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Articles 49681 - 49710 of 255950
Full-Text Articles in Life Sciences
Hydrogeochemical Analysis Of Unconfined Groundwater In The Surrounding Salt Farming Areas Of Pademawu, Madura, Indonesia, Arya Gemilang Wisnu, Jantama Wisha Ulung, Agus Mardyanto Mas
Hydrogeochemical Analysis Of Unconfined Groundwater In The Surrounding Salt Farming Areas Of Pademawu, Madura, Indonesia, Arya Gemilang Wisnu, Jantama Wisha Ulung, Agus Mardyanto Mas
ASEAN Journal on Science and Technology for Development
The Pademawu coast has rapidly transformed into salt ponds, causing seawater intrusion and pollution. This study aims to examine the quality of groundwater in the surrounding settlement area of Pademawu and assess its eligibility for daily use. The psychochemical parameters of groundwater are measured in situ. Groundwater samples from several stations are analyzed in the laboratory and used to collect several chemical compounds, including Ca2+, Mg2+, Na+, K+, HCO3-, Cl-, SO42-, Fe2+, Mn2+, F-, NO2-, NO3, and CaCO3. The detected concentrations are then used to calculate TH, sodium adsorption ratio (SAR), %Na, PI, KR, and MH. Hydrochemical calculation and interpretation …
Design Of High Gain And Improved Front-To-Back Ratio Multilayer Microstrip Patch Antenna Using Modified Feed Line, Deb Partha Kumar, Moyra Tamasi, Bhattacharyya Bidyut Kumar
Design Of High Gain And Improved Front-To-Back Ratio Multilayer Microstrip Patch Antenna Using Modified Feed Line, Deb Partha Kumar, Moyra Tamasi, Bhattacharyya Bidyut Kumar
ASEAN Journal on Science and Technology for Development
A novel high gain miniaturized rectangular microstrip patch antenna is proposed with a high front-to-back ratio (FBR) using a modified feed line and two single-sided substrate layers to operate at 2.4 GHz frequency. The feed line is modified using a step impedance technique to achieve resonance at the operating frequency. The matched impedance of the feed line helps achieve enhanced bandwidth and antenna miniaturization. The substrate layers are introduced to achieve an enhanced gain and FBR of 6.329 dBi and 27.64 dB, respectively. The impedance bandwidths of 106.9 and 94.1 MHz are achieved for the two separate designs. These proposed …
Using Convergent Parallel Mixed Methods And Datasets For Science, Technology, And Innovation Policy Dynamics Research In Indonesia, Putera Prakoso Bhairawa, Suryanto Suryanto, Ningrum Sinta, Widianingsih Ida, Rianto Yan
Using Convergent Parallel Mixed Methods And Datasets For Science, Technology, And Innovation Policy Dynamics Research In Indonesia, Putera Prakoso Bhairawa, Suryanto Suryanto, Ningrum Sinta, Widianingsih Ida, Rianto Yan
ASEAN Journal on Science and Technology for Development
The application of mixed methods has been widely implemented in several studies, particularly in the field of public policy; however, the implementation of convergent parallel mixed methods has been limited. Thus, such methods are appropriate to reveal the science, technology, and innovation (STI) policy dynamics in Indonesia during the 1945–2020 period, as policy dynamics research attempts to reveal the evolution of the changes regarding the policy itself. The following five concepts are analyzed through convergent parallel mixed methods: 1) regime/government change, 2) institutional change/transformation, 3) change in policy issuance, direction, and content, 4) actor role and existence, and 5) policy …
Black Soldier Fly (Hermetia Illucens) As A Potential Agent Of Organic Waste Bioconversion, Purnamasari Listya, Khasanah Himmatul
Black Soldier Fly (Hermetia Illucens) As A Potential Agent Of Organic Waste Bioconversion, Purnamasari Listya, Khasanah Himmatul
ASEAN Journal on Science and Technology for Development
