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Articles 49171 - 49200 of 255945
Full-Text Articles in Life Sciences
Spatial Patterns Of Woody Plant Encroachment In A Temperate Grassland, Dillon T. Fogarty, Robert B. Peterson, Dirac Twidwell
Spatial Patterns Of Woody Plant Encroachment In A Temperate Grassland, Dillon T. Fogarty, Robert B. Peterson, Dirac Twidwell
Department of Agronomy and Horticulture: Faculty Publications
Context Woody encroachment is the process whereby grasslands transition to a woody-dominated state. This process is a global driver of grassland decline and is ultimately the outcome of increased woody plant recruitment in grasslands. Yet, little is known about how recruitment distances structure spatial patterns of encroachment.
Objectives Here, we develop a recruitment curve to describe the scatter of woody plant recruitment around seed sources and examine how this structures spatial patterns of encroachment.
Methods We developed a recruitment curve for Juniperus virginiana using an encroachment dataset that captures spread from tree plantings into treeless grassland sites in the Nebraska …
The Use Of Non-Model Drosophila Species To Study Natural Variation In Tor Pathway Signaling, Tessa Steenwinkel, Kailee K. Hamre, Thomas Werner
The Use Of Non-Model Drosophila Species To Study Natural Variation In Tor Pathway Signaling, Tessa Steenwinkel, Kailee K. Hamre, Thomas Werner
Michigan Tech Publications, Part 1
Nutrition and growth are strongly linked, but not much is known about how nutrition leads to growth. To understand the connection between nutrition through the diet, growth, and proliferation, we need to study the phenotypes resulting from the activation and inhibition of central metabolic pathways. One of the most highly conserved metabolic pathways across eukaryotes is the Target of Rapamycin (TOR) pathway, whose primary role is to detect the availability of nutrients and to either induce or halt cellular growth. Here we used the model organism Drosophila melanogaster (D. mel.) and three non-model Drosophila species with different dietary needs, Drosophila …
Mise Au Point Et Validation D’Une Approche Terrain De Prédiction Des Chargements Au Dos Basée Sur Des Données De Laboratoire, Alain Delisle, François Thénault, André Plamondon, Hakim Mecheri
Mise Au Point Et Validation D’Une Approche Terrain De Prédiction Des Chargements Au Dos Basée Sur Des Données De Laboratoire, Alain Delisle, François Thénault, André Plamondon, Hakim Mecheri
Rapports de recherche scientifique
Les troubles musculosquelettiques (TMS) et particulièrement ceux au bas du dos affectent de nombreux travailleuses et travailleurs chaque année au Québec (Vézina et al., 2011). Le chargement mécanique au bas dos est reconnu comme un facteur de risque pouvant mener au développement de maux de dos, et la manutention de charges peut occasionner des chargements importants et répétés. La façon habituelle de quantifier le chargement au dos des individus est d’estimer le moment qui s’exerce à l’articulation lombo-sacrée (L5/S1). L’estimation de ce moment se fait généralement en laboratoire et nécessite la connaissance de la position et de l’orientation de …
Comparing Three Wearable Accelerometers To Measure Early Activity After Cardiac Surgery, Charles H. Brown, Lisa Yanek, Ryan Healy, Tiffany Tsay, Junrui Di, Lee Goeddel, Daniel Young, Vadim Zipunnikov, Jennifer Schrack, Cardiac Surgery Mobility Working Group
Comparing Three Wearable Accelerometers To Measure Early Activity After Cardiac Surgery, Charles H. Brown, Lisa Yanek, Ryan Healy, Tiffany Tsay, Junrui Di, Lee Goeddel, Daniel Young, Vadim Zipunnikov, Jennifer Schrack, Cardiac Surgery Mobility Working Group
Physical Therapy Faculty Research
Objective:
Wearable activity monitors can provide detailed data on activity after cardiac surgery and discriminate a patient's risk for hospital-based outcomes. However, comparative data for different monitoring approaches, as well as predictive ability over clinical characteristics, are lacking. In addition, data on specific thresholds of activity are needed. The objective of this study was to compare 3 wearable activity monitors and 1 observational mobility scale in discriminating risk for 3 hospital-based outcomes, and to establish clinically relevant step thresholds.
