mitigate this negative externality has led to the emergence of the concept of integrated pest and pollinator management (IPPM) to achieve both pest and pollinator management, leading to complementary or synergistic benefits for yield and quality of the harvest. This paper aims to evaluate the potential economic and welfare impact of IPPM in avocado production systems in Kenya and Tanzania. We utilize both primary and secondary data and employed the economic surplus model. On average the potential economic …
The Role Of L-Alanine Signaling In Aspergillus Fumigatus Biofilm Adherence, Carbon Catabolism, And Echinocandin Susceptibility., Joshua D. Kerkaert
The Role Of L-Alanine Signaling In Aspergillus Fumigatus Biofilm Adherence, Carbon Catabolism, And Echinocandin Susceptibility., Joshua D. Kerkaert
Dartmouth College Ph.D Dissertations
Aspergillus fumigatus is a saprophytic filamentous fungus that participates in environmental carbon and nitrogen cycles through the degradation of complex organic substrates. In addition to its ecological role, A. fumigatus is the primary causative agent of a spectrum of diseases depending on the immune status of the individual, the most lethal of which is invasive aspergillosis (IA). Treatment strategies for IA are limited and far too frequently fail. Despite the high rates of treatment failure, antifungal resistance remains relatively low, albeit rising at a concerning rate. Insights into this discrepancy between the rate of treatment failure and the rate of …
Genetic Diversity Of Diaphorina Citri (Hemiptera: Liviidae) Unravels Phylogeographic Structure And Invasion History Of Eastern African Populations, Inusa Jacob Ajene, Fathiya Mbarak Khamis, Barbara Van Asch, Gerhard Pietersen, Nurhussen Seid, Anne Wambui Wairimu, Fidelis Levi Ombura, Komivi Senyo Akutse, Mamoudou Sétamou, Sevgan Subramanian, Samira Mohammed, Sunday Ekesi
Genetic Diversity Of Diaphorina Citri (Hemiptera: Liviidae) Unravels Phylogeographic Structure And Invasion History Of Eastern African Populations, Inusa Jacob Ajene, Fathiya Mbarak Khamis, Barbara Van Asch, Gerhard Pietersen, Nurhussen Seid, Anne Wambui Wairimu, Fidelis Levi Ombura, Komivi Senyo Akutse, Mamoudou Sétamou, Sevgan Subramanian, Samira Mohammed, Sunday Ekesi
All Peer-Reviewed Publications
The Asian citrus psyllid (Diaphorina citri Kuwayama) is a key pest of Citrus sp. worldwide, as it acts as a vector for Candidatus Liberibacter asiaticus, the bacterial pathogen that causes citrus Huanglongbing. Diaphorina citri has been reported in Kenya, Tanzania, and more recently in Ethiopia. This study assessed the genetic diversity and phylogeographic structure of the pest to gain insights into the potential sources of its introduction into Africa. Population structure and differentiation of D. citri populations from China, Ethiopia, Kenya, Tanzania, and the USA were assessed using 10 microsatellite loci. Additionally, five new complete mitogenomes of D. citri collected …
Observing The Distribution Of Mosquito Bites On Humans To Inform Personal Protection Measures Against Malaria And Dengue Vectors, Winifrida P. Mponzi, Johnson K. Swai, Emmanuel W. Kaindoa, Khamis Kifungo, Alvaro E. Eiras, Elis P.A. Batista, Nancy S. Matowo, Peter O. Sangoro, Marceline F. Finda, Arnold S. Mmbando, Tegemeo Gavana, Halfan S. Ngowo, Fredros O. Okumu
Observing The Distribution Of Mosquito Bites On Humans To Inform Personal Protection Measures Against Malaria And Dengue Vectors, Winifrida P. Mponzi, Johnson K. Swai, Emmanuel W. Kaindoa, Khamis Kifungo, Alvaro E. Eiras, Elis P.A. Batista, Nancy S. Matowo, Peter O. Sangoro, Marceline F. Finda, Arnold S. Mmbando, Tegemeo Gavana, Halfan S. Ngowo, Fredros O. Okumu
All Peer-Reviewed Publications
Background Understanding mosquito biting behaviours is important for designing and evaluating protection methods against nuisance biting and mosquito-borne diseases (e.g. dengue, malaria and zika). We investigated the preferred biting sites by Aedes aegypti and Anopheles arabiensis on adult volunteers in standing or sleeping positions; and estimated the theoretical protection limits affordable from protective clothing or repellent-treated footwear. Methods Adult volunteers dressed in shorts and t-shirts were exposed to infection-free laboratory-reared mosquitoes inside screened chambers from 6am to noon (for day-biting Ae. aegypti) or 6pm to midnight (night-biting An. arabiensis). Attempted bites on different body parts were recorded. Comparative observations were …