The use of black soldier fly (BSF) as a bioconversion agent has become an emerging breakthrough in waste processing. Organic wastes, such as household waste and livestock manure, can be used as a growth medium for BSF larvae and converted into favorable products. The average composting time of BSF larvae is around 12– 15 days, which is faster than that of microbes or earthworms (4–5 weeks). BSF shows potential as a feed and food ingredient because it has a high nutritional content, such as enzyme, chitin, medium-chain fatty acid, and antimicrobial peptides, and can be used as a functional food …
Defect And Distortion In Powder Bed Fusion Of Metal Additive Manufacturing Parts, Maurya Ajay Kumar, Kumar Amit
Defect And Distortion In Powder Bed Fusion Of Metal Additive Manufacturing Parts, Maurya Ajay Kumar, Kumar Amit
ASEAN Journal on Science and Technology for Development
One of the state-of-the-art technologies for metal fabrication is laser powder bed fusion, which includes the following printing techniques: selective laser melting, selective laser sintering, direct metal laser sintering, and electron beam melting. This work examines defect formation in laser powder bed fusion, predominately focusing on selective laser melting. It also explores recent research findings on defect formation and classification and analyzes various internal defects, such as porosity, lack of fusion, balling, and solidification cracking. The influence of process parameters on defect formation and the effect of defects on mechanical properties are analyzed. This review also discusses defect inspection technologies …
Zero Discharge Of Nutrient Solution To The Environment In A Soilless Greenhouse Cucumber Production System, Xiaotao Ding, Lizhong He, Rongguang Li, Tingting Qian, Hongmei Zhang, Haijun Jin, Jiawei Cui, Hong Wang, Qiang Zhou, Jun Zou, Dafeng Hui, Yuping Jiang, Kun He, Jizhu Yu
Zero Discharge Of Nutrient Solution To The Environment In A Soilless Greenhouse Cucumber Production System, Xiaotao Ding, Lizhong He, Rongguang Li, Tingting Qian, Hongmei Zhang, Haijun Jin, Jiawei Cui, Hong Wang, Qiang Zhou, Jun Zou, Dafeng Hui, Yuping Jiang, Kun He, Jizhu Yu
Biology Faculty Research
With the development of the economy and society, more attention is being paid to energy costs and the potential environmental pollution caused by vegetable cultivation. The aim of this study was to investigate the impacts of zero discharge of nutrient solutions on cucumber growth, leaf photosynthesis, and the yield and quality of cucumber under greenhouse conditions. The results show that zero discharge treatment did not change plant height, stem diameter, internode length, leaf area, net photosynthetic rate (Pn), stomatal conductance (Gs), intercellular CO2 concentration (Ci), transpiration rate (Tr), and leaf relative chlorophyll content on the most measurement days. Only Pn …
Machine Learning-Based Peripheral Artery Disease Identification Using Laboratory-Based Gait Data, Ali Al-Ramini, Mahdi Hassan, Farah Fallahtafti, Mohammad Ali Takallou, Hafizur Rahman, Basheer Qolomany, Iraklis Pipinos, Fadi Alsaleem, Sara A. Myers
Machine Learning-Based Peripheral Artery Disease Identification Using Laboratory-Based Gait Data, Ali Al-Ramini, Mahdi Hassan, Farah Fallahtafti, Mohammad Ali Takallou, Hafizur Rahman, Basheer Qolomany, Iraklis Pipinos, Fadi Alsaleem, Sara A. Myers
Journal Articles
Peripheral artery disease (PAD) manifests from atherosclerosis, which limits blood flow to the legs and causes changes in muscle structure and function, and in gait performance. PAD is underdiagnosed, which delays treatment and worsens clinical outcomes. To overcome this challenge, the purpose of this study is to develop machine learning (ML) models that distinguish individuals with and without PAD. This is the first step to using ML to identify those with PAD risk early. We built ML models based on previously acquired overground walking biomechanics data from patients with PAD and healthy controls. Gait signatures were characterized using ankle, knee, …
Polymorphism & Parasites: Structure, Diversity And Selection Of The Mhcii Genes In A Weakly Electric Fish, Brachyhypopomus Occidentalis, Bruna L. Silva