Methods:
Cardiac surgery patients were enrolled between June 2016 and August 2017 in a cohort study. Postoperative activity was measured by …
Legal Regulation Of Food Safety Information Sharing In Online Direct Selling Of Edible Agricultural Products, Jiang Ding, Chen He-Fang
Legal Regulation Of Food Safety Information Sharing In Online Direct Selling Of Edible Agricultural Products, Jiang Ding, Chen He-Fang
Food and Machinery
There are some problems in the legal regulation of safety information sharing, such as the lack of necessary standards and norms, the lack of effective guarantee for the authenticity of food safety information sharing and the lack of corresponding accountability system for improper information sharing.In this regard, we can optimize and construct the legal regulation of food safety information sharing in online direct selling of edible agricultural products from the aspects of building a unified food safety information sharing standard for online direct selling of agricultural products, building a diversified information sharing supervision mechanism combining the government, network platform and …
Ecological Interactions Disrupted By Habitat Alteration In The Neotropics, Aniko Toth, Andrew Allen, S. Kathleen Lyons, John Alroy
Ecological Interactions Disrupted By Habitat Alteration In The Neotropics, Aniko Toth, Andrew Allen, S. Kathleen Lyons, John Alroy
School of Biological Sciences: Faculty Publications
Ecological interactions help determine the distribution of species across landscapes and play crucial roles in ecosystem services such as pollination, seed dispersal, and pest control1. Human disturbances, particularly habitat alteration, have the potential to modify or erase ecological interactions2,3 and so jeopardise the processes they control. While examples of interactions becoming rewired under human influence have been recorded, studies of this process for speciose assemblages at regional to continental scales are uncommon4 and obstructed by logistical difficulties2. The consequences for ecological communities and people are therefore poorly understood. Here we show that human habitat alteration is associated with …
Smokejumper Obituary: Dibble, Neil Lawrence (North Cascades 1950), National Smokejumper Association
Smokejumper Obituary: Dibble, Neil Lawrence (North Cascades 1950), National Smokejumper Association
Smokejumper Obituaries
No abstract provided.
Wastewater-Informed Public Health Intervention Playbook
Wastewater-Informed Public Health Intervention Playbook
Sustain Magazine
As the SARS-CoV-2 pandemic quickly spread from country to country and continent to continent in 2020, governments and scientists needed a way to track COVID-19 through populations in order to position public health interventions in the most impactful locations. Having a decision-based risk framework may help to guide policy creation that could minimize or prevent possible outbreaks and surges of infection within communities. The University of Louisville in partnership with Louisville’s Department of Public Health and Wellness tested this strategy in 2021 and 2022. This Wastewater-Informed Public Health Intervention Playbook describes the decisions and actions of that academic and public …
Ractopamine At The Center Of Decades-Long Scientific And Legal Disputes: A Lesson On Benefits, Safety Issues, And Conflicts, Kumail Abbas, Aqeel Raza, Ross D. Vasquez, Marri Jmelou M. Roldan, Nemi Malhotra, Jong-Chin Huang, Olivia Erin M. Buenafe, Kelvin H. -C Chen, Shin-Shin Liang, Chung-Der Hsiao
Ractopamine At The Center Of Decades-Long Scientific And Legal Disputes: A Lesson On Benefits, Safety Issues, And Conflicts, Kumail Abbas, Aqeel Raza, Ross D. Vasquez, Marri Jmelou M. Roldan, Nemi Malhotra, Jong-Chin Huang, Olivia Erin M. Buenafe, Kelvin H. -C Chen, Shin-Shin Liang, Chung-Der Hsiao
Chemistry Faculty Publications
Ractopamine (RAC) is a synthetic phenethanolamine, β–adrenergic agonist used as a feed additive to develop leanness and increase feed conversion efficiency in different farm animals. While RAC has been authorized as a feed additive for pigs and cattle in a limited number of countries, a great majority of jurisdictions, including the European Union (EU), China, Russia, and Taiwan, have banned its use on safety grounds. RAC has been under long scientific and political discussion as a controversial antibiotic as a feed additive. Here, we will present significant information on RAC regarding its application, detection methods, conflicts, and legal divisions that …
Webinars As A Tool For Increasing Awareness Of Diabetes Prevention And Management Programs, Cindy Jenkins, Carrie Durward, April Litchford, Catherine Hansen, Annette Prall, Caitlyn Jasumback