Microhabitat And Patch Selection Detection From Gps Tracking Collars Of Semi-Free Ranging Mashona Cattle Within A Semi-Arid Environment, C. Gwatirisa, B. T. Mudereri, T. Chitata, C. Mukanga, M. M. Ngwenya, J. V. Muzvondiwa, R. Mugandani, M. Sungirai
Microhabitat And Patch Selection Detection From Gps Tracking Collars Of Semi-Free Ranging Mashona Cattle Within A Semi-Arid Environment, C. Gwatirisa, B. T. Mudereri, T. Chitata, C. Mukanga, M. M. Ngwenya, J. V. Muzvondiwa, R. Mugandani, M. Sungirai
All Peer-Reviewed Publications
Over the last 30 years, the global positioning system (GPS) tracking collars have significantly enhanced livestock grazing behavior studies. Practices designed to understand and improve livestock grazing distribution can now be accurately and cost-effectively monitored with GPS tracking. The behavior and spatiotemporal microhabitat selection of Mashona cattle relative to the season in a semi-free-range grazing system was evaluated using a low‐cost GPS herd activity monitoring (GPSHAM) collar. The GPSHAM automatically logged the position of the lead cow at 20-second intervals over a 7–hour daily grazing period. Additionally, the GPS data was complemented by visually observing the lead cow during daylight …
Spatial Representation In Postrhinal Cortex, Patrick Lachance
Spatial Representation In Postrhinal Cortex, Patrick Lachance
Dartmouth College Ph.D Dissertations
Animals rely on a variety of internal and external cues to orient themselves when navigating their environments and determining their current spatial context. Information regarding these cues enters the brain from the navigator’s first-person perspective. Information of this type is considered to be egocentric, or self-centered. However, decades of behavioral, electrophysiological, and imaging research suggest that the brain contains a rich collection of spatial representations that are unrestricted by the animal’s first-person perspective, and instead are defined relative to the surrounding environment. These representations are considered allocentric, or world-centered. Despite an abundance of promising modeling work, the specific mechanisms by …
Smokejumper Magazine, July 2022, National Smokejumper Association
Smokejumper Magazine, July 2022, National Smokejumper Association
Smokejumper and Static Line Magazines
This issue of the National Smokejumper Association (NSA) Smokejumper Magazine contains the following articles: Message from the President; Militant Environmental Activism; My Year in South Vietnam; "The Mouse that Soared" Book Review; Odds and Ends; National Smokejumper Association Position Statements; Recording Smokejumper History: 1945 Rookies-The End of the Civilian Public Service Years; Dixie Fire Destruction Didn't Have To Happen; Sounding Off from the Editor; Wildland Firefighters Not Served Well by Albuquerque Service Center; "Tell Us About Our Father"; Old Smokejumper Memories of High Mountain Two Jumper Fire; More Smokejumper's Stories (1954-56); Good Sam Funds at Work; NSA Restoring Our Nation's …
In Vivo And In Vitro Investigations Of Mammalian Stem Cell Development: Neurogenesis And Pituitary Progenitors, Allison Culver
In Vivo And In Vitro Investigations Of Mammalian Stem Cell Development: Neurogenesis And Pituitary Progenitors, Allison Culver
Theses and Dissertations
Human development is tightly regulated by complex mechanisms to pattern the early embryo and form specialized tissues. Understanding this regulation is of fundamental importance and can help further understand disease pathologies. Because it is difficult to observe the processes of interest, researchers must rely on the use of model systems. Our research goal is to combine both animal models and in vitro stem cell cultures to address key questions about the mechanisms of development for both the pituitary gland and brain. It is estimated that there are 290-455 cases per million of congenital hypopituitarism. In addition, autism spectrum disorder (ASD) …
What Are Mycorrhizal Traits?, V. Bala Chaudhary, E. Penelope Holland, Suw Charman-Anderson, Aidee Guzman, Lukas Bell-Dereske, Tanya E. Cheeke, Adriana Corrales, Jessica Duchicela, Cameron Egan, Pushpa G. Soti
What Are Mycorrhizal Traits?, V. Bala Chaudhary, E. Penelope Holland, Suw Charman-Anderson, Aidee Guzman, Lukas Bell-Dereske, Tanya E. Cheeke, Adriana Corrales, Jessica Duchicela, Cameron Egan, Pushpa G. Soti
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Highlights
- Applying trait-based approaches to ecological research on mycorrhizal symbioses broadens ecological inferences, but there is no single unified framework to unite disparate language, terminology, and methods across the many multidisciplinary scientists studying mycorrhizas.
