Life Sciences Commons^™

Redox-Mediated Inactivation Of The Transcriptional Repressor Rcrr Is Responsible For Uropathogenic Escherichia Coli’S Increased Resistance To Reactive Chlorine Species, Sadia Sultana, Mary E. Crompton, Kennadi Meurer, Olivia Jankiewicz, Grace H. Morales, Colton Johnson, Elise Horbach, Kevin Pierre Hoffmann, Pooja Kr, Ritika Shah, Greg M. Anderson, Jonathan E. Schmitz, Maria Hadjifrangiskou, Alessandro Foti, Jan-Ulrik Dahl

Faculty Publications – Biological Sciences

The ability to overcome stressful environments is critical for pathogen survival in the host. One challenge for bacteria is the exposure to reactive chlorine species (RCS), which are generated by innate immune cells as a critical part of the oxidative burst. Hypochlorous acid (HOCl) is the most potent antimicrobial RCS and is associated with extensive macromolecular damage in the phagocytized pathogen. However, bacteria have evolved defense strategies to alleviate the effects of HOCl-mediated damage. Among these are RCS-sensing transcriptional regulators that control the expression of HOCl-protective genes under non-stress and HOCl stress. Uropathogenic Escherichia coli (UPEC), the major causative agent …

Accelerometry-Based Self-Reported Fatigue Detection During Repeat Bouts Of Sub-Maximal Fatiguing Exercise, Jacob Michael Thomasson Cartwright

Master's Theses (2009 -)

Successful sensor-based fatigue detection is an essential component of remote physical rehabilitation and activity monitoring healthcare systems. Several studies have investigated accelerometry use to detect the presence of neuromuscular fatigue pre- and post-extended bouts of exertion. Similarly, others have investigated the use of a plethora of other sensors to detect neuromuscular fatigue throughout fatiguing exercise. However, there are significant gaps in the literature concerning accelerometry-based neuromuscular fatigue detection throughout fatiguing exercise and the detection of perceived fatigue. Thus, the principal aim of this study was to develop a procedure capable of detecting perceived fatigue using data collected via wearable accelerometers …

Somatostatin Regulates Circadian Clock Function And Photic Processing, Deborah A. M. Joye

Dissertations (1934 -)

Daily and seasonal rhythms are programmed by neural circuits that use daily timing and duration of light to anticipate predictable environmental changes (i.e., day length, temperature, food, predation). Daily and annual changes in light modulate human health to produce both positive and negative effects, but neural mechanisms underlying light-driven changes in the brain remain poorly understood. In mammals, light is processed and encoded by the brain’s central clock, the suprachiasmatic nucleus (SCN). The SCN also encodes day length (i.e., photoperiod) to regulate annual fluctuations in mammalian physiology, but it’s not clear precisely how the SCN network achieves this. One signal …

The Ventral Hippocampus Dynamically Regulates Amygdala Encoding And Learned Fear, Matthew Richard Herbst

Dissertations (1934 -)

The nervous system has evolved a set of survival circuits optimized to respond to environmental threats. Adaptive threat responding requires learning to predict when and where a threat may occur based on available cues. Such learning depends on a distributed network of brain structures, but there is much we do not understand about how these brain areas interact to support fear memory. Addressing this gap is crucial for understanding anxiety- and fear-related disorders as dysfunction in fear learning networks is implicated in the development and persistence of pathological fear states. In my dissertation work, I used a rodent model of …

Natural Enemies And Biological Control Of Stink Bugs (Hemiptera: Heteroptera) In North America, Blessing Ademokoya, Kacie Athey, John R. Ruberson

Department of Entomology: Faculty Publications

Stink bugs comprise a significant and costly pest complex for numerous crops in the United States, including row crops, vegetables, and tree fruits and nuts. Most management relies on the use of broad-spectrum and disruptive insecticides with high human and environmental risks associated with them. Growing concerns about pesticide resistance in stink bugs are forcing pest managers to explore safer and more sustainable options. Here, we review the diverse suite of natural enemies of stink bugs in the US, noting that the egg and the late nymphal and adult stages of stink bugs are the most commonly attacked by parasitoids, …

Mapping And Selection Of Downy Mildew Resistance In Spinach Cv. Whale By Low Coverage Whole Genome Sequencing, Gehendra Bhattarai, Dotun Olaoye, Beiquan Mou, James C. Correll, Ainong Shi