Webinars As A Tool For Increasing Awareness Of Diabetes Prevention And Management Programs, Cindy Jenkins, Carrie Durward, April Litchford, Catherine Hansen, Annette Prall, Caitlyn Jasumback
Outcomes and Impact Quarterly
Stakeholders sought to reduce the burden of preventable diabetes among adults in Utah via a “Food as Medicine” webinar series. The “Food as Medicine” webinar series sought to increase awareness of and enrollment in public diabetes programs. Evaluation results from the webinar series indicated an increase in awareness of diabetes programs and nutrition information needed to improve personal diabetes management.
Study On The Three-Level Synergy Mechanism Of Regional Public Brand Of Agricultural Products, He Jie, Zhang Xi-Hua, Wan Jin, Tang Gui-Zhen, He Guo-Qing
Study On The Three-Level Synergy Mechanism Of Regional Public Brand Of Agricultural Products, He Jie, Zhang Xi-Hua, Wan Jin, Tang Gui-Zhen, He Guo-Qing
Food and Machinery
Through combing the collaborative mode among the three-level brands of 'city-county-enterprise' in Zhejiang Province, this review explores how to get out of the conflict among the main levels of regional public brands under the background of common prosperity, effectively promote the industrial revitalization and common prosperity in the regional plate, and provide reference and guidance for the management collaborative innovation of regional public brands of all-class agricultural products.
Setting The Stage For The Next Farm Bill Debate, Bradley D. Lubben
Setting The Stage For The Next Farm Bill Debate, Bradley D. Lubben
Cornhusker Economics
The 2018 Farm Bill is set to expire in September 2023. New farm bill legislation will be needed by then if authority is to be extended for a wide range of programs from farm support to conservation, nutrition assistance, credit, trade promotion, rural development, research and education, and more.
The agricultural committees in Congress have already held initial hearings and many agricultural and other interest groups have noted their policy priorities. However, formal debate on a new farm bill is not expected to begin in earnest until early 2023 when a new session of Congress convenes.
While the formal debate …
Cooperative Extension’S Capacity To Address Food Insecurity By Supporting Food Recovery Organizations, H. Lester Schonberger, Lily L. Yang, Melissa Chase, Tiffany Drape, Sarah Misyak, Renee Boyer
Cooperative Extension’S Capacity To Address Food Insecurity By Supporting Food Recovery Organizations, H. Lester Schonberger, Lily L. Yang, Melissa Chase, Tiffany Drape, Sarah Misyak, Renee Boyer
Journal of Extension
Virginia Cooperative Extension (VCE) educators are uniquely positioned to support the food recovery organizations (FROs) which address hunger-related needs resulting from food insecurity. Based on an online survey to measure how VCE educators have engaged with FROs and their experiences, respondents who previously supported FROs did so across multiple programming areas, and those who had not indicated an interest while also experiencing barriers. Respondents also reported the need for context- and audience-specific resources particular to the spectrum of food recovery. Addressing barriers and resource needs through a transdisciplinary eXtension Food Recovery Community of Practice may support educators in doing this …
Conflict Of Energies: Spatially Modeling Mule Deer Caloric Expenditure In Response To Oil And Gas Development, Sam Chambers, Miguel L. Villarreal, Olivia Duane, Seth M. Munson, Erica F. Stuber, Gayle Tyree, Eric K. Waller, Michael C. Duniway
Conflict Of Energies: Spatially Modeling Mule Deer Caloric Expenditure In Response To Oil And Gas Development, Sam Chambers, Miguel L. Villarreal, Olivia Duane, Seth M. Munson, Erica F. Stuber, Gayle Tyree, Eric K. Waller, Michael C. Duniway
Wildland Resources Faculty Publications
Context
Wildlife avoid human disturbances, including roads and development. Avoidance and displacement of wildlife into less suitable habitat due to human development can affect their energy expenditures and fitness. The heart rate and oxygen uptake of large mammals varies with both natural aspects of their habitat (terrain, climate, predators, etc.) and anthropogenic influence (noise, light, fragmentation, etc.). Although incorporating physiological analyses of energetics can inform the impacts of both development and conservation, management decisions rarely incorporate individuals’ energetic requirements when deciding on locations for potential development.