- We propose an inclusive framework for trait-based mycorrhizal ecology aimed to stimulate scientists around the world to collect and use more mycorrhizal trait data, particularly in understudied areas. This would widen our understanding regarding the ecological role of mycorrhizal symbioses at individual, species, community, and ecosystem scales.
- Analyzing how mycorrhizal symbioses fit within existing trait definitions highlights significant theoretical and empirical knowledge gaps, novel questions, and …
The Effect Of Interventions To Prevent Type 2 Diabetes On The Development Of Diabetic Retinopathy: The Dpp/Dppos Experience, Neil H White, Qing Pan, William C Knowler, Emily B Schroeder, Dana Dabelea, Emily Y Chew, Barbara Blodi, Ronald B Goldberg, Xavier Pi-Sunyer, Christine Darwin, Mathias Schlögl, David M Nathan
The Effect Of Interventions To Prevent Type 2 Diabetes On The Development Of Diabetic Retinopathy: The Dpp/Dppos Experience, Neil H White, Qing Pan, William C Knowler, Emily B Schroeder, Dana Dabelea, Emily Y Chew, Barbara Blodi, Ronald B Goldberg, Xavier Pi-Sunyer, Christine Darwin, Mathias Schlögl, David M Nathan
Children’s Nutrition Research Center Staff Publications
Objective: To determine whether interventions that slow or prevent the development of type 2 diabetes in those at risk reduce the subsequent prevalence of diabetic retinopathy.
Research design and methods: The Diabetes Prevention Program (DPP) randomized subjects at risk for developing type 2 diabetes because of overweight/obesity and dysglycemia to metformin (MET), intensive lifestyle intervention (ILS), or placebo (PLB) to assess the prevention of diabetes. During the DPP and DPP Outcome Study (DPPOS), we performed fundus photography over time on study participants, regardless of their diabetes status. Fundus photographs were graded using the Early Treatment Diabetic Retinopathy Study grading system, …
Kinetin Ameliorates Cisplatin‐Induced Hepatotoxicity And Lymphotoxicity Via Attenuating Oxidative Damage, Cell Apoptosis And Inflammation In Rats, Moustafa Fathy, Mostafa A. Darwish, Al Shaimaa M. Abdelhamid, Gehad M. Alrashedy, Othman Ali Othman, Muhammad Naseem, Thomas Dandekar, Eman M. Othman
Kinetin Ameliorates Cisplatin‐Induced Hepatotoxicity And Lymphotoxicity Via Attenuating Oxidative Damage, Cell Apoptosis And Inflammation In Rats, Moustafa Fathy, Mostafa A. Darwish, Al Shaimaa M. Abdelhamid, Gehad M. Alrashedy, Othman Ali Othman, Muhammad Naseem, Thomas Dandekar, Eman M. Othman
All Works
Though several previous studies reported the in vitro and in vivo antioxidant effect of kinetin (Kn), details on its action in cisplatin‐induced toxicity are still scarce. In this study we eval-uated, for the first time, the effects of kinetin in cisplatin (cp)‐ induced liver and lymphocyte toxicity in rats. Wistar male albino rats were divided into nine groups: (i) the control (C), (ii) groups 2,3 and 4, which received 0.25, 0.5 and 1 mg/kg kinetin for 10 days; (iii) the cisplatin (cp) group, which received a single intraperitoneal injection of CP (7.0 mg/kg); and (iv) groups 6, 7, 8 and …
Water-Soluble Porphyrin Complexes For The Biological Inactivation Of Fentanyl, Anneli Nina
Water-Soluble Porphyrin Complexes For The Biological Inactivation Of Fentanyl, Anneli Nina
Theses and Dissertations
This work aimed to investigate the degradation of fentanyl in aqueous solutions using unsupported water-soluble cobalt(III) porphyrins (55 and 56), AuNP supported water-soluble cobalt(III) porphyrins (67 and 68), and liposome supported water-soluble cobalt(III) porphyrins (69 and 70). Complexes 55, 56, 68, and 69 have been shown to remove fentanyl from aqueous solutions at 37 ºC. The degradation of fentanyl, and the identification of breakdown products were analyzed with the use of time-of-flight mass spectrometry (TOFMS). Complex 55 has been shown to completely degrade fentanyl at 37 ºC in as little as two hours with a 400 mol% catalyst loading. Complex …
Characterization Of The Responses To Chronic Stress In Caenorhabditis Elegans, Amy Laura Knight
Characterization Of The Responses To Chronic Stress In Caenorhabditis Elegans, Amy Laura Knight
Theses and Dissertations