Horticulture Faculty Publications and Presentations

Spinach (Spinacia oleracea) is a popular leafy vegetable crop and commercial production is centered in California and Arizona in the US. The oomycete Peronospora effusa causes the most important disease in spinach, downy mildew. A total of nineteen races of P. effusa are known, with more than 15 documented in the last three decades, and the regular emergence of new races is continually overcoming the genetic resistance to the pathogen. This study aimed to finely map the downy mildew resistance locus RPF3 in spinach, identify single nucleotide polymorphism (SNP) markers associated with the resistance, refine the candidate genes …

Genome-Wide Identification And Salt Stress Response Analysis Of The Bzip Transcription Factor Family In Sugar Beet, Yongyong Gong, Xin Liu, Sixue Chen, Hongli Li, Huizi Duanmu

Faculty and Student Publications

As one of the largest transcription factor families in plants, bZIP transcription factors play important regulatory roles in different biological processes, especially in the process of stress response. Salt stress inhibits the growth and yield of sugar beet. However, bZIP-related studies in sugar beet (Beta vulgaris L.) have not been reported. This study aimed to identify the bZIP transcription factors in sugar beet and analyze their biological functions and response patterns to salt stress. Using bioinformatics, 48 BvbZIP genes were identified in the genome of sugar beet, encoding 77 proteins with large structural differences. Collinearity analysis showed that three pairs …

Filling The Third Circle With Interdisciplinary Lesson Planning: A Case Study Of Pre-Service Teachers, Garrett Steede, Rebecca D. Swenson, Troy D. Mckay

Journal of Human Sciences and Extension

The three-circle model of agricultural education focuses on the importance of in-class instruction, supervised agricultural experiences, and FFA involvement. The agricultural communications career pathway is available to students through agricultural communications supervised agricultural experiences (SAE) programs and career development events within FFA. However, specific curriculum that teaches agricultural communications in the classroom is not readily available. The purpose of this qualitative case study was to examine the interdisciplinary lesson planning and integration process of pre-service teachers with focus on opportunities and limitations to teaching communication in the agriculture, food, and natural resources (AFNR) curriculum. In this case study, four pre-service …

Grains, Seeds And Hay Industry Funding Scheme Annual Report 2021/2022, Department Of Primary Industries And Regional Development, Western Australia, Grains, Seeds And Hay Industry Funding Scheme

Agriculture reports

No abstract provided.

Sheep And Goat Industry Funding Scheme Annual Report 2021/2022, Department Of Primary Industries And Regional Development, Western Australia, Sheep And Goat Industry Funding Scheme

Agriculture reports

No abstract provided.

Volatiles In Berries: Biosynthesis, Composition, Bioavailability, And Health Benefits, Inah Gu, Luke Howard, Sun-Ok Lee

Food Science Faculty Publications and Presentations

Abstract

Alzheimer's Disease, Dylan L. Weber

Student Publications

An overview of the background, etiology, pathophysiology, clinical features, diagnosis, treatment and prevention of Alzheimer's disease.

Sediment Accumulation And Carbon Burial In Four Hadal Trench Systems, Kazumasa Oguri, Pere Masqué, Matthias Zabel, Heather A. Stewart, Gillian Mackinnon, Ashley A. Rowden, Peter Berg, Frank Wenzhöfer, Ronnie N. Glud

Research outputs 2022 to 2026

Hadal trenches are considered to act as depocenters for organic material, although pathways for the material transport and deposition rates are poorly constrained. Here we assess focusing, deposition and accumulation of material and organic carbon in four hadal trench systems underlying different surface ocean productivities; the eutrophic Atacama and Kuril-Kamchatka trenches, the mesotrophic Kermadec trench and the oligotrophic Mariana Trench. The study is based on the distributions of naturally occurring ²¹⁰Pb_ex, ¹³⁷Cs and total organic carbon from recovered sediment cores and by applying previously quantified benthic mineralization rates. Periods of steady deposition and discreet mass-wasting deposits were …

Species Traits And Geomorphic Setting As Drivers Of Global Soil Carbon Stocks In Seagrass Meadows, H. Kennedy, J. F. Pagès, D. Lagomasino, A. Arias-Ortiz, P. Colarusso, J. W. Fourqurean, M. N. Githaiga, J. L. Howard, D. Krause-Jensen, T. Kuwae, Paul S. Lavery, P. I. Macreadie, N. Marbà, Pere Masqué, I. Mazarrasa, T. Miyajima, Oscar Serrano, C. M. Duarte

Research outputs 2022 to 2026

Our knowledge of the factors that can influence the stock of organic carbon (OC) that is stored in the soil of seagrass meadows is evolving, and several causal effects have been used to explain the variation of stocks observed at local to national scales. To gain a global-scale appreciation of the drivers that cause variation in soil OC stocks, we compiled data on published species-specific traits and OC stocks from monospecific and mixed meadows at multiple geomorphological settings. Species identity was recognized as an influential driver of soil OC stocks, despite their large intraspecific variation. The most important seagrass species …