Polymorphism & Parasites: Structure, Diversity And Selection Of The Mhcii Genes In A Weakly Electric Fish, Brachyhypopomus Occidentalis, Bruna L. Silva
Graduate Masters Theses
The major histocompatibility complex (MHC) class II molecules play a key role in inducing an immune response, by presenting foreign peptides to T-lymphocytes. They are considered one of the most polymorphic genes in the vertebrate genome and diversity has been associated with species diversification mediated by parasite, viral and bacterial infections. While MHC genes are well documented in teleost fish, none thus far have been described in the Gymnotiform order – a highly diverse group of neotropical electric fishes. Using a combination of a recently annotated genome and whole genome resequencing data, I identified and characterized both the classical MHCII …
Global Variation In Nonstructural Carbohydrate Stores In Response To Climate, Meghan Blumstein, Jess T. Gersony, Jordi Martínez-Vilalta, Anna Sala
Global Variation In Nonstructural Carbohydrate Stores In Response To Climate, Meghan Blumstein, Jess T. Gersony, Jordi Martínez-Vilalta, Anna Sala
Biological Sciences: Faculty Publications
Woody plant species store nonstructural carbohydrates (NSCs) for many functions.While known to buffer against fluctuations in photosynthetic supply, such as at night, NSC stores are also thought to buffer against environmental extremes, such as drought or freezing temperatures by serving as either back-up energy reserves orosmolytes. However, a clear picture of how NSCs are shaped by climate is still lack-ing. Here, we update and leverage a unique global database of seasonal NSC storage measurements to examine whether maximum total NSC stores and the amount of soluble sugars are associated with clinal patterns in low temperatures or aridity, indicating they may …
Comparative Risks Of Initial Aortic Events Associated With Genetic Thoracic Aortic Disease, Julie De Backer, Anji T Yetman, Elena Cervi, Sherene Shalhub, Richmond Jeremy, Scott Lemaire, Maral Ouzounian, Arturo Evangelista, Catherine Boileau, Guillaume Jondeau, Dianna M Milewicz
Comparative Risks Of Initial Aortic Events Associated With Genetic Thoracic Aortic Disease, Julie De Backer, Anji T Yetman, Elena Cervi, Sherene Shalhub, Richmond Jeremy, Scott Lemaire, Maral Ouzounian, Arturo Evangelista, Catherine Boileau, Guillaume Jondeau, Dianna M Milewicz
Faculty, Staff and Student Publications
BACKGROUND: Pathogenic variants in 11 genes predispose individuals to heritable thoracic aortic disease (HTAD), but limited data are available to stratify the risk for aortic events associated with these genes.
OBJECTIVES: This study sought to compare the risk of first aortic event, specifically thoracic aortic aneurysm surgery or an aortic dissection, among 7 HTAD genes and variant types within each gene.
METHODS: A retrospective cohort of probands and relatives with rare variants in 7 genes for HTAD (n = 1,028) was assessed for the risk of first aortic events based on the gene altered, pathogenic variant type, sex, proband status, …
The Role Of Emotion Regulation In Long-Term Weight Loss Maintenance: A Cross-Sectional Study, Karyn M. Aiello
The Role Of Emotion Regulation In Long-Term Weight Loss Maintenance: A Cross-Sectional Study, Karyn M. Aiello
Graduate Masters Theses
While many weight loss interventions have resulted in significant weight loss, maintaining that weight loss long-term continues to be challenging for most, with long-term weight loss maintenance (LTWLM) rates as low as 20% among participants of clinical weight loss studies. Those who struggle with LTWLM exhibit many shared characteristics, including lower mental health composite scores; high levels of perceived stress; and lower rates of adherence to WLM behaviors. One explanation for this might be that emotion regulation (ER) skills are stronger among those who are successful at LTWLM, and therefore more successful at self-regulating for the goal of LTWLM.