Exposure to chronic temperature stress influences organismal phenotypes that are important for human health, agriculture, and ecology. In this thesis, the model organism Caenorhabditis elegans was used to study the effects of temperature stress on reproduction and lifespan. It was found that worms demonstrated a rapid shut down in egg-laying between 18-24 hours of exposure to 28°C. Despite this reproductive defect, the overall lifespan of worms was unaffected. At the molecular level, heat shock factor 1 (HSF-1), a regulator of the protective molecular pathway known as the heat shock response (HSR), was identified as important for progeny production during heat …
Identifying Novel Pharmacogenetic Markers For Cancer Treatments: Exploiting Cancers Deficient In The Nucleotide Pool Sanitizing Hydrolases Nudt15 And Nudt18, Jacob Chandler Massey
Identifying Novel Pharmacogenetic Markers For Cancer Treatments: Exploiting Cancers Deficient In The Nucleotide Pool Sanitizing Hydrolases Nudt15 And Nudt18, Jacob Chandler Massey
Theses and Dissertations
The NUDIX hydrolases are a super family of enzymes with purported enzymatic activities of nucleotide hydrolases. The activity of the founding member, NUDT1 (also known as MTH1) is established to be a nucleotide hydrolase for d-8-oxoGTP, which is a mutagenic precursor if incorporated into DNA. Therefore, its activity serves to sanitize the nucleotide pool of mutagenic precursors. While known to be highly conserved among all organisms, the enzymatic and biological functions for nearly all the family members remain largely unexplored and unknown. Substrates of family members have been found to include canonical (deoxy)nucleotide triphosphates, oxidized (deoxy)nucleotide triphosphates, and non-nucleoside polyphosphates. …
Molecular And Morphological Investigations Of Grouper (Serranidae) Biodiversity In Saudi Arabia, Mohammad Saeed Al Jazza Alqahtani
Molecular And Morphological Investigations Of Grouper (Serranidae) Biodiversity In Saudi Arabia, Mohammad Saeed Al Jazza Alqahtani
Theses and Dissertations
Chapter 1: The seas surrounding the Arabian Peninsula, which represent the northernmost portion of the Indian Ocean, are considered to have the highest aquatic biodiversity among the worlds marine regions. Seas that surround the Arabian Peninsula include the Red Sea, the Gulf of Aden, the Arabian Sea, the Gulf of Oman, and the Arabian Gulf. In aggregate, this area harbors a large number of endemic and more widespread marine species, including fishes, echinoderms, and corals.
There are unique challenges involved in grouper species identification in the Arabian region including ‘familiar’ Arabic species designations that are not standardized in the Arabic …
Detection Of Microcystin Aerosol Particles, Alexis D. Dabney
Detection Of Microcystin Aerosol Particles, Alexis D. Dabney
Theses and Dissertations
Harmful Algal Blooms (HABs) are a growing global concern due to their increased prevalence and magnitude, frequency, and duration in affecting both aquatic ecosystems and human health (Brooks et al. 2015). In a series of experiments, lab-generated aerosol particles containing Microcystis and Microseira were captured using filters to analyze for concentrations of Microcystin, Saxitoxin, and Lyngbya toxins. The solutions were found to contain aerosols but did not contain detectable levels of Microcystin, Saxitoxin, and Lyngbya toxins following analysis by HPLC-MS. While the techniques for generating aerosols were shown to be effective, the generation and analysis of toxins did not produce …
Physical Activity And Stress Between American Students And Asian International Students At The University Of South Carolina, Hao Lei
Theses and Dissertations
Many college students are physically inactive and have high levels of stress, and this may be worse among increasing number of international students studying in the US. This study investigated the relationship between physical activity and stress among American students (n=92) and Asian international students (n=64). The Mann-Whitney test was used to compare MET minutes/week from the International Physical Activity Questionnaire short form between those two groups. The independent-samples t test compared the mean of stress from the Perceived Stress Scale between those two groups. Chi-square test was used to compare the percentage of Asian international students and American students …