Amphibian Occupancy And Diversity On A Post-Mined Landscape, Emma M. Buckardt

Electronic Theses & Dissertations

Amphibian populations are declining globally, with habitat loss and fragmentation being a leading cause for their decline. Anthropogenic changes to a landscape, such as urbanization, agriculture, and surface mining, leave few native habitats intact, which can influence amphibian populations and communities to varying degrees. Amphibians can provide insight into the health of ecosystems because they are sensitive to changes in their environment. Thus, they can be considered indicator species in anthropogenically altered wetlands. The goal of this study was to characterize amphibian communities that are using surface mined lands that have undergone vegetative succession. For Chapter I, we used call …

Genome-Wide Identification Of The A20/An1 Zinc Finger Proteon Family Genes In Ipomoea Batatas And Its Two Relatives And Function Analysis Of Ibsap16 In Salinity Tolerance, Hao Xie, Qiangqiang Yang, Xiaoxiao Wang, Michael Schläppi, Hui Yan, Meng Kou, Wei Tang, Xin Wang, Yungang Zhang, Qiang Li, Shaojun Dai, Yaju Liu

Biological Sciences Faculty Research and Publications

Stress-associated protein (SAP) genes—encoding A20/AN1 zinc-finger domain-containing proteins—play pivotal roles in regulating stress responses, growth, and development in plants. They are considered suitable candidates to improve abiotic stress tolerance in plants. However, the SAP gene family in sweet potato (Ipomoea batatas) and its relatives is yet to be investigated. In this study, 20 SAPs in sweet potato, and 23 and 26 SAPs in its wild diploid relatives Ipomoea triloba and Ipomoea trifida were identified. The chromosome locations, gene structures, protein physiological properties, conserved domains, and phylogenetic relationships of these SAPs were analyzed systematically. Binding motif analysis of IbSAPs indicated that …

Structural And Transient Kinetic Analysis On Mechanism-Based Inactivators Of Human Ornithine Aminotransferase, Arseniy Butrin

Dissertations

HCC, Hepatocellular carcinoma, MBI, Mechanism-based inactivator, OAT, Ornithine Aminotransferase

The Role Of Gut Microbiome And Scfa Butyrate In The Development Of Obesity Associated Pre-Hfpef, Jomana Hatahet

Dissertations

No abstract provided.

The Roles Of A Probiotic Exopolysaccharide In Breast Cancer, Mai Rachel Nguyen

Dissertations

breast cancer, exopolysaccharide, probiotic

Distinct Roles For Free Fatty Acid Receptor 3 (Ffar3) In Vagal And Spinal Afferents Regulating Energy Balance And Glucose Homeostasis, Tyler M. Cook

Dissertations

energy balance, glucose homeostasis, gut-brain axis, microbiome, nutrient sensing, satiety

Elucidating The Mechanisms Underlying How Vmp1 Regulates Inflammatory Responses, Stephanie Zack

Dissertations

autophagy, inflammation, mitochondria, NLRP3 inflammasome, SERCA, VMP1

Elucidating The Mechanisms Of Immune Regulation By Bacillus Subtilis, Jesus Zamora-Pineda

Dissertations

bacillus subtilis, exopolysaccharides, inflammation, probiotics, tlr4

Interplay Between Human Microbiota And Celiac Disease, John James Colgan

Master's Theses

Celiac disease is an autoimmune disorder of the small intestine in which gluten, an energy-storage protein in wheat and other cereals, elicits an immune response leading to villous atrophy. Despite a strong genetic component, the disease arises sporadically over the lifetime leading us to hypothesize the microbiome might be a trigger. Here, we re-examined 16S data from 3 prior studies examining celiac disease and the microbiome with newer computational tools: the dada2 and PICRUSt 2 pipelines. Our results both confirmed findings of previous studies and generated new data regarding the celiac microbiome of India and Mexico. The datasets were also …

Interrogating Antagonistic Differences Among Pseudomonas Aeruginosa Cdia Alleles, Haotian Yang

Master's Theses

Bacteria are complex social organisms that live within mixed communities where microorganisms compete for limited resources. We studied Contact-Dependent Growth Inhibition (CDI), a particular type of competition mediated by a type 5b, or two-partner, secretion system that is widely spread among Gram-negative bacteria. CdiB and CdiA make up the two-partner secretion system that mediates CDI. CdiB translocates CdiA to the cell surface, and CdiA delivers its C-terminal toxin domain to the target cell. The C-terminal toxin (Tox) domain of CdiA is highly diverse. We studied Tox domains of various Pseudomonas aeruginosa clinical isolates. We found different strains that contain unique …