The …
Molecular Analysis Of Short- Versus Long-Term Survivors Of High-Grade Serous Ovarian Carcinoma, Elaine Stur, Emine Bayraktar, Graziela Zibetti Dal Molin, Sherry Y Wu, Lingegowda S Mangala, Ying Wang, Sara Corvigno, Hu Chen, Han Liang, Shelley S Tworoger, Douglas A Levine, Susan K Lutgendorf, Jinsong Liu, Kathleen N Moore, Keith A Baggerly, Beth Y Karlan, Anil K Sood
Molecular Analysis Of Short- Versus Long-Term Survivors Of High-Grade Serous Ovarian Carcinoma, Elaine Stur, Emine Bayraktar, Graziela Zibetti Dal Molin, Sherry Y Wu, Lingegowda S Mangala, Ying Wang, Sara Corvigno, Hu Chen, Han Liang, Shelley S Tworoger, Douglas A Levine, Susan K Lutgendorf, Jinsong Liu, Kathleen N Moore, Keith A Baggerly, Beth Y Karlan, Anil K Sood
Faculty, Staff and Student Publications
Despite having similar histologic features, patients with high-grade serous ovarian carcinoma (HGSC) often experience highly variable outcomes. The underlying determinants for long-term survival (LTS, ≥10 years) versus short-term survival (STS, < 3 years) are largely unknown. The present study sought to identify molecular predictors of LTS for women with HGSC. A cohort of 24 frozen HGSC samples was collected (12 LTS and 12 STS) and analyzed at DNA, RNA, and protein levels. OVCAR5 and OVCAR8 cell lines were used for in vitro validation studies. For in vivo studies, we injected OVCAR8 cells into the peritoneal cavity of female athymic nude mice. From RNAseq analysis, 11 genes were found to be differentially expressed between the STS and LTS groups (fold change > 2; false discovery rate < 0.01). In the subsequent validation cohort, transmembrane protein 62 (TMEM62) was found to be related to LTS. CIBERSORT analysis showed that T cells (follicular helper) were found at higher levels in tumors from LTS than STS groups. In vitro data using OVCAR5 and OVCAR8 cells showed decreased proliferation with TMEM62 overexpression and positive correlation with a longevity-regulating pathway (KEGG HSA04213) at the RNA level. In vivo analysis using the OVCAR8-TMEM62-TetON model showed decreased tumor burden in mice with high- vs. low-expressing TMEM62 tumors. Our results demonstrate that restoring TMEM62 may be a novel approach for treatment of HGSC. These findings may have implications for biomarker and intervention strategies to help improve patient outcomes
Contributions Of Circulating Micrornas For Early Detection Of Lung Cancer, Jody Vykoukal, Johannes F Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J Ostrin, Cristina Ivan, Mark D Thornquist, Matt J Barnett, Ziding Feng, George A Calin, Samir M Hanash
Contributions Of Circulating Micrornas For Early Detection Of Lung Cancer, Jody Vykoukal, Johannes F Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J Ostrin, Cristina Ivan, Mark D Thornquist, Matt J Barnett, Ziding Feng, George A Calin, Samir M Hanash
Faculty, Staff and Student Publications
There is unmet need to develop circulating biomarkers that would enable earlier interception of lung cancer when more effective treatment options are available. Here, a set of 30 miRNAs, selected from a review of the published literature were assessed for their predictive performance in identifying lung cancer cases in the pre-diagnostic setting. The 30 miRNAs were assayed using sera collected from 102 individuals diagnosed with lung cancer within one year following blood draw and 212 controls matched for age, sex, and smoking status. The additive performance of top-performing miRNA candidates in combination with a previously validated four-protein marker panel (4MP) …
Herbaceous Production Lost To Tree Encroachment In United States Rangelands, Scott L. Morford, Brady W. Allred, Dirac L. Twidwell Jr, Matthew O. Jones, Jeremy D. Maestas, Caleb P. Roberts, David E. Naugle
Herbaceous Production Lost To Tree Encroachment In United States Rangelands, Scott L. Morford, Brady W. Allred, Dirac L. Twidwell Jr, Matthew O. Jones, Jeremy D. Maestas, Caleb P. Roberts, David E. Naugle
Department of Agronomy and Horticulture: Faculty Publications
1. Rangelands of the United States provide ecosystem services that benefit society and rural economies. Native tree encroachment is often overlooked as a primary threat to rangelands due to the slow pace of tree cover expansion and the positive public perception of trees. Still, tree encroachment fragments these landscapes and reduces herbaceous production, thereby threatening habitat quality for grassland wildlife and the economic sustainability of animal agriculture.