Objectives
We aimed to estimate the change in expected energy expenditure, numerically and spatially, …
The Heterogeneity In The Landscape Of Gene Dominance In Maize Is Accompanied By Unique Chromatin Environments, Liangwei Yin, Gen Xu, Jinliang Yang, Meixia Zhao
The Heterogeneity In The Landscape Of Gene Dominance In Maize Is Accompanied By Unique Chromatin Environments, Liangwei Yin, Gen Xu, Jinliang Yang, Meixia Zhao
Department of Agronomy and Horticulture: Faculty Publications
Subgenome dominance after whole-genome duplication (WGD) has been observed in many plant species. However, the degree to which the chromatin environment affects this bias has not been explored. Here, we compared the dominant subgenome (maize1) and the recessive subgenome (maize2) with respect to patterns of sequence substitutions, genes expression, transposable element accumulation, small interfering RNAs, DNA methylation, histone modifications, and accessible chromatin regions (ACRs). Our data show that the degree of bias between subgenomes for all the measured variables does not vary significantly when both of the WGD genes are located in pericentromeric regions. Our data further indicate that the …
Next-Generation Technologies Unlock New Possibilities To Track Rangeland Productivity And Quantify Multi-Scale Conservation Outcomes, Caleb P. Roberts, David E. Naugle, Brady W. Allred, Victoria M. Donovan, Dillon T. Fogarty, Matthew O. Jones, Jeremy D. Maestas, Andrew C. Olsen, Dirac L. Twidwell Jr
Next-Generation Technologies Unlock New Possibilities To Track Rangeland Productivity And Quantify Multi-Scale Conservation Outcomes, Caleb P. Roberts, David E. Naugle, Brady W. Allred, Victoria M. Donovan, Dillon T. Fogarty, Matthew O. Jones, Jeremy D. Maestas, Andrew C. Olsen, Dirac L. Twidwell Jr
Department of Agronomy and Horticulture: Faculty Publications
Historically, relying on plot-level inventories impeded our ability to quantify large-scale change in plant biomass, a key indicator of conservation practice outcomes in rangeland systems. Recent technological advances enable assessment at scales appropriate to inform management by providing spatially comprehensive estimates of productivity that are partitioned by plant functional group across all contiguous US rangelands. We partnered with the Sage Grouse and Lesser Prairie-Chicken Initiatives and the Nebraska Natural Legacy Project to demonstrate the ability of these new datasets to quantify multi-scale changes and heterogeneity in plant biomass following mechanical tree removal, prescribed fire, and prescribed grazing. In Oregon’s sagebrush …
External Validation Of A Prediction Model For Estimating Fat Mass In Children And Adolescents In 19 Countries: Individual Participant Data Meta-Analysis, Mohammed T Hudda, Jonathan C K Wells, Linda S Adair, Jose R A Alvero-Cruz, Maxine N Ashby-Thompson, Martha N Ballesteros-Vásquez, Jesus Barrera-Exposito, Benjamin Caballero, Elvis A Carnero, Geoff J Cleghorn, Peter S W Davies, Malgorzata Desmond, Delan Devakumar, Dympna Gallagher, Elvia V Guerrero-Alcocer, Ferdinand Haschke, Mary Horlick, Houda Ben Jemaa, Ashraful I Khan, Amani Mankai, Makama A Monyeki, Hilde L Nashandi, Luis Ortiz-Hernandez, Guy Plasqui, Felipe F Reichert, Alma E Robles-Sardin, Elaine Rush, Roman J Shypailo, Jakub G Sobiecki, Gill A Ten Hoor, Jesús Valdés, V Pujitha Wickramasinghe, William W Wong, Richard D Riley, Christopher G Owen, Peter H Whincup, Claire M Nightingale