A Rationally Designed Synthetic Antimicrobial Peptide Against Pseudomonas-Associated Corneal Keratitis: Structure-Function Correlation, Sk Abdul Mohid, Prerana Sharma, Amani Alghalayini, Tripti Saini, Debarun Datta, Mark D. P. Willcox, Haydar Ali, Sreyan Raha, Achintya Singha, Nirakar Sahoo
A Rationally Designed Synthetic Antimicrobial Peptide Against Pseudomonas-Associated Corneal Keratitis: Structure-Function Correlation, Sk Abdul Mohid, Prerana Sharma, Amani Alghalayini, Tripti Saini, Debarun Datta, Mark D. P. Willcox, Haydar Ali, Sreyan Raha, Achintya Singha, Nirakar Sahoo
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Contact lens wearers are at an increased risk of developing Pseudomonas-associated corneal keratitis, which can lead to a host of serious ocular complications. Despite the use of topical antibiotics, ocular infections remain a major clinical problem, and a strategy to avoid Pseudomonas-associated microbial keratitis is urgently required. The hybrid peptide VR18 (VARGWGRKCPLFGKNKSR) was designed to have enhanced antimicrobial properties in the fight against Pseudomonas-induced microbial keratitis, including contact lens-related keratitis. In this paper, VR18's modes of action against Pseudomonas membranes were shown by live cell Raman spectroscopy, live cell NMR, live-cell fluorescence microscopy and measures taken using sparsely tethered bilayer …
Emergence Activity At Hibernacula Differs Among Four Bat Species Affected By White-Nose Syndrome, Reilly T. Jackson, Emma V. Wilcox, John M. Zobel, Riley F. Bernard
Emergence Activity At Hibernacula Differs Among Four Bat Species Affected By White-Nose Syndrome, Reilly T. Jackson, Emma V. Wilcox, John M. Zobel, Riley F. Bernard
Biological Sciences Faculty Publications and Presentations
Prior to the introduction of white-nose syndrome (WNS) to North America, temperate bats were thought to remain within hibernacula throughout most of the winter. However, recent research has shown that bats in the southeastern United States emerge regularly from hibernation and are active on the landscape, regardless of their WNS status. The relationship between winter activity and susceptibility to WNS has yet to be explored but warrants attention, as it may enable managers to implement targeted management for WNS-affected species. We investigated this relationship by implanting 1346 passive integrated transponder (PIT) tags in four species that vary in their susceptibility …
Differential Impacts Of Hhv-6a Versus Hhv-6b Infection In Differentiated Human Neural Stem Cells, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos
Differential Impacts Of Hhv-6a Versus Hhv-6b Infection In Differentiated Human Neural Stem Cells, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos
Biological Sciences Faculty Publications and Presentations
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7. Initially, HHV-6A and HHV-6B were considered as two variants of the same virus (i.e., HHV6). Despite high overall genetic sequence identity (~90%), HHV-6A and HHV-6B are now recognized as two distinct viruses. Sequence divergence (e.g., >30%) in key coding regions and significant differences in physiological and biochemical profiles (e.g., use of different receptors for viral entry) underscore the conclusion that HHV-6A and HHV-6B are distinct viruses of the β-herpesvirinae. Despite these viruses being …
Vegetative Phenologies Of Lianas And Trees In Two Neotropical Forests With Contrasting Rainfall Regimes, Jose A. Medina-Vega, S. Joseph Wright, Frans Bongers, Stefan A. Schnitzer, Frank J. Sterck
Vegetative Phenologies Of Lianas And Trees In Two Neotropical Forests With Contrasting Rainfall Regimes, Jose A. Medina-Vega, S. Joseph Wright, Frans Bongers, Stefan A. Schnitzer, Frank J. Sterck
Biological Sciences Faculty Research and Publications
- Among tropical forests, lianas are predicted to have a growth advantage over trees during seasonal drought, with substantial implications for tree and forest dynamics. We tested the hypotheses that lianas maintain higher water status than trees during seasonal drought and that lianas maximize leaf cover to match high, dry-season light conditions, while trees are more limited by moisture availability during the dry season.
- We monitored the seasonal dynamics of predawn and midday leaf water potentials and leaf phenology for branches of 16 liana and 16 tree species in the canopies of two lowland tropical forests with contrasting rainfall regimes in …