2. Recent innovations in satellite remote sensing permit the tracking of tree encroachment and the corresponding impact on herbaceous production. We analysed tree cover change and herbaceous production across the western United States …
Host Species And Captivity Distinguish The Microbiome Compositions Of A Diverse Zoo-Resident Non-Human Primate Population, Maya O. Wills, Robin R. Shields-Cutler, Emily Brunmeier, Madison Weissenborn, Tami Murphy, Dan Knights, Timothy J. Johnson, Jonathan B. Clayton
Host Species And Captivity Distinguish The Microbiome Compositions Of A Diverse Zoo-Resident Non-Human Primate Population, Maya O. Wills, Robin R. Shields-Cutler, Emily Brunmeier, Madison Weissenborn, Tami Murphy, Dan Knights, Timothy J. Johnson, Jonathan B. Clayton
Department of Food Science and Technology: Faculty Publications
Vast numbers of microorganisms inhabit the mammalian gastrointestinal tract in a complex community referred to as the gut microbiome. An individual’s microbiome may be impacted by genetics, diet, and various environmental factors, and has been associated with many health states and diseases, though specific explanations are lacking. While these communities are well-studied in human populations, non-human primates (NHPs), in particular zoo-resident or captive NHPs, offer distinct advantages to increasing our understanding of factors that influence gut microbiome composition. Here, we characterize the gut microbiome composition of a phylogenetically diverse cohort of NHPs residing in the same urban zoo. We show …
Increased Extent Of Waterfowl Grazing Lengthens The Recovery Time Of A Colonizing Seagrass (Halophila Ovalis) With Implications For Seagrass Resilience, Caitlyn M. O’Dea, Paul S. Lavery, Chanelle L. Webster, Kathryn M. Mcmahon
Increased Extent Of Waterfowl Grazing Lengthens The Recovery Time Of A Colonizing Seagrass (Halophila Ovalis) With Implications For Seagrass Resilience, Caitlyn M. O’Dea, Paul S. Lavery, Chanelle L. Webster, Kathryn M. Mcmahon
Research outputs 2022 to 2026
Herbivore distributions and abundance are shifting because of climate change, leading to intensified grazing pressure on foundation species such as seagrasses. This, combined with rapidly increasing magnitudes of change in estuarine ecosystems, may affect seagrass resilience. While the overall resilience of seagrasses is generally well-studied, the timeframes of recovery has received comparatively little attention, particularly in temperate estuaries. We investigated how the recovery time (RT) of seagrass is affected by simulated grazing in a southwestern Australian estuary. Whilst excluding swans, we simulated different grazing intensities (25, 50, 75, and 100 % removal from 1 m2 plots) at four locations in …
Evaluation Of Vicinity-Based Hidden Markov Models For Genotype Imputation
Evaluation Of Vicinity-Based Hidden Markov Models For Genotype Imputation
Faculty, Staff and Student Publications
BACKGROUND: The decreasing cost of DNA sequencing has led to a great increase in our knowledge about genetic variation. While population-scale projects bring important insight into genotype-phenotype relationships, the cost of performing whole-genome sequencing on large samples is still prohibitive. In-silico genotype imputation coupled with genotyping-by-arrays is a cost-effective and accurate alternative for genotyping of common and uncommon variants. Imputation methods compare the genotypes of the typed variants with the large population-specific reference panels and estimate the genotypes of untyped variants by making use of the linkage disequilibrium patterns. Most accurate imputation methods are based on the Li-Stephens hidden Markov …
In Silico And In Vitro Studies Of Taiwan Chingguan Yihau (Nricm101) On Tnf-Α/Il-1Β-Induced Human Lung Cells, Yih-Dih Cheng, Chi‑Cheng Lu, Yuan-Man Hsu, Fuu-Jen Tsai, Da-Tian Bau, Shih-Chang Tsai, Ching-Chang Cheng, Jen-Jyh Lin, Yuang-Yu Huang, Yu-Ning Juan, Yu-Jen Chiu, Sheng-Chu Kuo, Jai-Sing Yang, Lii-Tzu Wu
In Silico And In Vitro Studies Of Taiwan Chingguan Yihau (Nricm101) On Tnf-Α/Il-1Β-Induced Human Lung Cells, Yih-Dih Cheng, Chi‑Cheng Lu, Yuan-Man Hsu, Fuu-Jen Tsai, Da-Tian Bau, Shih-Chang Tsai, Ching-Chang Cheng, Jen-Jyh Lin, Yuang-Yu Huang, Yu-Ning Juan, Yu-Jen Chiu, Sheng-Chu Kuo, Jai-Sing Yang, Lii-Tzu Wu
BioMedicine
COVID-19 pandemic has been a global outbreak of coronavirus (SARS-CoV-2 virus) since 2019. Taiwan Chingguan Yihau (NRICM101) is the first traditional Chinese medicine (TCM) classic herbal formula and is widely used for COVID-19 patients in Taiwan and more than 50 nations. This study is to investigate in silico target fishing for the components of NRICM101 and to explore whether NRICM101 inhibits cytokines-induced normal human lung cell injury in vitro. Our results showed that network prediction of NRICM101 by a high throughput target screening platform showed that NRICM101 has multiple functions that may affect cytokine regulation to prevent human lung cell …
Ethanol Leaf Extract Of Hoslundia Opposita In In Vivo Antioxidant And Hepatoprotective Activity Using An Animal Model, Fred Coolborn Akharaiyi, Odoligie Imarhiagbe, Lucky Efe Isunu, Adebayo Thomas Ajibola
Ethanol Leaf Extract Of Hoslundia Opposita In In Vivo Antioxidant And Hepatoprotective Activity Using An Animal Model, Fred Coolborn Akharaiyi, Odoligie Imarhiagbe, Lucky Efe Isunu, Adebayo Thomas Ajibola
BioMedicine
Introduction and aim: The liver is a useful organ that is responsible for the detoxification of harmful substances from the body. Its vital role is of importance hence it should be protected from damages in order to function normally. The management of liver diseases with orthodox medicine has been found to have side effects thus its effective management with folklore has been found better.