External Validation Of A Prediction Model For Estimating Fat Mass In Children And Adolescents In 19 Countries: Individual Participant Data Meta-Analysis, Mohammed T Hudda, Jonathan C K Wells, Linda S Adair, Jose R A Alvero-Cruz, Maxine N Ashby-Thompson, Martha N Ballesteros-Vásquez, Jesus Barrera-Exposito, Benjamin Caballero, Elvis A Carnero, Geoff J Cleghorn, Peter S W Davies, Malgorzata Desmond, Delan Devakumar, Dympna Gallagher, Elvia V Guerrero-Alcocer, Ferdinand Haschke, Mary Horlick, Houda Ben Jemaa, Ashraful I Khan, Amani Mankai, Makama A Monyeki, Hilde L Nashandi, Luis Ortiz-Hernandez, Guy Plasqui, Felipe F Reichert, Alma E Robles-Sardin, Elaine Rush, Roman J Shypailo, Jakub G Sobiecki, Gill A Ten Hoor, Jesús Valdés, V Pujitha Wickramasinghe, William W Wong, Richard D Riley, Christopher G Owen, Peter H Whincup, Claire M Nightingale
Children’s Nutrition Research Center Staff Publications
Objective: To evaluate the performance of a UK based prediction model for estimating fat-free mass (and indirectly fat mass) in children and adolescents in non-UK settings.
Design: Individual participant data meta-analysis.
Setting: 19 countries.
Participants: 5693 children and adolescents (49.7% boys) aged 4 to 15 years with complete data on the predictors included in the UK based model (weight, height, age, sex, and ethnicity) and on the independently assessed outcome measure (fat-free mass determined by deuterium dilution assessment).
Main outcome measures: The outcome of the UK based prediction model was natural log transformed fat-free mass (lnFFM). Predictive performance statistics of …
Are U.S. Consumers Willing To Pay More By The Lake? An Analysis Of Preferences For Great Lakes Region Fish, April Athnos, Simone Valle De Souza, Kwamena Quagrainie, Chinonso Etumnu, William Knudson, Ronald E. Kinnunen, Paul Hitchens
Are U.S. Consumers Willing To Pay More By The Lake? An Analysis Of Preferences For Great Lakes Region Fish, April Athnos, Simone Valle De Souza, Kwamena Quagrainie, Chinonso Etumnu, William Knudson, Ronald E. Kinnunen, Paul Hitchens
Department of Agricultural Economics Faculty Publications
U.S. per capita seafood consumption is historically high due to population and income growth and consumer preference shifts toward healthy protein options. Despite this expansion, U.S. fisheries, especially those in the Great Lakes region, no longer fulfill domestic demand due to pressure on fish stocks and regulatory constraints. Instead, aquaculture and imports fill the gap. Rainbow trout, yellow perch, and walleye—three species historically produced in the North Central Region (NCR)—exemplify such trends. To expand marketing opportunities for NCR aquaculture producers, this study estimates willingness to pay (WTP) for these species and several search and credence fish attributes. We designed and …
Weather Information And Decision-Support Tool Needs Assessment, Lily Calderwood, Glen Koehler, Sean Birkel, Erin H. Roche
Weather Information And Decision-Support Tool Needs Assessment, Lily Calderwood, Glen Koehler, Sean Birkel, Erin H. Roche
Journal of Extension
University of Maine researchers developed three commodity-specific grower focus groups (lowbush blueberry, apple, mixed vegetable) to discuss and survey 1) current access to weather information, and 2) interest in weather-based decision support tools. NOAA National Weather Service (30%) (n=47) was most commonly cited as a weather information source. Growers ranked greater forecast accuracy (31%) and localization (19%) (n=48) as highest priorities. Only 34% of growers reported current use of weather-based decision support tools, but 86% expressed interest in future use (n=134). The project team is using grower input to improve weather data access and decision-support tools for Maine farmers.