Integrating Current Analyses Of The Breast Cancer Microbiome, Sidra Sohail

Master's Theses

Breast cancer is the leading cause of cancer death for women in the US. Many cancertypes have significant associations with their resident microbial communities - emerging evidence suggests that breast cancers also interact with the local tissue-associated microbiota. Studies have examined the relationship between breast cancer and its microbiome, however, the studies varied in their approaches used to evaluate these relationships. Microbiome research advances rapidly and analysis pipelines and databases are updated frequently. This dynamic environment makes inter-study comparisons and superficial evaluations challenging as no two studies are using the same standards for evaluation. Researchers have observed the microbiota of …

Role Of Tetraspanins In Sars-Cov-2 Fusion And Entry, Marcos Saul Santiago Figueroa

Master's Theses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic the world has been facing in recent years. Even as new countermeasures are developed, there is still much we don’t know in terms of its entry into host cells. Tetraspanins are transmembrane proteins that are near ubiquitous amongst cell types. They fulfill numerous roles, including that of a viral co-receptor. Here, we considered whether tetraspanins, specifically CD9, CD63, and CD81 influence SARS-CoV-2 fusion and entry. Using ACE2-LgBit and tetraspanin overexpressing EVs and HeLa cells, we find that the presence of excess tetraspanins inhibit fusion and entry. However, we …

Stable Coexistence Or Competitive Exclusion? Fern Endophytes Demonstrate Rapid Turnover Favoring A Dominant Fungus, Brett Steven Younginger, Nathan U. Stewart, Mehmet Ali Balkan, Daniel J. Ballhorn

Biology Faculty Publications and Presentations

Fungal endophytes are critical members of the plant microbiome, but their community dynamics throughout an entire growing season are underexplored. Additionally, most fungal endophyte research has centred on seed-reproducing hosts, while spore-reproducing plants also host endophytes and may be colonized by unique community members. In order to examine annual fungal endophyte community dynamics in a spore-reproducing host, we explored endophytes in a single population of ferns, Polystichum munitum, in the Pacific Northwest. Through metabarcoding, we characterized the community assembly and temporal turnover of foliar endophytes throughout a growing season. From these results, we selected endophytes with outsized representations in …

Synthesis Of 1,2,3-Triazole-Thymol Derivatives As Potential Antimicrobial Agents, Justice Kwaku Addo, Ernest Owusu-Ansah, Nicholas T.K.D. Dayie, Xavier Cheseto, Baldwyn Torto

All Peer-Reviewed Publications

Background: Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it a candidate for structural modification. Thus, this study incorporated the triazole moiety on thymol and the chlorination of thymol moiety to help improve its biological potency. Materials and methods: A series of ten 1,2,3-triazole-thymol derivatives 1–10 were synthesized from thymol, by a click reaction between O-propargyl terminal alkyne of thymol and its chlorothymol with benzyl azide and substituted benzyl azides. Their structures were confirmed by spectroscopic methods (1H-NMR, 13C-NMR, IR, GC-MS-EI/CI and LC-ESI-QTOF-MS). The Well diffusion method using Müeller-Hinton agar plates was used …

Stemficohort1preinterviewdata, Rebecca L. Sansom, Bryn Stclair, Jamie Jensen, Richard West

ScholarsArchive Data

The science, technology, engineering, and mathematics faculty institute (STEMFI) is a National Science Foundation funded project designed to provide support, measurement, and training to BYU faculty developing their own student-centered curriculum.

This PDF file contains pre-institute participation interview data from the first cohort of faculty involved in the STEM faculty institute (2018).

Screening And Assessment Of Cancer-Related Fatigue: An Executive Summary And Road Map For Clinical Implementation, Joy C. Cohn, Shana Harrington Pt, Ph.D., Jeannette Q. Lee, Daniel Malone, Mary Insana Fisher

Faculty Publications

Background:

Cancer-related fatigue (CRF) prevalence is reported as high as 90%. Cancer-related fatigue is multidimensional and associated with lower health-related quality of life. Effective screening and assessment are dependent upon use of valid, reliable, and clinically feasible measures. This Executive Summary of the Screening and Assessment of Cancer-related Fatigue Clinical Practice Guideline provides recommendations for best measures to screen and assess for CRF based on the quality and level of evidence, psychometric strength of the tools, and clinical utility.

Methods:

After a systematic review of the literature, studies evaluating CRF measurement tools were assessed for quality; data extraction included psychometrics …