Materials and Methods: The leaves of H. oppisota harvested from a forest was processed and extracted with ethanol. The extract concentrations of 100 to 400 mg/ml was used to evaluate acute toxicity, biochemical analysis, …
The Evaluation Of Serum Lipid Profile And Apolipoprotein C-1 In The Iranian Patients Of Oral Squamous Cell Carcinoma, Walaa Alazzawi, Zahra Shahsavari, Hanieh Babaei, Hadis Firouzpour, Abbas Karimi, Afsaneh Goudarzi
The Evaluation Of Serum Lipid Profile And Apolipoprotein C-1 In The Iranian Patients Of Oral Squamous Cell Carcinoma, Walaa Alazzawi, Zahra Shahsavari, Hanieh Babaei, Hadis Firouzpour, Abbas Karimi, Afsaneh Goudarzi
BioMedicine
Background: The key role of apolipoprotein C-1 (ApoC-1) is reported in breast, pancreas and lung cancer. However, no information is available on potential difference of ApoC-1 between OSCC patients and healthy individuals. This work aimed to examine the serum ApoC-1 level as well as lipid profile values between OSCC patients and healthy control groups.
Material and Methods: In this study, 44 blood samples from 22 OSCC patients and 22 healthy individuals were collected to determine the values of lipid profile and ApoC-1 concentration using colorimetric method and Enzyme-Linked Immunosorbent Assay (ELISA), respectively.
Results: A significant decrease in serum lipid profile …
Lep G2548a Polymorphism Is Associated With Increased Serum Leptin And Insulin Resistance Among T2dm Malaysian Patients, Layth Ahmed Ali, Khairunadwa Jemon, Nurriza Ab Latif, Suhaili Abu Bakar, Sharifah Sakinah Syed Alwi
Lep G2548a Polymorphism Is Associated With Increased Serum Leptin And Insulin Resistance Among T2dm Malaysian Patients, Layth Ahmed Ali, Khairunadwa Jemon, Nurriza Ab Latif, Suhaili Abu Bakar, Sharifah Sakinah Syed Alwi
BioMedicine
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome that is rapidly increasing across the world, especially in Malaysia. Leptin plays a vital role in the regulation of metabolism through its effect on peripheral tissues. G2548A polymorphism in the LEP gene promoter has been associated with insulin resistance, leptin, and type 2 diabetes mellitus across different population, but has not been inclusively reported within the Malaysian population.
Objective: Thus, our study aimed to investigate the impact of G2548A polymorphism on serum leptin levels and insulin resistance among Malaysian T2DM patients.