Engaging Farmers, Culinary Schools, And Communities In Value-Added Production To Strengthen Local Food Systems, Lauren B. Errickson, Ethan D. Schoolman, Virginia Quick, Sarah Davis, Anthony Capece
Engaging Farmers, Culinary Schools, And Communities In Value-Added Production To Strengthen Local Food Systems, Lauren B. Errickson, Ethan D. Schoolman, Virginia Quick, Sarah Davis, Anthony Capece
Journal of Extension
Value-added products can generate farm income and improve community food access, yet lack of available kitchen infrastructure and labor can limit farm production capacity. This project explored how community-based culinary schools might fill the gap. A unique “product share” model was identified and piloted, meeting the collective needs of farmers, a culinary school, and urban consumers. By researching farmer crop availability and business model preferences, and aligning value-added production with community food preferences, we demonstrate a successful pilot indicative that similar initiatives can be replicated in other metropolitan areas, with potential to engage cross-disciplinary extension professionals.
The Go Wild With Whole Grains! School-Based Program: Positive Impacts Among Children, Joshua Bailey, Sara Van Offelen, Hyunjun Kim, Marla Reicks
The Go Wild With Whole Grains! School-Based Program: Positive Impacts Among Children, Joshua Bailey, Sara Van Offelen, Hyunjun Kim, Marla Reicks
Journal of Extension
Whole grain foods have been associated with health benefits, yet are underconsumed by youth compared to recommendations. This study evaluated impacts of a school-based curriculum among children in grades 3-5 to address barriers to intake (2018-2019) (n = 1,748). Surveys before and after the program indicated youth were more willing to try and better able to identify whole grain foods. Open-ended responses confirmed findings regarding increased ability to identify whole grain foods, increased preferences and perceptions of availability. Together, these impacts could increase the likelihood that youth can meet whole grain intake recommendations to improve diet quality and health.
Protecting Cattle Feedyard Workers In The Central States Region: Exploring State, Regional, And National Data On Fatal And Nonfatal Injuries In Agriculture And The Beef Production Sector, Athena K. Ramos, Suraj Adhikari, Risto Rautiainen, Aaron Yoder
Protecting Cattle Feedyard Workers In The Central States Region: Exploring State, Regional, And National Data On Fatal And Nonfatal Injuries In Agriculture And The Beef Production Sector, Athena K. Ramos, Suraj Adhikari, Risto Rautiainen, Aaron Yoder
Journal of Extension
Working in agriculture can be dangerous. Despite ongoing efforts of Extension, animal production worker safety has not been adequately addressed. We present state, regional, and national counts and rates on fatal and nonfatal injuries in agriculture and animal production using publicly available data from the Bureau of Labor Statistics. We found that animal production had a high number of fatal injuries and a higher rate of nonfatal injuries than the average within agriculture. More needs to be done to protect livestock workers from injury. Extension professionals can play a key role in increasing safety knowledge and changing behaviors.
Teaching Educators Basic Fruit Tree Grafting Methods, Jeffrey C. Wilson, Wayne Porter, Casey Barickman
Teaching Educators Basic Fruit Tree Grafting Methods, Jeffrey C. Wilson, Wayne Porter, Casey Barickman
Journal of Extension
Hands-on education has proven to be successful in teaching basic grafting methods. MSU Extension developed and conducted eleven statewide workshops teaching Extension Agents and Master Gardeners preferred fruit tree grafting methods. The hands-on workshops provided specialists, agents, and Master Gardeners training on teaching fruit tree grafting classes for clientele. Each workshop consisted of a pre-test, a PowerPoint presentation, a post-test, and a grafting demonstration. Post-test scores showed a significant gain in knowledge over pre-test scores. This training can be replicated/adapted by other organizations to conduct educational outreach.
The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.
The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.
Faculty and Staff Scholarship
We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and age-related diseases which contribute to increased morbidity with age. Geriatric populations are rarely considered in the development of environmental regulations or in toxicology research. Today, life expectancy is often into one’s 80s or beyond, which means multiple decades living as a geriatric individual. Hence, adverse health effects and late-onset diseases might be due to environmental exposures as a geriatric, and we currently have no way of …
Insular Cortical Circuits As An Executive Gateway To Decipher Threat Or Extinction Memory Via Distinct Subcortical Pathways, Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Xue Gu, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li, Tian-Le Xu
Insular Cortical Circuits As An Executive Gateway To Decipher Threat Or Extinction Memory Via Distinct Subcortical Pathways, Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Xue Gu, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li, Tian-Le Xu
Faculty, Staff and Student Publications
Threat and extinction memories are crucial for organisms' survival in changing environments. These memories are believed to be encoded by separate ensembles of neurons in the brain, but their whereabouts remain elusive. Using an auditory fear-conditioning and extinction paradigm in male mice, here we discovered that two distinct projection neuron subpopulations in physical proximity within the insular cortex (IC), targeting the central amygdala (CeA) and nucleus accumbens (NAc), respectively, to encode fear and extinction memories. Reciprocal intracortical inhibition of these two IC subpopulations gates the emergence of either fear or extinction memory. Using rabies-virus-assisted tracing, we found IC-NAc projection neurons …
Gastrointestinal Microbiome Disruption And Antibiotic-Associated Diarrhea In Children Receiving Antibiotic Therapy For Community-Acquired Pneumonia, Jiye Kwon, Yong Kong, Martina Wade, Derek J Williams, Clarence Buddy Creech, Emmanuel B Walter, Jeffrey S Gerber, Jason G Newland, Meghan E Hofto, Mary Allen Staat, Henry F Chambers, Vance G Fowler, W Charles Huskins, Melinda M Pettigrew
Gastrointestinal Microbiome Disruption And Antibiotic-Associated Diarrhea In Children Receiving Antibiotic Therapy For Community-Acquired Pneumonia, Jiye Kwon, Yong Kong, Martina Wade, Derek J Williams, Clarence Buddy Creech, Emmanuel B Walter, Jeffrey S Gerber, Jason G Newland, Meghan E Hofto, Mary Allen Staat, Henry F Chambers, Vance G Fowler, W Charles Huskins, Melinda M Pettigrew
Faculty, Staff and Student Publications
Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotics. We examined the gastrointestinal microbiota in children treated with β-lactams for community-acquired pneumonia. Data were from 66 children (n = 198 samples), aged 6-71 months, enrolled in the SCOUT-CAP trial (NCT02891915). AAD was defined as ≥1 day of diarrhea. Stool samples were collected on study days 1, 6-10, and 19-25. Samples were analyzed using 16S ribosomal RNA gene sequencing to identify associations between patient characteristics, microbiota characteristics, and AAD (yes/no). Nineteen (29%) children developed AAD. Microbiota compositional profiles differed between AAD groups (permutational multivariate analysis of variance, P < .03) and across visits (P < .001). Children with higher baseline relative abundances of 2 Bacteroides species were less likely to experience AAD. Higher baseline abundance of Lachnospiraceae and amino acid biosynthesis pathways were associated with AAD. Children in the AAD group experienced prolonged dysbiosis (P < .05). Specific gastrointestinal microbiota profiles are associated with AAD in children.