Methods: This case-control study involved …
Neovasculogenic Effect Of 11,12-Epoxyeicosatrienoic Acid Involves The Akt/Enos Signaling Pathways In Human Endothelial Progenitor Cells, Hung-Chang Hung, Jia-Ning Syu, Che-Yi Chao, Shu-Ming Huang, Cheng-Chieh Lin, Mei-Due Yang, Shu-Yao Tsai, Feng-Yao Tang
Neovasculogenic Effect Of 11,12-Epoxyeicosatrienoic Acid Involves The Akt/Enos Signaling Pathways In Human Endothelial Progenitor Cells, Hung-Chang Hung, Jia-Ning Syu, Che-Yi Chao, Shu-Ming Huang, Cheng-Chieh Lin, Mei-Due Yang, Shu-Yao Tsai, Feng-Yao Tang
BioMedicine
The 11,12-epoxy-eicosatrienoic acid (11,12-EET) is formed from arachidonic acid (AA) by cytochrome P450 2J2 (CYP 2J2) epoxygenase and function as an effector in blood vessels. Human endothelial progenitor cells (hEPCs), a preceding cell source for endothelial cells (ECs), involve in the vascular tissue repairing by postnatal neovasculogenesis. However, the effect of 11, 12-EET on hEPCs and neovasculogenesis is not well known. In the current study, we examined the function of 11, 12-EET in hEPCs-mediated neovasculogenesis by using tubular formation analysis, Western Blotting assay, immunofluorescence staining, flow cytometry analysis and zymogram analysis. The results suggest that 11, 12-EET significantly induces neovasculogenesis …
Preliminary Study Of Structural Changes Of Glucose-6-Phosphate Dehydrogenase Deficiency Variants, Naveen Eugene Louis, Muaawia Ahmed Hamza, Puteri Nur Sarah Diana Engku Baharuddin, Shamini Chandran, Nurriza Ab Latif, Mona Awad Alonazi, Khairul Bariyyah Abd Halim, Arjumand Warsy, Syazwani Itri Amran
Preliminary Study Of Structural Changes Of Glucose-6-Phosphate Dehydrogenase Deficiency Variants, Naveen Eugene Louis, Muaawia Ahmed Hamza, Puteri Nur Sarah Diana Engku Baharuddin, Shamini Chandran, Nurriza Ab Latif, Mona Awad Alonazi, Khairul Bariyyah Abd Halim, Arjumand Warsy, Syazwani Itri Amran
BioMedicine
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency disorder affecting over 400 million individuals worldwide. G6PD protects red blood cells (RBC) from the harmful effects of oxidative substances. There are more than 400 G6PD mutations, of which 186 variants have shown to be linked to G6PD deficiency by decreasing the activity or stability of the enzyme. Different variants manifest different clinical phenotypes which complicate comprehending the mechanism of the disease. In order to carry out computational approaches to elucidate the structural changes of different G6PD variants that are common to the Asian population, a complete G6PD monomer-ligand complex …
Phenotype And Genotype In A Taiwanese Girl With Sotos Syndrome, Wei-De Lin, Chung-Hsing Wang, Fuu-Jen Tsai, I-Ching Chou
Phenotype And Genotype In A Taiwanese Girl With Sotos Syndrome, Wei-De Lin, Chung-Hsing Wang, Fuu-Jen Tsai, I-Ching Chou
BioMedicine
Rare copy number variations have been linked to an important source of mutation in many psychopathological traits and neurodevelopmental disorders. In this study, we describe a Taiwanese girl with mental retardation and mild macrocephaly who underwent a childhood psychological evaluation for several years first. When she was 5 years old, she came to our hospital for further diagnosis. We conducted molecular cytogenetic tests and confirmed she actually has Sotos syndrome. We compared our case with two others with very similar deletion regions, but their phenotypes were heterogeneous. Sotos syndrome is very rare in Taiwan, and it is suggested that genetic …
Covid19 Vaccines And The Misinterpretation Of Perceived Side Effects, Raymond Palmer
Covid19 Vaccines And The Misinterpretation Of Perceived Side Effects, Raymond Palmer
BioMedicine
In the era of Covid19 and mass vaccination programs, the anti-vaccination movement across the world is currently at an all-time high. Much of this anti-vaccination sentiment could be attributed to the alleged side effects that are perpetuated across social media from anti-vaccination groups. Fear mongering and misinformation being peddled by people with no scientific training to terrorise people into staying unvaccinated is not just causing people to remain susceptible to viral outbreaks, but could also be causing more side effects seen in the vaccination process. This brief review will offer data that may demonstrate that misinformation perpetuated by the anti-vaccination …