Mechanistic Insight Into Functionally Different Human Islet Polypeptide (Hiapp) Amyloid: The Intrinsic Role Of The C-Terminal Structural Motifs, Dibakar Sarkar, Narayan Chandra Maity, Gourav Shome, Kyriakos Gabriel Varnava, Vijayalekshmi Sarojini, Subramanian Vivekanandan, Nirakar Sahoo, Sourav Kumar, Atin Kumar Mandal, Ranjit Biswas, Anirban Bhunia
Mechanistic Insight Into Functionally Different Human Islet Polypeptide (Hiapp) Amyloid: The Intrinsic Role Of The C-Terminal Structural Motifs, Dibakar Sarkar, Narayan Chandra Maity, Gourav Shome, Kyriakos Gabriel Varnava, Vijayalekshmi Sarojini, Subramanian Vivekanandan, Nirakar Sahoo, Sourav Kumar, Atin Kumar Mandal, Ranjit Biswas, Anirban Bhunia
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Targeting amyloidosis requires high-resolution insight into the underlying mechanisms of amyloid aggregation. The sequence-specific intrinsic properties of a peptide or protein largely govern the amyloidogenic propensity. Thus, it is essential to delineate the structural motifs that define the subsequent downstream amyloidogenic cascade of events. Additionally, it is important to understand the role played by extrinsic factors, such as temperature or sample agitation, in modulating the overall energy barrier that prompts divergent nucleation events. Consequently, these changes can affect the fibrillation kinetics, resulting in structurally and functionally distinct amyloidogenic conformers associated with disease pathogenesis. Here, we have focused on human Islet …
Broiler Vitamin Nutrition Guidelines, Nelson E. Ward
Broiler Vitamin Nutrition Guidelines, Nelson E. Ward
Proceedings of the Arkansas Nutrition Conference
In a time of record feed prices, nutritionists and production managers continue to look for opportunities to lower growout costs. Even though their contribution seldom exceeds 1-2% of feed costs, vitamins are not immune to this cost-crunching scrutiny. Furthermore, in late 2017, an unparalleled drop in global vitamin supply resulted in sharply increased prices, and in some cases, outright shortages. Such events have placed pressure on vitamin fortification levels in broiler feeds. Nutritionists decide on the fortification rates based on a variety of criteria – bird age, production phase, field experience, research trials, and so forth. The rapid change in …
Evaluation Of Phenotype-Driven Gene Prioritization Methods For Mendelian Diseases., Julius O B Jacobsen, Catherine Kelly, Valentina Cipriani, Peter N Robinson, Damian Smedley
Evaluation Of Phenotype-Driven Gene Prioritization Methods For Mendelian Diseases., Julius O B Jacobsen, Catherine Kelly, Valentina Cipriani, Peter N Robinson, Damian Smedley
Faculty Research 2022
Yuan et al. recently described an independent evaluation of several phenotype-driven gene prioritization methods for Mendelian disease on two separate, clinical datasets. Although they attempted to use default settings for each tool, we describe three key differences from those we currently recommend for our Exomiser and PhenIX tools. These influence how variant frequency, quality and predicted pathogenicity are used for filtering and prioritization. We propose that these differences account for much of the discrepancy in performance between that reported by them (15-26% diagnoses ranked top by Exomiser) and previously published reports by us and others (72-77%). On a set of …
Research On Main Components, Bioactivities Of Staphylea Bumalda Dc. And Its Development And Application Progress, Me Ya-Mei, Jing Ji-Yue, Ling Jia-Cheng, Wang Wen-Shu
Research On Main Components, Bioactivities Of Staphylea Bumalda Dc. And Its Development And Application Progress, Me Ya-Mei, Jing Ji-Yue, Ling Jia-Cheng, Wang Wen-Shu
Food and Machinery
In this review, the nutritional components such as protein, amino acids, vitamins, polysaccharides and oil were discussed. The active components, including phenols, flavonoids, triterpenes and the bioactivities such as antioxidant, hypoglycemic and neuroprotection were summarized, the application of S. bumalda DC. as a new raw food material and functional food were also prospected.