Ncoa4 Regulates Iron Recycling And Responds To Hepcidin Activity And Lipopolysaccharide In Macrophages, Cole A. Guggisberg, Juyoung Kim, Jaekwon Lee, Xiaoli Chen, Moon-Suhn Ryu
Ncoa4 Regulates Iron Recycling And Responds To Hepcidin Activity And Lipopolysaccharide In Macrophages, Cole A. Guggisberg, Juyoung Kim, Jaekwon Lee, Xiaoli Chen, Moon-Suhn Ryu
Department of Biochemistry: Faculty Publications
Macrophages, via erythrophagocytosis, recycle iron from effete erythrocytes to newly developing red blood cells. Conversion of potentially cytotoxic levels of iron from its heme into nonheme form during iron recycling is safely accomplished via coordinated regulations of cellular iron transport and homeostasis. Herein, we demonstrate the roles and regulation of NCOA4 (nuclear receptor coactivator 4)-mediated ferritinophagy in macrophages after erythrophagocytosis using the mouse macrophage cell line J774 cells. Ferritin in J774 cells increased with the rise of nonheme iron by erythrocyte ingestion and declined when total cellular iron contents subsequently decreased. NCOA4, a selective autophagic cargo receptor for ferritin, was …
Assessing Age-Specific Vaccination Strategies And Post-Vaccination Reopening Policies For Covid-19 Control Using Seir Modeling Approach
Faculty, Staff and Student Publications
As the availability of COVID-19 vaccines, it is badly needed to develop vaccination guidelines to prioritize the vaccination delivery in order to effectively stop COVID-19 epidemic and minimize the loss. We evaluated the effect of age-specific vaccination strategies on the number of infections and deaths using an SEIR model, considering the age structure and social contact patterns for different age groups for each of different countries. In general, the vaccination priority should be given to those younger people who are active in social contacts to minimize the number of infections, while the vaccination priority should be given to the elderly …
Intracellular Hemin Is A Potent Inhibitor Of The Voltage-Gated Potassium Channel Kv10.1, Nirakar Sahoo, Kefan Yang, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Intracellular Hemin Is A Potent Inhibitor Of The Voltage-Gated Potassium Channel Kv10.1, Nirakar Sahoo, Kefan Yang, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing recognition of heme as a non-genomic modulator of ion channel functions. Here, we show that intracellular free heme and hemin modulate human ether à go-go (hEAG1, Kv10.1) voltage-gated potassium channels. Application of hemin to the intracellular side potently inhibits Kv10.1 channels with an IC50 of about 4 nM under ambient and 63 nM under reducing conditions in a weakly voltage-dependent manner, …
Application Of Polynomial Regression Model For Joint Stiffness, Youngmin Chun, Craig Mcgowan, Jinah Kim, Joshua P. Bailey
Application Of Polynomial Regression Model For Joint Stiffness, Youngmin Chun, Craig Mcgowan, Jinah Kim, Joshua P. Bailey
International Journal of Exercise Science
International Journal of Exercise Science 15(1): 1236-1245, 2022. Quasi-stiffness (joint stiffness) is often used to characterize leg properties during athletic and other activities and has been reported by a single slope of angle-moment curve. However, the joint angle-moment relationship of some relationship are not effectively represented by a simple linear regression model. Thus, the purpose of this analysis was to investigate the benefits of utilizing a 2nd order polynomial regression (quadratic) model as compared to the linear model when calculating lower extremity joint stiffness incorporating subdivided eccentric phases. Thirty healthy and active college students performed 15 drop jumps from …
Review Of The Cybocephalidae (Coleoptera) Of North America And The West Indies With Descriptions Of Two New Species Of Cybocephalus Erichson, Trevor Randall Smith
Review Of The Cybocephalidae (Coleoptera) Of North America And The West Indies With Descriptions Of Two New Species Of Cybocephalus Erichson, Trevor Randall Smith
Insecta Mundi
The nineteen species of Cybocephalidae (Coleoptera) occurring in North America and the West Indies (including Trinidad) are listed and keyed. Cybocephalus skelleyi new species and Cybocephalus edmondsoni new species are described, and Cybocephalus carrabeus T. R. Smith is found to be a new synonym of Cybocephalus geoffereysmithi T. R. Smith. Illustrations of morphological features, including detailed drawings of male genitalia, host records and distribution data, are provided.